CN102935242A - Traditional Chinese medicine-assisted imaging preparation for ultrasonic image diagnosis, and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine-assisted imaging preparation for ultrasonic image diagnosis. The traditional Chinese medicine comprises the raw material drugs: rhizoma corydalis, rhizoma cyperi, angelica sinensis, pseudo-ginseng, rhizoma atractylodis, fructus gardeniae, medicated leaven, tangerine peel, prunus mume, akebia fruit, seville orange flower, pinellia ternate, cortex magnoliae officinalis, poria cocos, calcined concha arcae, calcined egg shell, agastache rugosus and perilla stem. The traditional Chinese medicine-assisted imaging preparation has the beneficial effects of being safe to use, free from pain, wound, toxicity and anaphylactic reaction, short in examination time, high in imaging rate, convenient to use and low in cost, thus providing a new technology and a new method for the early accurate diagnosis of diseases, providing powerful basis for the clinical diagnosis and being an ideal auxiliary imaging preparation; and furthermore, the preparation technology is simple and practical.

Description

Auxiliary video picture preparation of a kind of ultrasonoscopy diagnosis Chinese medicine and preparation method thereof

Technical field

The present invention relates to the engineering of traditional Chinese medicine technical field, relate in particular to a kind of ultrasonoscopy diagnosis Chinese medicine for B ultrasonic and assist video picture preparation and preparation method thereof.

Background technology

The ultrasonoscopy diagnosis is one of important diagnostic method in the medical science.Ultrasound wave has three greatly effects to material: the one, mechanism because ultrasonic energy is huge, often makes material particle do the altofrequency mechanical vibration, thus produce smash, cohesion, agitation effects.The 2nd, warm-heat effect, ul-trasonic irradiation is when material, and its energy is absorbed by material, thereby makes material temperature rising phenomenon.The 3rd, cavitation, ul-trasonic irradiation is on liquid the time, in the zone of liquid internal stress weakness (if any microcosmic bubble etc.) owing to the acoustic pressure great variety becomes sparse, at this moment around under the effect of fluid molecule pulling force, form a little cavity, be cavitation.This cavity time of staying is not long, again collapse under huge acoustic pressure effect, because cavity forms and disappears, producing a large amount of bubbles will affect the ultrasonic diagnosis effect, so eliminating bubble is the Main Function of ultrasonic contrast agent.

At present, for B ultrasonic gastrointestinal contrast agent, prior art has been put down in writing the contrast agent that 100 order fine powders by Endoconcha Sepiae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20% are mixed with, gastrointestinal disease had convergence, antacid effect, but weak point is the patient takes that to produce strong echo luminous point behind the contrast agent not enough, reflecting effect is not good, and the coat of the stomach level shows unintelligible; After the patient took this contrast agent, the gastric acid strong reaction had pain and sense of discomfort, is unfavorable for the ultrasonic contrast of gastrointestinal, can not use this contrast agent to the gastrorrhagia patient.

Another kind of fast ultrasonic image-developing liquor preparation method is that bitter bucket, MIXIANG, abdomen floss, Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae, sucrose are mixed in proportion by decocting, distill, concentrating, and makes imaging liquid, and good video picture rate reaches 87%.Used bitter bucket in this prescription, flavor is extremely bitter, thereby improves mouthfeel with sucrose, and sucrose enters the easy bubble that produces in the gastric juice, thereby influential to imaging results, in addition, this invention product is without therapeutical effect.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the traditional theory of Chinese medical science of China, in the ultrasound diagnosis process, a kind of use safety, avirulence are provided, have had no side effect, review time is short, and the video picture rate is high, auxiliary video picture preparation of ultrasonoscopy diagnosis Chinese medicine easy to use and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides the auxiliary video picture preparation of a kind of ultrasonoscopy diagnosis Chinese medicine, wherein, comprise following raw medicinal material in the described Chinese medicine: Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, FLOS MUME, Fructus Akebiae, CitrusaurantiumL.Var.amara Engl., the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Concha Arcae (calcined), forge Ovum crusta Gallus domesticus, Herba Pogostemonis and Caulis Perillae.

Wherein: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably: 10～20 parts of Rhizoma Corydalis, 10～20 parts of Rhizoma Cyperis, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts of Radix Notoginseng, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Gardeniaes, 20～30 parts of Massa Medicata Fermentata, 20～30 parts of Pericarpium Citri Reticulataes, 10～20 parts of FLOS MUME, 5～10 parts of Fructus Akebiaes, 10～20 parts of CitrusaurantiumL.Var.amara Engl.s, 10～15 parts of the Rhizoma Pinelliaes, 10～20 parts of Cortex Magnoliae Officinalis, 10～20 parts in Poria, 15～25 parts of Concha Arcae (calcined), forge 15～25 parts of Ovum crusta Gallus domesticuss, 10～15 parts of 10～15 parts of Herba Pogostemoniss and Caulis Perillaes.

Wherein: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can also be preferably: 10～15 parts of Rhizoma Corydalis, 10～15 parts of Rhizoma Cyperis, 15～18 parts of Radix Angelicae Sinensis, 15～18 parts of Radix Notoginseng, 15～20 parts of Rhizoma Atractylodis, 15～20 parts of Fructus Gardeniaes, 20～25 parts of Massa Medicata Fermentata, 20～25 parts of Pericarpium Citri Reticulataes, 15～20 parts of FLOS MUME, 5～8 parts of Fructus Akebiaes, 10～15 parts of CitrusaurantiumL.Var.amara Engl.s, 10～12 parts of the Rhizoma Pinelliaes, 10～15 parts of Cortex Magnoliae Officinalis, 15～20 parts in Poria, 20～25 parts of Concha Arcae (calcined), forge 15～20 parts of Ovum crusta Gallus domesticuss, 12～15 parts of 10～12 parts of Herba Pogostemoniss and Caulis Perillaes.

