CN102895572A - Traditional Chinese medical composition for treatment of rheumatoid arthritis - Google Patents
Traditional Chinese medical composition for treatment of rheumatoid arthritis Download PDFInfo
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- CN102895572A CN102895572A CN2012104256817A CN201210425681A CN102895572A CN 102895572 A CN102895572 A CN 102895572A CN 2012104256817 A CN2012104256817 A CN 2012104256817A CN 201210425681 A CN201210425681 A CN 201210425681A CN 102895572 A CN102895572 A CN 102895572A
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- rheumatoid arthritis
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- 206010039073 rheumatoid arthritis Diseases 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 19
- 210000000582 semen Anatomy 0.000 claims abstract description 7
- 241000237636 Pheretima Species 0.000 claims description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 5
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000243684 Lumbricus Species 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000011505 plaster Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 230000002085 persistent effect Effects 0.000 description 4
- 239000002574 poison Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 206010023232 Joint swelling Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
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- 241000721047 Danaus plexippus Species 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medical composition for treatment of rheumatoid arthritis. The traditional Chinese medical composition is prepared from the following Chinese medicine in parts by weight: 30-50 parts of plaster, 10-30 parts of rhizoma anemarrhenae, 10-30 parts of cortex phellodendri, 10-30 parts of rhizoma atractylodis, 15-60 parts of radix paeoniae rubra, 6-10 parts of manyleaf paris rhizome, 20-60 parts of raw poria cocos, 15-50 parts of semen coicis, 10-20 parts of fructus forsythiae, 20-50 parts of honeysuckle stem, 10-20 parts of radix achyranthis bidentatae, 6-20 parts of lumbricus, 6-15 parts of cassia twig, 6-20 parts of radix saposhnikoviae, 10-60 parts of rheum officinale and 6-15 parts of liquorice. The traditional Chinese medical composition has the advantages of accurate efficacy and no toxic or side effects and is worthy of clinical promotion and application.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rheumatoid arthritis, be specifically related to a kind of Chinese medicine composition for the treatment of rheumatoid arthritis.
Background technology
Rheumatoid arthritis is red, swollen, hot with the part, bitterly, gets coldly then to relax, and is principal character, can accompany General Symptoms, such as symptoms such as afternoon low grade fever to 37 ~ 38 degree, sweating, dry stool, thirsty, red tongue, yellow fur, rapid pulse.Diagnosis basis has laboratory indexes, erythrocyte sedimentation rate, anti-" O ", rheumatoid factor etc., and the multifactor body preponderance of YANG QI of the cause of disease is felt exopathogen again, and is evil in transconversion into heat, interior harmony musculus cutaneus muscles and bones joint, and the meridians blood vessels, or by due to direct feeling rheumatism pyretic toxicity or the severe pathogenic cold.
The Chinese medicine of existing treatment rheumatoid arthritis has a lot, but major part is for anemofrigid-damp arthralgia, after so the patient takes often uncertain therapeutic efficacy cut, cause patient's the course of disease to prolong and maybe can not effect a radical cure, become clinical problem demanding prompt solution so invent a kind of Chinese medicine for the treatment of the rheumatoid arthritis that pyretic arthralgia causes.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of rheumatoid arthritis.
Technical scheme of the present invention is as follows:
A kind of Chinese medicine composition for the treatment of rheumatoid arthritis is prepared from by the Chinese crude drug of following weight portion: Gypsum Fibrosum 30 ~ 50, the Rhizoma Anemarrhenae 10 ~ 30, Cortex Phellodendri 10 ~ 30, Rhizoma Atractylodis 10 ~ 30, Radix Paeoniae Rubra 15 ~ 60, Rhizoma Paridis 6 ~ 10, Rhizoma Smilacis Glabrae 20 ~ 60, Semen Coicis 15 ~ 50, Fructus Forsythiae 10 ~ 20, Caulis Lonicerae 20 ~ 50, Radix Achyranthis Bidentatae 10 ~ 20, Pheretima 6 ~ 20, Ramulus Cinnamomi 6 ~ 15, Radix Saposhnikoviae 6 ~ 20, Radix Et Rhizoma Rhei 10 ~ 60, Radix Glycyrrhizae 6 ~ 15.
Preparation method:
Get above each flavor, add 10 times, the decocting of 8 times of amounts boils 2 times, and each 2 hours, filter, merging filtrate, being concentrated into relative density is that 1.15-1.25 is for subsequent use.
The present invention can also adopt the modern pharmaceutical technology to take more to be conducive to the method for effective ingredient stripping, crude drug is extracted, also can add pharmaceutically suitable adjuvant on the basis of extracting solution simultaneously and be prepared into the dosage forms such as pill, tablet, capsule, granule, sustained-release preparation.
