CN102872347A - Oral medicine for treating hand-foot-and-mouth diseases and preparation method of oral medicine - Google Patents
Oral medicine for treating hand-foot-and-mouth diseases and preparation method of oral medicine Download PDFInfo
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Abstract
The invention relates to oral medicine for treating hand-foot-and-mouth diseases and a preparation method of the oral medicine. The oral medicine comprises raw material medicine including rabdosia amethystoides, fritillary, radix semiaquilegiae, fragrant ainsliaea, cortex lycii radicis, radix scrophulariae, achyranthes root, junci medulla, dendrobe, rattlesnake plantain, white atractylodes rhizome, hyacinth bean and goldhair hedyotis herb. The oral medicine has the advantages that the taking is convenient, the effect taking is fast, the curative effect is high, the curing is high, no side effect exists, and the oral medicine is suitable for various user groups with hand-foot-and-mouth diseases in different degrees.
Description
Technical field
The invention belongs to field of medicaments, particularly relate to oral drugs for the treatment of hand-foot-mouth disease and preparation method thereof.
Background technology
Hand-foot-mouth disease (generally including hand-foot-mouth disease, throat, oral ulcer, herpes etc., the general designation hand-foot-mouth disease) is a kind of child's infectious disease of in recent years finding, has another name called dermexanthesis vesicle stomatitis.Hand-foot-mouth disease is multiple is born in child below 5 years old, can cause the herpes at the positions such as hands, foot, oral cavity, and the minority infant can cause the complication such as myocarditis, pulmonary edema, AME.If indivedual children with serious disease PD are fast, cause death.This disease forms ulcer as main clinic symptoms behind hands, foot and oral mucosa herpes or ulceration.
Doctor trained in Western medicine is commonly considered as the infectious disease that caused by enterovirus, and the enterovirus that causes hand-foot-mouth disease has 20 polytypes, and is wherein common with coxsackie virus A 16-type (Cox A16) and enterovirns type 71 (EV71).Western medical treatment is commonly used the medicines such as acyclovir, valaciclovir, famciclovir, antiviral drugs as high-efficiency broad spectrum, have obvious shortening heating and skin lesion healing time, alleviate the effect of herpes of mouth pain, but easily cause the acute renal infringement, and affect child's subsequent growth growth, anti-virus ability etc., and high fever, 10 days, first quarter moon are difficult to recovery from illness.According to national medical science think heart channel intenseness of heat, send out and to be aphtha, and " the total little opinion side of children's's health. the sick opinion of lip " in the discussion of " pathogenic wind toxic is damp and hot; with its empty place work; fight in vim and vigour, then give birth to skin ulcer " because the evil poison of row during diseases caused by exogenous pathogenic factor, enter through mouth and nose, evil poison accumulates the lung spleen, involves in the body, sends out skin outward and forms.Because of its site of pathological change different, therefore herpes, pimple can come across hands, foot, buttocks and even whole body, but common with the palm of the hand, vola.Etiological is retention of heat in the spleen and stomach or flaming up of heart-fire and cause, and is clinical take excess syndrome as many.The cause of disease of hand-foot-mouth disease is diseases caused by exogenous pathogenic factor seasonal pathogen epidemic disease poison, the internal injury damp-heat accumulation, and heart-fire is flourishing, and sick position is dirty at lung, spleen, the heart three; Its basic pathogenesis is diseases caused by exogenous pathogenic factor seasonal pathogen epidemic disease poison, defends table and is held back Lung Qi obstraction, disease is seen heating, cough, watery nasal discharge, is felt sick, vomiting etc., because plain body retention of damp-heat in the interior, heart channel fire are contained, interior diplomacy are striven, steam in dispute on the fire of heart channel, damp-heat in the spleen and stomach is fumigated in extremity, then sends out to be herpes.The evil poison of primary disease impression is the heresy