CN102961655B - Externally used pharmaceutical composition for treating eruption - Google Patents

Abstract

The invention provides an externally used pharmaceutical composition for treating eruption. The externally used pharmaceutical composition is an externally used preparation prepared by the following active ingredients in parts by weight: 14-26 parts of fructus kochiae, 14-26 parts of fructus cnidii, 14-26 parts of chaulmoogra tree seeds, 14-26 parts of radix sophorae flavescentis, 14-26 parts of smilax glabra, 14-26 parts of cortex dictamni, 8-16 parts of radix lithospermi, and 8-16 parts of herba schizonepetae. The invention further provides a preparation method and applications for the pharmaceutical composition. The pharmaceutical composition can effectively eliminate or greatly relieve the symptoms of eruption diseases such as eczema, prurigo and the like, can eliminate disease source influence of hypersensitivity and the like and heal the primary diseases, and provides a new choice for clinical medicine.

Description

A kind of externally-applied medicinal composition for the treatment of eruption

Technical field

The present invention relates to a kind of externally-applied medicinal composition for the treatment of eruption.

Background technology

Eruption, refers to that the redness of skin face or the symptom of red and white rash point appear exceeding in skin.How to invade because the heresies such as wind heat, rheumatism, epidemic disease poison are outer, accumulate due to strongly fragrant skin.Be common in rubella, measles, milk fiber crops, dermatosis is as eczema, poison of drug, miliaria cancer, scabies, popular urticaria, itching eruption due to wind-heat in blood, pityriasis rose, premenstrual urticaria, rubella during pregnancy etc., and the multiple diseases caused by exogenous pathogenic factor epidemic febrile disease such as scarlet fever.Common eruption has eczema, prurigo, rubella etc.

Eczema, the high dermis and the epidermis inflammation that cause for multiple inside and outside factor, a kind of common anaphylaxis, inflammatory skin disease, with erythra multiformity, symmetrical, violent pruritus, repeatedly outbreak, easily developing into chronic is feature, is mainly divided into acute eczema, subacute eczema and chronic eczema three classes.The patient of eczema can have multiple irritated factor, as to allergy such as fish, shrimp, beef and mutton, spirits, sucks pollen, dirt demodicid mite, Pilus Caprae seu Ovis and feather etc. allergy also can occur.Suffer from chronic cholecystitis, gingivitis, tonsillitis, intestinal parasitic disease etc., cold, the damp and hot and stimulation of scratching etc. all can become risk factor.Men and women, old and young all can fall ill, and taking natural endowment sensitive subjects as many, without obviously seasonal, but usually recur winter.

Prurigo, i.e. prurigo nodularis, is a kind of chronic inflammatory disease dermatoses, itches and damages as feature with nodositas taking play.The cause of disease and sting, gastrointestinal dysfunction, endocrine metabolism obstacle and nervous and mental factors are relevant.Primary disease women is common, and skin lesion is apt to occur in extremity, is also found in waist buttocks, sees at most shank and stretches side.This sick pathological change is non-specific chronic inflammatory disease, and epidermis has hyperkeratosis and parakeratosis, prickle cell layer plumpness, and intraepidermal edema, can there is vesicle in epidermis shallow-layer.Intradermal Mild edema, blood vessel has lymphocytic infiltration around.Prurigo nodularis pathology epidermis has obvious hyperkeratosis and acanthosis, is papillomatous hyperplasia, high dermis histiocyte, lymphocytic infiltration.

From the understanding angle of doctor trained in Western medicine, the concrete cause of disease of eczema and prurigo etc. is all indefinite, pathogeny is difficult to accurate assurance, therefore, there is no the specific medicament of such disease for the treatment of, be only all generally to give the treatments such as antisensitizer, hormone and vitamin C, and antisensitizer and hormone all can produce obvious toxic and side effects to human body, once and drug withdrawal, will recur, very bounce-back, makes the state of an illness more serious, for example, corticosteroids medicine, can produce dependency, after drug withdrawal, primary affection bounce-back increases the weight of and the side effect of secondary, often makes patient suffering can't bear.In addition, a lot of Western medicine itself are exactly the main cause that causes eczema eruption.In view of above all situations, seek the treatment of Chinese medicine, just seem very urgent.

The eruption illness such as Chinese traditional treatment eczema, prurigo are with a long history, in the historical document of the traditional Chinese medical science, send out position difference according to eczema, and have the appellations such as " acute eczema ", " eczema of ear ", " atopic eczema ", " eczema of scrotum ", " infantile eczema ".In treatment, no matter be eczema, prurigo or other eruption illness, can summarize some pattern of syndrome, then determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to the etiology and pathogenesis in Chinese medicine.After all, the traditional Chinese medical science thinks that eczema, prurigo are due to damp, pathogenic heat, ailment said due to cold or exposure, and that heresy enters is gradually dark, and hematozemia impairment of YIN has increased again the pathomechanism of blood-deficiency and wind-dry.Clinically, according to wet, heat, wind three evil who many who is few, often can the side's of sending medication and get effect; As for blood-deficiency and wind-dry pattern of syndrome, also prescription treatment is pointedly controlled.