Gypsum Fibrosum is sweet, cold in the prescription provided by the invention, and matter heavily gas is light, the energy clearing away heat-fire; Fructus Forsythiae rises floating a surname and falls apart, and it is burning hot to let out all meridians; The Caulis Lonicerae the meridian dredging, kind wind heat poison heresy of separating meridians; Rhizoma Paridis heat-clearing and toxic substances removing, blood stasis dispelling expectorant are monarch drug altogether; Join Rhizoma Atractylodis, Cortex Phellodendri heat clearing and damp drying; Rhizoma Smilacis Glabrae solution hundred poison, sharp joint, disconnected moor; The Semen Coicis heat clearing away is impairment of YIN not, and dehumidifying does not help dry, and QI invigorating is not grown damp and hot; Rhizoma Anemarrhenae clearing away heat and nourishing YIN, Radix Paeoniae Rubra removing heat from blood and promoting blood circulation, inducing menstruation to relieve menalgia.Assistant is got its heat clearing away cold in nature, all-pervasive characteristic with Pheretima; Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, ignite descending; Go out body with Radix Et Rhizoma Rhei row fire, poison, wet, the stasis of blood, expectorant.Ramulus Cinnamomi, the loose poison of Radix Saposhnikoviae dispelling wind, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.More than each medicine share, jointly reach the treatment rheumatoid arthritis purpose.
Clinical data
1. case is originated: rheumatoid arthritis patients to our hospital is totally 80 examples.
2. diagnostic criteria
2.1 criteria for classification in 1987 of Western medicine diagnose standard reference American Rheumatism Association revision, possess 4 persons in following 7: (1) deadlock in morning is 1h at least, persistent period 〉=6 week; (2) 3 or 3 above swollen joints, persistent period 〉=6 week; (3) wrist, the palm refer to, proximal interphalangeal joint is swollen, persistent period 〉=6 week; (4) symmetry swollen joint, persistent period 〉=6 week; (5) subcutaneous nodule; (6) the x line of hands and wrist changes (having at least osteoporosis and joint to ask that the crack is narrow); (7) rheumatoid factor (RF) positive.
2.2 tcm syndrome is dialectical according to reference " new Chinese medicine guideline of clinical investigations ".Syndrome of cold-dampness blocking collaterals (anemofrigid-damp arthralgia, cold-damp folder stasis of blood type): arthralgia swelling, local fear of cold, color of the leather are not red, and that touches is not hot, the joint joint stuffiness, morning is stiff, joint deformity.Inferior disease: lusterless complexion, the limbs fear of cold, clear urine in large amounts, it is normal or rare half congealed to defecate.White or the whiten of pale tongue tongue, deep-slow pulse or heavy weak or heavy tight or heavy sliding slow.
3. criterion of therapeutical effect
Criterion of therapeutical effect is with reference to " new Chinese medicine guideline of clinical investigations "
Clinical cure: symptom all disappears, and it is normal that functional activity recovers, and main doctor trained in Western medicine physico-chemical examination index is normal;
Produce effects: symptomatology disappears or cardinal symptom is eliminated, and function of joint is recovered substantially, can participate in normal operation and work, physico-chemical examination index normal;
Effectively: the cardinal symptom elimination, main function of joint is substantially recovered or is had made marked progress, and can't take care of oneself transfers self-care to, perhaps loses the job and work capacity transfers work to and ability to work is recovered to some extent, and mainly the physico-chemical examination index makes moderate progress;
Invalid: and compare before the treatment, each side is all without progressive.
3. therapeutic scheme: take the present invention and prepare medicine, a weight portion is potion, every day potion, minute morning, noon and afternoon take for three times, seven days is a course for the treatment of.Observe the curative effect after 3 courses for the treatment of.
4. therapeutic outcome
After 3 courses for the treatment of, clinical cure 20 examples wherein, produce effects 41 examples, effective 14 examples, invalid 5 examples, total effective rate reaches 93.7%, illustrates that cured substance rate of the present invention is high, can be used for clinical treatment to rheumatoid arthritis fully.
The specific embodiment
The present invention is described further below in conjunction with embodiment.
Embodiment 1
Take by weighing Gypsum Fibrosum 30g, Rhizoma Anemarrhenae 10g, Cortex Phellodendri 10g, Rhizoma Atractylodis 10g, Radix Paeoniae Rubra 15g, Rhizoma Paridis 6g, Rhizoma Smilacis Glabrae 20g, Semen Coicis 15g, Fructus Forsythiae 10g, Caulis Lonicerae 20g, Radix Achyranthis Bidentatae 10g, Pheretima 6g, Ramulus Cinnamomi 6g, Radix Saposhnikoviae 6g, Radix Et Rhizoma Rhei 10g, Radix Glycyrrhizae 6g, add 10 times, the decocting of 8 times of amounts boils 2 times, each 2 hours, filter, merging filtrate is concentrated into relative density and is 1.15 for subsequent use.