of special epidemic disease poison, this damp and hot heresy has strong infectiousness, their early stage is the scorchingly hot lung spleen that injures, cause lung to be defended becoming estranged and see heating, watery nasal discharge, tussicula, swallow the cold symptoms such as red, severe one vomiting and diarrhoea occurs and waits the damage of the spleen syndrome, then scorchingly hotly enter blood, follow capable whole body, and spleen governing limbs, have one's ideas straightened out in mouth, the evil impairment of the spleen then hand-foot-mouth disease is subjected to heresy and heat, and heat stagnation is rash, poison is vesiculated thoroughly, cause that erythema occurs at the hand-foot-mouth disease position, the gradual change vesicle, and stomatalgia, pharyngalgia, sialorrhea, refusing to eat, agitation and the brothers symptoms such as pain of itching appear.At present in the public technology, the group medicine for the treatment of hand-foot-mouth disease has: a kind of Chinese medicine for the treatment of hand-foot-mouth disease is that Semen Oroxyli, Radix Scutellariae, Cortex Phellodendri, Radix Gentianae, Folium Isatidis, Radix Isatidis, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Salviae Chinensis, Pseudobulbus Cremastrae Seu Pleiones and Radix Glycyrrhizae are raw material, different qualities according to every flavor Chinese medicine is prepared in proportion, through decocting, filter, bottle, sterilizing, make according to a conventional method Chinese medicine decoction.
A kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease comprises oral medicine and medicine for external use, and wherein oral medicine is to be formed by Radix Glycyrrhizae, Rhizoma Coptidis, Rhizoma Zingiberis Recens, Radix Bupleuri, Folium Salicis Babylonicae, Flos Helianthi, Herba Taraxaci, Fructus Fici, Folium Lycii, Radix Brassicae rapae, Fructus Solani melongenae, Herba Menthae, Alumen compatibility; Medicine for external use be by Folium solani verbascifolii, Folium Salicis Babylonicae, Herba Taraxaci, Fructus Fici, Fructus Lycii, Lumbricus, Herba Violae, Flos Lonicerae, Cortex Dictamni, Herba Agrimoniae, Calomelas, Camphora,, Borneolum Syntheticum, Radix Camelliae sinensis compatibility form.The Chinese medicine preparation curative effect of above-mentioned treatment hand-foot-mouth disease can not be satisfactory.
Summary of the invention
The object of the invention is to overcome the medicament Shortcomings of above-mentioned prior art treatment hand-foot-mouth disease, hold through the inventor and to pass the traditional Chinese medical science secret recipe handed down from one's ancestors and be engaged in for a long time the exploitation of infectious disease traditional Chinese medical science industry and practise medicine of many generations, through for many years clinical practice, according to the medical knowledge of traditional Chinese medical science prescription theoretical " negative and positive are taken into account; treating both the principal and secondary aspects of a disease; the spleen cardiopulmonary are all thin " and up-to-date nano-pulverization technology, exploitation provides a kind of easy absorption, instant effect, evident in efficacy, cure rate is high, easy to use, the hand-foot-mouth disease that has no side effect (generally includes hand-foot-mouth disease, throat, oral ulcer, herpes etc., general designation hand-foot-mouth disease) oral medicine and preparation method thereof.
The oral medicine for the treatment of hand-foot-mouth disease provided by the invention, its feature comprise following bulk drugs (Chinese herbal medicine) component and weight portion, and through selected, extraction or ovendry power are broken into the oral drugs of fine powder:
Herba Rabdosiae glaucocalycis 8-30 weight portion, Bulbus Fritillariae Uninbracteatae 3-15 weight portion, Radix Semiaquilegiae 3-10 weight portion, Herba Ainsliaeae Fragrantis 1.5-10 weight portion, Cortex Lycii 1.5-15 weight portion, Radix Scrophulariae 1.5-15 weight portion, Radix Achyranthis Bidentatae 1.5-10 weight portion, Medulla Junci 0.5-5 weight portion, Herba Dendrobii 1-7 weight portion, Herba goodyearae repentis 0.5-3 weight portion, Rhizoma Atractylodis Macrocephalae 1-4 weight portion, Seem Lablab Album 1.5-10 weight portion, Herba Hedyotidis Chrysotrichae 1-6 weight portion.