From the above, the harm of eczema, prurigo is very large, and doctor trained in Western medicine there is no the serious toxic and side effects that good plan and Western medicine bring and can cause more larger problems in treatment.Review the traditional Chinese medical science, there is method for the treatment of rule for the treatment of thought---the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of original science, there is again the effective outer treating method through long-term practice inspection, and Chinese medicine is pressed after tcm prescription theory reasonable compatibility, its toxic and side effects is little, stable curative effect, thereby, adopt at present the dermexanthesis illness such as Chinese medicine eczema, prurigo to there is suitable advantage.

The external application Chinese medicine compound recipe of existing treatment eczema, prurigo etc., all has certain therapeutical effect at present, still, more or less all has some defects, therefore, develops a kind of more excellent external medicine composition and seems particularly necessary.

Summary of the invention

The object of the present invention is to provide the externally-applied medicinal composition of the good external curing eczema of a kind of drug effect, prurigo and multiple dermexanthesis illness, and its production and use.

The invention provides a kind of externally-applied medicinal composition for the treatment of eruption, it is the external preparation being prepared from by the crude drug of following weight proportion:

Fructus Kochiae 14-26 part, Fructus Cnidii 14-26 part, Semen Hydnocarpi 14-26 part, Radix Sophorae Flavescentis 14-26 part, Rhizoma Smilacis Glabrae 14-26 part, Cortex Dictamni 14-26 part, Radix Arnebiae (Radix Lithospermi) 8-16 part, Herba Schizonepetae 8-16 part.

Further, it is the external preparation being prepared from by the crude drug of following weight proportion:

Fructus Kochiae 18-22 part, Fructus Cnidii 18-22 part, Semen Hydnocarpi 18-22 part, Radix Sophorae Flavescentis 18-22 part, Rhizoma Smilacis Glabrae 18-22 part, Cortex Dictamni 18-22 part, Radix Arnebiae (Radix Lithospermi) 10-14 part, Herba Schizonepetae 10-14 part.

Further preferably, it is the external preparation being prepared from by the crude drug of following weight proportion:

20 parts of the Fructus Kochiae, 20 parts of Fructus Cnidiis, 20 parts of Semen Hydnocarpi, 20 parts of Radix Sophorae Flavescentiss, 20 parts of Rhizoma Smilacis Glabraes, 20 parts of Cortex Dictamni, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Herba Schizonepetae.

Wherein, it is to be active component by the water of the medicated powder of the crude drug of described weight proportion, crude drug or extractive with organic solvent, adds the external preparation that pharmaceutically conventional adjuvant or complementary composition are prepared into.

Wherein, described external preparation is powder, unguentum, suspensoid, liniment or lotion.

The present invention also provides the preparation method of above-mentioned externally-applied medicinal composition, and it comprises following operating procedure:

(1) by prescription weight proportion weighting raw materials;

(2) crude drug is directly beaten to powder add water or organic solvent extraction after, add the conventional adjuvant of pharmacy or complementary composition to be prepared into external preparation.

The present invention also provides the above-mentioned externally-applied medicinal composition purposes in the medicine of preparation treatment eruption.

Further, described medicine is the medicine for the treatment of eczema or prurigo.

Further, described eczema is acute, subacute or chronic eczema.

Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, to the etiology unknown such as eczema, prurigo, complicated difficult look into, doctor trained in Western medicine without specific medicament, treatment very difficult illness regulate and control, can obtain therapeutic effect better than Western medicine, that more thoroughly and substantially have no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, pharmaceutical composition of the present invention is just being followed this principle.

In traditional Chinese medical science traditional theory, the dermexanthesis illness such as eczema, prurigo do not go out damp, ailment said due to cold or exposure, the large exopathogenic factor of pathogenic heat three, and this three large exopathogenic factor is except direct infection, also can the conversion such as worm is excessive, eating and drinking without temperance, natural endowment deficiency in origin by experiencing.As plain body virtual loss, natural endowment is not resistance to, and wet, wind, hot three heresies can be taken advantage of a weak point, and visitor, in skin, sends out as primary disease.If eating and drinking without temperance, the product of the wind symptom heat-dissipatings such as surfeit is pungent, fish raw meat, or be addicted to drink and injure taste, dysfunction of the spleen in transportation, damp and hot interior life, feels rheumatism pathogenic heat again, inside and outside combined pathogens, the biphase knot of fighting, the excessive skin of invading, sends out as rash.Or plain body weakness, the spleen being blocked by dampness, failure of skin and muscle to be nourished, or damp and hot accumulateing for a long time, consumption impairment of YIN blood, blood-deficiency and wind-dry, failure of skin and muscle to be nourished, all can dermexanthesis.

