CA2737920A1 - Peptidomimetic macrocycles - Google Patents

Peptidomimetic macrocycles Download PDF

Info

Publication number
CA2737920A1
CA2737920A1 CA2737920A CA2737920A CA2737920A1 CA 2737920 A1 CA2737920 A1 CA 2737920A1 CA 2737920 A CA2737920 A CA 2737920A CA 2737920 A CA2737920 A CA 2737920A CA 2737920 A1 CA2737920 A1 CA 2737920A1
Authority
CA
Canada
Prior art keywords
amino acid
peptidomimetic macrocycle
macrocycle
peptidomimetic
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2737920A
Other languages
English (en)
French (fr)
Inventor
Huw M. Nash
Rosana Kapeller-Libermann
Jia-Wen Han
Tomi K. Sawyer
Justin Noehre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of CA2737920A1 publication Critical patent/CA2737920A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2737920A 2008-09-22 2009-09-22 Peptidomimetic macrocycles Abandoned CA2737920A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9916508P 2008-09-22 2008-09-22
US61/099,165 2008-09-22
PCT/US2009/057930 WO2010034031A1 (en) 2008-09-22 2009-09-22 Peptidomimetic macrocycles

Publications (1)

Publication Number Publication Date
CA2737920A1 true CA2737920A1 (en) 2010-03-25

Family

ID=41692050

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2737920A Abandoned CA2737920A1 (en) 2008-09-22 2009-09-22 Peptidomimetic macrocycles

Country Status (8)

Country Link
US (1) US20120178700A1 (cg-RX-API-DMAC7.html)
EP (1) EP2334697A1 (cg-RX-API-DMAC7.html)
JP (1) JP2012510430A (cg-RX-API-DMAC7.html)
CN (1) CN102884074A (cg-RX-API-DMAC7.html)
AU (1) AU2009294874A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0920889A2 (cg-RX-API-DMAC7.html)
CA (1) CA2737920A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010034031A1 (cg-RX-API-DMAC7.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0720306A2 (pt) 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
CA2678941C (en) 2007-02-23 2018-11-27 Aileron Therapeutics, Inc. Triazole macrocycle systems
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
WO2010034034A1 (en) 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
BRPI0920899A2 (pt) 2008-11-24 2016-04-26 Aileron Therapeutics Inc macrociclos peptidomiméticos com propriedades melhoradas
BRPI1006139A2 (pt) 2009-01-14 2017-05-30 Aileron Therapeutics Inc macrociclos peptidomiméticos
US20130072439A1 (en) 2009-09-22 2013-03-21 Huw M. Nash Peptidomimetic macrocycles
MX355543B (es) 2010-08-13 2018-04-20 Aileron Therapeutics Inc Star Macrociclos peptidomiméticos.
EP2627662B1 (en) 2010-10-13 2015-09-16 Bristol-Myers Squibb Company Methods for preparing macrocycles and macrocycle stabilized peptides
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
WO2013096755A1 (en) 2011-12-21 2013-06-27 New York University Proteolytically resistant hydrogen bond surrogate helices
JP6450191B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス,インコーポレイテッド ペプチドミメティック大環状化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
CA2933701C (en) 2013-12-18 2022-05-31 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
WO2016049355A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
EP3294318A4 (en) * 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. Mcl−1のモジュレーターとしてのペプチド模倣大環状分子
US10639348B2 (en) * 2016-03-15 2020-05-05 Idp Discovery Pharma, S.L. Peptides with anti-cancer activity
AU2018305923B2 (en) * 2017-07-25 2022-05-05 Idp Discovery Pharma, S.L. Anticancer peptides
WO2019025432A1 (en) * 2017-08-01 2019-02-07 Idp Discovery Pharma, S.L. PEPTIDES WITH ANTICANCER ACTIVITY
AU2018328057A1 (en) * 2017-09-08 2020-04-23 Idp Discovery Pharma, S.L. New treatments of multiple myeloma
JP2024522196A (ja) 2021-06-09 2024-06-11 ザ スクリプス リサーチ インスティテュート 長時間作用型デュアルgip/glp-1ペプチドコンジュゲートおよび使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633933A1 (en) * 1992-03-23 1995-01-18 Imperial Cancer Research Technology Limited Leucine zippers
US7192713B1 (en) * 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
BRPI0720306A2 (pt) * 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
CA2678941C (en) * 2007-02-23 2018-11-27 Aileron Therapeutics, Inc. Triazole macrocycle systems
KR20160061439A (ko) * 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드

Also Published As

Publication number Publication date
AU2009294874A1 (en) 2010-03-25
WO2010034031A1 (en) 2010-03-25
US20120178700A1 (en) 2012-07-12
JP2012510430A (ja) 2012-05-10
BRPI0920889A2 (pt) 2017-10-10
EP2334697A1 (en) 2011-06-22
CN102884074A (zh) 2013-01-16

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140923