The oral medicine for the treatment of hand-foot-mouth disease provided by the invention, its feature comprises following bulk drugs component and weight portion, through selected, extraction or ovendry power are broken into the oral drugs of fine powder:
Be preferably Herba Rabdosiae glaucocalycis 8-25 weight portion, Bulbus Fritillariae Uninbracteatae 3-10 weight portion, Radix Semiaquilegiae 3.5-8 weight portion, Herba Ainsliaeae Fragrantis 1.5-8 weight portion, Cortex Lycii 1.5-12 weight portion, Radix Scrophulariae 1.5-13 weight portion, Radix Achyranthis Bidentatae 1.5-8 weight portion, Medulla Junci 0.5-4 weight portion, Herba Dendrobii 1-5 weight portion, Herba goodyearae repentis 0.5-2.5 weight portion, Rhizoma Atractylodis Macrocephalae 1-3 weight portion, Seem Lablab Album 1.5-7 weight portion, Herba Hedyotidis Chrysotrichae 1-5 weight portion.
The oral medicine for the treatment of hand-foot-mouth disease provided by the invention, its feature comprises following bulk drugs component and weight portion, through selected, extraction or ovendry power are broken into the oral drugs of fine powder:
More preferably Herba Rabdosiae glaucocalycis 8 weight portions, Bulbus Fritillariae Uninbracteatae 3 weight portions, Radix Semiaquilegiae 3.5 weight portions, Herba Ainsliaeae Fragrantis 1.5 weight portions, Cortex Lycii 1.5 weight portions, Radix Scrophulariae 1.5 weight portions, Radix Achyranthis Bidentatae 1.5 weight portions, Medulla Junci 0.5 weight portion, Herba Dendrobii 1 weight portion, Herba goodyearae repentis 0.5 weight portion, the Rhizoma Atractylodis Macrocephalae 1 weight portion, Seem Lablab Album 1.5 weight portions, Herba Hedyotidis Chrysotrichae 1 weight portion.
The preparation method of the oral drugs for the treatment of hand-foot-mouth disease provided by the invention comprises the following steps:
1), with marketable material medicine component: Herba Rabdosiae glaucocalycis, Bulbus Fritillariae Uninbracteatae, Radix Semiaquilegiae, Herba Ainsliaeae Fragrantis, Cortex Lycii, Radix Scrophulariae, Radix Achyranthis Bidentatae, Medulla Junci, Herba Dendrobii, Herba goodyearae repentis, the Rhizoma Atractylodis Macrocephalae, Seem Lablab Album, Herba Hedyotidis Chrysotrichae.Carry out respectively selectedly, remove defective crude drug and impurity, after cleaning, do not have standby (commercially available common apparatus) in 40 ℃ of maneuvers routinely with oven dry, under gnotobasis, dry respectively, perhaps can under sunlight, dry, then carry out sterilization treatment.
2), with step 1) the dried crude drug that obtains is placed in fine pulverizer or the nanometer pulverizer (all being the commercially available prod) by the weight portion of above-mentioned raw materials medicine component and carries out the sterile working, is ground into fine powder or the nanoscale powder (particle diameter 10 of fine powder
-4-10
-6M, the nanoscale powder comprises the Subnano-class powder, particle diameter is 10
-6-10
-9M) oral drugs very easily dissolve, permeate, and are conducive to human body and better absorb, and reach instant effect, short treating period, effect that cure rate is high.。Again with the fine powder that obtains or nanoscale powder with fill capsule device (all being the commercially available prod) sterile working, fill becomes as 0.5 gram, one capsules, capsule is packed into as sealing in the plastic bottle again, is placed on the shady and cool ventilation place and preserves or dispatch from the factory.Or again with the fine powder that obtains or nanoscale powder with bagging equipment (all being the commercially available prod) sterile working, to filter the packing infusion of packed one-tenth 15 grams of cotton paper aseptic package bag/bag.When taking, the packing infusion was got away blister 10-20 minute with 150-300ml, or added water 400-500ml 5-10 at a simmer minute.