Embodiment 2
Take by weighing Gypsum Fibrosum 50g, Rhizoma Anemarrhenae 30g, Cortex Phellodendri 30g, Rhizoma Atractylodis 30g, Radix Paeoniae Rubra 60g, Rhizoma Paridis 10g, Rhizoma Smilacis Glabrae 60g, Semen Coicis 50g, Fructus Forsythiae 20g, Caulis Lonicerae 50g, Radix Achyranthis Bidentatae 20g, Pheretima 20g, Ramulus Cinnamomi 15g, Radix Saposhnikoviae 20g, Radix Et Rhizoma Rhei 60g, Radix Glycyrrhizae 15g, add 10 times, the decocting of 8 times of amounts boils 2 times, each 2 hours, filter, merging filtrate is concentrated into relative density and is 1.25 for subsequent use.
Embodiment 3
Take by weighing Gypsum Fibrosum 40g, Rhizoma Anemarrhenae 20g, Cortex Phellodendri 20g, Rhizoma Atractylodis 20g, Radix Paeoniae Rubra 40g, Rhizoma Paridis 8g, Rhizoma Smilacis Glabrae 40g, Semen Coicis 35g, Fructus Forsythiae 15g, Caulis Lonicerae 35g, Radix Achyranthis Bidentatae 15g, Pheretima 14g, Ramulus Cinnamomi 10g, Radix Saposhnikoviae 12g, Radix Et Rhizoma Rhei 40g, Radix Glycyrrhizae 10g, add 10 times, the decocting of 8 times of amounts boils 2 times, each 2 hours, filter, merging filtrate is concentrated into relative density and is 1.20 for subsequent use.
Claims (1)
1. Chinese medicine composition for the treatment of rheumatoid arthritis is prepared from by the Chinese crude drug of following weight portion: Gypsum Fibrosum 30 ~ 50, the Rhizoma Anemarrhenae 10 ~ 30, Cortex Phellodendri 10 ~ 30, Rhizoma Atractylodis 10 ~ 30, Radix Paeoniae Rubra 15 ~ 60, Rhizoma Paridis 6 ~ 10, Rhizoma Smilacis Glabrae 20 ~ 60, Semen Coicis 15 ~ 50, Fructus Forsythiae 10 ~ 20, Caulis Lonicerae 20 ~ 50, Radix Achyranthis Bidentatae 10 ~ 20, Pheretima 6 ~ 20, Ramulus Cinnamomi 6 ~ 15, Radix Saposhnikoviae 6 ~ 20, Radix Et Rhizoma Rhei 10 ~ 60, Radix Glycyrrhizae 6 ~ 15.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210425681.7A CN102895572B (en) | 2012-10-31 | 2012-10-31 | Traditional Chinese medical composition for treatment of rheumatoid arthritis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210425681.7A CN102895572B (en) | 2012-10-31 | 2012-10-31 | Traditional Chinese medical composition for treatment of rheumatoid arthritis |
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| Publication Number | Publication Date |
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| CN102895572A true CN102895572A (en) | 2013-01-30 |
| CN102895572B CN102895572B (en) | 2014-07-23 |
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| CN201210425681.7A Expired - Fee Related CN102895572B (en) | 2012-10-31 | 2012-10-31 | Traditional Chinese medical composition for treatment of rheumatoid arthritis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656216A (en) * | 2013-12-12 | 2014-03-26 | 黄根强 | Traditional Chinese medicine for treating rheumatoid arthritis |
| CN104800802A (en) * | 2015-04-29 | 2015-07-29 | 朱锴 | Medicine for treating osteoarthritis and preparation method of medicine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273835A (en) * | 2000-02-22 | 2000-11-22 | 陈永贵 | Chinese medicine for treating rheumatism |
| CN1327841A (en) * | 2001-05-04 | 2001-12-26 | 刘玉福 | Medicine for treating rheumatoid arthritis |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
| CN102091311A (en) * | 2011-01-26 | 2011-06-15 | 蚌埠丰原涂山制药有限公司 | Traditional Chinese medicinal composition for treating rheumatoid arthritis and preparation method thereof |
-
2012
- 2012-10-31 CN CN201210425681.7A patent/CN102895572B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273835A (en) * | 2000-02-22 | 2000-11-22 | 陈永贵 | Chinese medicine for treating rheumatism |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
| CN1327841A (en) * | 2001-05-04 | 2001-12-26 | 刘玉福 | Medicine for treating rheumatoid arthritis |
| CN102091311A (en) * | 2011-01-26 | 2011-06-15 | 蚌埠丰原涂山制药有限公司 | Traditional Chinese medicinal composition for treating rheumatoid arthritis and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656216A (en) * | 2013-12-12 | 2014-03-26 | 黄根强 | Traditional Chinese medicine for treating rheumatoid arthritis |
| CN104800802A (en) * | 2015-04-29 | 2015-07-29 | 朱锴 | Medicine for treating osteoarthritis and preparation method of medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102895572B (en) | 2014-07-23 |
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