CN102940495B - High sensitivity near-infrared tissue blood oxygen detection sensor probe - Google Patents
High sensitivity near-infrared tissue blood oxygen detection sensor probe Download PDFInfo
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- CN102940495B CN102940495B CN201210487036.8A CN201210487036A CN102940495B CN 102940495 B CN102940495 B CN 102940495B CN 201210487036 A CN201210487036 A CN 201210487036A CN 102940495 B CN102940495 B CN 102940495B
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- tube
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- light sensitive
- blood oxygen
- high sensitivity
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 239000008280 blood Substances 0.000 title claims abstract description 18
- 210000004369 blood Anatomy 0.000 title claims abstract description 18
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 18
- 239000001301 oxygen Substances 0.000 title claims abstract description 18
- 239000000523 sample Substances 0.000 title claims abstract description 17
- 230000035945 sensitivity Effects 0.000 title claims abstract description 15
- 238000001514 detection method Methods 0.000 title abstract description 5
- 239000000758 substrate Substances 0.000 claims abstract description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000741 silica gel Substances 0.000 claims description 8
- 229910002027 silica gel Inorganic materials 0.000 claims description 8
- 229960001866 silicon dioxide Drugs 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 5
- 239000008393 encapsulating agent Substances 0.000 claims description 3
- 238000005259 measurement Methods 0.000 abstract description 5
- 238000005286 illumination Methods 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 2
- 238000009434 installation Methods 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000003566 sealing material Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 12
- 230000000287 tissue oxygenation Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000002496 oximetry Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a high sensitivity near-infrared tissue blood oxygen detection sensor probe. A main luminescent tube, a first auxiliary luminescent tube, a second auxiliary luminescent tube, a near-end light sensitive tube and a far-end light sensitive tube which are located on the same straight line are fixed on a non-transparent soft substrate, a transparence window is engraved on a sealing material which is located right above the positions of the main luminescent tube, the near-end light sensitive tube and the far-end light sensitive tube, the adjacent near-end light sensitive tube and the far-end light sensitive tube are irradiated through the first auxiliary luminescent tube and the second auxiliary luminescent tube respectively, and the defect that the near-end light sensitive tube and the far-end light sensitive tube are poor in nonlinearity and responsivity under the extremely weak illumination condition can be effectively overcome. According to the high sensitivity near-infrared tissue blood oxygen detection sensor probe, characteristic parameters of the main luminescent tube and the two light sensitive tubes memorized by a memory device and distance between the main luminescent tube and the light sensitive tubes are utilized, so that the problem that the measurement accuracy is affected caused by element parameter dispersity and errors of element installation positions in the production process is effectively solved, and automatic calibration of the probe of the tissue blood oxygen detection sensor is achieved.
Description
Technical field
The present invention relates to a kind of medical treatment and detect apparatus, particularly a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe.
Technical background
Near infrared spectrum (NIRS) technology can be used for human body tissue oxygenation situation, wavelength can penetrate the tissue of certain depth at the near infrared light of 650～950nm, by placing detector by near infrared light tissue with in the place of several centimetres of distances, the intensity of illumination of reflection subcutaneous tissue molecular concentration can be detected, thereby the noinvasive that can be used for tissue blood oxygen situation is monitored continuously.These wavelength belong to Non-ionizing radiation, under normally used low power density, can not damage biological tissue, are a kind of safe and practical clinical noinvasive detection techniques.Because tissue has high scattering properties, the optical signal that the detector of placing in the place apart from incident illumination number centimetre detects is often very faint, has a strong impact on certainty of measurement.
Summary of the invention
In order to overcome the defect existing in above-mentioned prior art, the object of the present invention is to provide a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe, realize that fast response time, certainty of measurement are high, the tissue Oximetry of good stability.
For reaching above object, technical scheme of the present invention is:
A kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe is fixed three luminous tubes, two photosensitive tubes and a memory device 6 on opaque soft substrate, all with medical silica-gel, seals; One of them luminous tube is that the light emitting diode of integrated two kinds of wavelength is called main light emission pipe 1, and another two luminous tubes are common light emitting diode, is called the first auxiliary luminous tube 4 and the second auxiliary luminous tube 5; Two photosensitive tubes are different from the distance of main light emission pipe 1, and the photosensitive tube of near distance is called near-end photosensitive tube 2, and the photosensitive tube of distance is called far-end photosensitive tube 3; The auxiliary luminous tube 5 of the auxiliary luminous tube 4, second of main light emission pipe 1, the first, near-end photosensitive tube 2 and far-end photosensitive tube 3 are located on the same line, and on the encapsulant directly over the position of main light emission pipe 1, near-end photosensitive tube 2 and far-end photosensitive tube 3, engrave transparent window.
Main light emission pipe 1 is a with the distance of near-end photosensitive tube 2, and main light emission pipe 1 is b with the distance of far-end photosensitive tube 3, and wherein a is not less than 20mm, and b is not less than 30mm, and b-a is not more than 10mm.