Or the dried crude drug that 1. step is obtained, by the said ratio weight portion, pack into (or in modern infuser device) in the aseptic molten device, be soaked in water, the consumption of water is as the criterion to soak the powder stock medicine, cover tightly sealing after, place in the anti-Liang Chu that ventilates below 20 ℃ and to soak 7-15 days, preferred 10 days, take out medicinal liquid.With the medicinal liquid filter plant that obtains, under gnotobasis with the finished product medicinal liquid of medical filtration Cheng Chunqing, then use filling apparatus, as in 200 milliliters of plastic bags or plastic bottle or the vial, sealing bottleneck or bag mouth finished product medicinal liquid oral drugs dispatch from the factory or preserve in the container of packing under gnotobasis.
Also can with the pure clear liquid medicine of above-mentioned immersion, adopt the dry fill of modern dry filling apparatus (commercially available spray drying filling apparatus) to become the fine grained oral drugs of every bag 5 gram-10 grams.
Or using modern production technology " whole part " extraction equipment and the fast dissolving orally drug particles made, above-mentioned finished product oral drugs all meet the state health standards requirement.
In the oral drugs and manufacture method thereof for the treatment of hand-foot-mouth disease provided by the invention, described oral drugs can be liquid medicine, fine grained or instant granular, powder or tablet etc.Described oral drugs are formulated with weight by the crude drug (Chinese herbal medicine) of respectively distinguishing the flavor of in the above-mentioned prescription, the crude drug of wherein respectively distinguishing the flavor of needs the factors such as the age, state of an illness weight, disease time according to each department, patient, the appropriate dosage of adjusting the crude drug of respectively distinguishing the flavor of helps to accelerate to cure.
Following crude drug (Chinese herbal medicine) effect of respectively distinguishing the flavor of is
Herba Rabdosiae glaucocalycis: dispelling wind, regulate the flow of vital energy, pain relieving, cure cold, cough, headache, abdominal distention, dysmenorrhea.
Bulbus Fritillariae Uninbracteatae: removing heat-phlegm, dissipating depression of QI eliminating stagnation, lung abscess, acute mastitis, sore.
Radix Semiaquilegiae: heat-clearing and toxic substances removing, detumescence, eliminating stagnation diuresis, subduing inflammation, infantile convulsion etc.
Herba Ainsliaeae Fragrantis: heat clearing away, dampness removing, removing heat from blood, detoxifcation, pharyngolaryngitis.
Cortex Lycii: heat clearing away, removing heat from blood, control asthenia hectic fever night sweat, lung-heat, cough with asthma, carbuncle, malignant boil.
Radix Scrophulariae: nourishing YIN to lower pathogenic fire, relieving restlessness detoxifcation, laryngopharynx swelling and pain.
Radix Achyranthis Bidentatae: give birth to dissipating blood stasis blood, detumescence, sore throat bitterly swollen, ripe with mending tripe kidney, bone and muscle strengthening.
Medulla Junci: clearing heart fire, the treating stranguria heart of sharp dung, tiredly be insomnia, the nocturnal fretfulness in infants, sore throat.
Herba Dendrobii (comprise Herba Dendrobii, Dendrobium nobile etc. are especially take Herba Dendrobii as good): the stomach reinforcing that promotes the production of body fluid, clearing away heat and nourishing YIN, control consumption of body fluid caused by febrile disease, xerostomia excessive thirst.
Herba goodyearae repentis: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, hard masses softening and resolving, control tracheitis etc.
The Rhizoma Atractylodis Macrocephalae (especially take Rhizoma Atractylodis Macrocephalae (parched) as good): spleen reinforcing stomach reinforcing, dampness and in.
Seem Lablab Album (especially take stir-fried kidney beans as good): spleen invigorating and in, the removing dampness of relieving summer heat.
