CN102884084B - 抗her2抗体及组合物 - Google Patents
抗her2抗体及组合物 Download PDFInfo
- Publication number
- CN102884084B CN102884084B CN201180022307.6A CN201180022307A CN102884084B CN 102884084 B CN102884084 B CN 102884084B CN 201180022307 A CN201180022307 A CN 201180022307A CN 102884084 B CN102884084 B CN 102884084B
- Authority
- CN
- China
- Prior art keywords
- antibody
- sequence
- heavy chain
- light
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31055210P | 2010-03-04 | 2010-03-04 | |
DKPA201070085 | 2010-03-04 | ||
DKPA201070085 | 2010-03-04 | ||
US61/310,552 | 2010-03-04 | ||
US35413310P | 2010-06-11 | 2010-06-11 | |
US61/354,133 | 2010-06-11 | ||
US201061428014P | 2010-12-29 | 2010-12-29 | |
US61/428,014 | 2010-12-29 | ||
PCT/IB2011/050903 WO2011107957A1 (en) | 2010-03-04 | 2011-03-03 | Anti-her2 antibodies and compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102884084A CN102884084A (zh) | 2013-01-16 |
CN102884084B true CN102884084B (zh) | 2016-12-07 |
Family
ID=44541704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180022307.6A Expired - Fee Related CN102884084B (zh) | 2010-03-04 | 2011-03-03 | 抗her2抗体及组合物 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2542589A4 (hr) |
JP (1) | JP6039428B2 (hr) |
CN (1) | CN102884084B (hr) |
TW (1) | TW201141519A (hr) |
WO (1) | WO2011107957A1 (hr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8883149B2 (en) | 2008-09-15 | 2014-11-11 | Yeda Research And Development Co. Ltd. | Antibody combinations and use of same for treating cancer |
US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
CA2816520C (en) | 2010-11-01 | 2017-11-21 | Symphogen A/S | Anti-her3 antibodies and compositions |
EP2710038B1 (en) | 2011-05-16 | 2018-01-17 | Yeda Research and Development Co. Ltd. | COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER |
CN104428318B (zh) | 2012-05-02 | 2018-09-25 | 西福根有限公司 | 人源化泛her抗体组合物 |
EP3838923B1 (en) | 2012-08-24 | 2024-05-01 | The Regents of The University of California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
RU2656161C1 (ru) * | 2013-11-19 | 2018-05-31 | Ремеджен, Лтд. | Анти-неr2 антитело и его конъюгат |
CN104974261B (zh) * | 2014-04-01 | 2019-06-14 | 三生国健药业(上海)股份有限公司 | 重组抗her2/ps双特异性抗体、其制备方法和应用 |
BR112017011170A2 (pt) * | 2014-12-18 | 2018-02-27 | Hoffmann La Roche | método para determinar a citotoxicidade dependente do complemento de uma composição |
CN106831987B (zh) * | 2015-12-04 | 2020-01-21 | 浙江大学 | 一种抗人her2抗体及其编码基因和应用 |
CN109154600A (zh) * | 2016-06-16 | 2019-01-04 | 豪夫迈·罗氏有限公司 | 用于确定cdc诱导抗体的测定法和方法 |
SG11201811559WA (en) | 2016-06-27 | 2019-01-30 | Univ California | Cancer treatment combinations |
CN107137424A (zh) * | 2017-05-15 | 2017-09-08 | 广州领晟医疗科技有限公司 | 一种利用正常小鼠建立her2阳性肿瘤的动物模型的方法 |
WO2019173911A1 (en) * | 2018-03-13 | 2019-09-19 | Zymeworks Inc. | Anti-her2 biparatopic antibody-drug conjugates and methods of use |
CN109134656A (zh) * | 2018-09-12 | 2019-01-04 | 四川妙和生物科技有限公司 | 一种抗her2多克隆抗体 |
WO2020191434A1 (en) * | 2019-03-22 | 2020-10-01 | Olivia Newton-John Cancer Research Institute | Anti-her2 binding molecules |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999055367A1 (en) * | 1998-04-24 | 1999-11-04 | The Regents Of The University Of California | INTERNALIZING ErbB2 ANTIBODIES |
WO2006087637A2 (en) * | 2005-02-21 | 2006-08-24 | Hellenic Pasteur Institute | Anti her2/neu antibody |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6794128B2 (en) * | 1998-04-24 | 2004-09-21 | The Regents Of The University Of California | Methods of selecting internalizing antibodies |
JP2006516117A (ja) * | 2002-11-21 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 抗ErbB2抗体を用いた非悪性疾病または疾患の治療 |
US7498142B2 (en) * | 2006-01-31 | 2009-03-03 | Yeda Research And Development Co., Ltd. | Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies |
JP5719298B2 (ja) * | 2008-08-29 | 2015-05-13 | シムフォゲン・アクティーゼルスカブSymphogen A/S | 組換え抗上皮増殖因子受容体抗体組成物 |
-
2011
- 2011-03-03 EP EP11750275.7A patent/EP2542589A4/en not_active Withdrawn
- 2011-03-03 CN CN201180022307.6A patent/CN102884084B/zh not_active Expired - Fee Related
- 2011-03-03 WO PCT/IB2011/050903 patent/WO2011107957A1/en active Application Filing
- 2011-03-03 JP JP2012555532A patent/JP6039428B2/ja not_active Expired - Fee Related
- 2011-03-03 TW TW100107086A patent/TW201141519A/zh unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999055367A1 (en) * | 1998-04-24 | 1999-11-04 | The Regents Of The University Of California | INTERNALIZING ErbB2 ANTIBODIES |
WO2006087637A2 (en) * | 2005-02-21 | 2006-08-24 | Hellenic Pasteur Institute | Anti her2/neu antibody |
Non-Patent Citations (1)
Title |
---|
The HER-2-Targeting Antibodies Trastuzumab and Pertuzumab Synergistically Inhibit the Survival of Breast Cancer Cells;Rita Nahta,et al.;《Cancer Research》;20040401;第64卷(第7期);摘要和第2343页左栏第2-3段,第2344页右栏最后1段 * |
Also Published As
Publication number | Publication date |
---|---|
EP2542589A4 (en) | 2013-08-07 |
TW201141519A (en) | 2011-12-01 |
EP2542589A1 (en) | 2013-01-09 |
JP6039428B2 (ja) | 2016-12-07 |
WO2011107957A1 (en) | 2011-09-09 |
JP2013520984A (ja) | 2013-06-10 |
CN102884084A (zh) | 2013-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161207 Termination date: 20200303 |
|
CF01 | Termination of patent right due to non-payment of annual fee |