CN103127236B - Traditional Chinese medicine compound for treatment of rheumatic arthritis and preparation method thereof - Google Patents
Traditional Chinese medicine compound for treatment of rheumatic arthritis and preparation method thereof Download PDFInfo
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- CN103127236B CN103127236B CN201310090468.XA CN201310090468A CN103127236B CN 103127236 B CN103127236 B CN 103127236B CN 201310090468 A CN201310090468 A CN 201310090468A CN 103127236 B CN103127236 B CN 103127236B
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 201000003068 rheumatic fever Diseases 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000008589 Cortex Fraxini Substances 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 38
- 244000025254 Cannabis sativa Species 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 241000628997 Flos Species 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000003809 water extraction Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 7
- 244000018716 Impatiens biflora Species 0.000 abstract 1
- 235000015912 Impatiens biflora Nutrition 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 241001251949 Xanthium sibiricum Species 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 235000008113 selfheal Nutrition 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 14
- 230000036407 pain Effects 0.000 description 13
- 230000003203 everyday effect Effects 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 10
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 5
- 210000000629 knee joint Anatomy 0.000 description 5
- 206010039073 rheumatoid arthritis Diseases 0.000 description 5
- 230000008034 disappearance Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 210000003423 ankle Anatomy 0.000 description 3
- 206010003246 arthritis Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 210000003797 carpal joint Anatomy 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 210000000323 shoulder joint Anatomy 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000036487 Arthropathies Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000905957 Channa melasoma Species 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 244000257039 Duranta repens Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000009525 Myocarditis Diseases 0.000 description 1
- 206010036030 Polyarthritis Diseases 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 210000000544 articulatio talocruralis Anatomy 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035620 dolor Effects 0.000 description 1
- 210000001513 elbow Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 210000000811 metacarpophalangeal joint Anatomy 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 208000030428 polyarticular arthritis Diseases 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000002832 shoulder Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001171 synovial bursa Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a traditional Chinese medicine compound for treatment of rheumatic arthritis and a preparation method thereof. The traditional Chinese medicine compound comprises xanthium sibiricum, radix bupleuri, selfheal, cortex fraxini, impatiens balsamina, ramulus mori, cortex periplocae, mangnolia officinalis and exocarpium benincasae. According to the traditional Chinese medicine compound, the components, proportion and the preparation method of the traditional Chinese medicine compound are defined, so that the product prepared by the method has a remarkable effect on treatment of rheumatic arthritis, has no side effects, and is low in cost, and the rheumatic arthritis is not easy to relapse.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, especially a kind of Chinese medicine composition for the treatment of rheumatic arthritis and preparation method thereof.
Background technology
Typical case's performance of rheumatic arthritis is slight or moderate heating, migratory polyarthritis, the joint of getting involved mostly is the large joint such as knee joint, ankle, shoulder, elbow wrist, commonly by a joint, be transferred to another joint; pathological changes part presents redness, scorching hot, severe pain part patient also has several joints to fall ill simultaneously; atypical patient only has arthralgia and without other inflammation performances, acute inflammation generally disappears in 2-4 week and do not stay sequela, but Chang Fanfu outbreak.If active rheumatism affects heart and myocarditis can occur even leaves over valve disorder.
The one, joint is red, swollen, hot, pain is obvious, and stiff, site of pathological change is usually the large joints of lower limb such as knee joint, hip, ankle, is secondly shoulder, elbow, carpal joint, and brothers' little joint is rare.The 2nd, pain migration is indefinite, and a period of time is this joint outbreak, and a period of time is that joint is uncomfortable, but durante dolors is not long, within several days, just can disappear.Blood chemical examination erythrocyte sedimentation rate is accelerated, and anti-" 0 " titre raises, rheumatoid factor negative.Seldom recurrence after healing, deformity is not stayed in joint, and some patients can leave over heart change.
Rheumatism is at the chronic pain that is medically articulations digitorum manus and surrounding soft tissue's unknown cause thereof.Rheumatism refers to that the different but common ground of a large class cause of disease, for involving joint and surrounding soft tissue, comprises the disease of flesh, ligament, synovial bursa, fascia.Arthropathy has pain outward still with swelling and moving obstacle, is outbreak and alleviates the chronic course of disease alternately.Because patient's blood circulation is obstructed, cause muscle or organize needed nutrition to carry by blood circulation, cause patient's muscle to lack nutrition and accelerated ageing becomes stiff, serious meeting causes patient's muscle and blood vessel atrophy, some patients were and can occur that joint disables and viscera function exhaustion.