Wherein: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably again and be 12～15 parts of Rhizoma Corydalis, 12～15 parts of Rhizoma Cyperis, 16～18 parts of Radix Angelicae Sinensis, 16～18 parts of Radix Notoginseng, 15～18 parts of Rhizoma Atractylodis, 15～18 parts of Fructus Gardeniaes, 22～25 parts of Massa Medicata Fermentata, 22～25 parts of Pericarpium Citri Reticulataes, 18～20 parts of FLOS MUME, 6～8 parts of Fructus Akebiaes, 10～12 parts of CitrusaurantiumL.Var.amara Engl.s, 10～12 parts of the Rhizoma Pinelliaes, 12～15 parts of Cortex Magnoliae Officinalis, 15～18 parts in Poria, 22～25 parts of Concha Arcae (calcined), forge 18～20 parts of Ovum crusta Gallus domesticuss, 12～14 parts of 10～12 parts of Herba Pogostemoniss and Caulis Perillaes.

When prepared dosage form was tablet, its preparation method may further comprise the steps:

The first step is mixed in proportion the various raw medicinal materials of described Chinese medicine, adds determining alcohol with respect to 3～6 times of mixture qualities and be 85～95% ethanol, reflux 2～4 hours is extracted merge extractive liquid, 2～3 times, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure is recycled to without the alcohol flavor; The medicinal residues that filtration obtains add the distilled water with respect to 4～8 times of described medicinal residues quality again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix further concentrating under reduced pressure, desolventizing with the concentrated solution of the alcohol extract that obtains previously, drying obtains and gets dry extract;

Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, sieve, and obtains 600 orders～800 purpose micropowders;

The 3rd step, micropowders with the second step acquisition, adding is sieved mix homogeneously with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch, granulate, drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting gets the tablet finished product.

When prepared dosage form was powder, its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the starch with respect to 5～8 times of mixture qualities, and powder is pulverized and be screened into to stirring and evenly mixing, obtains powder.

When prepared dosage form was oral solutions, its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilizing namely obtains oral liquid.

In order to solve the problems of the technologies described above, the invention provides the preparation method of the auxiliary video picture preparation of a kind of above-mentioned ultrasonoscopy diagnosis Chinese medicine, prepared dosage form is tablet, may further comprise the steps:

The first step is mixed in proportion the various raw medicinal materials of described Chinese medicine, adds determining alcohol with respect to 3～6 times of mixture qualities and be 85～95% ethanol, reflux 2～4 hours is extracted merge extractive liquid, 2～3 times, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure is recycled to without the alcohol flavor; The medicinal residues that filtration obtains add the distilled water with respect to 4～8 times of described medicinal residues quality again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix further concentrating under reduced pressure, desolventizing with the concentrated solution of the alcohol extract that obtains previously, drying obtains and gets dry extract;

Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, sieve, and obtains 600 orders～800 purpose micropowders;

The 3rd step, micropowders with the second step acquisition, adding is sieved mix homogeneously with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch, granulate, drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting gets the tablet finished product.

In order to solve the problems of the technologies described above, the present invention provides again the preparation method of the auxiliary video picture preparation of a kind of above-mentioned ultrasonoscopy diagnosis Chinese medicine, and prepared dosage form is powder, may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the starch with respect to 5～8 times of mixture qualities, and powder is pulverized and be screened into to stirring and evenly mixing, obtains powder.

In order to solve the problems of the technologies described above, the present invention provides the preparation method of the auxiliary video picture preparation of a kind of above-mentioned ultrasonoscopy diagnosis Chinese medicine again, and prepared dosage form is oral solutions, may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilizing namely obtains oral liquid.

Beneficial effect of the present invention: use safety, no pain, without wound, avirulence, without anaphylaxis, review time is short, the video picture rate is high, easy to use, cost is low, for correctly diagnosing in early days of disease provides a kind of new technique, new method, for clinical diagnosis provides strong foundation, be comparatively desirable auxiliary development preparation, and preparation technology is simple, practical.

The specific embodiment

The invention provides the auxiliary video picture preparation of a kind of ultrasonoscopy diagnosis Chinese medicine, comprise following raw medicinal material in the described Chinese medicine: Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, FLOS MUME, Fructus Akebiae, CitrusaurantiumL.Var.amara Engl., the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Concha Arcae (calcined), forge Ovum crusta Gallus domesticus, Herba Pogostemonis and Caulis Perillae.

The pharmacology of various raw medicinal materials is as follows:

Rhizoma Corydalis: another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Acrid in the mouth, hardship, warm in nature.Return spleen, heart channel.Invigorate blood circulation, circulation of qi promoting, pain relieving.Be used for all pain diseases of stagnation of QI-blood, anesthesia, calmness, relieving convulsion is coughed etc.Cure mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.Analgesia, calmness, syngignoscism are arranged." medicine origin ": control depressed the stagnating of taste and do not fall apart, main asthenia cold diarrhea, cardiac and abdominal pain, the therapeutic method to keep the adverse QI flowing downwards helps digestion.

Rhizoma Cyperi: acrid in the mouth, little hardship, sweet, property is flat.Dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving is in the accent of regulating the flow of vital energy.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast." detailed outline " carries it: the cold epidemic disease of loose seasonal epidemic pathogens, and sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal.

