CN102940713A - Health care oral liquid for gastric ulcer and preparation method of health care oral liquid - Google Patents

Abstract

The invention discloses a health care oral liquid for gastric ulcer and a preparation method of the health care oral liquid. The health care oral liquid comprises raw materials of, by weight, 3 parts of fructus evodiae fruits, 30 parts of pilose asiabell roots, 15 parts of coptidis rhizome, 15 parts of Indian bread, 15 parts of medicated leaven, 10 parts of dried tangerine peels, 5 parts of liquorice roots and 2 parts of passion fruits. The health care oral liquid for the gastric ulcer has a deep cleaning mechanism and is capable of penetrating into the most subtle parts of intestines and stomach, absorbing harmful substances in the body through active genes of the oral liquid and thoroughly discharging the harmful substances, so that flora constitutions in intestinal canal can be improved, the shielding effect of protecting intestines and stomach from absorbing the harmful substances is achieved, and effects of tonifying the spleen, soothing the liver, calming the adverse-rising energy and preventing vomiting can be achieved. The health care oral liquid is used for treating gastric ulcer and the like and has the advantages of being small in taking dosage, convenient to take, rapid in absorption, high in bioavailability, convenient to carry, accurate in quantification, stable in quality and simple in production process.

Description

A kind of healthcare dietetic liquid for gastric ulcer and preparation method thereof

Technical field

The invention belongs to Chinese medicine health-care medicine technical field, particularly a kind of healthcare dietetic liquid for gastric ulcer and preparation method thereof.

Background technology

Peptic ulcer refers to the tissue injury that surpasses muscular layer of mucosa that gastrointestinal mucosa is caused by peptic digestion liquid autodigestion, can betide gastral any position, wherein common with stomach and duodenum, be gastric ulcer and duodenal ulcer, its cause of disease, clinical symptoms and Therapeutic Method basic simlarity are clarified a diagnosis main by gastroscopy.Gastric ulcer is modal a kind of in the peptic ulcer, mainly refers to the tissue injury that surpasses muscular layer of mucosa that gastric mucosa is caused by peptic digestion liquid autodigestion.

Gastric ulcer is one of commonly encountered diseases in the population of China, frequently-occurring disease.As the common type in the peptic ulcer, the geographical distribution of gastric ulcer roughly has the north trend that south raises, and is apt to occur in the larger winter and spring of climate change.In addition, male's sickness rate is apparently higher than the women, may be irregular with smoking, life and diet, work and ambient pressure and psychologic factors be closely related.In recent years, the sickness rate of gastric ulcer begins on a declining curve, yet it still belongs to one of modal disease in the digestive system disease.Its occur mainly with the damage factor of gastroduodenal mucosa and mucosa self-defense reparation factor between loss of equilibrium relevant.Helicobacter pylori (H. pylori) infection, NSAID (non-steroidal anti-inflammatory drug) (NSAID is such as aspirin), gastric acid secretion be the commonly encountered diseases that causes ulcer unusually because of.Typical ulcer pain has the characteristics of chronicity, periodicity and rhythmicity.Wherein, gastric ulcer is apt to occur at stomach angle and gastric antrum little curved more, is more common in Elderly male patient, and its morbidity has certain relation with seasonal variations.

The gastric ulcer symptom often is not true to type and can shows as upper abdominal pain and epigastric discomfort etc.The overwhelming majority people various dyspeptic symptoms can appear, but have also without any symptom, until develop complications.That its common complication mainly contains is hemorrhage, perforation, pyloric obstruction, canceration.Common gastrointestinal symptom and General Symptoms mainly contain burn feeling behind belch, acid regurgitation, big belly, the breastbone, feel sick, vomiting, poor appetite etc.Burn feeling is because cardiochalasia is felt sick, vomitted many reflection ulcer and may point out ulcer to be in active stage behind acid regurgitation and the breastbone.Frequent vomiting dyspepsia, the prompting pyloric obstruction.Some patients were has autonomic nervous dysfunction's symptoms such as insomnia, hyperhidrosis.The Chinese medicine preparation of the existing treatment gastric ulcer of existing market.The difficulty of taking medicine reaches the effective blood drug concentration time long, carries inconvenience, and dosage is large, and medicining times is many, and the time is long.