Herba Hedyotidis Chrysotrichae: removing damp-heat, relaxing muscles and tendons to promote blood circulation.
The herbal mediciment of respectively distinguishing the flavor of in the above-mentioned prescription all is to have unique effects and effect, mutual compatibility, one is mutually collaborative each other, and is theoretical according to traditional Chinese medical science prescription, select medicine reasonable, heat-clearing toxin-expelling functions is powerful, and is evident in efficacy, adopts the medical knowledge balance the body equilibrium between yin and yang of " negative and positive are taken into account, treating both the principal and secondary aspects of a disease, spleen cardiopulmonary all thin ", promote lung, spleen, the heart three dirty working in coordination with, improve human body immunity's effect.Adopt again modern nano-pulverization technology, make the herbal agent granularity (particle diameter) of respectively distinguishing the flavor of reach Subnano-class or nanoscale (10
-6To 10
-9Rice), namely reach the atomic fine particle of submolecule or molecular level, more good dissolving, infiltration very easily absorbs, and reaches instant effect, short treating period, effect that cure rate is high.
In the oral drugs and manufacture method thereof according to treatment hand-foot-mouth disease provided by the invention, device therefor all is the commercially available prod, according to the rules operation, particularly the quality raw materials Chinese herbal medicine is crude drug, extract with modern production technique " whole part " and the fast dissolving orally medicine material made according to traditional decoction method effect, need not to decoct instant-drink.Also can adopt traditional traditional Chinese medical science to decoct, raw material be decocted alone take (twice-daily) alone.
The oral drugs for the treatment of hand-foot-mouth disease provided by the invention and the characteristics of manufacture method thereof are to hold to pass the traditional Chinese medical science secret recipe handed down from one's ancestors and be engaged in for a long time the exploitation of infectious disease traditional Chinese medical science industry and practise medicine of many generations, through for many years clinical practice, combine according to the medical knowledge of traditional Chinese medical science prescription theoretical " negative and positive are taken into account, treating both the principal and secondary aspects of a disease, spleen cardiopulmonary all thin " and up-to-date nano-pulverization technology, more good dissolving, infiltration, compatibility is fabulous mutually, very easily absorb, reach instant effect, short treating period, evident in efficacy, cure rate is high, easy to use, the oral medicine of the treatment hand-foot-mouth disease that has no side effect.
The specific embodiment
The present invention further specifies the present invention with the following example, but protection domain of the present invention is not limited to the following example.
Embodiment 1
With the marketable material medicine respectively through selected, removing defective crude drug and impurity cleans again, dry the dried crude drug by sterilization treatment: Herba Rabdosiae glaucocalycis 3.0kg, Bulbus Fritillariae Thunbergii 1.5kg, Radix Semiaquilegiae 1.5kg, Herba Ainsliaeae Fragrantis 1kg, Cortex Lycii 1.5kg, Radix Scrophulariae 1.5kg, Radix Achyranthis Bidentatae 1.0kg, Medulla Junci 0.5kg, Herba Dendrobii 0.7kg, Herba goodyearae repentis 0.3kg, Rhizoma Atractylodis Macrocephalae (parched) 0.4kg, stir-fried kidney beans 1.0kg, Herba Hedyotidis Chrysotrichae 0.6kg is mixed and puts into aseptic modern infuser device, be soaked in water, crude drug is as the criterion the consumption of water to soak not, after covering tightly sealing, soaked ten days in ventilating and cooling place below 20 ℃, take out medicinal liquid, in filter plant, under the aseptic condition, be filtered into pure clear liquid medicine, then use filling apparatus, under aseptic condition, fill becomes in every bag of 200 milliliters of plastic bags, becomes oral liquid medicine (every twice-daily, each a bag).