Radix Angelicae Sinensis: warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Radix Notoginseng: warm in nature, sweet in the mouth, little hardship are returned liver, stomach warp, have hemostasis, dissipating blood stasis, and detumescence, the effect of pain relieving cures mainly haematemesis, hemoptysis, epistaxis is had blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia falls and pounces on blood stasis, traumatic hemorrhage, the cards such as carbuncle pain.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for retention of dampness in middle-JIAO, wind and cold is held wet exterior syndrome under the arm, rheumatic Bi syndrome, distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness; The asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention; Damp-edema; The exterior syndrome folder is wet; Heavy sensation of the body pain; The arthromyodynia warm nature; Podomere is ached and is being weighed; The flaccidity folds in a garment.

Fructus Gardeniae: have another name called Yellow Fructus Gardeniae, Fructus Gardeniae, white toad, Mu Dan, bright, ancient wine vessel, stand, more peach, Fructus Gardeniae, yellow Ovum Gallus domesticus, yellow sprout are sub etc., are the fruits of Maguireothamnus speciosus Fructus Gardeniae.Bitter in the mouth, cold in nature.GUIXIN, liver, lung, stomach, tri-jiao channel.The pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; The externally used detumescence pain relieving.Be used for calentura vexed, jaundice due to damp-heat, the puckery pain of stranguria, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles etc.; External treatment bruise pain.

Massa Medicata Fermentata: acrid in the mouth, sweet, warm in nature.Enter spleen, stomach warp.Promoting digestion and removing stagnation, invigorating the spleen and regulating the stomach induces sweat.Cure mainly flu dyspepsia, epigastric distension and distress, dyspepsia, diarrhoea.To general incoordination between the spleen and stomach, get ill from overeating stagnant, infantile malnutrition is also effective in cure.Massa Medicata Fermentata is hot sweet warm in nature, the strong and stomach invigorating of the power that helps digestion and in, be suitable for the disease that various food stagnations do not disappear.

Pericarpium Citri Reticulatae: another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.Warm in nature, acrid in the mouth, bitter in the mouth.Enter spleen channel, stomach warp, lung meridian.Regulating qi-flowing for strengthening spleen, in the accent, dampness is reduced phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.Temperature can circulation of qi promoting, and suffering can be dispersed, and is bitter and sluice.

FLOS MUME: another name Flos Pruni mume, flower bud of Japanese apricot. or the green prunus mume (sieb.) sieb.et zucc. of Fructus Armeniacae Mume.Sour in the mouth, puckery, property is flat.Return liver, stomach, lung meridian.The soothing liver-QI stomach function regulating, activating QI to eliminate phlegm.Be used for the breast side of body, abdominal distention, globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizziness, scrofula.

Fructus Akebiae: the wooden ratan of plants of Lardizabalaceae threeleaf akebia Akebia tri foliata (Thunb.) Koidz..Bitter in the mouth, cold in nature; Return liver, spleen channel.Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, dysentery, lumbago, costalgia, hernia, dysmenorrhea, uterus tenesmus.(" Chinese medicine voluminous dictionary ")

CitrusaurantiumL.Var.amara Engl.: be the alabastrum of rutaceae CitrusaurantiumL.Var.amara Engl. CitrusaurantiumL.var.amaraEngl., call turn green orange, turtle turtle; Acrid in the mouth, little hardship, property is flat; Liver-smoothing, qi-regulating, stomach function regulating preventing or arresting vomiting, promoting the circulation of QI to alleviate the stagnation in middle-JIAO help digestion, and reduce phlegm.Be used for the vexed distending pain of breast abdomen, accumulation of food in the stomach and intes tine due to indigestion, anorexia, nausea and vomiting, stomachache, stomachache.

The Rhizoma Pinelliae: acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, vanishing sputum and dispelling knot, externally used detumescence pain relieving.Be used for cold-phlegm syndrome, adverse rising of stomach-QI vomiting, swollen ulcer drug, venom etc.

Cortex Magnoliae Officinalis: have another name called pachydermia, pipe, magnolia hypoleuca, strong Piao, Cortex Magnoliae Officinalis, CORTEX MAGNOLIAE OFFICINALIS.Bitter in the mouth, suffering; Warm in nature.Return spleen,, large intestine channel.The circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, the gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest is breathed with cough.

Poria: sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.

Concha Arcae: salty in the mouth, property is flat.Return lung, stomach, Liver Channel.The expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.Be used for the long-pending knot of pertinacious phlegm, the thickness difficulty is coughed up, goiter, scrofula, abdominal mass mass in the abdomen, stomachache pantothenic acid.Get clean Concha Arcae and put in the appropriate vessel, in smokeless stove fire, be calcined to crisply, taking-up cools, and pulverizes, and gets Concha Arcae (calcined).Concha Arcae (calcined) is mainly used in relieving gastric hyperacidity to alleviate stomachache, and relieving gastric hyperacidity to alleviate stomachache power is strong, cures mainly stomachache pantothenic acid etc.

Ovum crusta Gallus domesticus: shell outside Phasianidae animal chicken Gallus gallus domosticus Brisson is laid eggs.Collect eggshell, dry.Lightly seasoned, property is flat.Convergence antacid is replenished the calcium.Be used for chronic gastritis, gastric and duodenal ulcers, rickets.

