CN102884074A - 拟肽大环化合物 - Google Patents

拟肽大环化合物 Download PDF

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Publication number
CN102884074A
CN102884074A CN2009801429897A CN200980142989A CN102884074A CN 102884074 A CN102884074 A CN 102884074A CN 2009801429897 A CN2009801429897 A CN 2009801429897A CN 200980142989 A CN200980142989 A CN 200980142989A CN 102884074 A CN102884074 A CN 102884074A
Authority
CN
China
Prior art keywords
amino acid
peptidomimetic macrocycle
alkyl
peptide
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801429897A
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English (en)
Chinese (zh)
Inventor
H·M·纳什
R·卡佩勒-利伯曼
J-w·韩
T·K·索耶
J·诺伊赫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of CN102884074A publication Critical patent/CN102884074A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2009801429897A 2008-09-22 2009-09-22 拟肽大环化合物 Pending CN102884074A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9916508P 2008-09-22 2008-09-22
US61/099,165 2008-09-22
PCT/US2009/057930 WO2010034031A1 (en) 2008-09-22 2009-09-22 Peptidomimetic macrocycles

Publications (1)

Publication Number Publication Date
CN102884074A true CN102884074A (zh) 2013-01-16

Family

ID=41692050

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801429897A Pending CN102884074A (zh) 2008-09-22 2009-09-22 拟肽大环化合物

Country Status (8)

Country Link
US (1) US20120178700A1 (cg-RX-API-DMAC7.html)
EP (1) EP2334697A1 (cg-RX-API-DMAC7.html)
JP (1) JP2012510430A (cg-RX-API-DMAC7.html)
CN (1) CN102884074A (cg-RX-API-DMAC7.html)
AU (1) AU2009294874A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0920889A2 (cg-RX-API-DMAC7.html)
CA (1) CA2737920A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010034031A1 (cg-RX-API-DMAC7.html)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106642A (zh) * 2014-09-24 2017-08-29 艾瑞朗医疗公司 拟肽大环化合物及其制剂
CN107614003A (zh) * 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
CN109071622A (zh) * 2016-03-15 2018-12-21 Idp研发制药有限公司 具有抗癌活性的肽
CN111263768A (zh) * 2017-07-25 2020-06-09 Idp研发制药有限公司 抗癌肽
CN111405903A (zh) * 2017-09-08 2020-07-10 Idp研发制药有限公司 多发性骨髓瘤的新疗法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0720306A2 (pt) 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
CA2678941C (en) 2007-02-23 2018-11-27 Aileron Therapeutics, Inc. Triazole macrocycle systems
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
WO2010034034A1 (en) 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
BRPI0920899A2 (pt) 2008-11-24 2016-04-26 Aileron Therapeutics Inc macrociclos peptidomiméticos com propriedades melhoradas
BRPI1006139A2 (pt) 2009-01-14 2017-05-30 Aileron Therapeutics Inc macrociclos peptidomiméticos
US20130072439A1 (en) 2009-09-22 2013-03-21 Huw M. Nash Peptidomimetic macrocycles
MX355543B (es) 2010-08-13 2018-04-20 Aileron Therapeutics Inc Star Macrociclos peptidomiméticos.
EP2627662B1 (en) 2010-10-13 2015-09-16 Bristol-Myers Squibb Company Methods for preparing macrocycles and macrocycle stabilized peptides
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
WO2013096755A1 (en) 2011-12-21 2013-06-27 New York University Proteolytically resistant hydrogen bond surrogate helices
JP6450191B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
CA2933701C (en) 2013-12-18 2022-05-31 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
WO2019025432A1 (en) * 2017-08-01 2019-02-07 Idp Discovery Pharma, S.L. PEPTIDES WITH ANTICANCER ACTIVITY
JP2024522196A (ja) 2021-06-09 2024-06-11 ザ スクリプス リサーチ インスティテュート 長時間作用型デュアルｇｉｐ／ｇｌｐ－１ペプチドコンジュゲートおよび使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633933A1 (en) * 1992-03-23 1995-01-18 Imperial Cancer Research Technology Limited Leucine zippers
US7192713B1 (en) * 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
BRPI0720306A2 (pt) * 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
CA2678941C (en) * 2007-02-23 2018-11-27 Aileron Therapeutics, Inc. Triazole macrocycle systems
KR20160061439A (ko) * 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106642A (zh) * 2014-09-24 2017-08-29 艾瑞朗医疗公司 拟肽大环化合物及其制剂
CN107106642B (zh) * 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
CN107614003A (zh) * 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
CN109071622A (zh) * 2016-03-15 2018-12-21 Idp研发制药有限公司 具有抗癌活性的肽
CN109071622B (zh) * 2016-03-15 2023-01-13 Idp研发制药有限公司 具有抗癌活性的肽
CN111263768A (zh) * 2017-07-25 2020-06-09 Idp研发制药有限公司 抗癌肽
CN111263768B (zh) * 2017-07-25 2023-10-13 Idp研发制药有限公司 抗癌肽
CN111405903A (zh) * 2017-09-08 2020-07-10 Idp研发制药有限公司 多发性骨髓瘤的新疗法

Also Published As

Publication number Publication date
CA2737920A1 (en) 2010-03-25
AU2009294874A1 (en) 2010-03-25
WO2010034031A1 (en) 2010-03-25
US20120178700A1 (en) 2012-07-12
JP2012510430A (ja) 2012-05-10
BRPI0920889A2 (pt) 2017-10-10
EP2334697A1 (en) 2011-06-22

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Application publication date: 20130116