CN102895575B - Medicine composition for treating rashes as well as preparation method and application thereof - Google Patents

Abstract

The invention provides a medicine composition for treating rashes. The medicine composition is a preparation prepared from the following active pharmaceutical ingredients in parts by weight: 20-40 parts of lemna minor, 17-31 parts of coix seed, 17-31 parts of rhizoma smilacis glabrae, 10-20 parts of belvedere fruit, 7-13 parts of radix sophorae flavescentis, 7-13 parts of cortex dictamni, 7-13 parts of rhizoma atractylodes, 17-31 parts of flaxseed, 7-13 parts of periostracum cicadae, 2-5 parts of Chinese tamarisk twig, 4-8 parts of fineleaf schizonepeta herb, 4-8 parts of divaricate saposhnikovia root, 5-11 parts of great burdock achene, 17-31 parts of gypsum, 7-13 parts of rhizoma anemarrhenae, 7-13 parts of cortex phellodendri, 10-20 parts of Sinkiang arnebia root, 8-16 parts of radix rehmanniae, 7-13 parts of angelica sinensis and 2-5 parts of liquorice. The invention also provides a preparation method and an application of the medicine composition. The medicine composition can effectively eliminate or greatly relieve the symptoms of such rash diseases as eczema, prurigo and rubella, can cure the primary diseases to some extent and provides a new choice for clinical medication.

Description

A kind of pharmaceutical composition for the treatment of eruption and its production and use

Technical field

The present invention relates to a kind of pharmaceutical composition for the treatment of eruption and its production and use.

Background technology

Eruption, refers to that the redness of skin face or the symptom of red and white rash point appear exceeding in skin.How because the heresies such as wind heat, rheumatism, epidemic disease poison are outer, to invade, accumulate due to strongly fragrant skin.Be common in rubella, measles, milk fiber crops, dermatosis is as eczema, poison of drug, miliaria cancer, scabies, popular urticaria, itching eruption due to wind-heat in blood, pityriasis rose, premenstrual urticaria, rubella during pregnancy etc., and the multiple diseases caused by exogenous pathogenic factor epidemic febrile disease such as scarlet fever.Common eruption has eczema, prurigo, rubella etc.

Eczema, the high dermis and the epidermis inflammation that cause for multiple inside and outside factor, that a kind of common anaphylaxis, inflammatory skin are sick, with erythra multiformity, symmetrical, violent pruritus, repeatedly outbreak, easily developing into chronic is feature, is mainly divided into acute eczema, subacute eczema and chronic eczema three classes.The patient of eczema can have multiple irritated factor, as to allergy such as fish, shrimp, beef and mutton, spirits, sucks pollen, dirt demodicid mite, Pilus Caprae seu Ovis and feather etc. and also allergy can occur.Suffer from chronic cholecystitis, gingivitis, tonsillitis, intestinal parasitic disease etc., cold, the damp and hot and stimulation of scratching etc. all can become risk factor.Men and women, old and young all can fall ill, and take natural endowment sensitive subjects as many, without obviously seasonal, but usually recur winter.

Prurigo, prurigo nodularis, is a kind of chronic inflammatory disease dermatoses, the play of take is itched and nodositas infringement is feature.The cause of disease and sting, gastrointestinal dysfunction, endocrine metabolism obstacle and nervous and mental factors are relevant.Primary disease women is common, and skin lesion is apt to occur in extremity, is also found in waist buttocks, sees at most shank and stretches side.This sick pathological change is non-specific chronic inflammatory disease, and epidermis has hyperkeratosis and parakeratosis, and prickle cell layer is plump, intraepidermal edema, and can there is vesicle in epidermis shallow-layer.Intradermal Mild edema, blood vessel has lymphocytic infiltration around.Prurigo nodularis pathology epidermis has obvious hyperkeratosis and acanthosis, is papillomatous hyperplasia, high dermis histiocyte, lymphocytic infiltration.

Understanding angle from doctor trained in Western medicine, the concrete cause of disease of eczema and prurigo etc. is all indefinite, pathogeny is difficult to accurate assurance, therefore, there is no the specific medicament of such disease for the treatment of, be only all generally to give the treatments such as antisensitizer, hormone and vitamin C, and antisensitizer and hormone all can produce obvious toxic and side effects to human body, once 1 and drug withdrawal, will recur, very bounce-back, makes the state of an illness more serious, for example, corticosteroids medicine, can produce dependency, after drug withdrawal, primary affection bounce-back increases the weight of the side effect with secondary, often makes patient suffering can't bear.In addition, a lot of Western medicine itself are exactly the main cause that causes eczema eruption.In view of above all situations, seek the treatment of Chinese medicine, just seem very urgent.

The eruption illness such as Chinese traditional treatment eczema, prurigo are with a long history, in the historical document of the traditional Chinese medical science, different according to position that eczema is sent out, and have the appellations such as " acute eczema ", " eczema of ear ", " atopic eczema ", " eczema of scrotum ", " infantile eczema ".In treatment, no matter be eczema, prurigo or other eruption illness, can summarize some pattern of syndrome, then determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to the etiology and pathogenesis in Chinese medicine.Thereby, adopt at present the dermexanthesis illness such as Chinese medicine eczema, prurigo to there is suitable advantage.