The first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 are close to respectively near-end photosensitive tube 2 and far-end photosensitive tube 3, and auxiliary luminous tube is less than 5mm with the photosensitive tube distance of facing mutually.
Two centre wavelengths of described main light emission pipe 1 are respectively
with
wherein
wave-length coverage is 650～805nm,
wave-length coverage is 850～950nm,
be not less than 50nm.
The first described auxiliary luminous tube 4 and the wave-length coverage of the second auxiliary luminous tube 5 are 650nm～950nm.
Described opaque soft backing material is medical silica-gel.
Effect of the present invention is: the tissue oxygenation detecting sensor realizing with the present invention has that fast response time, precision are high, the feature of good stability.By the first auxiliary luminous tube 4, irradiate respectively with the second auxiliary luminous tube 5 near-end photosensitive tube 2 and the far-end photosensitive tube 3 facing mutually, can effectively overcome the low shortcoming of non-linear and responsiveness that near-end photosensitive tube 2 and far-end photosensitive tube 3 exist under atomic weak light conditions.Utilize the main light emission pipe 1 of memory device 6 preservations and the characteristic parameter of two photosensitive tubes 2,3, and distance a and the b of main light emission pipe 1 and near-end photosensitive tube 2 and far-end photosensitive tube 3, can effectively overcome in process of production due to the parameters decentralization of components and parts and a difficult problem for components and parts installation position error effect certainty of measurement, realize the auto-scaling of tissue oxygenation detecting sensor probe.When the present invention detects for tissue blood oxygen, can effectively improve the certainty of measurement of tissue oxygenation.
Accompanying drawing explanation
Accompanying drawing is sensor construction schematic diagram of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, structural principle of the present invention and operation principle are described in detail.
With reference to accompanying drawing, a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe is fixed three luminous tubes, two photosensitive tubes and a memory device 6 on opaque soft substrate, all with medical silica-gel, seals; One of them luminous tube is that the light emitting diode of integrated two kinds of wavelength is called main light emission pipe 1, and another two luminous tubes are common light emitting diode, is called the first auxiliary luminous tube 4 and the second auxiliary luminous tube 5; Two photosensitive tubes are different from the distance of main light emission pipe 1, and the photosensitive tube of near distance is called near-end photosensitive tube 2, and the photosensitive tube of distance is called far-end photosensitive tube 3; The auxiliary luminous tube 5 of the auxiliary luminous tube 4, second of main light emission pipe 1, the first, near-end photosensitive tube 2 and far-end photosensitive tube 3 are located on the same line, and on the encapsulant directly over the position of main light emission pipe 1, near-end photosensitive tube 2 and far-end photosensitive tube 3, engrave transparent window.
Main light emission pipe 1 is a with the distance of near-end photosensitive tube 2, and main light emission pipe 1 is b with the distance of far-end photosensitive tube 3, and wherein a is not less than 20mm, and b is not less than 30mm, and b-a is not more than 10mm.
The first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 are close to respectively near-end photosensitive tube 2 and far-end photosensitive tube 3, and auxiliary luminous tube is less than 5mm with the photosensitive tube distance of facing mutually.
Two centre wavelengths of described main light emission pipe 1 are respectively
with
wherein
wave-length coverage is 650～805nm,
wave-length coverage is 850～950nm,
be not less than 50nm.
The first described auxiliary luminous tube 4 and the wave-length coverage of the second auxiliary luminous tube 5 are 650nm～950nm, can be identical wavelength, can be also different wave lengths.
Described opaque soft backing material is medical silica-gel.
Operation principle of the present invention is:
By the first auxiliary luminous tube 4, irradiate respectively with the second auxiliary luminous tube 5 near-end photosensitive tube 2 and the far-end photosensitive tube 3 facing mutually, background light intensity while increasing near-end photosensitive tube 2 and 3 work of far-end photosensitive tube, overcomes the low shortcoming of non-linear and responsiveness that near-end photosensitive tube 2 and far-end photosensitive tube 3 exist under atomic weak light conditions.The light intensity of the first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 meets when main light emission pipe 1 is not luminous, the output signal of two photosensitive tubes 2,3 full scale 1/10 ~ 1/5 between; Memory device 6 is for storing wavelength value, the luminous efficiency of main light emission pipe 1, the sensitivity of near-end photosensitive tube 2 and far-end photosensitive tube 3, the linearity, light transfer characteristic, and distance a and the b of main light emission pipe 1 and near-end photosensitive tube 2 and far-end photosensitive tube 3, utilize memory device 6 stored informations to realize the auto-scaling of tissue oxygenation detecting sensor probe.