For above-mentioned damp, ailment said due to cold or exposure, the large exopathogenic factor of pathogenic heat three, in pharmaceutical composition of the present invention, Fructus Kochiae merit, at clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, is mainly used to eczema, rubella, skin pruritus, therefore elect monarch drug as.Fructus Cnidii removing toxic substances killing parasites for relieving itching, dampness, dispel the wind, be usually used in eczema, scabies; Semen Hydnocarpi dispeiling pathogenic wind and removing dampness, detoxicating and killing parasites are antipruritic; Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide, antiallergic, cure mainly damp and hot, skin pruritus, noxious dampness skin infection; Cortex Dictamni heat clearing and damp drying, dispelling wind for relieving itching, removing toxic substances; Above four tastes are all ministerial drug, and principal drug assistance is for principal contradiction.The rash promoting the circulation of blood removing heat from blood of should invigorating blood circulation, Radix Arnebiae (Radix Lithospermi) is just having removing heat from blood and promoting blood circulation, the effect of removing toxic substances rash, and is usually used in eczema, and Rhizoma Smilacis Glabrae removing toxic substances, dehumidifying, therefore the two all can help above-mentioned all product; Herba Schizonepetae dispelling wind and promoting eruption, can work in coordination with and dispel the wind with Semen Hydnocarpi, Radix Sophorae Flavescentis.This three tastes medicine all belongs to adjuvant drug, assists a ruler in governing a country together monarch drug, ministerial drug, and to cut from different perspectives disease institute, too many levels, many target spots ground are integrated and regulated ground performance therapeutical effect.In foregoing invention medicament composing prescription, respectively organize flavour of a drug " location of determining a post ", post is clearly demarcated, complements each other, and has brought into play the exclusive compound compatibility medication of Chinese medicine as the analyze mentally sexology research methodology of row army as structuring the formation, therefore can obtain good efficacy with external treatment approach.

The symptom of the eruption such as eczema, prurigo illness can effectively eliminate or greatly alleviate in external treatment mode to pharmaceutical composition of the present invention, can eliminate to a certain extent the source of disease impacts such as allergy, cures its primary disease, for clinical application provides a kind of new selection.

Detailed description of the invention

The preparation of embodiment 1 pharmaceutical composition of the present invention

Get 20 grams of the Fructus Kochiae, 20 grams of Fructus Cnidiis, 20 grams of Semen Hydnocarpi, 20 grams of Radix Sophorae Flavescentiss, 20 grams of Rhizoma Smilacis Glabraes, 20 grams of Cortex Dictamni, 12 grams of Radix Arnebiae (Radix Lithospermi)s, 12 grams of Herba Schizonepetae.Each flavour of a drug take according to quantity, mix with enough water purification, after intense fire is fried boiling, changes slow fire and decoct 15 minutes to 20 minutes again.Collect after decocting liquid, then decoct with water 2 times, merge decocting liquid each time, obtain lotion.

The preparation of embodiment 2 pharmaceutical compositions of the present invention

Get 14 grams of the Fructus Kochiae, 26 grams of Fructus Cnidiis, 26 grams of Semen Hydnocarpi, 26 grams of Radix Sophorae Flavescentiss, 26 grams of Rhizoma Smilacis Glabraes, 26 grams of Cortex Dictamni, 16 grams of Radix Arnebiae (Radix Lithospermi)s, 16 grams of Herba Schizonepetae.Each flavour of a drug take according to quantity, beat after powder, mix, and obtain powder.

The preparation of embodiment 3 pharmaceutical compositions of the present invention

Get 26 grams of the Fructus Kochiae, 14 grams of Fructus Cnidiis, 14 grams of Semen Hydnocarpi, 14 grams of Radix Sophorae Flavescentiss, 14 grams of Rhizoma Smilacis Glabraes, 14 grams of Cortex Dictamni, 8 grams of Radix Arnebiae (Radix Lithospermi)s, 8 grams of Herba Schizonepetae.Each flavour of a drug take according to quantity, mix with enough water purification, after intense fire is fried boiling, changes slow fire and decoct 15 minutes to 20 minutes again.Collect after decocting liquid, then decoct with water 2 times, merge decocting liquid each time, hold over night, gets supernatant and obtains liniment.