Summary of the invention

The object of the present invention is to provide the pharmaceutical composition of the good treatment eczema of a kind of drug effect, prurigo and multiple eruption illness, and its production and use.

The invention provides a kind of pharmaceutical composition for the treatment of eruption, it is the preparation that the crude drug by following weight proportion is prepared from:

Herba Spirodelae 20-40 part, Semen Coicis 17-31 part, Rhizoma Smilacis Glabrae 17-31 part, Fructus Kochiae 10-20 part, Radix Sophorae Flavescentis 7-13 part, Cortex Dictamni 7-13 part, Rhizoma Atractylodis 7-13 part, Semen Lini 17-31 part, Periostracum Cicadae 7-13 part, Cacumen Tamaricis 2-5 part, Herba Schizonepetae 4-8 part, Radix Saposhnikoviae 4-8 part, Fructus Arctii 5-11 part, Gypsum Fibrosum 17-31 part, Rhizoma Anemarrhenae 7-13 part, Cortex Phellodendri 7-13 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, Radix Rehmanniae 8-16 part, Radix Angelicae Sinensis 7-13 part, Radix Glycyrrhizae 2-5 part.

Further, it is the preparation being prepared from by the crude drug that contains following weight proportion:

Herba Spirodelae 26-34 part, Semen Coicis 22-26 part, Rhizoma Smilacis Glabrae 22-26 part, Fructus Kochiae 13-17 part, Radix Sophorae Flavescentis 8-12 part, Cortex Dictamni 8-12 part, Rhizoma Atractylodis 8-12 part, Semen Lini 22-26 part, Periostracum Cicadae 8-12 part, Cacumen Tamaricis 2-4 part, Herba Schizonepetae 5-7 part, Radix Saposhnikoviae 5-7 part, Fructus Arctii 7-9 part, Gypsum Fibrosum 22-26 part, Rhizoma Anemarrhenae 8-12 part, Cortex Phellodendri 8-12 part, Radix Arnebiae (Radix Lithospermi) 13-17 part, Radix Rehmanniae 10-14 part, Radix Angelicae Sinensis 8-12 part, Radix Glycyrrhizae 2-4 part.

Further preferably, it is the preparation being prepared from by the crude drug that contains following weight proportion:

30 parts, Herba Spirodelae, 24 parts of Semen Coiciss, 24 parts of Rhizoma Smilacis Glabraes, 15 parts of the Fructus Kochiae, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Cortex Dictamni, 10 parts of Rhizoma Atractylodis, 24 parts of Semen Lini, 10 parts of Periostracum Cicadaes, 3 parts of Cacumen Tamariciss, 6 parts of Herba Schizonepetae, 6 parts of Radix Saposhnikoviaes, 8 parts of Fructus Arctiis, 24 parts, Gypsum Fibrosum, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Cortex Phellodendris, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Radix Rehmanniae, 10 parts of Radix Angelicae Sinensis, 3 parts, Radix Glycyrrhizae.

Wherein, described Gypsum Fibrosum is Gypsum Fibrosum, and described Radix Rehmanniae is Radix Rehmanniae.

Wherein, described preparation is oral formulations.

The present invention also provides the preparation method of above-mentioned pharmaceutical composition, and it comprises following operating procedure:

(1) by prescription weight proportion weighting raw materials;

(2) get crude drug, after extracting in water, extract obtained, add that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.

The present invention also provides the above-mentioned pharmaceutical composition purposes in the medicine of preparation treatment eruption.

Further, described medicine is the medicine for the treatment of eczema, prurigo or rubella.

Further, described eczema is acute eczema, subacute eczema or chronic eczema.

Further, described medicine is antipruritic medicine.

Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, to the etiology unknowns such as eczema, prurigo, complicated difficult look into, doctor trained in Western medicine without specific medicament, treatment very difficult illness regulate and control, can obtain better than Western medicine, more thoroughly and the therapeutic effect substantially having no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, pharmaceutical composition of the present invention is just being followed this principle.

In traditional Chinese medical science traditional theory, the eruption illness such as eczema, prurigo, are exopathogenic factor mainly with damp, ailment said due to cold or exposure, pathogenic heat, and this three large exopathogenic factor is except direct infection, also can the conversion such as worm is excessive, eating and drinking without temperance, natural endowment deficiency in origin by experiencing.As plain body virtual loss, natural endowment is not resistance to, and wet, wind, hot three heresies can be taken advantage of a weak point, and visitor, in skin, sends out as primary disease.If eating and drinking without temperance, the product of the wind symptom heat-dissipatings such as surfeit is pungent, fish raw meat, or be addicted to drink and injure taste, dysfunction of the spleen in transportation, damp and hot interior life, feels rheumatism pathogenic heat again, inside and outside combined pathogens, the biphase knot of fighting, the excessive skin of invading, sends out as rash.Or plain body is weak, the spleen being blocked by dampness, failure of skin and muscle to be nourished, or damp and hot accumulateing for a long time, consumption impairment of YIN blood, blood-deficiency and wind-dry, failure of skin and muscle to be nourished, all can dermexanthesis.