Herba Pogostemonis: herba agastachis rugosae, Lysimachia capillipes Hemsl, Da Ye Herba Menthae, mountain Fructus Foeniculi, cat handle, Herba microtoenae insuavis, with sweet and sour flavor, Herba Stachydis Japonicae, Herba Pileae Notatae (Herba Oreocnides frutescentis), He Xiang etc.Acrid in the mouth; Slightly warm in nature.Enter lung, spleen, stomach warp.Dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.Be used for the summertime flu; The cold and heat headache; Breast gastral cavity painful abdominal mass is vexed; Vomiting is had loose bowels; Vomiting during pregnancy; Nasal sinusitis; Tinea manus and pedis.

Caulis Perillae: have another name called Caulis Perillae, the dry stem of labiate Folium Perillae Perillafrutescens (L.) Britt..Acrid in the mouth, warm in nature.Return lung, spleen channel.Regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Be used for the chest and diaphragm painful abdominal mass vexed, gastralgia, belch vomiting, frequent fetal movement.

Wherein: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably: 10～20 parts of Rhizoma Corydalis, 10～20 parts of Rhizoma Cyperis, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts of Radix Notoginseng, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Gardeniaes, 20～30 parts of Massa Medicata Fermentata, 20～30 parts of Pericarpium Citri Reticulataes, 10～20 parts of FLOS MUME, 5～10 parts of Fructus Akebiaes, 10～20 parts of CitrusaurantiumL.Var.amara Engl.s, 10～15 parts of the Rhizoma Pinelliaes, 10～20 parts of Cortex Magnoliae Officinalis, 10～20 parts in Poria, 15～25 parts of Concha Arcae (calcined), forge 15～25 parts of Ovum crusta Gallus domesticuss, 10～15 parts of 10～15 parts of Herba Pogostemoniss and Caulis Perillaes.

Wherein: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can also be preferably: 10～15 parts of Rhizoma Corydalis, 10～15 parts of Rhizoma Cyperis, 15～18 parts of Radix Angelicae Sinensis, 15～18 parts of Radix Notoginseng, 15～20 parts of Rhizoma Atractylodis, 15～20 parts of Fructus Gardeniaes, 20～25 parts of Massa Medicata Fermentata, 20～25 parts of Pericarpium Citri Reticulataes, 15～20 parts of FLOS MUME, 5～8 parts of Fructus Akebiaes, 10～15 parts of CitrusaurantiumL.Var.amara Engl.s, 10～12 parts of the Rhizoma Pinelliaes, 10～15 parts of Cortex Magnoliae Officinalis, 15～20 parts in Poria, 20～25 parts of Concha Arcae (calcined), forge 15～20 parts of Ovum crusta Gallus domesticuss, 12～15 parts of 10～12 parts of Herba Pogostemoniss and Caulis Perillaes.

Wherein: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably again and be 12～15 parts of Rhizoma Corydalis, 12～15 parts of Rhizoma Cyperis, 16～18 parts of Radix Angelicae Sinensis, 16～18 parts of Radix Notoginseng, 15～18 parts of Rhizoma Atractylodis, 15～18 parts of Fructus Gardeniaes, 22～25 parts of Massa Medicata Fermentata, 22～25 parts of Pericarpium Citri Reticulataes, 18～20 parts of FLOS MUME, 6～8 parts of Fructus Akebiaes, 10～12 parts of CitrusaurantiumL.Var.amara Engl.s, 10～12 parts of the Rhizoma Pinelliaes, 12～15 parts of Cortex Magnoliae Officinalis, 15～18 parts in Poria, 22～25 parts of Concha Arcae (calcined), forge 18～20 parts of Ovum crusta Gallus domesticuss, 12～14 parts of 10～12 parts of Herba Pogostemoniss and Caulis Perillaes.

When prepared dosage form was tablet, its preparation method may further comprise the steps:

The first step is mixed in proportion the various raw medicinal materials of described Chinese medicine, adds determining alcohol with respect to 3～6 times of mixture qualities and be 85～95% ethanol, reflux 2～4 hours is extracted merge extractive liquid, 2～3 times, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure is recycled to without the alcohol flavor; The medicinal residues that filtration obtains add the distilled water with respect to 4～8 times of described medicinal residues quality again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix further concentrating under reduced pressure, desolventizing with the concentrated solution of the alcohol extract that obtains previously, drying obtains and gets dry extract;

Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, sieve, and obtains 600 orders～800 purpose micropowders;

The 3rd step, micropowders with the second step acquisition, adding is sieved mix homogeneously with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch, granulate, drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting gets the tablet finished product.

When prepared dosage form was powder, its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the starch with respect to 5～8 times of mixture qualities, and powder is pulverized and be screened into to stirring and evenly mixing, obtains powder.

When prepared dosage form was oral solutions, its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilizing namely obtains oral liquid.

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.

Embodiment 1: the tablet of the present invention's preparation

Get Rhizoma Corydalis 150g, Rhizoma Cyperi 140g, Radix Angelicae Sinensis 170g, Radix Notoginseng 170g, Rhizoma Atractylodis 150g, Fructus Gardeniae 150g, Massa Medicata Fermentata 230, Pericarpium Citri Reticulatae 250g, FLOS MUME 190g, Fructus Akebiae 70g, CitrusaurantiumL.Var.amara Engl. 110g, Rhizoma Pinelliae 110g, Cortex Magnoliae Officinalis 130g, Poria 160g, Concha Arcae (calcined) 240g, forge Ovum crusta Gallus domesticus 200g, Herba Pogostemonis 110g and Caulis Perillae 130g.

