CN102949545A - Pharmaceutical composition for treating urinary tract infection and preparation method thereof - Google Patents

Abstract

The invention relates to a pharmaceutical composition for treating urinary tract infection and a preparation method thereof. The pharmaceutical composition is prepared from amur corktree bark, oriental waterplantain rhizome, lilac pink herb, dandelion, plantain seed and christina loosestrife according to the traditional Chinese medicine basic theory, has effects of clearing away heat and drying dampness, and inducing diuresis for treating stranguria, can be used for treating frequent micturition, urgent urination and painful urination caused by urinary tract infection caused by downward flow of damp-heat, is used in clinically for many years and has obvious curative effects.

Description

A kind of pharmaceutical composition for the treatment of urinary tract infection and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition for the treatment of urinary tract infection, more specifically say a kind of pharmaceutical composition and preparation method thereof for the treatment of urinary tract infection of the effect with clearing away heat-damp and promoting diuresis, inducing diuresis for treating stranguria syndrome.

Background technology

Urinary tract infection is a kind of comparatively common disease.In the outpatient service first visit, account for 2%～3.8% take urinary tract symptom as main.In lineup group's generaI investigation of China, the incidence rate of urinary tract infection is 2.31%.Material Takeoff according to Europe dialysis and the center of transplanting in patients of chronic renal failure, accounts for 20% by what chronic pyelonephritis caused.The women once suffered from urinary tract infection person within a certain period in all one's life about 10%～20%, and it is about 6% that Symptomatic urinary tract infection person occured in 1 year the adult women, with the married woman of childbearing age for the most common.

Doctor trained in Western medicine is thought, urinary tract infection mainly is to infect the Urinary system inflammation that causes by antibacterial, any pathogenic bacterium are invaded urinary tract all can cause urinary tract infection, but the most common pathogenic bacterium are intestinal gram negative bacilli, wherein bacillus coli is the most common, accounts for 80～90% of acute urinary tract infection, and antibacterial is invaded urinary system can be by up, blood, lymph road and 4 approach of direct extension, more than infection is the most common, and hematogenous infection takes second place.The factor relevant with morbidity also has the urinary tract infraction except bacterium factors, the destruction of VUR, immunoreation, women's predisposing factor, local damage and defense mechanism and organism metabolism are unusual etc.Its main pathology is changed to mucous hyperemia, edema and a large amount of neutrophil infiltration, enters uplink extended and falls ill.

The traditional Chinese medical science thinks that urinary tract infection is stranguria, and its pathogeny is: 1. damp-heat in the urinary bladder: damp-heat accumulation is in bladder, disturbance in functioning of QI, disturbance in water passage; 2. deficiency of spleen and stomach: spleen kidney deficiency worn with age, or because of quench one's thirst, the disease such as edema injures taste, or the reason consumption impairment of the spleen kidney such as overfatigue, or the pyretic stranguria disease prolongs and with the passing of time consumes impairment of QI and impairment of YIN, all can cause deficiency of spleen and stomach, dysfunction of the spleen in transportation, deficiency of QI in middle-JIAO, instability of kidney QI, bladder qi dysfunction; 3. kidney qi loss: with the passing of time gonorrhea injures kidney yin, the deficiency of YIN and damp and hot souvenir, and functioning of bladder is unfavorable.So this sick base therapy rule is heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome.

Medicine of the present invention take " heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome " as the Therapeutic Principle, through systematic study, science compatibility, has been developed a kind of pure Chinese medicinal preparation for the treatment of urinary tract infection take Chinese medical theory as guidance.

Summary of the invention

Purpose of the present invention just provides a kind of pharmaceutical composition for the treatment of urinary tract infection and preparation method thereof, and this pharmaceutical composition has the effect of clearing away heat-damp and promoting diuresis, inducing diuresis for treating stranguria syndrome, and clinical practice is in urinary tract infection such as frequent micturition, urgent micturition, dysureas.This pharmaceutical composition can be prepared into different dosage form for needs of patients in addition, is convenient to take, and is easy to carry.

