CN102947331B - 包含额外的二硫键的胰岛素类似物 - Google Patents

包含额外的二硫键的胰岛素类似物 Download PDF

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Publication number
CN102947331B
CN102947331B CN201180030864.2A CN201180030864A CN102947331B CN 102947331 B CN102947331 B CN 102947331B CN 201180030864 A CN201180030864 A CN 201180030864A CN 102947331 B CN102947331 B CN 102947331B
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China
Prior art keywords
human insulin
insulin
desb30 human
desb30
desb27
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Expired - Fee Related
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CN201180030864.2A
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English (en)
Chinese (zh)
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CN102947331A (zh
Inventor
S.卢德维格森
F.胡巴莱克
T.B.克杰尔德森
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201180030864.2A 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素类似物 Expired - Fee Related CN102947331B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167033 2010-06-23
EP10167033.9 2010-06-23
US35950010P 2010-06-29 2010-06-29
US61/359500 2010-06-29
PCT/EP2011/060382 WO2011161124A1 (en) 2010-06-23 2011-06-21 Insulin analogues containing additional disulfide bonds

Publications (2)

Publication Number Publication Date
CN102947331A CN102947331A (zh) 2013-02-27
CN102947331B true CN102947331B (zh) 2016-08-03

Family

ID=43242459

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180030864.2A Expired - Fee Related CN102947331B (zh) 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素类似物

Country Status (5)

Country Link
US (1) US8815798B2 (cg-RX-API-DMAC7.html)
EP (1) EP2585484A1 (cg-RX-API-DMAC7.html)
JP (1) JP5973427B2 (cg-RX-API-DMAC7.html)
CN (1) CN102947331B (cg-RX-API-DMAC7.html)
WO (1) WO2011161124A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2910570T3 (en) 2008-03-18 2017-01-30 Novo Nordisk As Protease-stabilized acylated insulin analogues.
JP5931857B2 (ja) 2010-06-23 2016-06-08 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン誘導体
WO2012123519A2 (en) * 2011-03-15 2012-09-20 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
US20140357838A1 (en) * 2011-12-21 2014-12-04 Novo Nordisk A/S N-Terminally Modified Insulin Derivatives
MX366636B (es) 2013-10-07 2019-07-17 Novo Nordisk As Nuevo derivado de un análogo de insulina.
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3341403B1 (en) 2015-08-25 2022-01-05 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物
TW201917134A (zh) 2017-08-17 2019-05-01 丹麥商諾佛 儂迪克股份有限公司 新穎的醯基化胰島素類似物及其用途
IL319162A (en) 2019-12-11 2025-04-01 Novo Nordisk As New insulin analogs and their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
IL114160A (en) 1994-06-17 2006-12-31 Novo Nordisk As Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
KR20030004317A (ko) 1999-12-29 2003-01-14 노보 노르디스크 에이/에스 인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
BRPI0413276B8 (pt) 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
AU2004295023A1 (en) 2003-12-03 2005-06-16 Novo Nordisk A/S Single-chain insulin
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
KR101729986B1 (ko) 2006-09-22 2017-04-25 노보 노르디스크 에이/에스 프로테아제 내성 인슐린 유사체
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
WO2009112583A2 (en) * 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
WO2011028813A2 (en) * 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Improved insulin stability through amino acid substitution;Brems D N等;《Protein Engineering》;19920901;第5卷(第6期);全文 *
Insulin structure and stablility;Brange J等;《pharmaceutical biotechnology》;19930101;第5卷;全文 *

Also Published As

Publication number Publication date
US20130172247A1 (en) 2013-07-04
WO2011161124A1 (en) 2011-12-29
JP5973427B2 (ja) 2016-08-23
JP2013530702A (ja) 2013-08-01
CN102947331A (zh) 2013-02-27
US8815798B2 (en) 2014-08-26
EP2585484A1 (en) 2013-05-01

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Granted publication date: 20160803

Termination date: 20190621