, for rheumatic arthritis, be now generally the method for taking western medicine, be difficult to be effected a radical cure, easily recurrence.The general curative effect of existing Chinese medicine composition is not very remarkable.
Summary of the invention
The invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthritis and preparation method thereof, by limiting composition and the proportioning thereof of Chinese medicine composition, and the preparation method of Chinese medicine composition, make the product that the present invention makes have remarkable result on for rheumatic arthritis treatment, and be free from side effects, be not easy recurrence, cost is low.
The invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthritis, Chinese medicine composition is prepared from by the raw material of following weight: Herba Xanthii grass 25-30g, Radix Bupleuri 20-25g, Spica Prunellae 20-25g, Cortex Fraxini 15-20g, Flos Impatientis 10-15g, Ramulus Mori 25-30g, Cortex Periplocae 20-25g, Cortex Magnoliae Officinalis 10-15g, Exocarpium Benincasae 25-30g.
To be Chinese medicine composition be comprised of the raw material of following weight preferred scheme: Herba Xanthii grass 26g, Radix Bupleuri 24g, Spica Prunellae 23g, Cortex Fraxini 18g, Flos Impatientis 13g, Ramulus Mori 27g, Cortex Periplocae 22g, Cortex Magnoliae Officinalis 13g, Exocarpium Benincasae 28g.
Preferred scheme is that Chinese medicine composition also comprises Herba Pteridis Multifidae 23g.
Preferred scheme is that Chinese medicine composition also comprises Cortex Cinnamomi 22g.
Preferred scheme is that Chinese medicine composition also comprises Radix Glycyrrhizae 28g.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthritis, comprises the steps:
(1) raw material in above-mentioned each formula is divided into A group and B group, A group is Herba Xanthii grass, Spica Prunellae, Cortex Fraxini, Ramulus Mori, Cortex Periplocae, Cortex Magnoliae Officinalis, and B group is all the other compositions;
(2) A group raw material extracts through conventional water extraction process, makes extractum fine powder;
(3) B group raw material is ground into fine powder, mixes with above-mentioned extractum fine powder, stirs, and as required, makes Chinese medicinal granule, powder, capsule.
The application of the Chinese medicine composition that the present invention makes aspect preparation treatment rheumatic arthritis medicine.
The application when Chinese medicine composition that the present invention makes adds Herba Pteridis Multifidae aspect preparation treatment medicine for treating rheumatoid arthritis.
The application when Chinese medicine composition that the present invention makes adds Cortex Cinnamomi aspect preparation treatment rheumatic fever medicine.
The application when Chinese medicine composition that the present invention makes adds Radix Glycyrrhizae aspect preparation treatment ankylosing spondylitis medicine.
The present invention uses rheumatic arthritis patient, adds after different compositions, and rheumatoid arthritis, rheumatic fever and ankylosing spondylitis are had to good curative effect.Product of the present invention have treatment cycle short, be free from side effects, be not easy recurrence, feature that cost is low.
The specific embodiment
Below the present invention is further detailed explanation.
Embodiment 1
Formula 1: Herba Xanthii grass 26g, Radix Bupleuri 24g, Spica Prunellae 23g, Cortex Fraxini 18g, Flos Impatientis 13g, Ramulus Mori 27g, Cortex Periplocae 22g, Cortex Magnoliae Officinalis 13g, Exocarpium Benincasae 28g
Formula 2: Herba Xanthii grass 26g, Radix Bupleuri 23g, Spica Prunellae 23g, Cortex Fraxini 17g, Flos Impatientis 12g, Ramulus Mori 28g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 14g, Exocarpium Benincasae 26g
Formula 3: Herba Xanthii grass 27g, Radix Bupleuri 24g, Spica Prunellae 22g, Cortex Fraxini 16g, Flos Impatientis 15g, Ramulus Mori 26g, Cortex Periplocae 24g, Cortex Magnoliae Officinalis 13g, Exocarpium Benincasae 28g
Formula 4: Herba Xanthii grass 26g, Radix Bupleuri 24g, Spica Prunellae 23g, Cortex Fraxini 18g, Flos Impatientis 13g, Ramulus Mori 27g, Cortex Periplocae 22g, Cortex Magnoliae Officinalis 13g, Exocarpium Benincasae 28g, Herba Pteridis Multifidae 23g
Formula 5: Herba Xanthii grass 26g, Radix Bupleuri 24g, Spica Prunellae 23g, Cortex Fraxini 18g, Flos Impatientis 13g, Ramulus Mori 27g, Cortex Periplocae 22g, Cortex Magnoliae Officinalis 13g, Exocarpium Benincasae 28g, Cortex Cinnamomi 22g
Formula 6: Herba Xanthii grass 26g, Radix Bupleuri 24g, Spica Prunellae 23g, Cortex Fraxini 18g, Flos Impatientis 13g, Ramulus Mori 27g, Cortex Periplocae 22g, Cortex Magnoliae Officinalis 13g, Exocarpium Benincasae 28g, Radix Glycyrrhizae 28g
Preparation method is as follows:
(1) above-mentioned raw materials is divided into A group and B group, A group is Herba Xanthii grass, Spica Prunellae, Cortex Fraxini, Ramulus Mori, Cortex Periplocae, Cortex Magnoliae Officinalis, and B group is all the other compositions;
(2) A group raw material extracts through conventional water extraction process, makes extractum fine powder;
(3) B group raw material is ground into fine powder, mixes with above-mentioned extractum fine powder, stirs, and as required, makes Chinese medicinal granule, powder, capsule.