Embodiment 2
With each marketable material medicine respectively through selected, remove defective crude drug and impurity, clean again the dried crude drug after drying and sterilizing is processed: Herba Rabdosiae glaucocalycis 10g, Bulbus Fritillariae Thunbergii 5g, Radix Semiaquilegiae 7g, Herba Ainsliaeae Fragrantis 3g, Cortex Lycii 3g, Radix Scrophulariae 3g, Radix Achyranthis Bidentatae 3g, Medulla Junci 1g, Herba Dendrobii 2g, Herba goodyearae repentis 1g, Rhizoma Atractylodis Macrocephalae (parched) 2g, stir-fried kidney beans 3g, Herba Hedyotidis Chrysotrichae 2g, be placed on common pottery fill with in slow fire boiling 2 hours, leach 300 to 400 milliliters of medicinal liquids, it is oral dose on the one, directly oral (twice-daily, each 150 milliliters-200 milliliters).
Embodiment 3
With commercially available each following bulk drugs respectively through selected, removing defective crude drug and impurity cleans again, in drying plant, dry, carry out again the dried crude drug after the aseptic process (treatment with ultraviolet light): Herba Rabdosiae glaucocalycis 8kg, Bulbus Fritillariae Uninbracteatae 3kg, Radix Semiaquilegiae 3.5kg, Herba Ainsliaeae Fragrantis 1.5kg, Cortex Lycii 1.5kg, Radix Scrophulariae 1.5kg, Radix Achyranthis Bidentatae 1.5kg, Medulla Junci 0.5kg, Herba Dendrobii 1kg, Herba goodyearae repentis 0.5kg, Rhizoma Atractylodis Macrocephalae 1kg, Seem Lablab Album 1.5kg, Herba Hedyotidis Chrysotrichae 1kg, in the full composition extraction equipment of modern crafts, make an instant medicine material, and fill with in every bag of sealed, sterile bag of 3-5 gram (2 bags of every days, each one bag).
Embodiment 4
The marketable material medicine is respectively through selected, removing defective crude drug and impurity cleans again, carry out the dried crude drug of aseptic process after the oven dry: Herba Rabdosiae glaucocalycis 25kg, Bulbus Fritillariae Thunbergii 10kg, Radix Semiaquilegiae 8kg, Herba Ainsliaeae Fragrantis 9kg, Cortex Lycii 13kg, Radix Scrophulariae 12kg, Radix Achyranthis Bidentatae 8kg, Medulla Junci 5kg, Herba Dendrobii 6kg, Herba goodyearae repentis 3kg, Rhizoma Atractylodis Macrocephalae (parched) 4kg, stir-fried kidney beans 9kg, Herba Hedyotidis Chrysotrichae 5kg are placed in the modern nanometer pulverizer, under aseptic condition, be ground into Ya Nami to nano level superfine powder (10
-6-10
-9The particle diameter of m), then in commercially available filling machine under the aseptic condition fill become the micropowder (twice-daily, every bag once) of every bag 15 gram/bag.
Embodiment 5
Embodiment 4 is ground into Ya Nami to nano level superfine powder (10
-6M-10
-9The particle diameter of m) in commercially available filling machine, under the aseptic condition, become the packed infusion of a micropowder oral drugs (twice-daily of every bag 15 gram/bag with filter cotton paper bag aseptic packaging fill, every bag once), got away blister 10-20 minute with 150-300ml when taking, or add water 400-500ml 5-10 at a simmer minute.
Take the oral drugs case for the treatment of hand-foot-mouth disease provided by the invention:
Case 1:
Zhu, electric power road, Wu Yun town, Jinyun county, woman, 18 years old, Jinyun Middle School Students.In October, 2011, occur dizzy, with feel sick, fever, the tip of the tongue, throat pain when eating pain symptom also occurs even if gulp down saliva.Medical through Jinyun county people's hospital, be diagnosed as hand-foot-mouth disease, need suspend schooling and isolate for treatment.Introduce to the inventor through the doctor and to punish treatment, take above-mentioned example 1 oral drugs, afterwards recovery from illness in 3 days.