For achieving the above object, the pharmaceutical composition for the treatment of urinary tract infection provided by the invention is prepared from by the processing of the crude drug of following weight parts:

Cortex Phellodendri 10-20 part Rhizoma Alismatis 10-15 part Herba Dianthi 5-10 part

Herba Taraxaci 10-20 part Herba Plantaginis 8-15 part Herba Lysimachiae 5-10 part.

Preferred plan is prepared from by the processing of the crude drug of following weight parts:

8 parts of 12 portions of Herba Dianthis of 15 portions of Rhizoma Alismatis of Cortex Phellodendri

8 parts of 12 portions of Herba Lysimachiaes of 15 portions of Herba Plantaginiss of Herba Taraxaci.

A kind of pharmaceutical composition for the treatment of urinary tract infection of the present invention can be prepared into capsule, tablet, granule.

Described weight portion can be the weight metering units such as gram, two, jin, kilogram, ton.

Pharmaceutical composition of the present invention can adopt the ingredients of conventional method in will writing out a prescription to carry out in proportion compatibility, makes various clinical applicable dosage forms by existing preparation process, and used ingredients is the Chinese crude drug that commercially available process is up to the standards.

Preparation method of the present invention comprises the steps:

(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;

(2) get the Six-element Chinese medicines such as Cortex Phellodendri, Rhizoma Alismatis, Herba Dianthi, Herba Taraxaci, Herba Plantaginis, Herba Lysimachiae and add 4～6 times of water gagings decoctions 2～4 times, each 2-4 hour, filter, merging filtrate is condensed into the extractum that relative density is 1.15-1.25; Add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying, sterilization, granulation or filled capsules or tabletting get final product.

The preferred version of preparation method of the present invention comprises the steps:

(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;

(2) get the Six-element Chinese medicines such as Cortex Phellodendri, Rhizoma Alismatis, Herba Dianthi, Herba Taraxaci, Herba Plantaginis, Herba Lysimachiae and add 5 times of water gagings and decoct 3 times, each 3 hours, filter, merging filtrate is condensed into relative density and is 1.20 extractum; Add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying, sterilization, granulation or filled capsules or tabletting get final product.

Why the present invention selects above-mentioned medical material as raw material, is because they have following effect:

Cortex Phellodendri: heat clearing and damp drying, pathogenic fire purging is except steaming, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.

Rhizoma Alismatis: diuresis, clearing away damp-heat.Be used for dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.

Herba Dianthi: inducing diuresis for treating stranguria syndrome, removing blood stasis stimulates the menstrual flow.Be used for pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction is drenched the puckery pain of drop, the menstruation apolipsis.

Herba Taraxaci: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

Herba Plantaginis: clearing away heat and promoting diuresis, eliminate the phlegm removing heat from blood, detoxifcation.Be used for the edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.

Herba Lysimachiae: eliminating damp-heat, treating stranguria, detumescence.Be used for pyretic stranguria, the husky pouring urinated and puckeryly had a pain jaundice dark coloured urine, carbuncle furuncle, venom, liver and bile stone, lithangiuria.

Pharmaceutical composition provided by the invention has the effect of clearing away heat-damp and promoting diuresis, inducing diuresis for treating stranguria syndrome, is used for the urinary tract inflammation of frequent micturition that damp invasion of lower energizer causes, urgent micturition, dysurea.

In order to illustrate that medicine of the present invention has significant curative effect to the treatment urinary tract infection, the present invention is through clinical treatment 150 examples, 85 examples of fully recovering, produce effects 4l example, 14 examples that take a turn for the better, invalid 10 examples.Cure rate 56.7%, obvious effective rate 27.3%, improvement rate 9.3%, inefficiency 6.7%.

The specific embodiment

Below with embodiment a kind of pharmaceutical composition for the treatment of urinary tract inflammation of the present invention and preparation method thereof is further described; this will help the present invention and effect thereof are further understood; embodiment does not limit protection scope of the present invention, and its protection domain is decided by claim.

