CN102895315A - 一种含连翘提取液的纳米银抑菌组合物 - Google Patents
一种含连翘提取液的纳米银抑菌组合物 Download PDFInfo
- Publication number
- CN102895315A CN102895315A CN2012103665173A CN201210366517A CN102895315A CN 102895315 A CN102895315 A CN 102895315A CN 2012103665173 A CN2012103665173 A CN 2012103665173A CN 201210366517 A CN201210366517 A CN 201210366517A CN 102895315 A CN102895315 A CN 102895315A
- Authority
- CN
- China
- Prior art keywords
- fructus forsythiae
- extracting solution
- water
- silver
- nano silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 21
- 230000003385 bacteriostatic effect Effects 0.000 title abstract 6
- 239000000284 extract Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 4
- 241000894006 Bacteria Species 0.000 claims description 38
- 230000002401 inhibitory effect Effects 0.000 claims description 30
- 241000191938 Micrococcus luteus Species 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- KFFCKOBAHMGTMW-LGQRSHAYSA-N Forsythin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC=3)[C@@H]2CO1 KFFCKOBAHMGTMW-LGQRSHAYSA-N 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 238000001556 precipitation Methods 0.000 claims description 12
- JJVGFDTWFVSBIM-UHFFFAOYSA-N Phillyrin Natural products COc1ccc(cc1OC)C2OCC3C2COC3c4ccc(OC)c(OC5OC(CO)C(O)C(O)C5O)c4 JJVGFDTWFVSBIM-UHFFFAOYSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 9
- FDBMFXMFZNNOQV-UHFFFAOYSA-N silver;tetradecanoic acid Chemical compound [Ag].CCCCCCCCCCCCCC(O)=O FDBMFXMFZNNOQV-UHFFFAOYSA-N 0.000 claims description 9
- 238000005303 weighing Methods 0.000 claims description 7
- 241001333951 Escherichia coli O157 Species 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 6
- 239000012567 medical material Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 230000008034 disappearance Effects 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical class CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 238000005374 membrane filtration Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 241001646719 Escherichia coli O157:H7 Species 0.000 abstract description 18
- 239000003814 drug Substances 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 239000000022 bacteriostatic agent Substances 0.000 abstract 4
- 241000598860 Garcinia hanburyi Species 0.000 abstract 1
- 241000192041 Micrococcus Species 0.000 abstract 1
- 229940117709 gamboge Drugs 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000000452 restraining effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 72
- 230000000844 anti-bacterial effect Effects 0.000 description 32
- 229910052709 silver Inorganic materials 0.000 description 26
- 239000004332 silver Substances 0.000 description 26
- 239000007788 liquid Substances 0.000 description 25
- 239000001888 Peptone Substances 0.000 description 14
- 238000013207 serial dilution Methods 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 235000015278 beef Nutrition 0.000 description 10
- 239000012530 fluid Substances 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 5
- 239000006137 Luria-Bertani broth Substances 0.000 description 4
- 108010080698 Peptones Proteins 0.000 description 4
- 239000003708 ampul Substances 0.000 description 4
- 230000001332 colony forming effect Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 239000002054 inoculum Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000002105 nanoparticle Substances 0.000 description 4