Its preparation method may further comprise the steps:

The first step is mixed the various raw medicinal materials of above-mentioned Chinese medicine, adds determining alcohol with respect to 5 times of mixture qualities and be 90% ethanol, and reflux 3 hours is extracted 2 times, and merge extractive liquid, filters and obtains alcohol extract, and the alcohol extract concentrating under reduced pressure is recycled to without alcohol and distinguishes the flavor of; The medicinal residues that filtration obtains add respectively the distilled water with respect to 6 times of medicinal residues quality again, decoct 3 hours, decoct 2 times, filter respectively, merging filtrate gets water extraction liquid, and water extraction liquid concentrating under reduced pressure mixes with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure, desolventizing, drying obtains and gets dry extract;

Second step, the dried cream that the first step is obtained is placed in the super micron mill to be pulverized 2 hours, sieved, and obtained 700 purpose micropowders;

The 3rd step with the micropowders that second step obtains, added microcrystalline Cellulose with respect to 0.2 times of its quality, 0.1 times of lactose, 0.2 times starch, sieved, mix homogeneously is granulated, and drying adds with respect to 0.02 times of magnesium stearate of micropowders quality, granulate, tabletting gets the tablet finished product.

Embodiment 2: the powder of the present invention's preparation

Get Rhizoma Corydalis 140g, Rhizoma Cyperi 120g, Radix Angelicae Sinensis 150g, Radix Notoginseng 150g, Rhizoma Atractylodis 160g, Fructus Gardeniae 160g, Massa Medicata Fermentata 200, Pericarpium Citri Reticulatae 200g, FLOS MUME 160g, Fructus Akebiae 50g, CitrusaurantiumL.Var.amara Engl. 130g, Rhizoma Pinelliae 100g, Cortex Magnoliae Officinalis 100g, Poria 150g, Concha Arcae (calcined) 220g, forge Ovum crusta Gallus domesticus 180g, Herba Pogostemonis 100g and Caulis Perillae 120g.

Its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 8 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 2 hours, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 3 times of its quality, decocted 3 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the starch with respect to 6 times of mixture qualities, and powder is pulverized and be screened into to stirring and evenly mixing, obtains powder.

Embodiment 3: the oral solutions of the present invention's preparation

Get Rhizoma Corydalis 120g, Rhizoma Cyperi 110g, Radix Angelicae Sinensis 160g, Radix Notoginseng 160g, Rhizoma Atractylodis 150g, Fructus Gardeniae 170g, Massa Medicata Fermentata 240, Pericarpium Citri Reticulatae 220g, FLOS MUME 180g, Fructus Akebiae 80g, CitrusaurantiumL.Var.amara Engl. 140g, Rhizoma Pinelliae 120g, Cortex Magnoliae Officinalis 130g, Poria 170g, Concha Arcae (calcined) 250g, forge Ovum crusta Gallus domesticus 160g, Herba Pogostemonis 120g and Caulis Perillae 130g.

Its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 2 hours, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 4 times of its quality, decocted 3 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the distilled water with respect to 3 times of amounts of powder quality, 0.1 times sucrose, and 0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilizing namely obtains oral liquid.

Acute toxicity test

In distilled water, respectively give 4 group white mice feeding dispensings or wiping with 80 times, 120 times, 150 times and 230 times of clinical consumption per day with the tablet dissolved of the embodiment of the invention 1 preparation, observed 7; All white mice are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

Long term toxicity test

With the tablet of the embodiment of the invention 1 preparation by 16.25,31.47 and 63.19g crude drug/kg be dissolved in the water, to 3 groups of mices difference 16 weeks of continuous use, every day 2 times, and after 4 weeks of drug withdrawal, the result shows: Chinese medicine of the present invention all has no significant effect indexs such as the hair of 3 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 16 weeks of medication and 4 weeks of drug withdrawal, Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to the mice long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

The pharmacological experiment explanation:

Pharmacodynamic experiment

One, the tablet of the auxiliary video picture preparation of Chinese medicine of the present invention is on the impact of small intestine movement of mice motion

1 test material

1.1 experimental animal: by 100 of medical college biological study chamber, Shandong ICR mices, male and female half and half, body weight 17～22g.

1.2 trial drug:

1.2.1 the tablet of the auxiliary video picture preparation of Chinese medicine of the present invention.With the tablet of the auxiliary video picture preparation of Chinese medicine of the present invention with dissolved in distilled water become 0.467,0.233, the medicinal liquid of 0.117g crude drug/ml is stand-by.

1.2.2 (Xinxiang City, Henan Province Chang Le pharmaceutical factory H41020226), becomes 0.01mg/ml solution with normal saline dilution before using to atropine sulfate injection.

1.2.3 active carbon; Arabic gum (make and contain 10% Radix Acaciae senegalis, the charcoal end distilled water suspension of 5% active carbon).

1.3 testing equipment: the T-500 electronic balance (the two outstanding test instrunment in Changshu factory, numbering: 256), PL203 precise electronic balance.