Embodiment 1

Used crude drug is Cortex Phellodendri 100g, Rhizoma Alismatis 100g, Herba Dianthi 50g, Herba Taraxaci 100g, Herba Plantaginis 80g, Herba Lysimachiae 50g in the present embodiment;

Its preparation method is:

Get Cortex Phellodendri, Rhizoma Alismatis, Herba Dianthi, Herba Taraxaci, Herba Plantaginis, Herba Lysimachiae and add 4 times of water gagings and decoct 2 times, each 2 hours, filter, merging filtrate is condensed into relative density and is 1.15 extractum; It is an amount of to add starch, granulate, and drying, sterilization, granulation 500g gets final product.

Embodiment 2

Used crude drug is Cortex Phellodendri 200g, Rhizoma Alismatis 150g, Herba Dianthi 100g, Herba Taraxaci 200g, Herba Plantaginis 150g, Herba Lysimachiae 100g in the present embodiment;

Its preparation method is:

Get Cortex Phellodendri, Rhizoma Alismatis, Herba Dianthi, Herba Taraxaci, Herba Plantaginis, Herba Lysimachiae and add 6 times of water gagings and decoct 4 times, each 4 hours, filter, merging filtrate is condensed into relative density and is 1.25 extractum; It is an amount of to add starch, granulate, and drying, sterilization, granulation is pressed into 1000, gets final product.

Embodiment 3

Used crude drug is Cortex Phellodendri 150g, Rhizoma Alismatis 120g, Herba Dianthi 80g, Herba Taraxaci 150g, Herba Plantaginis 120g, Herba Lysimachiae 80g in the present embodiment;

Its preparation method is:

Get Cortex Phellodendri, Rhizoma Alismatis, Herba Dianthi, Herba Taraxaci, Herba Plantaginis, Herba Lysimachiae and add 5 times of water gagings and decoct 3 times, each 3 hours, filter, merging filtrate is condensed into relative density and is 1.20 extractum; Add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying, sterilization, granulation, filled capsules is made 1000, gets final product.

Claims (5)

1. pharmaceutical composition for the treatment of urinary tract infection is characterized in that being prepared from by the crude drug processing of following weight parts:

Cortex Phellodendri 10-20 part Rhizoma Alismatis 10-15 part Herba Dianthi 5-10 part

Herba Taraxaci 10-20 part Herba Plantaginis 8-15 part Herba Lysimachiae 5-10 part.

2. a kind of pharmaceutical composition for the treatment of urinary tract infection according to claim 1 is characterized in that being prepared from by the crude drug processing of following weight parts:

8 parts of 12 portions of Herba Dianthis of 15 portions of Rhizoma Alismatis of Cortex Phellodendri

8 parts of 12 portions of Herba Lysimachiaes of 15 portions of Herba Plantaginiss of Herba Taraxaci.

3. one of them described a kind of pharmaceutical composition for the treatment of urinary tract infection according to claim 1 and 2 is characterized in that preparation is capsule, tablet, granule.

4. according to claim 1 or 2 one of them described a kind of preparation method that are used for the treatment of the pharmaceutical composition of urinary tract infection, it is characterized in that comprising the steps:

(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;

(2) get the Six-element Chinese medicines such as Cortex Phellodendri, Rhizoma Alismatis, Herba Dianthi, Herba Taraxaci, Herba Plantaginis, Herba Lysimachiae and add 4～6 times of water gagings decoctions 2～4 times, each 2-4 hour, filter, merging filtrate is condensed into the extractum that relative density is 1.15-1.25; Add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying, sterilization, granulation or filled capsules or tabletting get final product.

5. a kind of preparation method for the treatment of the pharmaceutical composition of urinary tract infection according to claim 4 is characterized in that comprising the steps:

(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;

(2) get the Six-element Chinese medicines such as Cortex Phellodendri, Rhizoma Alismatis, Herba Dianthi, Herba Taraxaci, Herba Plantaginis, Herba Lysimachiae and add 5 times of water gagings and decoct 3 times, each 3 hours, filter, merging filtrate is condensed into relative density and is 1.20 extractum; Add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying, sterilization, granulation or filled capsules or tabletting get final product.