Prescription of the present invention, the Herba Spirodelae of being longer than removing dampness to relieve itching of take is monarch drug, more sends Semen Coicis and oozes dampness removing heat, Rhizoma Smilacis Glabrae, the Fructus Kochiae, Cortex Dictamni removing damp to relieve itching, Radix Sophorae Flavescentis, Rhizoma Atractylodis dampness, Semen Lini " by rheumatism gas ", assists monarch drug for ministerial drug altogether and plays a role.Itch and come from wind, antipruritic necessary dispelling wind, therefore prescription is with Periostracum Cicadae, Cacumen Tamaricis, Herba Schizonepetae, Radix Saposhnikoviae, Fructus Arctii exploitation space between skin and muscles, reaches the ailment said due to cold or exposure at skin table thoroughly, in order to do wind, from going out, takes on " left road " adjuvant drug.Primary disease pattern of syndrome belongs to heat, must removing summer-heat it, therefore make " Road " adjuvant drug Gypsum Fibrosum, Rhizoma Anemarrhenae removing summer-heat flesh heat, Cortex Phellodendri, Radix Sophorae Flavescentis heat clearing and damp drying, the Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi) removing heat from blood are warm.Traditional Chinese medical science inscription sentence has the instruction of " control wind and first control blood, blood wind is from going out ", thoroughly remove ailment said due to cold or exposure, also must nourishing and enriching blood promoting blood circulation and cooling blood, therefore send " right wing " adjuvant drug Radix Angelicae Sinensis, Semen Lini, Radix Rehmanniae nourishing and enriching blood, invigorate blood circulation, and the Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi) removing heat from blood.Making medicine Radix Glycyrrhizae, is the quality goods of conventional coordinating the actions of various ingredients in a prescription, and each medicine of system association, makes it jointly to bring into play drug effect.

As fully visible, in pharmaceutical composition of the present invention, it is clearly demarcated that each organizes flavour of a drug post, complements each other, and given full play to the sexology research methodology of analyzing mentally as the exclusive compound compatibility medication Ru Pai army of Chinese medicine structures the formation, therefore can obtain good efficacy.

The symptom of other eruption illness such as eczema, prurigo and rubella can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, can cure to a certain extent its primary disease, for clinical application provides a kind of new selection.

The specific embodiment

The preparation of embodiment 1 pharmaceutical composition of the present invention

Get 30 grams, Herba Spirodelae, 24 grams of Semen Coiciss, 24 grams of Rhizoma Smilacis Glabraes, 15 grams of the Fructus Kochiae, 10 grams of Radix Sophorae Flavescentiss, 10 grams of Cortex Dictamni, 10 grams of Rhizoma Atractylodis, 24 grams of Semen Lini, 10 grams of Periostracum Cicadaes, 3 grams of Cacumen Tamariciss, 6 grams of Herba Schizonepetae, 6 grams of Radix Saposhnikoviaes, 8 grams of Fructus Arctiis, 24 grams, Gypsum Fibrosum, 10 grams of the Rhizoma Anemarrhenaes, 10 grams of Cortex Phellodendris, 15 grams of Radix Arnebiae (Radix Lithospermi)s, 12 grams, the Radix Rehmanniae, 10 grams of Radix Angelicae Sinensis, 3 grams, Radix Glycyrrhizae.Each flavour of a drug take according to quantity, mix with enough water purification, after intense fire is fried boiling, changes slow fire and decoct 15 minutes to 20 minutes again.Collect after decocting liquid, then decoct with water 2 times, merge decocting liquid each time, obtain decoction.

The preparation of embodiment 2 pharmaceutical compositions of the present invention

Get 20 parts, Herba Spirodelae, 31 parts of Semen Coiciss, 31 parts of Rhizoma Smilacis Glabraes, 20 parts of the Fructus Kochiae, 13 parts of Radix Sophorae Flavescentiss, 13 parts of Cortex Dictamni, 13 parts of Rhizoma Atractylodis, 31 parts of Semen Lini, 13 parts of Periostracum Cicadaes, 5 parts of Cacumen Tamariciss, 8 parts of Herba Schizonepetae, 8 parts of Radix Saposhnikoviaes, 11 parts of Fructus Arctiis, 31 parts, Gypsum Fibrosum, 13 parts of the Rhizoma Anemarrhenaes, 13 parts of Cortex Phellodendris, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 16 parts of Radix Rehmanniae, 13 parts of Radix Angelicae Sinensis, 5 parts, Radix Glycyrrhizae; Each flavour of a drug take according to quantity, mix with enough water purification, after intense fire is fried boiling, changes slow fire and decoct 25 minutes again, collect after decocting liquid, then decoct with water 2 times, merge decocting liquid each time, concentrated, add proper starch, dextrin mixes rear granulation.

