CN102940495A - High sensitivity near-infrared tissue blood oxygen detection sensor probe - Google Patents
High sensitivity near-infrared tissue blood oxygen detection sensor probe Download PDFInfo
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- CN102940495A CN102940495A CN2012104870368A CN201210487036A CN102940495A CN 102940495 A CN102940495 A CN 102940495A CN 2012104870368 A CN2012104870368 A CN 2012104870368A CN 201210487036 A CN201210487036 A CN 201210487036A CN 102940495 A CN102940495 A CN 102940495A
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Abstract
The invention discloses a high sensitivity near-infrared tissue blood oxygen detection sensor probe. A main luminescent tube, a first auxiliary luminescent tube, a second auxiliary luminescent tube, a near-end light sensitive tube and a far-end light sensitive tube which are located on the same straight line are fixed on a non-transparent soft substrate, a transparence window is engraved on a sealing material which is located right above the positions of the main luminescent tube, the near-end light sensitive tube and the far-end light sensitive tube, the adjacent near-end light sensitive tube and the far-end light sensitive tube are irradiated through the first auxiliary luminescent tube and the second auxiliary luminescent tube respectively, and the defect that the near-end light sensitive tube and the far-end light sensitive tube are poor in nonlinearity and responsivity under the extremely weak illumination condition can be effectively overcome. According to the high sensitivity near-infrared tissue blood oxygen detection sensor probe, characteristic parameters of the main luminescent tube and the two light sensitive tubes memorized by a memory device and distance between the main luminescent tube and the light sensitive tubes are utilized, so that the problem that the measurement accuracy is affected caused by element parameter dispersity and errors of element installation positions in the production process is effectively solved, and automatic calibration of the probe of the tissue blood oxygen detection sensor is achieved.
Description
Technical field
The present invention relates to a kind of medical treatment and detect apparatus, particularly a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe.
Technical background
Near infrared spectrum (NIRS) technology can be used for human body tissue oxygenation situation, wavelength can penetrate the tissue of certain depth at the near infrared light of 650～950nm, by placing detector with the near infrared light tissue with in the place of several centimetres of distances, can detect the intensity of illumination of reflection subcutaneous tissue molecular concentration, thereby can be used for the noinvasive continuous monitoring of tissue blood oxygen situation.These wavelength belong to Non-ionizing radiation, can not damage biological tissue under normally used low power density, are a kind of safe and practical clinical noinvasive detection techniques.Because tissue has high scattering properties, the optical signal that the detector of placing in the place of distance incident illumination number centimetre detects is often very faint, has a strong impact on certainty of measurement.
Summary of the invention
In order to overcome the defective that exists in the above-mentioned prior art, the object of the present invention is to provide a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe, realize the tissue Oximetry of fast response time, certainty of measurement height, good stability.
For reaching above purpose, technical scheme of the present invention is:
A kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe is fixed three luminous tubes, two photosensitive tubes and a memory device 6 at opaque soft substrate, all seals with medical silica-gel; One of them luminous tube is that the light emitting diode of integrated two kinds of wavelength is called main light emission pipe 1, and two luminous tubes are common light emitting diode in addition, are called the first auxiliary luminous tube 4 and the second auxiliary luminous tube 5; Two photosensitive tubes are different from the distance of main light emission pipe 1, and the photosensitive tube of near distance is called near-end photosensitive tube 2, and the photosensitive tube of distance is called far-end photosensitive tube 3; Main light emission pipe 1, the first auxiliary luminous tube 4, the second auxiliary luminous tube 5, near-end photosensitive tube 2 and far-end photosensitive tube 3 are located on the same line, and the encapsulant directly over the position of main light emission pipe 1, near-end photosensitive tube 2 and far-end photosensitive tube 3 engraves transparent window.
Main light emission pipe 1 is a with the distance of near-end photosensitive tube 2, and main light emission pipe 1 is b with the distance of far-end photosensitive tube 3, and wherein a is not less than 20mm, and b is not less than 30mm, and b-a is not more than 10mm.
The first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 are close to respectively near-end photosensitive tube 2 and far-end photosensitive tube 3, and auxiliary luminous tube and the photosensitive tube that faces mutually distance are less than 5mm.
Two centre wavelengths of described main light emission pipe 1 are respectively
With
Wherein
Wave-length coverage is 650～805nm,
Wave-length coverage is 850～950nm,
Be not less than 50nm.
The wave-length coverage of the described first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 is 650nm～950nm.
Described opaque soft backing material is medical silica-gel.