2 test methods

Select 17～22g body weight mice, be divided into 5 groups by the method for body weight random stratified, be i.e. blank group, positive drug (atropine) group, the high, medium and low dosage group of Chinese medicinal tablet of the present invention.Every group 20, male and female half and half.Blank group and atropine group gavage distilled water 30ml/kg, high, medium and low dosage group is gavage Chinese medicinal tablet medicinal liquid 14 of the present invention, 7,3.5g crude drug/kg respectively, 1 time/d.After the gavage 7 days, can't help water 18h in experiment at dusk fasting the previous day, after the 8th day last administration 1h (atropine diluent 0.1mg/kg5min), each only organizes gavage charcoal end suspension 0.2ml/.Put to death animal behind the 20min; open the abdominal cavity and separate mesentery; see the coat of the stomach clear layer as seen, and after under these auxiliary video picture preparation clothes, all mucosas of stomach are played a protective role; can seeing gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature etc. on ultrasound display screen, to locate video picture obvious; each position focus is high-visible, and to perigastric organs such as liver, gallbladder, pancreas clear display, the clip front end is to pylorus; the rear end places on the pallet to the intestinal tube of ileocecus.Gently small intestinal is put into straight line, measures Length of intestine as " small intestinal total length ".Distance from pylorus to the prepared Chinese ink forward position is as " distance that prepared Chinese ink advances at enteral ".Formula calculates prepared Chinese ink propelling rate: prepared Chinese ink propelling rate=(prepared Chinese ink is in enteral advance distance/small intestinal total length) * 100%.

3 result of the tests

Compare with matched group, positive drug atropine group charcoal end forward position propelling rate obviously reduces (P＜0.05), and the gastric peristalsis of Chinese medicinal tablet of the present invention is obviously hyperfunction, compares with model control group, can obviously promote the gastrointestinal motility function.See Table 1.

The tablet of the auxiliary video picture preparation of table 1 Chinese medicine of the present invention is on the impact of the hyperfunction mouse small intestine motion of intestinal propulsion

Group

The example number

Forward position propelling rate %

Normal group	20	41.63±3.85
			Positive drug atropine group	20	56.27±9.39***
Tablet 3.5g crude drug/kg of the present invention	20	67.85±15.24**
			Tablet 7g crude drug/kg of the present invention	20	77.10±10.69
Tablet 14g crude drug/kg of the present invention	20	89.28±10.01

Annotate: compare with Normal group: P＜0.05, compare with model control group: * * P＜0.01, * * * P＜0.001.

Conclusion (of pressure testing): motion has obvious inhibitory action to the tablet 3.5g/kg of the auxiliary video picture preparation of Chinese medicine of the present invention to gastrointestinal motility hyperfunctioning mouse small intestine, increases with dosage, shows the trend that promotes the bowel movement effect.This test is from having studied the tablet in treatment gastropathy of the auxiliary video picture preparation of Chinese medicine of the present invention at aspects such as body and stripped function of intestinal canal impact, stopping leak, antibacterial, the anti-immunity of antiinflammatory, the Pharmacological Mechanism of enteritis, dysentery, can promote gastrointestinal motility, digestion, absorption, and certain bacteriostasis is arranged, and show the anti-immunization of stronger antiinflammatory.

Two, In vitro Bactericidal Experiments

Adopt the agar doubling dilution to measure the present invention to the minimum inhibitory concentration (MIC) of common pathogen.Tested bacterium is inoculated in the MH broth bouillon, cultivates after 18 hours for 35 ℃, adjust the turbidity that its turbidity reaches 0.5 Maxwell opacity tube standard, bacterial content is about 108CFU/ml.With 1: 10 (bacteria containing amount is 107CFU/ml approximately) of physiological saline solution dilution.Get respectively the medicinal liquid 2ml adding of having diluted for series concentration and perform in the flat board of labelling, get again the MH agar culture medium 18ml that has been chilled to about 50 ℃ after the thawing and be added to dull and stereotyped interior (medicine: agar=1: 9), make the abundant mixing of medicine and culture medium.The medicine ultimate density is respectively 200,100,50 ... 0.78,0.39mg/ml.The bacteria suspension that has prepared is inoculated on the pastille flat board with inoculating loop, and in 18 hours observed results of 35 ℃ of cultivations, the lowest concentration of drug that colony growth is suppressed fully is the MIC of this medicine to the detection bacterium.Single bacteria growing can be ignored.Medicine contrast and strain growth contrast are established in test simultaneously.The results are shown in Table 2.

Table 2 extracorporeal bacteria inhibitor test result

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Shigella flexneri	4.203

Paratyphoid bacillus A	10.34
		Bacillus paratyphosus B	25.2
Bacillus pyocyaneus	5.29
		Escherichia coli	48.42
Bacillus enteritidis	22.16
		Staphylococcus aureus	6.57

As seen from Table 2, medicine of the present invention all has certain antibacterial action to shigella flexneri, paratyphoid bacillus A, Bacillus paratyphosus B, escherichia coli, bacillus pyocyaneus, staphylococcus aureus, bacillus enteritidis.

Illustrate: the human intestines and stomach belongs to hollow organ; in the ordinary course of things; utilize B ultrasonic can not well show the coat of the stomach level; the present invention assists the Concha Arcae (calcined) in the video picture preparation and forges the calcium carbonate that all contains certain ingredients in the Ovum crusta Gallus domesticus; with in the gastric acid and after can produce the carbon dioxide bubble; and need the 100-300ml that drinks water when the auxiliary video picture preparation of Chinese medicine of the present invention is taken or after taking; play obvious relieving gastric hyperacidity to alleviate stomachache effect after making various Chinese Medicine and Clavicular; more clear on image; the strong reecho of point-like; see the coat of the stomach clear layer as seen; and after under these auxiliary video picture preparation clothes; the all mucosas of stomach are played a protective role; on ultrasound display screen, can see the gastral cavity size; form; cardia; pylorus; gastric antrum; duodenum; lesser gastric curvature; it is obvious that greater gastric curvatures etc. are located video picture; each position focus is high-visible, and to perigastric organs such as liver; gallbladder; the pancreas clear display also can be clarified a diagnosis to all status of lymph node metastasis of stomach.The auxiliary video picture preparation of the present invention help the shadow principle as follows: produce the carbon dioxide bubble in the calcium carbonate in the auxiliary video picture preparation and behind the gastric acid, drink water and be " flakes " phenomenon of swimming after 100～300 milliliters, because the stickum in the auxiliary video picture preparation is to ulcer, can build up on the cancerous protuberance mucomembranous surface, being fused into rope piece or light cliques graph and resembles, form obvious interface, because auxiliary video picture preparation can make the full difference of coat of the stomach mucosa aspect acoustic impedance that causes of gastral cavity, thereby show the stomach form, the position, the gastral cavity size, wall of stomach thickness, emptying time and gastropathy place situation; Can show gastrointestinal dysfunction; The pathological changes that shows small intestinal, caecum, each position of colon.