The preparation of embodiment 3 pharmaceutical compositions of the present invention

Get 40 parts, Herba Spirodelae, 17 parts of Semen Coiciss, 17 parts of Rhizoma Smilacis Glabraes, 10 parts of the Fructus Kochiae, 7 parts of Radix Sophorae Flavescentiss, 7 parts of Cortex Dictamni, 7 parts of Rhizoma Atractylodis, 17 parts of Semen Lini, 7 parts of Periostracum Cicadaes, 2 parts of Cacumen Tamariciss, 4 parts of Herba Schizonepetae, 4 parts of Radix Saposhnikoviaes, 5 parts of Fructus Arctiis, 17 parts, Gypsum Fibrosum, 7 parts of the Rhizoma Anemarrhenaes, 7 parts of Cortex Phellodendris, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Radix Rehmanniae, 7 parts of Radix Angelicae Sinensis, 2 parts, Radix Glycyrrhizae.Each flavour of a drug take according to quantity, mix with enough water purification, after intense fire is fried boiling, changes slow fire and decoct 15 minutes to 20 minutes again.Collect after decocting liquid, then decoct with water 2 times, merge decocting liquid each time, obtain decoction.

By test example, illustrate beneficial effect of the present invention below.

Clinical (outpatient service) treatment situation of test example pharmaceutical composition of the present invention

(1) accept patient's situation for medical treatment

Gender and the range of age: contain men and women, old and young, eczema, prurigo are in the majority with teenager, and other eruption illness such as rubella are in the majority with infant, neonate, possesses following symptom feature, accept altogether 156 examples for medical treatment, wherein eczema 51 examples, prurigo 76 examples, other eruption illness 29 examples such as rubella.

Symptom feature:

Eczema often has variform, easily alleviates, increases the weight of or recur, and border is generally not clear.Erythra easily betides both sides and is symmetry shape more or less, according to acute or chronic degree, there are erythema, pimple, vesicle, erosion, squama, crust, pigment to increase or reduce, chap or the different performance such as lichen sample, wherein several performances are often mixed in together, sometimes successively occur.If any secondary infection, also can there be the skin lesion such as pustule.

Acute eczema: fall ill rapider, skin lesion is pleomorphism, erythema, pimple, papulovesicle or vesicle are intensive easily oozes out in flakes, and blur margin, is dispersed in little pimple, papulovesicle around, often accompanies erosion, scabs, and as secondary infection, can occur pustule or dense crust.Conscious pruritus, its degree is difference according to state of an illness weight, diseased region and patient's toleration.But many plays are itched, Chang Yin scratches, soap hot water is scalded etc. and aggravate disease.As secondary infection, can accompany regional glandular enlargement, heating and general malaise.Acute eczema is as through processing suitably, in time, and erythra can take a turn for the better and disappear gradually, but is subject to after internal and external factor stimulates recur again, shows as acute attack or transfers subacute or chronic eczema to.In early days or acute phase, there is erythema in blocks in affected part, and the intensive or little pimple of evacuating, or the naked eyes difficulty vesicle of seeing, have large stretch of sepage and erosion when serious.

Subacute is stage between between acute and chronic eczema, often due to acute eczema, fails treatment or malpractice in time, makes due to course of disease delay 4 weeks above.At subacute state, sepage reduces and incrustation, and affected part, by scarlet dimmed red, does not have large stretch of erosion.

Chronic eczema does not often more transfer chronic eczema to because acute, subacute eczema show effect repeatedly, also has to start not obviously and because often scratching, rub or other stimulating, so that is chronic eczema person during morbidity beginning.It shows as illing skin and infiltrates plumpness, and rough surface is kermesinus or companion's pigmentation, and skin lesion mostly is limitation speckle, is common in brothers, shank, the fossa cubitalis, breast, pudendum, anus etc. and locates, clear-cut margin.The course of disease is several months or several years, also can be because of stimulation acute attack.In chronic states, sepage still less or bone dry and forming a scab, often mixes squama crust with squama, affected part color is darker or pigmentation occurs, sometimes hypopigmentation, easily there is breach in the position larger at dermatoglyph especially movement degree, and long-term friction is scratched and can be caused obvious lichen sample.

Prurigo: child's skin lesion of falling ill starts to be mainly red pimple, foxtail millet grain, to Semen phaseoli radiati size, can be also welt or papular urticaria sample erythra.Owing to scratching, can occur that scratch, blood crusts or eczema sample change.It is common site that extremity are stretched side, but back, Head And Face etc. all can occur.Subjective symptoms acute pruritus, leaves pigmentation after deflorescence.Can repeatedly show effect, axillary fossa and inguinal lymph nodes can enlargements.Minority infant extends to adult always.Middle age morbidity infringement mostly is circular pimple, Semen phaseoli radiati is to Semen Pisi sativi size, number is indefinite, small vesicle is arranged at pimple top, but vesicle often scratched and lose, and serosity incrustation is left in the broken rear surface of bleb, infringement occurs in batches, cause violent pruritus, owing to scratching for a long time, can occur scratch, lichenization and pigmentation, minority case leaves more afterwards point-like and scabs.Erythra is apt to occur in the positions such as extremity and trunk, buttocks.Or infringement is from the beginning of being pale red or red pimple, becomes very soon as the solid tuberosity of cheese, by Semen Pisi sativi, to thumbnail, is generally taupe or bronzing.Damage surperficial keratinization, coarse, be excipuliform, that touches has a solid sense.Conscious violent sufferings, owing to rubbing for a long time and scratching, occur bleeding and blood crusts, and skin around often has pigmentation and lichen sample to change, sometimes similar to nummular eczema.Infringement often occurs in extremity, especially common with shank, also can send out in back or other positions.Number is indefinite, and tuberosity has the trend of arranging file along limbs.This prurigo is more common in adult, and take women as many.