Summary of the invention

The purpose of this invention is to provide a kind of healthcare dietetic liquid for gastric ulcer and preparation method thereof; has degree of depth cleaning mechanism; go deep into the trickleest part of the intestines and stomach; by harmful substance in its active gene absorber with its thorough discharge; and the flora that can improve in the intestinal consists of; play the screen-wall effect that the protection the intestines and stomach is not absorbed with harmful substances, invigorating the spleen and relieving depression of liver-QI, the effect of stopping nausea and vomiting by lowering the adverse flow of QI.Be used for the diseases such as gastric ulcer.And taking dose is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, steady quality.

Technical scheme of the present invention is: design a kind of healthcare dietetic liquid for gastric ulcer, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 3 parts of Fructus Evodiaes, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Coptidis, 15 parts in Poria, 15 parts of Massa Medicata Fermentata, 10 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae, 2 parts of Passifolra edulis.

The preparation method of described a kind of healthcare dietetic liquid for gastric ulcer is characterized in that it may further comprise the steps:

1) takes by weighing raw material by following weight ratio: 3 parts of Fructus Evodiaes, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Coptidis, 15 parts in Poria, 15 parts of Massa Medicata Fermentata, 10 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae; 2 parts of Passifolra edulis;

2) deserve to be called the raw material of stating weight portion, add 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that the filtrate temperature is concentrated into relative density at 45-50 ℃;

3) ethanol is added above-mentioned clear paste and makes and contain alcohol amount and reach 60%, temperature 45-50 ℃ static, precipitate 48 hours, filtration, Recycled ethanol;

4) add that to account for gross weight be 0.5% active carbon, heat filtration 30 minutes;

5) add that to account for gross weight be 1% stevioside, taste masking;

6) adding distil water filters to total amount, packing, and sterilization gets final product.

Advantage of the present invention is: drug regimen involved in the present invention has invigorating the spleen and relieving depression of liver-QI, the effect of stopping nausea and vomiting by lowering the adverse flow of QI.Monarch drug Fructus Evodiae dispersing cold for relieving pain among the we wherein, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be used for headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.Radix Codonopsis has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc." Bencao Congxin " record: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than the middle feeble QI, mend in order to transfer, very smooth and proper ".The Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.Be used for conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.The Massa Medicata Fermentata invigorating the spleen and regulating the stomach is in the accent that helps digestion.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending. and Passifolra edulis can suppress harmful microorganism in gastral growth, the two has special elimination effect in conjunction with the alimentation function of getting rid of vivotoxin, whole intestinal stomach invigorating, improving body is had remarkable effect to colitis, gastroenteritis, hemorrhoid.Chinese medicine composition oral liquid taking dose of the present invention is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, steady quality.

The specific embodiment

The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.

Embodiment 1

A kind of healthcare dietetic liquid for gastric ulcer adopts following steps to make:

1) takes by weighing raw material by following weight ratio: 3 parts of Fructus Evodiaes, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Coptidis, 15 parts in Poria, 15 parts of Massa Medicata Fermentata, 10 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae; 2 parts of Passifolra edulis;

2) deserve to be called the raw material of stating weight portion, add 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that the filtrate temperature is concentrated into relative density at 45-50 ℃;

3) ethanol is added above-mentioned clear paste and makes and contain alcohol amount and reach 60%, temperature 45-50 ℃ static, precipitate 48 hours, filtration, Recycled ethanol;

4) add that to account for gross weight be 0.5% active carbon, heat filtration 30 minutes;

5) add that to account for gross weight be 1% stevioside, taste masking;

6) adding distil water filters to total amount, packing, and sterilization gets final product.

This clinical observation for the treatment of gastric ulcer for the healthcare dietetic liquid of gastric ulcer of the embodiment of the invention:

1 data and method

1.1 physical data

Select peptic gastric ulcer patient's 100 examples receive treatment voluntarily, male 40 examples, women 60 examples, age 25-65 year.All patients turn out to be gastric ulcer or duodenal ulcer through gastroscope in 1 week. and the ulcer size is between 3～20mm, and the ulcer number is no more than 2.During treating, must not take other drug.Be divided at random treatment group 1, treatment group 2, treatment group 3, matched group, every group of 25 examples; Each is organized the patient age symptom and consists of without significant difference.Has comparability (P〉0.05).

