CN102861261A - Chinese medicinal preparation for improving living quality of patient suffering from advanced malignant tumor - Google Patents
Chinese medicinal preparation for improving living quality of patient suffering from advanced malignant tumor Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for improving the living quality of a patient suffering from an advanced malignant tumor. The Chinese medicinal preparation is prepared from the following raw materials in parts by weight: 120 parts of coastal glehnia root, 120 parts of dwarf lilyturf root, 150 parts of kudzuvine root, 90 parts of lotus plumule, 120 parts of lily, 120 parts of Mongolian snakegourd root, 120 parts of astragalus, 150 parts of red-rooted salvia root, 150 parts of pearl barley, 90 parts of Chinese yam, 90 parts of barbary wolfberry fruit, 90 parts of rhizoma pinellinae praeparata, 120 parts of spreading hedyotis herb, 120 parts of barbed skullcap herb and 120 parts of dandelion. The Chinese medicinal preparation is prepared according to a certain proportion; and internal Chinese medicinal compound particles for improving the living quality of the patient suffering from the advanced malignant tumor have the effects of nourishing yin, promoting the production of body fluid, invigorating the spleen for eliminating dampness, tonifying the liver and kidney, detoxicating and resolving masses and the like through the coordinated action of each constituting medicament in a complex prescription, and have remarkable effects on deficiency of yin, body fluid deficiency, deficiency of liver and kidney, failure in working due to insufficiency of the spleen, internal accumulation of pathogenic toxins and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that improves malignant tumor patients with terminal life quality for oral administration.
Background technology
Cancer is the general designation of more than 100 kind of relevant disease, and all organs all are comprised of cell in people's health.Cell enlargement and differentiation can be satisfied somagenic need, and this orderly process can keep people healthy.Yet if cell continues division, these extra a large amount of cells just form tumor, and malignant tumor is exactly the said cancers of people.Contiguous tissue and organ can be invaded, be destroyed to the cell of malignant tumor.And cancerous cell can pass from tumor, enters blood or lymphsystem, and how cancer that Here it is forms new tumor from former position to other organ, and this process just is cancer metastasis.The progress of the malignant tumor state of an illness is the process of an active development, and according to the different stages of development of the state of an illness, its treatment is also different.Thereby palliative treatment stage late, keep the daily life staying idle at home ability of patient, improve its quality of life, be the major criterion of present late malignant tumour treatment.According to the health ministry investigation statistics, mortality of malignant tumors to 2000 a year city mortality of malignant tumors rises by a relatively large margin, is 30.24% than amplification before 10 years, and the rural area is 5.44% at this 10 years mortality of malignant tumors amplification degree.From beginning of the seventies to 2000 year, the town and country mortality of malignant tumors has larger growth, and city mortality of malignant tumors level has risen 59.71%, has risen 39.34% on the rural area.The treating malignant tumor method is mainly if any surgical intervention, radiotherapy, chemotherapy, biological reflection regulator and Chinese traditional treatment.Chinese traditional treatment is in the Therapeutic Method of tumor, the distinctive Chinese traditional treatment method of a kind of China is arranged, cooperate the treatment tumors such as operation, radiotherapy, chemotherapy and biological reflection dressing agent, both can improve overall health of patients, strengthen resistance against diseases, can alleviate side effect again, improve curative effect, be one of effective means in the Multimodality Therapy of Malignant Tumors.Its new treatment is such as the treatment of: gene-virus, nutritional support treatment and dietetic regulation etc.In a word, to the various symptomatic treatments of late malignant tumour, to delay its disease progression as maximum target.The toxicity that the patient is caused to reduce various treatments, thus patient's life quality improved.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation that improves malignant tumor patients with terminal life quality for oral administration.
The present invention for achieving the above object, the technical solution of employing is:
Improve the Chinese medicine preparation of malignant tumor patients with terminal life quality, this Chinese medicine preparation is made by the raw material of following weight parts: Radix Glehniae 100-140, Radix Ophiopogonis 100-140, Radix Puerariae 100-160, Plumula Nelumbinis 60-120, Bulbus Lilii 50-150, Radix Trichosanthis 110-130, Radix Astragali 100-150, Radix Salviae Miltiorrhizae 100-180, Semen Coicis 100-160, Rhizoma Dioscoreae 60-100, Fructus Lycii 80-100, Rhizoma Pinelliae Preparatum 80-100, Herba Hedyotidis Diffusae 100-150, Herba Scutellariae Barbatae 100-150, Herba Taraxaci 80-160.
Further, improve the Chinese medicine preparation of malignant tumor patients with terminal life quality, made by the raw material of following weight parts: Radix Glehniae 120, Radix Ophiopogonis 120, Radix Puerariae 150, Plumula Nelumbinis 90, Bulbus Lilii 120, Radix Trichosanthis 120, the Radix Astragali 120, Radix Salviae Miltiorrhizae 150, Semen Coicis 150, Rhizoma Dioscoreae 90, Fructus Lycii 90, Rhizoma Pinelliae Preparatum 90, Herba Hedyotidis Diffusae 120, Herba Scutellariae Barbatae 120, Herba Taraxaci 120.