Rubella, patient mostly is child.Sick just 1～2 day symptom is very light, can have low grade fever or moderate heating, slight cough, weak, have no appetite, pharyngalgia and the slight upper airway symptoms such as eye is rubescent.Infant oral mucosa is smooth, without hyperemia and mucous patch, and after ear, cervical lymph node enlargement, companion's mild tenderness.Conventionally in heating, after 1～2 day, occur erythra, erythra first, from neck surface, spread to whole body at 24 hours.Erythra is just sparse red grouper pimple, can merge similar measles with rear face and extremity erythra.Eruption second day starts, and face and extremity erythra become the red point of needle point sample, as scarlet fever sample erythra.

Above-mentioned various, its Chinese medicine tongue feeling pulse resembles and mostly all is yellow fur, floating and rapid pulse is strong, and children's, fingerprint is how purple or red, even thoroughly in QI GUAN the vital evergy pass.

(2) treatment standard

Recovery from illness: erythra, itch and other transference cures, it is abnormal that check has no index of correlation.

Evident in efficacy: erythra, the symptom such as itch disappear substantially, and patient does not show index testing result.

Curative effect is obvious: the number of times that the symptom such as itch occurs obviously reduces or degree obviously alleviates, and erythra disappears to some extent or sepage reduces and incrustation, or only has pigmentation in various degree.

There is certain effect: patient's symptom makes moderate progress.

Invalid: symptom still, is not improved.

(3) Therapeutic Method

1, the made decoction of embodiment 1, each serving with 200 to 400ml, or daily 1 bowl, the rice bowl used of having a meal (child dose by age cuts down according to the circumstance, take medicine by the preceding method dosing of cutting down according to the circumstance, but need to drink to add and day take number of times), every 4 hours to 6 hours, take once, take according to quantity on time.

2, science conditioning daily life, observe following points for attention:

(1) because allergy causes eczema person, should pursue as far as possible and isolated sensitization source, avoid sensitization once again.

1) the contact sensitization source in living environment comprises:

Daylight, ultraviolet, sweltering heat, dry, cold, humidity, friction, animal wool, skin, man-made fabric, artificial leather product, with wear relevant printing and dyeing agent bleach, brightener, mothproofing agent, antifungus agent, strong dose etc. clothes.

Various chemical substances, as cosmetics, soap, synthetic fibers etc.

The electromagnetic radiation that artificial building element, chemical coating, plastic, rubber, staple fibre, adhesive, waterproofing agent, domestic and office's electronic equipment produce, room cleaning agent, agrochemical.

The gas that chemical fuel burning produces, manufactures automobile, vessel, the material of aircraft, the bituminous paving of road, the pollen of the other green plants of road etc.

In detergent factory, manufacture all enzyme preparations of detergent, the toluene di-isocyanate(TDI) of plastics factory, the latex of rubber plant, the antibiotic of pharmaceutical factory and other chemical raw materials etc.

The sensitization source that some is relevant with modern way of life, applies some make up as made and cat, Psittacula alexandri fasciata etc.

Western medicine is also the especially topmost pathogenic factor of eczema eruption of some eczema.In general any chemicals all has the probability that causes eczema drug eruption, but common person mainly contains:

Ethylenediamines hydryllin is as aminophylline, piperazine; Antimalarial, beta-blocker; Benzoin tincture inhalant; Procaine, Acetohexamide; Para-aminosalicylic acid; Azo dye in food and medicine; Chlorothiazide, chlorpropamide, tolbutamide, chloral hydrate, chlorine iodine hydroxyl, iodide and organic iodide, Baryan; Streptomycin, kanamycin, gentamycin, paromomycin, nitroglycerine tablets, aminophylline suppository and ethylene diamine hydrochloride, amino hydrargyrum, Peruvian balsam, benzocaine and para-amino benzoic acid glycerol, opacifier, chlorobutanol, halogenation oxyquinoline frost, iodine, polygynax, nitrol ointment etc.Ampicillin, amoxicillin, nickel, heparin and hydrargyrum.Penicillin, methyldopa, allopurinol, indomethacin, sulfanilamide, golden preparation, quine, chloromycetin, clonidine and Bleomycin A5 etc.

2) some food can cause the allergy of food, thereby cause the generation (food sensitization) of eczema, easily cause that allergic food is a lot, first want fasting drinks and other pungent excitant foods, avoid fish, shrimp, Eriocheir sinensis, seafood, beef, Carnis caprae seu ovis, Carnis Canitis, Caulis Bambusae Germinatus, Oryza glutinosa etc. to be easy to sensitization and stodgy food, note observing the relation of diet and morbidity.The food of other easy sensitization and additive thereof also have:

Artificial food, instant food, anti-season food, for chemical fertilizer, pesticide, man-made feeds, the feed additive of food production, for allergens such as the antiseptic of food processing, ore deposit oxidant, spice, pigment, ripener, thickening agents.

The food of chemosynthesis, as glucide, acetic acid, citric acid, essence, synthetic dyestuffs etc.

The food of rich in proteins, as milk, egg etc.And some rich in proteins and stodgy food, as clams class, squid, sepiellae seu sepiae etc.