Embodiment 2
The Qin, man, 45 years old, within 2006, find trouble rheumatic arthritis, knee joint, ankle joint be red and swollen, bitterly, within 2010, starts to take Chinese medicine composition of the present invention after two weeks, and redness alleviates, pain relief, by the 6th week, recovers normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 1, a minute morning and evening takes for twice, takes clothes every day.
Lee, man, 45 years old, within 2005, find trouble rheumatic arthritis, knee joint, shoulder joint be red and swollen, bitterly, and limitation of activity, started to take Chinese medicine composition of the present invention for 2010 after three weeks, and redness alleviates, pain relief, by the 6th week, recovers normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 2, a minute morning and evening takes for twice, takes clothes every day, takes clothes every day.
Zhang, female, 56 years old, within 2007, find trouble rheumatic arthritis, knee joint, ankle, shoulder joint be red and swollen, bitterly, and limitation of activity, started to take Chinese medicine composition of the present invention for 2010 after three weeks, and redness alleviates, pain relief, by the 5th week, recovers normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 3, a minute morning and evening takes for twice, takes clothes every day.
As above, observe altogether 100 patients, all take aforesaid way to take medicine, find that cure rate is 63%, effective percentage is 97%, and inefficiency is 3%.
Criterion of therapeutical effect divide following what:
Cure: after treatment, clinical symptom disappearance;
Effective: after treatment, clinical symptoms is to some extent significantly improved.
Invalid: after treatment, clinical symptoms is slightly improved or without improvement.
Embodiment 3
Chen, female, 53 years old, within 2004, find trouble rheumatoid arthritis, metacarpophalangeal joints swelling, pain, difficult movable, started to take Chinese medicine composition of the present invention for 2010 after three weeks, and redness alleviates, pain relief, by the 6th week, recovers normal, does not recur so far.Take the granule that mode is made according to above-mentioned formula 4, a minute morning and evening takes for twice, takes clothes every day.
Field, female, 57 years old, finds trouble rheumatoid arthritis for 2003, carpal joint, toes arthroncus, pain, difficult movable, started to take Chinese medicine composition of the present invention for 2010 after two weeks, and redness alleviates, pain relief, by the 6th week, recover normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 4, a minute morning and evening takes for twice, takes clothes every day.
As above, observe altogether 20 routine patients, clinical symptom disappearance be 14 examples, what significantly alleviate is 5 examples.Illustrate that formula 4 can be as treatment rheumatoid arthritis.
Embodiment 4
Cattle, female, 55 years old, within 2003, find trouble rheumatic fever, heating, arthritis, started to take Chinese medicine composition of the present invention for 2010 after three weeks, and symptom alleviates, and by the 6th week, recovers normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 5, a minute morning and evening takes for twice, takes clothes every day.
Lin, female, 51 years old, within 2006, find trouble rheumatic fever, heating, erythra, arthritis, started to take Chinese medicine composition of the present invention for 2010 after three weeks, and symptom alleviates, and by the 7th week, recovers normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 5, a minute morning and evening takes for twice, takes clothes every day.
As above, observe altogether 20 routine patients, clinical symptom disappearance be 13 examples, what significantly alleviate is 4 examples.Illustrate that formula 5 can be as treatment rheumatic fever.