- 235000019319 peptone Nutrition 0.000 description 4
- 238000005498 polishing Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004744 fabric Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 239000006142 Luria-Bertani Agar Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000827798 Hemerocallis citrina Species 0.000 description 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
抑菌物质 | 加入抑菌剂后能数出来的菌落数 |
空白组 | 6.5×107 CFU/mL |
200 μL的连翘提取液 | 1.5×106 CFU/mL |
含2 μL浓度为10 mg/mL的纳米银 | 4.8×102 CFU/mL |
含100 μL的连翘提取液和1 μL浓度为10 mg/mL的纳米银溶液 | 0 CFU/mL |
抑菌物质 | 加入抑菌剂后能数出来的菌落数 |
空白组 | 5.7×106 CFU/mL |
150 μL的连翘提取液 | 2.0×106 CFU/mL |
含2 μL浓度为10 mg/mL的纳米银 | 4.8×102 CFU/mL |
含75 μL的连翘提取液和1 μL浓度为10 mg/mL的纳米银溶液 | 0 CFU/mL |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210366517.3A CN102895315B (zh) | 2012-09-28 | 2012-09-28 | 一种含连翘提取液的纳米银抑菌组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210366517.3A CN102895315B (zh) | 2012-09-28 | 2012-09-28 | 一种含连翘提取液的纳米银抑菌组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102895315A true CN102895315A (zh) | 2013-01-30 |
CN102895315B CN102895315B (zh) | 2014-02-26 |
Family
ID=47568001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210366517.3A Active CN102895315B (zh) | 2012-09-28 | 2012-09-28 | 一种含连翘提取液的纳米银抑菌组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102895315B (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6379712B1 (en) * | 2000-09-13 | 2002-04-30 | Globoasia, L.L.C. | Nanosilver-containing antibacterial and antifungal granules and methods for preparing and using the same |
US6660058B1 (en) * | 2000-08-22 | 2003-12-09 | Nanopros, Inc. | Preparation of silver and silver alloyed nanoparticles in surfactant solutions |
CN1598691A (zh) * | 2004-09-27 | 2005-03-23 | 北京化工大学 | 一种纳米脂肪酸银粉体的制备方法 |
WO2006071069A1 (en) * | 2004-12-29 | 2006-07-06 | Gaia Infonet Co., Ltd. | Bactericidal detergent composition |
WO2007032567A1 (en) * | 2005-09-13 | 2007-03-22 | Hyunkyung Shin | Manufacturing method of antimicrobial fiber using nano silver powder |
-
2012
- 2012-09-28 CN CN201210366517.3A patent/CN102895315B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660058B1 (en) * | 2000-08-22 | 2003-12-09 | Nanopros, Inc. | Preparation of silver and silver alloyed nanoparticles in surfactant solutions |
US6379712B1 (en) * | 2000-09-13 | 2002-04-30 | Globoasia, L.L.C. | Nanosilver-containing antibacterial and antifungal granules and methods for preparing and using the same |
CN1598691A (zh) * | 2004-09-27 | 2005-03-23 | 北京化工大学 | 一种纳米脂肪酸银粉体的制备方法 |
WO2006071069A1 (en) * | 2004-12-29 | 2006-07-06 | Gaia Infonet Co., Ltd. | Bactericidal detergent composition |
WO2007032567A1 (en) * | 2005-09-13 | 2007-03-22 | Hyunkyung Shin | Manufacturing method of antimicrobial fiber using nano silver powder |
US20090214771A1 (en) * | 2005-09-13 | 2009-08-27 | Hyunkyung Shin | Manufacturing Method of Antimicrobial Fiber Using Nano Silver Powder |
Non-Patent Citations (2)
Title |
---|
张恩户等: "连翘及其制剂抗菌效价的生物测定法", 《中国中医基础医学杂志》 * |
陈孝治等: "《药物处方手册》", 30 April 2010, 湖南科学技术出版社 * |
Also Published As
Publication number | Publication date |
---|---|
CN102895315B (zh) | 2014-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102895325B (zh) | 中药抑菌组合物 | |
CN113383798A (zh) | 一种新型复合制剂及其在细菌性病害中的应用 | |
CN104855684B (zh) | 一种抗菌中药微生物发酵制剂及其制备方法和用途 | |