The preparation of embodiment 4 pharmaceutical compositions of the present invention

Get 18 grams of the Fructus Kochiae, 22 grams of Fructus Cnidiis, 22 grams of Semen Hydnocarpi, 22 grams of Radix Sophorae Flavescentiss, 22 grams of Rhizoma Smilacis Glabraes, 22 grams of Cortex Dictamni, 14 grams of Radix Arnebiae (Radix Lithospermi)s, 14 grams of Herba Schizonepetae.First add after 80% ethanol extraction, collect alcohol extract, medicinal residues, at extracting in water, are collected water extraction liquid; Alcohol extract is reclaimed after ethanol, and water extraction liquid mixes, filter, after supernatant concentration, add appropriate emulsifiable paste matrix, be prepared into ointment.

The preparation of embodiment 5 pharmaceutical compositions of the present invention

Get 22 grams of the Fructus Kochiae, 18 grams of Fructus Cnidiis, 18 grams of Semen Hydnocarpi, 18 grams of Radix Sophorae Flavescentiss, 18 grams of Rhizoma Smilacis Glabraes, 18 grams of Cortex Dictamni, 10 grams of Radix Arnebiae (Radix Lithospermi)s, 10 grams of Herba Schizonepetae.Each flavour of a drug take according to quantity, mix with enough water purification, after intense fire is fried boiling, changes slow fire and decoct 15 minutes to 20 minutes again.Collect after decocting liquid, then decoct with water 2 times, merge decocting liquid each time, obtain lotion.

Illustrate beneficial effect of the present invention by test example below.

Clinical (outpatient service) treatment situation of test example pharmaceutical composition of the present invention

(1) accept patient's situation for medical treatment

Gender and the range of age: contain that should not or to be reluctant to accept square medicine for oral administration suitable or gladly use the men and women, old and young of outer treating method because of a variety of causes, possesses following symptom feature, accept altogether 39 examples for medical treatment, wherein eczema 20 examples, prurigo 19 examples, other eruption illness many cases but do not count the present invention.

Symptom feature:

Eczema often has variform, easily alleviates, increases the weight of or recur, and border is generally not clear.Erythra easily betides both sides and is symmetry shape more or less, there are erythema, pimple, vesicle, erosion, squama, crust, pigment to increase or reduce, chap or the different performance such as lichen sample according to acute or chronic degree, wherein several performances are often mixed in together, sometimes successively occur.If any secondary infection, also can there be the skin lesion such as pustule.

Acute eczema: fall ill rapider, skin lesion is pleomorphism, erythema, pimple, papulovesicle or vesicle are intensive easily oozes out in flakes, and blur margin, is dispersed in little pimple, papulovesicle around, often accompanies erosion, scabs, and as secondary infection, can occur pustule or dense crust.Conscious pruritus, its degree is difference according to state of an illness weight, diseased region and patient's toleration.But many plays are itched, Chang Yin scratches, soap hot water is scalded etc. and aggravate disease.As secondary infection, can accompany regional glandular enlargement, heating and general malaise.Acute eczema as through suitably, in time process, erythra can take a turn for the better and disappear gradually, but be subject to internal and external factor stimulate after recur again, show as acute attack or transfer subacute or chronic eczema to.In early days or acute phase, there is erythema in blocks in affected part, and the intensive or little pimple of evacuating, or the naked eyes difficulty vesicle of seeing, have large stretch of sepage and erosion when serious.

Subacute is stage between between acute and chronic eczema, often fails treatment or malpractice in time due to acute eczema, makes due to course of disease delay 4 weeks above.At subacute state, sepage reduces and incrustation, and affected part, by scarlet dimmed red, does not have large stretch of erosion.

Chronic eczema does not often more transfer chronic eczema to because acute, subacute eczema show effect repeatedly, also has to start not obviously and because often scratching, rub or other stimulating, so that when beginning morbidity is chronic eczema person.It shows as illing skin and infiltrates plumpness, and rough surface is kermesinus or companion's pigmentation, and skin lesion mostly is limitation speckle, is common in brothers, shank, the fossa cubitalis, breast, pudendum, anus etc. and locates, clear-cut margin.The course of disease is several months or several years, also can be because of stimulation acute attack.In chronic states, sepage still less or bone dry and forming a scab, often mixes squama crust with squama, affected part color is darker or pigmentation occurs, sometimes hypopigmentation, easily there is breach in the position larger at dermatoglyph especially movement degree, and long-term friction is scratched and can be caused obvious lichen sample.