The auxiliary video picture preparation of the Chinese medicine that B ultrasonic of the present invention uses is the auxiliary video picture preparation of pure Chinese medicine, no side effects, taking convenience; video picture is clear, strengthens the effect of gastric protective barrier, the hemostasis and pain-relieving antacid; diagnosis is accurate, through clinical the taking of 127 examples, the various gastrointestinal disease of clarifying a diagnosis.Can get rid of the stomach bubble in oral this product 5-13 minute, and eliminate mucus and make coat of the stomach structure clear display, the clear stomach different lesions that shows, imaging results is good, and resolving power is high, image stabilization, can carry out the gastric B ultrasonic examination inspection with various ordinary ultrasonography b instruments, and have invigorating the stomach and promoting digestion, the de-swelling analgesic effect.According to the clinical diagnosis experiment, good visualization ratio 95.3%, general visualization ratio 3.9% can go out superficial gastritis, hypertrophic gastritis, prolapse of gastric mucosa, gastric cancer, pyloric part tumor, gastroptosis and duodenitis etc. by auxiliary diagnosis.

Concrete case:

The field, male, 62 years old.The main cause epigastrium discontinuity pain companion body heavily alleviates was admitted to hospital in 5 months.It is uncomfortable that the patient epigastrium pain occurred without obvious inducement before 5 months, is discontinuity, to other positions radiation, pain aperiodicity and regularity, and with glutted discomfort after the feed, idol has nauseating, without vomiting, without heating, once at other hospital admissions, be diagnosed as " gastric ulcer ", gave antiinflammatory, press down acid (concrete medicine is not quite clear) treatment, symptom is without being clearly better.The patient is over nearly 1 month, and stomachache and epigastrium feeling of repletion increase the weight of, and appetite descends, and is weak, with nausea and vomiting, vomitus is gastric content, and idol has melena, without the mucus bloody purulent stool, stool every day 1-2 time, shaping about weight loss 8kg, is satisfied and is come the further diagnosis and treatment of my institute over nearly 5 months.Through the auxiliary video picture preparation of the oral embodiment of the invention 1, after 8 minutes, show body of stomach lesser curvature side and the swollen thing of gastric antrum section ulcer type at the B ultrasonic diagnostic screen, scope is 5cm approximately, is diagnosed as gastric cancer.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims (10)

1. a ultrasonoscopy diagnosis Chinese medicine is assisted the video picture preparation, it is characterized in that, comprise following raw medicinal material in the described Chinese medicine: Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, FLOS MUME, Fructus Akebiae, CitrusaurantiumL.Var.amara Engl., the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Concha Arcae (calcined), forge Ovum crusta Gallus domesticus, Herba Pogostemonis and Caulis Perillae.

2. ultrasonoscopy diagnosis Chinese medicine as claimed in claim 1 is assisted the video picture preparation, and it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: 10～20 parts of Rhizoma Corydalis, 10～20 parts of Rhizoma Cyperis, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts of Radix Notoginseng, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Gardeniaes, 20～30 parts of Massa Medicata Fermentata, 20～30 parts of Pericarpium Citri Reticulataes, 10～20 parts of FLOS MUME, 5～10 parts of Fructus Akebiaes, 10～20 parts of CitrusaurantiumL.Var.amara Engl.s, 10～15 parts of the Rhizoma Pinelliaes, 10～20 parts of Cortex Magnoliae Officinalis, 10～20 parts in Poria, 15～25 parts of Concha Arcae (calcined), forge 15～25 parts of Ovum crusta Gallus domesticuss, 10～15 parts of 10～15 parts of Herba Pogostemoniss and Caulis Perillaes.

3. ultrasonoscopy diagnosis Chinese medicine as claimed in claim 1 or 2 is assisted the video picture preparation, and it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: 10～15 parts of Rhizoma Corydalis, 10～15 parts of Rhizoma Cyperis, 15～18 parts of Radix Angelicae Sinensis, 15～18 parts of Radix Notoginseng, 15～20 parts of Rhizoma Atractylodis, 15～20 parts of Fructus Gardeniaes, 20～25 parts of Massa Medicata Fermentata, 20～25 parts of Pericarpium Citri Reticulataes, 15～20 parts of FLOS MUME, 5～8 parts of Fructus Akebiaes, 10～15 parts of CitrusaurantiumL.Var.amara Engl.s, 10～12 parts of the Rhizoma Pinelliaes, 10～15 parts of Cortex Magnoliae Officinalis, 15～20 parts in Poria, 20～25 parts of Concha Arcae (calcined), forge 15～20 parts of Ovum crusta Gallus domesticuss, 12～15 parts of 10～12 parts of Herba Pogostemoniss and Caulis Perillaes.