Case 2:
Relax certain, Shu Hong town, Jinyun county, man, 4 years old.In March, 2012, find hand-foot-mouth disease after, at Jinyun county people's hospital hospitalization 14 days, high fever, county hospital requires to transfer from one hospital to another treatment, introduces to the inventor by the Hospital Logistic personnel and punishes treatment.Take above-mentioned example 2 prescription potions, hyperpyrexia is namely moved back, serve on 5 doses after recovery from illness.
Example 3 diseases:
Lee, Huang Ming village, Qi Li township, Jinyun county, the man, 2 years old, find hand-foot-mouth disease after, at Jinyun county people's hospital hospitalization 7 days, high fever, introduce to the inventor through the nurse of Jinyun county people's hospital and to punish treatment, take 5 doses with above-mentioned example 3 prescriptions, fully recovered afterwards in 5 days.
Case 4:
Lu, Hu Zhen town, Jinyun county, the woman, 2 years old, find hand-foot-mouth disease after, successively in the Yongkang, Jinhua, Lishui City the People's Hospital hospitalization meter more than 20 days, herpes does not disappear, and face lip side ulcer, can not dehisce.Introduce to the inventor through boss Bei Yinmei and to punish treatment, take 3 doses by above-mentioned example 5 prescriptions after, can dehisce to eat food in the 3rd day, posterior lip side incrustation in 7 days comes off, and takes altogether 7 doses of medicines recoveries from illness.
Case 5:
Shut out certain, Du Tang village, Qi Li township, Jinyun county, man, 3 years old, twins, find hand-foot-mouth disease after, Jinyun county people's hospital hospitalization 5 days, high fever, after punish treatment to the inventor upon somebody's introduction, take 1 dose of above-mentioned example 5 packed infusion after hyperpyrexia namely move back, then take afterwards recovery from illness in 4 days.
Claims (4)
1. oral drugs for the treatment of hand-foot-mouth disease is characterized in that comprising following bulk drugs component and weight portion thereof, are broken into the oral drugs of fine powder through selected, extraction or ovendry power
Herba Rabdosiae glaucocalycis 8-30 weight portion, Bulbus Fritillariae Uninbracteatae 3-15 weight portion, Radix Semiaquilegiae 3-10 weight portion, Herba Ainsliaeae Fragrantis 1.5-10 weight portion, Cortex Lycii 3-15 weight portion, Radix Scrophulariae 1.5-15 weight portion, Radix Achyranthis Bidentatae 1.5-10 weight portion, Medulla Junci 0.5-5 weight portion, Herba Dendrobii 1-7 weight portion, Herba goodyearae repentis 0.5-3 weight portion, Rhizoma Atractylodis Macrocephalae 1-4 weight portion, Seem Lablab Album 1.5-10 weight portion, Herba Hedyotidis Chrysotrichae 1-6 weight portion.
2. according to claim 1 the oral drugs for the treatment of hand-foot-mouth disease is characterized in that comprising following raw materials according component and weight portion thereof, are broken into the oral drugs of fine powder through selected, extraction or ovendry power
Herba Rabdosiae glaucocalycis 8-25 weight portion, Bulbus Fritillariae Uninbracteatae 3-10 weight portion, Radix Semiaquilegiae 3.5-8 weight portion, Herba Ainsliaeae Fragrantis 1.5-8 weight portion, Cortex Lycii 1.5-12 weight portion, Radix Scrophulariae 1.5-13 weight portion, Radix Achyranthis Bidentatae 1.5-8 weight portion, Medulla Junci 0.5-4 weight portion, Herba Dendrobii 1-5 weight portion, Herba goodyearae repentis 0.5-2 weight portion, Rhizoma Atractylodis Macrocephalae 1-3 weight portion, Seem Lablab Album 1.5-7 weight portion, Herba Hedyotidis Chrysotrichae 1-5 weight portion.