Prurigo: child's skin lesion of falling ill starts to be mainly red pimple, and foxtail millet grain, to Semen phaseoli radiati size, can be also welt or papular urticaria sample erythra.Can occur that owing to scratching scratch, blood crusts or eczema sample change.It is common site that extremity are stretched side, but back, Head And Face etc. all can occur.Subjective symptoms acute pruritus, leaves pigmentation after deflorescence.Can repeatedly show effect, axillary fossa and inguinal lymph nodes can enlargements.Minority infant extends to adult always.Middle age morbidity infringement mostly is circular pimple, Semen phaseoli radiati is to Semen Pisi sativi size, number is indefinite, small vesicle is arranged at pimple top, but vesicle often scratched and lose, and serosity incrustation is left in the broken rear surface of bleb, infringement occurs in batches, cause violent pruritus, can occur scratch, lichenization and pigmentation owing to scratching for a long time, minority case leaves more afterwards point-like and scabs.Erythra is apt to occur in the positions such as extremity and trunk, buttocks.Or infringement is from the beginning of being pale red or red pimple, becomes very soon as the solid tuberosity of cheese, to thumbnail, is generally taupe or bronzing by Semen Pisi sativi.Damage surperficial keratinization, coarse, be excipuliform, that touches has a solid sense.Conscious violent sufferings, owing to rubbing for a long time and scratching, occur bleeding and blood crusts, and skin around often has pigmentation and lichen sample to change, sometimes similar to nummular eczema.Infringement often occurs in extremity, especially common with shank, also can send out in back or other positions.Number is indefinite, and tuberosity has the trend of arranging file along limbs.This prurigo is more common in adult, and taking women as many.

Above-mentioned various, its Chinese medicine tongue feeling pulse resembles and mostly all is yellow fur, floating and rapid pulse is strong, and children's, fingerprint is how purple or red, even thoroughly in QI GUAN the vital evergy pass.

(2) treatment standard

Recovery from illness: erythra, itch and other transference cures, it is abnormal that inspection has no index of correlation.

Evident in efficacy: erythra, the symptom such as itch disappear substantially, and patient does not show index testing result.

Curative effect is obvious: the number of times that the symptom such as itch occurs obviously reduces or degree obviously alleviates, and erythra disappears to some extent or sepage reduces and incrustation, or only has pigmentation in various degree.

There is certain effect: patient's symptom makes moderate progress.

Invalid: symptom still, is not improved.

(3) Therapeutic Method

1, clean affected part, get the made lotion of embodiment 1, again and again wash and drench affected part.Every day at least 2 times to 3 times, it is better that pouring number of times is washed in increase.Wash 10 minutes to 15 minutes at every turn, then wipe dry.

2, science conditioning daily life, observe following points for attention:

(1) because allergy causes eczema person, should pursue as far as possible and isolated sensitization source, avoid sensitization once again.

1) the contact sensitization source in living environment comprises:

Daylight, ultraviolet, sweltering heat, dry, cold, humidity, friction, animal wool, skin, man-made fabric, artificial leather product, with wear relevant printing and dyeing agent bleach, brightener, mothproofing agent, antifungus agent, strong dose etc. clothes.

Various chemical substances, as cosmetics, soap, synthetic fibers etc.

Electromagnetic radiation, room cleaning agent, agrochemical that artificial building element, chemical coating, plastic, rubber, staple fibre, adhesive, waterproofing agent, domestic and office's electronic equipment produce.

The chemical fuel gas producing that burns, manufactures automobile, vessel, the material of aircraft, the bituminous paving of road, the pollen of the other green plants of road etc.

In detergent factory, manufacture all enzyme preparations of detergent, the toluene di-isocyanate(TDI) of plastics factory, the latex of rubber plant, the antibiotic of pharmaceutical factory and other chemical raw materials etc.

The sensitization source that some is relevant with modern way of life, applies some make up as made and cat, Psittacula alexandri fasciata etc.

Western medicine is also the especially topmost pathogenic factor of eczema eruption of some eczema.In general any chemicals all has the probability that causes eczema drug eruption, but common person mainly contains:

Ethylenediamines hydryllin is as aminophylline, piperazine; Antimalarial, beta-blocker; Benzoin tincture inhalant; Procaine, Acetohexamide; Para-aminosalicylic acid; Azo dye in food and medicine; Chlorothiazide, chlorpropamide, tolbutamide, chloral hydrate, chlorine iodine hydroxyl, iodide and organic iodide, Baryan; Streptomycin, kanamycin, gentamycin, paromomycin, nitroglycerine tablets, aminophylline suppository and ethylene diamine hydrochloride, amino hydrargyrum, Peruvian balsam, benzocaine and para-amino benzoic acid glycerol, opacifier, chlorobutanol, halogenation oxyquinoline frost, iodine, polygynax, nitrol ointment etc.Ampicillin, amoxicillin, nickel, heparin and hydrargyrum.Penicillin, methyldopa, allopurinol, indomethacin, sulfanilamide, golden preparation, quine, chloromycetin, clonidine and Bleomycin A5 etc.

2) some food can cause the allergy of food, thereby cause the generation (food sensitization) of eczema, easily cause that allergic food is a lot, first want fasting drinks and other pungent excitant foods, avoid fish, shrimp, Eriocheir sinensis, seafood, beef, Carnis caprae seu ovis, Carnis Canitis, Caulis Bambusae Germinatus, Oryza glutinosa etc. to be easy to sensitization and stodgy food, note observing the relation of diet and morbidity.The food of other easy sensitization and additive thereof also have:

Artificial food, instant food, anti-season food, for chemical fertilizer, pesticide, man-made feeds, the feed additive of food production, for allergens such as the antiseptic of food processing, ore deposit oxidant, spice, pigment, ripener, thickening agents.