There is irritating food, as wine, coffee, curry, cocoa, strong tea, Fructus Capsici, mustard, Pericarpium Zanthoxyli, Fructus Piperis, Rhizoma Zingiberis Recens, Herba Alii fistulosi, Bulbus Allii, Bulbus Allii Cepae, fried food etc.; .

The food that some is raw-eaten, as rareripe, raw Bulbus Allii, Rhizoma Zingiberis Recens etc., also has dry fruit and some fruit such as Semen Armeniacae Amarum, Semen Castaneae, Semen Juglandis, as Fructus Persicae, Fructus Vitis viniferae, Fructus Litchi, Fructus Musae, Fructus Ananadis comosi, Arillus Longan, Fructus Mangifera Indicae, Fructus Fragariae Ananssae, Durio Zibethinus murr, Arillus Longan, Fructus Litchi etc.

Some is rich in the food of antibacterial, as dead fish, dead shrimp, dead Eriocheir sinensis and stale meat.

Some is rich in the food of fungus, as mushroom, distiller grains, rice vinegar etc.

Some seed group food, as Semen arachidis hypogaeae, Semen Sesami, various beans Semen Viciae fabae etc. particularly.

Can isolate the food of histamine material, as Fructus Musae, Fructus Ananadis comosi, Fructus Solani melongenae, wine, yeast, chicken liver, beef, sausage.

Inhalation (inhalatio), as cigarette, pollen, dirt demodicid mite, certain micro-organisms etc.

Eczema avoid most boiling hot, grab, wash, gluttonous.Eczema is afraid of to stimulate very much, even if itch, can not scald or soap cleaning skin lesion place with hot water again, and more scratching, does not more stimulate eczema position, more can produce metabolite, increases the weight of the eczema state of an illness.In addition, though eczema should be noted skin health, there is the position of sepage will wash less as far as possible, should keep dry, and avoid contacting chemical washing articles for use and zest antipruritic agent.Gluttonous, refer to that eczema patients will keep a grip on mouth (inedible food is as detailed above).

(3) diet should be light, and the dish of having a meat diet less absorbs water fruit vegetable and the favourable food to sb.'s illness took a favorable turn more.Concrete as:

1) Fructus Momordicae charantiae: containing quinine.There is heat-clearing and toxic substances removing, removing dampness to relieve itching effect.Can be used for pyretic toxicity, furuncle, miliaria, eczema etc.

2) Fructus Lycopersici esculenti: Fructus Lycopersici esculenti is containing abundant vitamin A, vitamin B1, vitamin B2, vitamin C, nicotinic acid, vitamin E; Also contain malic acid, citric acid, the materials such as calcium, phosphorus, ferrum and tomatidine.There is the effects such as the cough-relieving of promoting the production of body fluid, invigorating the stomach and promoting digestion, removing heat from blood suppressing the hyperactive liver, heat clearing away.Fruit acid in Fructus Lycopersici esculenti has protective effect to vitamin C, so vitimin supplement C effectively; Tomatidine has inhibiting bacteria and diminishing inflammation, reduces vascular permeability effects, so external Fructus Lycopersici esculenti juice is smeared eczema, has certain antipruritic astriction.

3) Folium Allii tuberosi: Folium Allii tuberosi is containing carotene, vitamin B complex, vitamin C and calcium, phosphorus, ferrum, protein, cellulose etc.Folium Allii tuberosi also has the effect of detoxifying, removing dampness, therefore Chinese chive juice also can be put eczema outward on the skin.

4) Herba Apii graveolentis: Herba Apii graveolentis, containing abundant cellulose, vitamin B2 and vitamin C, also has a large amount of trace and macroelement, and Herba Apii graveolentis has the effects such as removing dampness, dampness removing, can effectively prevent and treat the recurrence of eczema.

5) concerned foodstuff is summarized as follows:

Light vegetable and freshwater product: green vegetable, Semen Nelumbinis, Rhizoma Nelumbinis, Folium Nelumbinis, Pedicellus et Pericarpium Trapae etc. are beneficial to skin.

Clearing away heat-damp and promoting diuresis food: Fructus Benincasae, Fructus Momordicae charantiae, Herba Apii graveolentis, Semen phaseoli radiati, Semen Phaseoli, Amaranthus mangostanus L., Herba Capsellae, Herba Portulacae, Fructus Cucumidis sativi, Caulis et Folium Lactucae sativae etc., can make the healthy recipes such as Fructus Benincasae lotus seed soup, Semen phaseoli radiati Semen Phaseoli soup.

Be rich in the food of vitamin and mineral: green leaf vegetable juice, Radix Dauci Sativae water, fruit drink, Tomato juice, puree, puree etc.

6) keep normal digestion and absorbability, do not hinder the intestines and stomach, free movement of the bowels.That food be take is light, vegetarian diet is as main, and few salt adding and sugar, in order to avoid cause in body water and sodium too much, increase the weight of oozing out and sufferings sense of erythra, cause skin to occur rotten to the corn.

(4) active treatment chronic disease, as dyspepsia, parasitic disease, diabetes, spiritual dysautonomia, shank vein varicose etc.In addition, hemolytic streptococcal infection is one of risk factor of this class illness, should avoid as far as possible the generation of flu, tonsillitis, pharyngitis, once occur, answers active treatment.