4. such as the auxiliary video picture preparation of the described ultrasonoscopy diagnosis of claims 1 to 3 Chinese medicine, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: 12～15 parts of Rhizoma Corydalis, 12～15 parts of Rhizoma Cyperis, 16～18 parts of Radix Angelicae Sinensis, 16～18 parts of Radix Notoginseng, 15～18 parts of Rhizoma Atractylodis, 15～18 parts of Fructus Gardeniaes, 22～25 parts of Massa Medicata Fermentata, 22～25 parts of Pericarpium Citri Reticulataes, 18～20 parts of FLOS MUME, 6～8 parts of Fructus Akebiaes, 10～12 parts of CitrusaurantiumL.Var.amara Engl.s, 10～12 parts of the Rhizoma Pinelliaes, 12～15 parts of Cortex Magnoliae Officinalis, 15～18 parts in Poria, 22～25 parts of Concha Arcae (calcined), forge 18～20 parts of Ovum crusta Gallus domesticuss, 12～14 parts of 10～12 parts of Herba Pogostemoniss and Caulis Perillaes.

5. such as the auxiliary video picture preparation of the described ultrasonoscopy diagnosis of claim 1 to 4 Chinese medicine, it is characterized in that, when prepared dosage form was tablet, its preparation method may further comprise the steps:

The first step is mixed in proportion the various raw medicinal materials of described Chinese medicine, adds determining alcohol with respect to 3～6 times of mixture qualities and be 85～95% ethanol, reflux 2～4 hours is extracted merge extractive liquid, 2～3 times, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure is recycled to without the alcohol flavor; The medicinal residues that filtration obtains add the distilled water with respect to 4～8 times of described medicinal residues quality again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix further concentrating under reduced pressure, desolventizing with the concentrated solution of the alcohol extract that obtains previously, drying obtains and gets dry extract;

Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, sieve, and obtains 600 orders～800 purpose micropowders;

The 3rd step, micropowders with the second step acquisition, adding is sieved mix homogeneously with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch, granulate, drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting gets the tablet finished product.

6. such as the auxiliary video picture preparation of the described ultrasonoscopy diagnosis of claim 1 to 4 Chinese medicine, it is characterized in that: when prepared dosage form was powder, its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the starch with respect to 5～8 times of mixture qualities, and powder is pulverized and be screened into to stirring and evenly mixing, obtains powder.

7. such as the auxiliary video picture preparation of the described ultrasonoscopy diagnosis of claim 1 to 4 Chinese medicine, it is characterized in that: when prepared dosage form was oral solutions, its preparation method may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilizing namely obtains oral liquid.

8. preparation method such as the auxiliary video picture preparation of the described ultrasonoscopy of claim 1 to 4 diagnosis Chinese medicine, it is characterized in that: prepared dosage form is tablet, may further comprise the steps:

The first step is mixed in proportion the various raw medicinal materials of described Chinese medicine, adds determining alcohol with respect to 3～6 times of mixture qualities and be 85～95% ethanol, reflux 2～4 hours is extracted merge extractive liquid, 2～3 times, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure is recycled to without the alcohol flavor; The medicinal residues that filtration obtains add the distilled water with respect to 4～8 times of described medicinal residues quality again, decocted 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets water extraction liquid, water extraction liquid concentrating under reduced pressure, mix further concentrating under reduced pressure, desolventizing with the concentrated solution of the alcohol extract that obtains previously, drying obtains and gets dry extract;

Second step, the dried cream that the first step is obtained is placed on pulverizes 1～2 hour in the super micron mill, sieve, and obtains 600 orders～800 purpose micropowders;

The 3rd step, micropowders with the second step acquisition, adding is sieved mix homogeneously with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, 0.1～0.3 times starch, granulate, drying adds with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting gets the tablet finished product.

9. preparation method such as the auxiliary video picture preparation of the described ultrasonoscopy of claim 1 to 4 diagnosis Chinese medicine, it is characterized in that: prepared dosage form is powder, may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the starch with respect to 5～8 times of mixture qualities, and powder is pulverized and be screened into to stirring and evenly mixing, obtains powder.

10. preparation method such as the auxiliary video picture preparation of the described ultrasonoscopy of claim 1 to 4 diagnosis Chinese medicine, it is characterized in that: prepared dosage form is oral solutions, may further comprise the steps:

The first step, with Rhizoma Corydalis, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Atractylodis, Fructus Gardeniae, Massa Medicata Fermentata, Pericarpium Citri Reticulatae,, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Poria, Herba Pogostemonis and Caulis Perillae be mixed in proportion, be that 70%～80% methanol is as solvent with determining alcohol, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that adds is 4～6 times of first step mixture quality;

Second step, get the distilled water that is equivalent to 5～10 times of surplus stock medical material mixture qualities, first with Concha Arcae (calcined) with after forging the Ovum crusta Gallus domesticus pulverizing, add in the distilled water, decocted 1～2 hour, and then FLOS MUME, Fructus Akebiae and CitrusaurantiumL.Var.amara Engl. are pulverized rear the adding continue in the decoction liquor to decoct 2～3 hours, filter, obtain the first filtrate; With the distilled water of filtering residue adding with respect to 2～4 times of its quality, decocted 1～3 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, the concentrated water of removing 2/3～3/4 volume adds determining alcohol and is 90～95% ethanol, makes determining alcohol reach 70%～80%, leaves standstill 12～24 hours, filter, and concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;

In the 3rd step, the powder mixing with the first step and second step acquisition adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilizing namely obtains oral liquid.