Embodiment mono-
Develop a kind of bedside detecting blood and oxygen in human brain instrument for neonate monitoring, the centre wavelength of main light emission pipe 1 is 735nm and 850nm, the first auxiliary luminous tube 4 is selected identical wavelength with the second auxiliary luminous tube 5, its value is 850nm, near-end photosensitive tube 2 and far-end photosensitive tube 3 are selected OPT101, and memory device 6 is selected serial Flash chip.The distance a=30mm of main light emission pipe 1 and near-end photosensitive tube 2, the distance b=40mm of main light emission pipe 1 and far-end photosensitive tube 3, backing material is medical silica-gel, its thickness is 1mm.On medical silica-gel substrate, directly over the position of corresponding main light emission pipe 1 and two photosensitive tubes, engrave 66mm
2transparent window.
In the present invention, memory device 6 can be placed on backing material, also can be placed in the lead-in wire being connected with sensor.
Claims (6)
1. high sensitivity near infrared tissue blood oxygen detecting sensor probe, is characterized in that, fixes three luminous tubes, two photosensitive tubes and a memory device (6) on opaque soft substrate, all with medical silica-gel, seals; One of them luminous tube is that the light emitting diode of integrated two kinds of wavelength is called main light emission pipe (1), and another two luminous tubes are common light emitting diode, is called the first auxiliary luminous tube (4) and the second auxiliary luminous tube (5); Two photosensitive tubes are different from the distance of main light emission pipe (1), and the photosensitive tube of near distance is called near-end photosensitive tube (2), and the photosensitive tube of distance is called far-end photosensitive tube (3); Main light emission pipe (1), the first auxiliary luminous tube (4), the second auxiliary luminous tube (5) near-end photosensitive tube (2) and far-end photosensitive tube (3) are located on the same line, and on the encapsulant directly over the position of main light emission pipe (1), near-end photosensitive tube (2) and far-end photosensitive tube (3), engrave transparent window.
2. according to a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe described in claims 1, it is characterized in that, main light emission pipe (1) is a with the distance of near-end photosensitive tube (2), main light emission pipe (1) is b with the distance of far-end photosensitive tube (3), wherein a is not less than 20mm, b is not less than 30mm, and b-a is not more than 10mm.
3. according to a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe described in claims 1, it is characterized in that, the first auxiliary luminous tube (4) and the second auxiliary luminous tube (5) are close to respectively near-end photosensitive tube (2) and far-end photosensitive tube (3), and auxiliary luminous tube is less than 5mm with the photosensitive tube distance of facing mutually.
4. according to a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe described in claims 1, it is characterized in that, two centre wavelengths of described main light emission pipe (1) are respectively λ 1 and λ 2, wherein λ 1 wave-length coverage is 650～805nm, λ 2 wave-length coverages are 850～950nm, and λ 2-λ 1 is not less than 50nm.
5. according to a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe described in claims 1, it is characterized in that, the first described auxiliary luminous tube (4) and the wave-length coverage of the second auxiliary luminous tube (5) are 650nm～950nm.
6. according to a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe described in claims 1, it is characterized in that, described opaque soft backing material is medical silica-gel.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210487036.8A CN102940495B (en) | 2012-11-26 | 2012-11-26 | High sensitivity near-infrared tissue blood oxygen detection sensor probe |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210487036.8A CN102940495B (en) | 2012-11-26 | 2012-11-26 | High sensitivity near-infrared tissue blood oxygen detection sensor probe |
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| CN102940495A CN102940495A (en) | 2013-02-27 |
| CN102940495B true CN102940495B (en) | 2014-04-23 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10215698B2 (en) * | 2014-09-02 | 2019-02-26 | Apple Inc. | Multiple light paths architecture and obscuration methods for signal and perfusion index optimization |
| CN104990038A (en) * | 2015-07-14 | 2015-10-21 | 广州光微健康科技有限公司 | Multi-wavelength light source |
| CN105266773B (en) * | 2015-11-04 | 2018-07-27 | 上海箩箕技术有限公司 | Pulse wave sensor and wearable electronic |
| CN108498074B (en) * | 2018-01-24 | 2019-01-29 | 西安交通大学 | The more light intensity near infrared light measurement methods of long-time micro energy lose |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5632273A (en) * | 1994-02-04 | 1997-05-27 | Hamamatsu Photonics K.K. | Method and means for measurement of biochemical components |
| CN1331953A (en) * | 2001-08-03 | 2002-01-23 | 天津大学 | Blood oxygen detecting sensor for newborn baby |
| CN1544919A (en) * | 2003-11-14 | 2004-11-10 | 清华大学 | Method for detecting newborn baby partial tissue oxygen saturation under oxygen absorption stimulation |
-
2012
- 2012-11-26 CN CN201210487036.8A patent/CN102940495B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5632273A (en) * | 1994-02-04 | 1997-05-27 | Hamamatsu Photonics K.K. | Method and means for measurement of biochemical components |
| CN1331953A (en) * | 2001-08-03 | 2002-01-23 | 天津大学 | Blood oxygen detecting sensor for newborn baby |
| CN1544919A (en) * | 2003-11-14 | 2004-11-10 | 清华大学 | Method for detecting newborn baby partial tissue oxygen saturation under oxygen absorption stimulation |
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