CN104178370A (zh) | 一种含中药成分的杀菌洗衣液及其制备方法 | |
CN104381343B (zh) | 一种水溶性复配抑菌剂及其制备方法 | |
CN103814967B (zh) | 一种水产消毒用的中草药颗粒制剂及其制备方法 | |
CN102895286B (zh) | 一种抑菌剂 | |
CN111662880A (zh) | 一株产气荚膜梭菌噬菌体、包括噬菌体的抑菌剂及制备方法和应用 | |
CN102895341B (zh) | 黄连提取物与纳米银抑菌组合物 | |
CN103099295A (zh) | 一种地肤子天然防腐剂及其制备方法 | |
CN113995744A (zh) | 一种组合物及其抗菌应用 | |
CN103054969B (zh) | 一种复合皮肤消毒剂及其制备方法 | |
CN104840401A (zh) | 一种护肤品用植物防腐剂 | |
CN102895315B (zh) | 一种含连翘提取液的纳米银抑菌组合物 | |
CN102895282B (zh) | 一种板蓝根提取液与纳米银抑菌组合物 | |
CN104983795B (zh) | 一种用于治疗呼吸道疾病的复方兽用抗菌制剂 | |
CN107535540A (zh) | 一种抗菌剂及其制备方法 | |
CN109316533B (zh) | 一种清除猪体内毒素的发酵中药复方制剂及其应用 | |
CN110583755A (zh) | 双组氨酸/铁皮石斛多糖复合抗菌剂及制备方法和应用 | |
CN110755368A (zh) | 盐酸小檗碱-苦参碱-羧甲基壳聚糖复合水凝胶及其制备方法和应用 | |
CN108721167B (zh) | 一种含有藤茶提取物的防腐剂组合物及其在制备化妆品中的用途 | |
CN107115369A (zh) | 马齿苋益生菌剂及其应用 | |
CN107115368A (zh) | 预防动物腹泻的石榴皮微生态制剂及其应用 | |
CN102824454B (zh) | 一种鱼金颗粒剂及其制备方法 | |
CN103977028A (zh) | 甘薯叶绿原酸与纳米氧化锌抑菌组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Huang Qingxi Inventor before: Wei Hua Inventor before: Xiong Yonghua Inventor before: Xu Hengyi Inventor before: Wang Lijun Inventor before: Guo Liang Inventor before: Xu Feng Inventor before: Wan Cuixiang Inventor before: Lai Weihua |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170623 Address after: 410000, Hunan Province, Changsha Town, Yuhua Town, Hunan environmental protection science and Technology Industrial Park Management Committee, office building, 2 floor Patentee after: ANSON BIOTECHNOLOGY CO.,LTD. Address before: 999 No. 330031 Jiangxi province Nanchang Honggutan University Avenue Patentee before: Nanchang University |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Nano-silver bacteriostatic composition containing fructus forsythiae extracting solution Effective date of registration: 20200601 Granted publication date: 20140226 Pledgee: Changsha Rural Commercial Bank Co.,Ltd. dezhengyuan sub branch Pledgor: ANSON BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020980002659 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200903 Granted publication date: 20140226 Pledgee: Changsha Rural Commercial Bank Co.,Ltd. dezhengyuan sub branch Pledgor: ANSON BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020980002659 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A nano silver antibacterial composition containing Forsythia suspensa extract Effective date of registration: 20201118 Granted publication date: 20140226 Pledgee: Bank of Changsha Co.,Ltd. Jincheng sub branch Pledgor: ANSON BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020980008173 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221024 Granted publication date: 20140226 Pledgee: Bank of Changsha Co.,Ltd. Jincheng sub branch Pledgor: ANSON BIOTECHNOLOGY CO.,LTD. Registration number: Y2020980008173 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A nano silver antibacterial composition containing forsythia suspensa extract Effective date of registration: 20221103 Granted publication date: 20140226 Pledgee: Bank of Changsha Co.,Ltd. Jincheng sub branch Pledgor: ANSON BIOTECHNOLOGY CO.,LTD. Registration number: Y2022430000097 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231107 Granted publication date: 20140226 Pledgee: Bank of Changsha Co.,Ltd. Jincheng sub branch Pledgor: ANSON BIOTECHNOLOGY CO.,LTD. Registration number: Y2022430000097 |