(5) moderately regularly use emollient cream, can prevent that skin is over-drying.But do not use hormone ointment to replace emollient cream, can select non-stimulated organic reparation emollient cream of releiving.

(6) should be as far as possible need not irritating fancy soap, the daily chemical products such as bath gel, detergent, select non-stimulated organic clean skin of releiving of eczema special use to reveal.While cleaning affected part, action will gently be rubbed, and does not peel off by force scurf, in order to avoid cause local infection, the course of disease is extended.

(7) can be aided with ice compress, contribute to alleviate the caused skin pruritus of eczema red and swollen, have certain antiinflammatory anti-allergic effects.

(8) can be aided with Chinese medicine decocting soup washout, have the effect of heat-clearing and toxic substances removing, dampness removing to stop itchin.

(9) strike a proper balance between work and rest, take a good rest, avoid overtired and spiritual hypertonicity.Hormonal change, gestation all can be brought out primary disease or it is increased the weight of, therefore women should especially note.

Shelter to clean, dry and comfortable, ventilate.Keep rule of life, strengthen physical training, health invigorating, adapts to cold and heat and changes.

(11) baby should also be noted that following item:

1) nursing and diet: breast feeding can alleviate the degree of eczema.Protide diatery supplement should a little later add, and the speed of adding wants slow.

2) infant of milk allergy, available bean milk, sheep milk etc. replace milk to feed.Or by milk boiling a few minutes to reduce its anaphylaxis.

3) to the infant of egg allergy, can singly eat egg yolk.

4) medicated clothing aspect: the collar of underclothes and all clothes should be cotton, clothing should be looser, light and soft, wear slightly coolerly.On bed, bedding is preferably cotton, and medicated clothing, medicated pillow, bedding etc. will often be changed, and keeps clean dry and comfortable.

5) daily life nursing aspect will be avoided overheated and perspire.Bathing skin protection is better with warm water, preferably carries out cutaneous sensibility mensuration, to understand the response situation of skin to skincare product used, and the generation of Polyglucan in time.Room temperature is unsuitable too high, otherwise can make eczema gargalesthesia increase the weight of.In environment, to reduce anaphylactogen, not keep a pet, not put carpet, not at indoor smoke, indoor will ventilation, cleaning is wet rubbing preferably, avoids airborne dust, or processes in family the dusty article such as curtain, framework with vacuum cleaner.

6) body temperature of infant can not shock heating quenching, keep the balance of body temperature.

(12) prurigo patient points for attention are substantially the same.

(13) rubella infant, except above-mentioned points for attention, should also be noted that:

1) should isolate for treatment in time, be partitioned to after eruption 1 week.

2) should lie up.Rubella complication seldom, once the complication such as bronchitis, pneumonia, otitis media or meningoencephalitis occur, should be treated in time.

3) to Close contacts, should strengthen medical observation, note its erythra and heating, in order to Discover the patients early.The contact class of mechanism of nursery schools and childcare centres, in incubation period planted agent and the isolation of other classes, does not receive new life, prevents from propagating.

(4) therapeutic outcome

Between many decades with other eruption illness such as embodiment 1 medicine composite for curing eczema, prurigo and rubella totally 156 examples, wherein eczema 51 examples, prurigo 76 examples, other eruption illness 29 examples such as rubella, have all obtained good curative effect.Treatment time, difference according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and to some extent, eczema, prurigo generally just had obvious effect in 5 days to 2 weeks, can finish treatment about 10 days～90 days, follow above-mentioned science conditioning simultaneously, receive merit.Other eruption illness such as rubella generally just had positive effect in 1 day to 3 days, can finish treatment about 3 days, by above-mentioned science Opsonizing method, carried out, and received merit.

By above-mentioned treatment standard, in 51 routine eczema patients, there are 14 example recoveries from illness, cure rate is 27.5%; 15 routine effects are remarkable, account for 29.5%; 10 routine successfuls, account for 19.6%; 6 examples have certain effect, account for 11.7%; 6 routine DeGrains (invalid), account for 11.7%.Total effective rate reaches 88.3%.

In 76 routine prurigo patients, have 26 example recoveries from illness, cure rate is 34.2%; 24 routine effects are remarkable, account for 31.6%; 9 routine successfuls, account for 11.8%; 10 examples have certain effect, account for 13%; 7 routine DeGrains (invalid), account for 9.4%.Total effective rate reaches 90.6%.

In other eruptions patients such as 29 routine rubellas, have 24 example recoveries from illness, cure rate reaches 82.8%; 4 routine effects are remarkable, account for 13.8%; 1 routine successful, accounts for 3.4%.Total effective rate reaches 100%.