Embodiment 5
Xiong, female, 53 years old, within 2006, find trouble ankylosing spondylitis, the back of the body, pain in the lumbar region pain, arthralgia, started to take Chinese medicine composition of the present invention for 2010 after three weeks, and symptom alleviates, and by the 8th week, recovers normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 6, a minute morning and evening takes for twice, takes clothes every day.
Poplar, female, 54 years old, within 2004, find trouble ankylosing spondylitis, arthralgia, deformation of spinal column, started to take Chinese medicine composition of the present invention for 2010 after three weeks, and symptom alleviates, and by the 9th week, recovers normal, so far not recurrence.Take the granule that mode is made according to above-mentioned formula 6, a minute morning and evening takes for twice, takes clothes every day.
As above, observe altogether 20 routine patients, clinical symptom disappearance be 13 examples, what significantly alleviate is 5 examples.Illustrate that formula 6 can be as treatment ankylosing spondylitis.
Above content is the further description of it being done in conjunction with structure of the present invention and work process, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (4)
1. a Chinese medicine composition for the treatment of rheumatic arthritis, is characterized in that: described Chinese medicine composition is prepared from by the raw material of following weight: Herba Xanthii grass 25-30g, Radix Bupleuri 20-25g, Spica Prunellae 20-25g, Cortex Fraxini 15-20g, Flos Impatientis 10-15g, Ramulus Mori 25-30g, Cortex Periplocae 20-25g, Cortex Magnoliae Officinalis 10-15g, Exocarpium Benincasae 25-30g.
2. the Chinese medicine composition for the treatment of rheumatic arthritis according to claim 1, is characterized in that: described Chinese medicine composition is comprised of the raw material of following weight: Herba Xanthii grass 26g, Radix Bupleuri 24g, Spica Prunellae 23g, Cortex Fraxini 18g, Flos Impatientis 13g, Ramulus Mori 27g, Cortex Periplocae 22g, Cortex Magnoliae Officinalis 13g, Exocarpium Benincasae 28g.
3. a preparation method for the Chinese medicine composition of the treatment rheumatic arthritis described in claim 1 or 2, comprises the steps:
(1) above-mentioned raw materials is divided into A group and B group, A group is Herba Xanthii grass, Spica Prunellae, Cortex Fraxini, Ramulus Mori, Cortex Periplocae, Cortex Magnoliae Officinalis, and B group is all the other compositions;
(2) A group raw material extracts through conventional water extraction process, makes extractum fine powder;
(3) B group raw material is ground into fine powder, mixes with above-mentioned extractum fine powder, stirs, and as required, makes Chinese medicinal granule, powder, capsule.
4. the application of Chinese medicine composition according to claim 1 and 2 aspect preparation treatment rheumatic arthritis medicine.
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| CN201310090468.XA CN103127236B (en) | 2013-03-14 | 2013-03-14 | Traditional Chinese medicine compound for treatment of rheumatic arthritis and preparation method thereof |
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| CN201310090468.XA CN103127236B (en) | 2013-03-14 | 2013-03-14 | Traditional Chinese medicine compound for treatment of rheumatic arthritis and preparation method thereof |
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| CN103127236B true CN103127236B (en) | 2014-08-20 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318367A (en) * | 2000-04-19 | 2001-10-24 | 尚宾泽 | Health care and medical Chinese medicine body wash |
| CN1814273A (en) * | 2005-12-05 | 2006-08-09 | 贾孝荣 | Chinese health-cave medicine acting through navel and prepartion thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06287144A (en) * | 1993-02-03 | 1994-10-11 | Takeda Chem Ind Ltd | Pharmaceutical preparation for common cold |
| KR20100120546A (en) * | 2009-05-06 | 2010-11-16 | 애경산업(주) | Composition for preventing and improving inflammation |
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2013
- 2013-03-14 CN CN201310090468.XA patent/CN103127236B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318367A (en) * | 2000-04-19 | 2001-10-24 | 尚宾泽 | Health care and medical Chinese medicine body wash |
| CN1814273A (en) * | 2005-12-05 | 2006-08-09 | 贾孝荣 | Chinese health-cave medicine acting through navel and prepartion thereof |
Non-Patent Citations (2)
| Title |
|---|
| JP特开平6-287144A 1994.10.11 |
| 肖和印等，.李素卿教授治疗幼年类风湿病经验.《北京中医药大学学报》.2000,第23卷第105-106页. * |
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