1.2 Therapeutic Method

The treatment group Primary Care is consistent, and matched group is not taken medicine.The treatment group 1 usefulness embodiment of the invention 1, every day three times, one time 1,30 is a course for the treatment of.Treatment group 2 is used Kuiyangning Capsules, and Tianjin Hong Rentang Pharmaceutical is produced, and each 3, swallows before sleeping; Treatment group 3 is used yangweishu capsules, and the refreshing Radix et rhizoma smilacinae japonicae in Hefei is already produced, and each 2, every day 3 times.

2 results

2.1 curative effect determinate standard

By People's Republic of China's Chinese medicine industry standard " disease of tcm Standardization of diagnosis and curative effect ".The ulcer kitchen range disappears or focus transfers cicatricial phase to by active stage, and gastralgia and other transference cures are produce effects; The ulcer kitchen range transfers healing stage to by active stage, and ulcer area dwindles 〉=and 50%, gastralgia and other sx↓s are effective; Unchanged or the ulcer area of ulcer kitchen range dwindles＜and 50%, symptom is invalid without being improved as.2.2 therapeutic outcome

?	Produce effects	Effectively	Invalid	Effective percentage
					Matched group	0	0	25	0%
Treatment group 1	15	9	1	96%
					Treatment group 2	10	13	2	92%
Treatment group 3	11	11	3	88%

3 discuss

The peptic ulcer prevalence is up to 5%～10%, serious harm people's health.It is the main factor that produces Peptic Ulcers that western medicine thinks that gastric acid is too high, mucosa protection weakens with helicobacter pylori infections etc.And Chinese medicine thinks that primary disease belongs to gastric abscess, vomiting, stomach painful abdominal mass category.Its morbidity is many by the diseases caused by exogenous pathogenic factor six climate exopathogens, internal injury caused by excess of seven emotions, and taste are become estranged, the mechanism of qi retardance; Or eating and drinking without temperance, irregular diet, overstrain, taste are impaired, and mechanism of qi is become estranged or deficiency-cold in middle-JIAO loses in replenishing vital QI with drugs of warm nature; Deficiency of stomach-Yin is lost due to make moist.Clinical syndrome differentiation is executed cards such as controlling common hyperactive liver-QI attacking the stomach, syndrome of liver-stomach heat, obstruction of collaterals by blood stasis, Deficiency and coldness of spleen and stomach, deficiency of stomach-Yin.So control wanting of pain, but examine the true heresy of its fruit, all work as to regulate the flow of vital energy as main.Adopt Chinese medicine to import administration, invigorating the spleen and relieving depression of liver-QI, stopping nausea and vomiting by lowering the adverse flow of QI reaches the healing purpose.And then illustrate that embodiment 1 affiliated prescription is reliably effective in this invention.

Claims (2)

1. a healthcare dietetic liquid that is used for gastric ulcer is characterized in that crude drug composition and weight proportion thereof that it contains are: 3 parts of Fructus Evodiaes, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Coptidis, 15 parts in Poria, 15 parts of Massa Medicata Fermentata, 10 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae, 2 parts of Passifolra edulis.

2. the preparation method of a kind of healthcare dietetic liquid for gastric ulcer according to claim 1 is characterized in that it may further comprise the steps:

1) takes by weighing raw material by following weight ratio: 3 parts of Fructus Evodiaes, 30 parts of Radix Codonopsis, 15 parts of Rhizoma Coptidis, 15 parts in Poria, 15 parts of Massa Medicata Fermentata, 10 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae; 2 parts of Passifolra edulis;

2) deserve to be called the raw material of stating weight portion, add 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that the filtrate temperature is concentrated into relative density at 45-50 ℃;

3) ethanol is added above-mentioned clear paste and makes and contain alcohol amount and reach 60%, temperature 45-50 ℃ static, precipitate 48 hours, filtration, Recycled ethanol;

4) add that to account for gross weight be 0.5% active carbon, heat filtration 30 minutes;

5) add that to account for gross weight be 1% stevioside, taste masking;

6) adding distil water filters to total amount, packing, and sterilization gets final product.