The food of chemosynthesis, as glucide, acetic acid, citric acid, essence, synthetic dyestuffs etc.

The food of rich in proteins, as milk, egg etc.And some rich in proteins and stodgy food, as clams class, squid, sepiellae seu sepiae etc.

There is irritating food, as wine, coffee, curry, cocoa, strong tea, Fructus Capsici, mustard, Pericarpium Zanthoxyli, Fructus Piperis, Rhizoma Zingiberis Recens, Herba Alii fistulosi, Bulbus Allii, Bulbus Allii Cepae, fried food etc.; .

The food that some is raw-eaten, as rareripe, raw Bulbus Allii, Rhizoma Zingiberis Recens etc., also has dry fruit and some fruit such as Semen Armeniacae Amarum, Semen Castaneae, Semen Juglandis, as Fructus Persicae, Fructus Vitis viniferae, Fructus Litchi, Fructus Musae, Fructus Ananadis comosi, Arillus Longan, Fructus Mangifera Indicae, Fructus Fragariae Ananssae, Durio Zibethinus murr, Arillus Longan, Fructus Litchi etc.

Some is rich in the food of antibacterial, as dead fish, dead shrimp, dead Eriocheir sinensis and stale meat.

Some is rich in the food of fungus, as mushroom, distiller grains, rice vinegar etc.

Some seed group food, as particularly Semen Viciae fabae etc. of Semen arachidis hypogaeae, Semen Sesami, various beans.

Can isolate the food of histamine material, as Fructus Musae, Fructus Ananadis comosi, Fructus Solani melongenae, wine, yeast, chicken liver, beef, sausage.

Inhalation (inhalatio), as cigarette, pollen, dirt demodicid mite, certain micro-organisms etc.

Eczema avoid most boiling hot, grab, wash, gluttonous.Eczema is afraid of to stimulate very much, even if itch, can not scald or soap cleaning skin lesion place with hot water again, and more scratching, does not more stimulate eczema position, more can produce metabolite, increases the weight of the eczema state of an illness.In addition, though eczema should be noted skin health, there is the position of sepage will wash less as far as possible, should keep dry, and avoid contacting chemical washing articles for use and zest antipruritic agent.Gluttonous, refer to that eczema patients will keep a grip on mouth (inedible food is as detailed above).

(3) diet should be light, and the dish of having a meat diet less absorbs water fruit vegetable and the favourable food to sb.'s illness took a favorable turn more.Concrete as:

1) Fructus Momordicae charantiae: containing quinine.There is heat-clearing and toxic substances removing, removing dampness to relieve itching effect.Can be used for pyretic toxicity, furuncle, miliaria, eczema etc.

2) Fructus Lycopersici esculenti: Fructus Lycopersici esculenti is containing abundant vitamin A, vitamin B1, vitamin B2, vitamin C, nicotinic acid, vitamin E; Also contain malic acid, citric acid, the materials such as calcium, phosphorus, ferrum and tomatidine.There is the effects such as the cough-relieving of promoting the production of body fluid, invigorating the stomach and promoting digestion, removing heat from blood suppressing the hyperactive liver, heat clearing away.Fruit acid in Fructus Lycopersici esculenti has protective effect to vitamin C, so vitimin supplement C effectively; Tomatidine has inhibiting bacteria and diminishing inflammation, reduces vascular permeability effects, has certain antipruritic astriction so external Fructus Lycopersici esculenti juice is smeared eczema.

3) Folium Allii tuberosi: Folium Allii tuberosi is containing carotene, vitamin B complex, vitamin C and calcium, phosphorus, ferrum, protein, cellulose etc.Folium Allii tuberosi also has effect of detoxifying, removing dampness, therefore Chinese chive juice also can be put eczema outward on the skin.

4) Herba Apii graveolentis: Herba Apii graveolentis, containing abundant cellulose, vitamin B2 and vitamin C, also has a large amount of trace and macroelement, and Herba Apii graveolentis has the effect such as removing dampness, dampness removing, can effectively prevent and treat the recurrence of eczema.

5) concerned foodstuff is summarized as follows:

Light vegetable and freshwater product: green vegetable, Semen Nelumbinis, Rhizoma Nelumbinis, Folium Nelumbinis, Pedicellus et Pericarpium Trapae etc. are beneficial to skin.