3. according to claim 1 the oral drugs for the treatment of hand-foot-mouth disease, it is characterized in that comprising following raw materials according component and weight portion thereof, be broken into oral drugs medicine Herba Rabdosiae glaucocalycis 8 weight portions, Bulbus Fritillariae Uninbracteatae 3 weight portions, Radix Semiaquilegiae 3.5 weight portions, Herba Ainsliaeae Fragrantis 1.5 weight portions, Cortex Lycii 1.5 weight portions, Radix Scrophulariae 1.5 weight portions, Radix Achyranthis Bidentatae 1.5 weight portions, Medulla Junci 0.5 weight portion, Herba Dendrobii 1 weight portion, Herba goodyearae repentis 0.5 weight portion, the Rhizoma Atractylodis Macrocephalae 1 weight portion, Seem Lablab Album 1.5 weight portions, Herba Hedyotidis Chrysotrichae 1 weight portion of fine powder through selected, extraction or ovendry power.
4. the preparation method of the oral drugs medicine of the arbitrary treatment hand-foot-mouth disease of a claim 1-3 comprises the following steps:
1), the crude drug component that claim 1-3 is arbitrary carries out respectively selectedly, removes defective raw material and impurity, after cleaning, with drying plant in 40 ℃ of maneuvers routinely, under gnotobasis, dry respectively, perhaps can under sunlight, dry, then carry out sterilization treatment;
2), with step 1) the dried crude drug that obtains is placed on by the arbitrary crude drug ingredients weight parts of claim 1-3 and carries out the sterile working in fine pulverizer or the nanometer pulverizer, be ground into the oral drugs of fine powder or nanoscale powder, again with the fine powder or the nanoscale powder fill capsule device sterile working that obtain, fill becomes capsule, or again with the fine powder or the nanoscale powder bagging equipment sterile working that obtain, to filter the packing infusion of packed one-tenth 15 grams of cotton paper aseptic package bag/bag;
Or with step 1) the dried crude drug that obtains, by the arbitrary crude drug ingredients weight parts of claim 1-3, pack in the aseptic molten device, be soaked in water, the consumption of water is as the criterion to soak the powder stock medicine, after covering tightly sealing, place immersion 7-15 days in the anti-Liang Chu that ventilates below 20 ℃, take out medicinal liquid, with the medicinal liquid filter plant that obtains, under gnotobasis, with the finished product medicinal liquid of medical filtration Cheng Chunqing, then use filling apparatus, finished product medicinal liquid oral drugs in 200 ml containers of under gnotobasis, packing into
Or with the pure clear liquid medicine of above-mentioned immersion, adopt the dry fill of modern dry filling apparatus to become the fine graineds of every bag 5 gram-10 grams;
Or use modern production technology " whole part " extraction equipment and the fast dissolving orally drug particles made.
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| CN103830634A (en) * | 2014-01-06 | 2014-06-04 | 崔磊 | Buccal tablet for treating oral ulcer |
| CN105998787A (en) * | 2016-06-15 | 2016-10-12 | 邹城众达知识产权咨询服务有限公司 | Drug for treating hand-foot-mouth disease |
| CN106309455A (en) * | 2016-08-16 | 2017-01-11 | 江苏康缘药业股份有限公司 | Application of peimisine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106386513A (en) * | 2016-12-23 | 2017-02-15 | 信阳师范学院 | Tissue-culture and rapid-propagation method for Goodyera biflora |
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| 《中医药临床杂志》 20100731 张国梁等 "手足口病中医治疗经验及预防方药研究概况" 第574-582页 1-4 第22卷, 第7期 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103830634A (en) * | 2014-01-06 | 2014-06-04 | 崔磊 | Buccal tablet for treating oral ulcer |
| CN105998787A (en) * | 2016-06-15 | 2016-10-12 | 邹城众达知识产权咨询服务有限公司 | Drug for treating hand-foot-mouth disease |
| CN106309455A (en) * | 2016-08-16 | 2017-01-11 | 江苏康缘药业股份有限公司 | Application of peimisine |
| CN106309455B (en) * | 2016-08-16 | 2019-02-05 | 江苏康缘药业股份有限公司 | The purposes of Peimisine |
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