Effect of the present invention is: the tissue oxygenation detecting sensor that realizes with the present invention has the characteristics of fast response time, precision height, good stability.Shine respectively near-end photosensitive tube 2 and the far-end photosensitive tube 3 that faces mutually by the first auxiliary luminous tube 4 with the second auxiliary luminous tube 5, can effectively overcome near-end photosensitive tube 2 and far-end photosensitive tube 3 and shine the low shortcoming of non-linear and responsiveness that exists in the situation at the atomic low light level.Utilize main light emission pipe 1 that memory device 6 preserves and two photosensitive tubes 2,3 characteristic parameter, and main light emission pipe 1 and near-end photosensitive tube 2 and far-end photosensitive tube 3 apart from a and b, can effectively overcome in process of production because the parameters decentralization of components and parts and the difficult problem of components and parts installation position error effect certainty of measurement realize the auto-scaling that the tissue oxygenation detecting sensor is popped one's head in.When the present invention is used for the detection of tissue blood oxygen, but the certainty of measurement of Effective Raise tissue oxygenation.
Description of drawings
Accompanying drawing is sensor construction sketch map of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing structural principle of the present invention and operation principle are described in detail.
With reference to accompanying drawing, a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe is fixed three luminous tubes, two photosensitive tubes and a memory device 6 at opaque soft substrate, all seals with medical silica-gel; One of them luminous tube is that the light emitting diode of integrated two kinds of wavelength is called main light emission pipe 1, and two luminous tubes are common light emitting diode in addition, are called the first auxiliary luminous tube 4 and the second auxiliary luminous tube 5; Two photosensitive tubes are different from the distance of main light emission pipe 1, and the photosensitive tube of near distance is called near-end photosensitive tube 2, and the photosensitive tube of distance is called far-end photosensitive tube 3; Main light emission pipe 1, the first auxiliary luminous tube 4, the second auxiliary luminous tube 5, near-end photosensitive tube 2 and far-end photosensitive tube 3 are located on the same line, and the encapsulant directly over the position of main light emission pipe 1, near-end photosensitive tube 2 and far-end photosensitive tube 3 engraves transparent window.
Main light emission pipe 1 is a with the distance of near-end photosensitive tube 2, and main light emission pipe 1 is b with the distance of far-end photosensitive tube 3, and wherein a is not less than 20mm, and b is not less than 30mm, and b-a is not more than 10mm.
The first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 are close to respectively near-end photosensitive tube 2 and far-end photosensitive tube 3, and auxiliary luminous tube and the photosensitive tube that faces mutually distance are less than 5mm.
Two centre wavelengths of described main light emission pipe 1 are respectively
With
Wherein
Wave-length coverage is 650～805nm,
Wave-length coverage is 850～950nm,
Be not less than 50nm.
The wave-length coverage of the described first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 is 650nm～950nm, can be identical wavelength, also can be different wave length.
Described opaque soft backing material is medical silica-gel.
Operation principle of the present invention is:
Shine respectively near-end photosensitive tube 2 and the far-end photosensitive tube 3 that faces mutually by the first auxiliary luminous tube 4 with the second auxiliary luminous tube 5, background light intensity when increasing near-end photosensitive tube 2 and 3 work of far-end photosensitive tube overcomes near-end photosensitive tube 2 and far-end photosensitive tube 3 and shines the low shortcoming of non-linear and responsiveness that exists in the situation at the atomic low light level.The light intensity of the first auxiliary luminous tube 4 and the second auxiliary luminous tube 5 satisfies when main light emission pipe 1 is not luminous, two photosensitive tubes 2,3 output signal full scale 1/10 ~ 1/5 between; Memory device 6 is used for wavelength value, the luminous efficiency of storage main light emission pipe 1, the sensitivity of near-end photosensitive tube 2 and far-end photosensitive tube 3, the linearity, light transfer characteristic, and main light emission pipe 1 and near-end photosensitive tube 2 and far-end photosensitive tube 3 apart from a and b, utilize memory device 6 stored informations to realize the auto-scaling of tissue oxygenation detecting sensor probe.
Embodiment one
Develop a kind of bedside detecting blood and oxygen in human brain instrument for the neonate monitoring, the centre wavelength of main light emission pipe 1 is 735nm and 850nm, the first auxiliary luminous tube 4 is selected identical wavelength with the second auxiliary luminous tube 5, its value is 850nm, near-end photosensitive tube 2 and far-end photosensitive tube 3 are selected OPT101, and memory device 6 is selected the serial Flash chip.Main light emission pipe 1 and near-end photosensitive tube 2 apart from a=30mm, the distance b=40mm of main light emission pipe 1 and far-end photosensitive tube 3, backing material is medical silica-gel, its thickness is 1mm.On the medical silica-gel substrate, engrave 66mm directly over the position of corresponding main light emission pipe 1 and two photosensitive tubes
2Transparent window.