Clearing away heat-damp and promoting diuresis food: Fructus Benincasae, Fructus Momordicae charantiae, Herba Apii graveolentis, Semen phaseoli radiati, Semen Phaseoli, Amaranthus mangostanus L., Herba Capsellae, Herba Portulacae, Fructus Cucumidis sativi, Caulis et Folium Lactucae sativae etc., can make the healthy recipe such as Fructus Benincasae lotus seed soup, Semen phaseoli radiati Semen Phaseoli soup.

Be rich in the food of vitamin and mineral: green leaf vegetable juice, Radix Dauci Sativae water, fruit drink, Tomato juice, puree, puree etc.

6) keep normal digestion and absorbability, do not hinder the intestines and stomach, free movement of the bowels.Food is taking light, vegetarian diet as main, and few salt adding and sugar, in order to avoid cause in body water and sodium too much, increase the weight of oozing out and sufferings sense of erythra, cause skin to occur rotten to the corn.

(4) active treatment chronic disease, as dyspepsia, parasitic disease, diabetes, spiritual dysautonomia, shank vein varicose etc.In addition, hemolytic streptococcal infection is one of risk factor of this class illness, should avoid as far as possible the generation of flu, tonsillitis, pharyngitis, once occur, answers active treatment.

(5) moderately regularly use emollient cream, can prevent that skin is over-drying.But do not use hormone ointment to replace emollient cream, can select non-stimulated organic reparation emollient cream of releiving.

(6) should be as far as possible need not irritating fancy soap, the daily chemical products such as bath gel, detergent, select the special non-stimulated organic clean skin of releiving of eczema to reveal.While cleaning affected part, action will gently be rubbed, and does not peel off by force scurf, in order to avoid cause local infection, the course of disease is extended.

(7) can be aided with ice compress, contribute to alleviate the caused skin pruritus redness of eczema, have certain antiinflammatory anti-allergic effects.

(8) can be aided with Chinese medicine decocting soup washout, have the effect of heat-clearing and toxic substances removing, dampness removing to stop itchin.

(9) strike a proper balance between work and rest, take a good rest, avoid overtired and spiritual hypertonicity.Hormonal change, gestation all can be brought out primary disease or it is increased the weight of, therefore women should especially note.

Shelter to clean, dry and comfortable, ventilate.Keep rule of life, strengthen physical training, health invigorating, adapts to cold and heat and changes.

(11) baby should also be noted that following item:

1) nursing and diet: breast feeding can alleviate the degree of eczema.Protide diatery supplement should a little later add, and the speed of adding wants slow.

2) infant of milk allergy, available bean milk, sheep milk etc. replace milk to feed.Or by milk boiling a few minutes to reduce its anaphylaxis.

3) can singly eat egg yolk to the infant of egg allergy.

4) medicated clothing aspect: the collar of underclothes and all clothes should be cotton, clothing should be looser, light and soft, wear slightly coolerly.On bed, bedding is preferably cotton, and medicated clothing, medicated pillow, bedding etc. will often be changed, and keeps clean dry and comfortable.

5) daily life nursing aspect will be avoided overheated and perspire.Bathing skin protection is better with warm water, preferably carries out cutaneous sensibility mensuration, to understand the response situation of skin to skincare product used, and the generation of Polyglucan in time.Room temperature is unsuitable too high, otherwise can make eczema gargalesthesia increase the weight of.In environment, to reduce anaphylactogen, not keep a pet, not put carpet, not at indoor smoke, indoor will ventilation, cleaning is wet rubbing preferably, avoids airborne dust, or processes in family the dusty article such as curtain, framework with vacuum cleaner.

6) body temperature of infant can not shock heating quenching, keep the balance of body temperature.

(12) prurigo patient points for attention are substantially the same.

(13) rubella infant, except above-mentioned points for attention, should also be noted that:

1) should isolate for treatment in time, be partitioned to after eruption 1 week.

2) should lie up.Rubella complication is little, once the complication such as bronchitis, pneumonia, otitis media or meningoencephalitis occur, should treat in time.

3) should strengthen medical observation to Close contacts, note its erythra and heating, in order to Discover the patients early.The contact class of mechanism of nursery schools and childcare centres, in incubation period planted agent and the isolation of other classes, does not receive new life, prevents from propagating.

(4) therapeutic outcome

Between many decades, with eruption illness men and women, old and young patient 39 examples such as embodiment 1 pharmaceutical composition external curing eczema, prurigo, all obtain good curative effect.Wherein eczema 20 examples, prurigo 19 examples.Treatment time, according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and to some extent difference, generally, in 2 thoughtful about 6 weeks visible significantly effects, one and a half months to five can finish treatment about six months, in accordance with above-mentioned science conditioning, receive merit simultaneously.

Specific as follows:

Treatment eczema 20 examples, treatment prurigo 19 examples.By above-mentioned treatment standard, in 20 routine eczema patients, there are 5 example recoveries from illness, cure rate is 25%; 6 routine effects are remarkable, account for 30%; 3 routine successfuls, account for 15%; 3 examples have certain effect, account for 15%; 3 routine DeGrains (invalid), account for 15%.Total effective rate is 85%.