Model case 1

Patient, man, 33 years old, married, body was more fat, had tobacco and wine history, its scrotum, lower limb (popliteal is curved is many) etc. many places there is eczema, eczema scrotum is commonly called as " eczema of scrotum ", this place is neural to distribute abundantly, very itches unbearably.While examining, see its scrotal swelling, skin lesion is erythema shape, has scarlet rotten to the corn face, and sepage is oozed out; Lower limb shin Tui is Ji the curved volume rash piece of also sending out of popliteal, and bilateral is symmetry substantially, has scratching trace and transudate.Unknown sensitization source, examines its pulse condition, and floating number is strong, and red tongue with yellowish and greasy fur, gives pharmaceutical composition of the present invention and give clothes (embodiment 1), take every day three times, and by above-mentioned " Therapeutic Method " it " 2 " points for attention science conditioning.Take medicine after 2 days, its sensation pruritus is alleviated to some extent, following the service one week, and symptom continues to alleviate, and advises it to adhere to taking medicine, can not drug withdrawal.After 6 weeks, its pruritus is eliminated, and skin lesion is dry, incrustation, after testing, and no abnormality seen index.

Model case 2

Patient, female, 10 years old.Infant eruption, two once doctor trained in Western medicine diagnosis and treatment a few days ago, examine as prurigo, give the treatments such as hismanal, vitamin C, it is murky that infant takes aftersensation, and time have hallucination sense, the head of a family to fear it to produce toxic and side effects, so drug withdrawal turns, ask tcm diagnosis and treatment.See its extremity, back and all send out big or small red pimple as volume Semen phaseoli radiati, have scratch, the sepage of blood and slime sample and blood crusts, readme acute pruritus unbearably.Floating and rapid pulse, red tongue with yellow fur.Bestow pharmaceutical composition of the present invention (embodiment 1), day takes 3 times, and 7 is a course for the treatment of, and between the course for the treatment of, drug withdrawal is had a rest 1, then continue to take, and by above-mentioned " Therapeutic Method " it " 2 " points for attention science conditioning.After 4 weeks, infant is good and sound already, and deflorescence only has slight pigmentation, has no Indexes Abnormality.

In sum, the symptom of other eruption illness such as eczema, prurigo and rubella can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, can cure to a certain extent its primary disease, for clinical application provides a kind of new selection.

Claims (1)

1. the purposes of following pharmaceutical composition in the medicine of preparation treatment prurigo, described pharmaceutical composition is the preparation that the crude drug by following weight proportion is prepared from:

Herba Spirodelae 20-40 part, Semen Coicis 17-31 part, Rhizoma Smilacis Glabrae 17-31 part, Fructus Kochiae 10-20 part, Radix Sophorae Flavescentis 7-13 part, Cortex Dictamni 7-13 part, Rhizoma Atractylodis 7-13 part, Semen Lini 17-31 part, Periostracum Cicadae 7-13 part, Cacumen Tamaricis 2-5 part, Herba Schizonepetae 4-8 part, Radix Saposhnikoviae 4-8 part, Fructus Arctii 5-11 part, Gypsum Fibrosum 17-31 part, Rhizoma Anemarrhenae 7-13 part, Cortex Phellodendri 7-13 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, Radix Rehmanniae 8-16 part, Radix Angelicae Sinensis 7-13 part, Radix Glycyrrhizae 2-5 part.

2, purposes according to claim 1, is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:

Herba Spirodelae 26-34 part, Semen Coicis 22-26 part, Rhizoma Smilacis Glabrae 22-26 part, Fructus Kochiae 13-17 part, Radix Sophorae Flavescentis 8-12 part, Cortex Dictamni 8-12 part, Rhizoma Atractylodis 8-12 part, Semen Lini 22-26 part, Periostracum Cicadae 8-12 part, Cacumen Tamaricis 2-4 part, Herba Schizonepetae 5-7 part, Radix Saposhnikoviae 5-7 part, Fructus Arctii 7-9 part, Gypsum Fibrosum 22-26 part, Rhizoma Anemarrhenae 8-12 part, Cortex Phellodendri 8-12 part, Radix Arnebiae (Radix Lithospermi) 13-17 part, Radix Rehmanniae 10-14 part, Radix Angelicae Sinensis 8-12 part, Radix Glycyrrhizae 2-4 part.

3, purposes according to claim 2, is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:

30 parts, Herba Spirodelae, 24 parts of Semen Coiciss, 24 parts of Rhizoma Smilacis Glabraes, 15 parts of the Fructus Kochiae, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Cortex Dictamni, 10 parts of Rhizoma Atractylodis, 24 parts of Semen Lini, 10 parts of Periostracum Cicadaes, 3 parts of Cacumen Tamariciss, 6 parts of Herba Schizonepetae, 6 parts of Radix Saposhnikoviaes, 8 parts of Fructus Arctiis, 24 parts, Gypsum Fibrosum, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Cortex Phellodendris, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Radix Rehmanniae, 10 parts of Radix Angelicae Sinensis, 3 parts, Radix Glycyrrhizae.

4, according to the purposes described in claim 1～3 any one, it is characterized in that: described Gypsum Fibrosum is Gypsum Fibrosum, described Radix Rehmanniae is Radix Rehmanniae.

5, purposes according to claim 4, is characterized in that: described preparation is oral formulations.

6, according to the purposes described in claim 1～5 any one, it is characterized in that: the preparation method of described pharmaceutical composition comprises following operating procedure:

(1) by prescription weight proportion weighting raw materials;

(2) get crude drug, after extracting in water, extract obtained, add that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.

7, purposes according to claim 1, is characterized in that: described medicine is antipruritic medicine.