Claims (6)
1. high sensitivity near infrared tissue blood oxygen detecting sensor probe is characterized in that, fixes three luminous tubes, two photosensitive tubes and a memory device (6) at opaque soft substrate, all seals with medical silica-gel; One of them luminous tube is that the light emitting diode of integrated two kinds of wavelength is called main light emission pipe (1), and two luminous tubes are common light emitting diode in addition, are called the first auxiliary luminous tube (4) and the second auxiliary luminous tube (5); Two photosensitive tubes are different from the distance of main light emission pipe (1), and the photosensitive tube of near distance is called near-end photosensitive tube (2), and the photosensitive tube of distance is called far-end photosensitive tube (3); Main light emission pipe (1), the first auxiliary luminous tube (4), the second auxiliary luminous tube (5) near-end photosensitive tube (2) and far-end photosensitive tube (3) are located on the same line, and the encapsulant directly over the position of main light emission pipe (1), near-end photosensitive tube (2) and far-end photosensitive tube (3) engraves transparent window.
2. according to claims 1 described a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe, it is characterized in that, main light emission pipe (1) is a with the distance of near-end photosensitive tube (2), main light emission pipe (1) is b with the distance of far-end photosensitive tube (3), wherein a is not less than 20mm, b is not less than 30mm, and b-a is not more than 10mm.
3. according to claims 1 described a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe, it is characterized in that, the first auxiliary luminous tube (4) and the second auxiliary luminous tube (5) are close to respectively near-end photosensitive tube (2) and far-end photosensitive tube (3), and auxiliary luminous tube and the photosensitive tube that faces mutually distance are less than 5mm.
4. according to claims 1 described a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe, it is characterized in that two centre wavelengths of described main light emission pipe (1) are respectively
With
Wherein
Wave-length coverage is 650～805nm,
Wave-length coverage is 850～950nm,
Be not less than 50nm.
5. according to claims 1 described a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe, it is characterized in that the wave-length coverage of the described first auxiliary luminous tube (4) and the second auxiliary luminous tube (5) is 650nm～950nm.
6. according to claims 1 described a kind of high sensitivity near infrared tissue blood oxygen detecting sensor probe, it is characterized in that described opaque soft backing material is medical silica-gel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210487036.8A CN102940495B (en) | 2012-11-26 | 2012-11-26 | High sensitivity near-infrared tissue blood oxygen detection sensor probe |
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| CN201210487036.8A CN102940495B (en) | 2012-11-26 | 2012-11-26 | High sensitivity near-infrared tissue blood oxygen detection sensor probe |
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| CN102940495A true CN102940495A (en) | 2013-02-27 |
| CN102940495B CN102940495B (en) | 2014-04-23 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104990038A (en) * | 2015-07-14 | 2015-10-21 | 广州光微健康科技有限公司 | Multi-wavelength light source |
| CN105266773A (en) * | 2015-11-04 | 2016-01-27 | 上海箩箕技术有限公司 | Pulse wave sensor and wearable electronic device |
| CN105380634A (en) * | 2014-09-02 | 2016-03-09 | 苹果公司 | multiple light paths architecture, obscuration methods for signal and perfusion index optimization |
| CN108498074A (en) * | 2018-01-24 | 2018-09-07 | 西安交通大学 | The more light intensity near infrared light measurement methods of long-time micro energy lose |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5632273A (en) * | 1994-02-04 | 1997-05-27 | Hamamatsu Photonics K.K. | Method and means for measurement of biochemical components |
| CN1331953A (en) * | 2001-08-03 | 2002-01-23 | 天津大学 | Blood oxygen detecting sensor for newborn baby |
| CN1544919A (en) * | 2003-11-14 | 2004-11-10 | 清华大学 | Method for detecting newborn baby partial tissue oxygen saturation under oxygen absorption stimulation |
-
2012
- 2012-11-26 CN CN201210487036.8A patent/CN102940495B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5632273A (en) * | 1994-02-04 | 1997-05-27 | Hamamatsu Photonics K.K. | Method and means for measurement of biochemical components |
| CN1331953A (en) * | 2001-08-03 | 2002-01-23 | 天津大学 | Blood oxygen detecting sensor for newborn baby |
| CN1544919A (en) * | 2003-11-14 | 2004-11-10 | 清华大学 | Method for detecting newborn baby partial tissue oxygen saturation under oxygen absorption stimulation |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105380634A (en) * | 2014-09-02 | 2016-03-09 | 苹果公司 | multiple light paths architecture, obscuration methods for signal and perfusion index optimization |
| CN105380634B (en) * | 2014-09-02 | 2019-10-11 | 苹果公司 | Multi-pass architectural framework and the optimization of masking methods for signal and perfusion index |
| CN104990038A (en) * | 2015-07-14 | 2015-10-21 | 广州光微健康科技有限公司 | Multi-wavelength light source |
| CN105266773A (en) * | 2015-11-04 | 2016-01-27 | 上海箩箕技术有限公司 | Pulse wave sensor and wearable electronic device |
| CN108498074A (en) * | 2018-01-24 | 2018-09-07 | 西安交通大学 | The more light intensity near infrared light measurement methods of long-time micro energy lose |
| CN108498074B (en) * | 2018-01-24 | 2019-01-29 | 西安交通大学 | The more light intensity near infrared light measurement methods of long-time micro energy lose |
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| CN102940495B (en) | 2014-04-23 |
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