In 19 routine prurigo patients, have 5 example recoveries from illness, cure rate is 26.3%; 8 routine effects are remarkable, account for 42.1%; 3 routine successfuls, account for 15.8%; 1 example has certain effect, accounts for 5.2%; 2 routine DeGrains (invalid), account for 10.6%.Total effective rate reaches 89.4%.

Model case 1

Patient, female, 15 years old, more fat, the symmetry shape eczemas of locating to happen suddenly such as its both feet back of the body, ankle, mostly were pimple, also have erythema, intensive in blocks, blur margin, the little pimple of locating also to sporadically appear such as shank, play is itched, and scratches to grab, and red tongue with yellow fur is micro-greasy.Give pharmaceutical composition of the present invention (prepared by embodiment 1), advise it frequently to wash.Patient abides by advise and treated for ten future, and skin lesion disappears to some extent, and pruritus is also slow.Adhere to continuing every day medicine and wash, go through recovery from illness in March, index is normal.

Model case 2

Patient, female, 41 years old, married, body was richer.See the skin lesion places such as its shank, pimple is Semen phaseoli radiati to Semen Pisi sativi size, mostly is pale red, also has redness, bronzing person, and small vesicle is arranged at its top having, and has minority to form a scab, and has scratch; Some pimples have become tuberosity, seemingly have along limbs file and tend to; Red tongue with thin and yellow fur, floating and rapid pulse, examine as prurigo.Give pharmaceutical composition of the present invention (prepared by embodiment 1), advise it frequently to wash.Patient's foam washing was less than 1 week, and pruritus greatly extenuates.After 3 weeks, skin lesion is to healing, and pruritus continues to alleviate.Be washed till more than 50, pruritus, erythra all disappear, rarely seen pigmentation dimly.

In sum, the symptom of the eruption such as eczema, prurigo illness can effectively eliminate or greatly alleviate in external treatment mode to pharmaceutical composition of the present invention, can eliminate to a certain extent the source of disease impacts such as allergy, cure its primary disease, for clinical application provides a kind of new selection.

Claims (9)

1. an externally-applied medicinal composition for the treatment of eruption, is characterized in that: it is the external preparation being prepared from by the crude drug of following weight proportion:

Fructus Kochiae 14-26 part, Fructus Cnidii 14-26 part, Semen Hydnocarpi 14-26 part, Radix Sophorae Flavescentis 14-26 part, Rhizoma Smilacis Glabrae 14-26 part, Cortex Dictamni 14-26 part, Radix Arnebiae (Radix Lithospermi) 8-16 part, Herba Schizonepetae 8-16 part.

2. externally-applied medicinal composition according to claim 1, is characterized in that: it is the external preparation being prepared from by the crude drug of following weight proportion:

Fructus Kochiae 18-22 part, Fructus Cnidii 18-22 part, Semen Hydnocarpi 18-22 part, Radix Sophorae Flavescentis 18-22 part, Rhizoma Smilacis Glabrae 18-22 part, Cortex Dictamni 18-22 part, Radix Arnebiae (Radix Lithospermi) 10-14 part, Herba Schizonepetae 10-14 part.

3. externally-applied medicinal composition according to claim 2, is characterized in that: it is the external preparation being prepared from by the crude drug of following weight proportion:

20 parts of the Fructus Kochiae, 20 parts of Fructus Cnidiis, 20 parts of Semen Hydnocarpi, 20 parts of Radix Sophorae Flavescentiss, 20 parts of Rhizoma Smilacis Glabraes, 20 parts of Cortex Dictamni, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Herba Schizonepetae.

4. according to the externally-applied medicinal composition described in claim 1～3 any one, it is characterized in that: it is to be active component by the water of the medicated powder of the crude drug of described weight proportion, crude drug or extractive with organic solvent, adds the external preparation that pharmaceutically conventional adjuvant is prepared into.

5. externally-applied medicinal composition according to claim 1, is characterized in that: described external preparation is powder, unguentum, suspensoid, liniment or lotion.

6. the preparation method of the externally-applied medicinal composition described in claim 1～3 any one, is characterized in that: it comprises following operating procedure:

(1) by prescription weight proportion weighting raw materials;

(2) crude drug is directly beaten to powder add water or organic solvent extraction after, add the conventional adjuvant of pharmacy to be prepared into external preparation.

7. the purposes of the externally-applied medicinal composition described in claim 1～5 any one in the medicine of preparation treatment eruption.

8. purposes according to claim 7, is characterized in that: described medicine is the medicine for the treatment of eczema or prurigo.

9. purposes according to claim 8, is characterized in that: described eczema is acute, subacute or chronic eczema.