The present invention selects Radix Glehniae, Radix Ophiopogonis, Radix Puerariae, Plumula Nelumbinis, Bulbus Lilii, Radix Trichosanthis, the Radix Astragali, Radix Salviae Miltiorrhizae, Semen Coicis, Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Pinelliae Preparatum, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Taraxaci kinds of traditional Chinese medicines to make decoction or granule.Radix Glehniae wherein, sweet little hardship is slightly cold, and returns lung stomach warp, nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, it is thirsty to be used for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Radix Ophiopogonis, sweet little hardship is slightly cold, and YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire, and is used for that dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat are quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Radix Puerariae, sweet hot cool, expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal, be used for fever caused by exogenous pathogens headache, stiffness of the nape, thirsty, quench one's thirst, measles is uncomfortable, hematodiarrhoea is had loose bowels the hypertension neck pain.Plumula Nelumbinis, bitter cold, clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding are used for heat attacking the pericardium, unconsciousness and delirium, disarmony between the heart and kidney, insomnia seminal emission, heat in blood haematemesis.Bulbus Lilii, sweet cold, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization are used for deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.Radix Trichosanthis, sweet little hardship is slightly cold, clearing away heat and promoting production of body fluid, detumescence and apocenosis, be used for calentura excessive thirst, lung-heat dry thirsty, interior-heat is quenched one's thirst, sore swollen toxin.The Radix Astragali, sweet tepor is returned the Liver and kidney warp, and nourishing YIN and supplementing blood, beneficial essence are filled out marrow, are used for the hepatic and renal YIN deficiency, and soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.Radix Salviae Miltiorrhizae, hardship is slightly cold, and stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire are used for that menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection are swollen and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.Semen Coicis, sweet light cold, spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus are used for edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis, verruca plana.Rhizoma Dioscoreae, sweet flat, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Fructus Lycii, sweet flat, nourishing the liver and kidney, replenishing vital essence to improve eyesight are used for that asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, blurred vision be not clear.Rhizoma Pinelliae Preparatum, Xin Wen returns the taste lung meridian, and drying dampness to eliminate phlegm is used for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.Herba Hedyotidis Diffusae, little hardship is sweet cold, and heat-clearing and toxic substances removing, dampness removing is treating stranguria, is used for carbuncle sore tumefacting virus, laryngopharynx swelling and pain, venom, the puckery pain of pyretic stranguria.Herba Scutellariae Barbatae, arduous cold, heat-clearing and toxic substances removing, blood stasis dispelling diuresis are used for furuncle poisoning, laryngopharynx swelling and pain, venom, fall and pounce on the pain of injury, edema, jaundice.Herba Taraxaci, bitter sweet cold, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome are used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis jaundice due to damp-heat, the puckery pain of pyretic stranguria.Make Chinese medicine preparation according to certain component, take orally and improve the Chinese native medicine compound prescription pellet of advanced tumor life in patients by respectively forming the synergism of medicine in the compound recipe, have the effects such as YIN nourishing and the production of body fluid promoting, invigorating the spleen for eliminating dampness, liver and kidney tonifying, detoxicating and resolving stagnation of pathogens, to deficiency of YIN Tianjin wound, deficiency of the liver and kindey, the spleen insufficiency of malignant tumor patients with terminal, knot waited and has remarkable result in poison was evil.
The specific embodiment
The present invention is described in detail below in conjunction with embodiment:
Embodiment 1
Improve the Chinese medicine preparation of malignant tumor patients with terminal life quality, this Chinese medicine preparation is made by the raw material of following weight parts: Radix Glehniae 100, Radix Ophiopogonis 100, Radix Puerariae 100, Plumula Nelumbinis 60, Bulbus Lilii 50, Radix Trichosanthis 110, the Radix Astragali 100, Radix Salviae Miltiorrhizae 100, Semen Coicis 100, Rhizoma Dioscoreae 60, Fructus Lycii 80, Rhizoma Pinelliae Preparatum 80, Herba Hedyotidis Diffusae 100, Herba Scutellariae Barbatae 100, Herba Taraxaci 80.
Embodiment 2
Improve the Chinese medicine preparation of malignant tumor patients with terminal life quality, this Chinese medicine preparation is made by the raw material of following weight parts: Radix Glehniae 140, Radix Ophiopogonis 140, Radix Puerariae 160, Plumula Nelumbinis 120, Bulbus Lilii 150, Radix Trichosanthis 130, the Radix Astragali 150, Radix Salviae Miltiorrhizae 180, Semen Coicis 160, Rhizoma Dioscoreae 100, Fructus Lycii 100, Rhizoma Pinelliae Preparatum 100, Herba Hedyotidis Diffusae 150, Herba Scutellariae Barbatae 150, Herba Taraxaci 160.
Embodiment 3
Improve the Chinese medicine preparation of malignant tumor patients with terminal life quality, made by the raw material of following weight parts: Radix Glehniae 120, Radix Ophiopogonis 120, Radix Puerariae 150, Plumula Nelumbinis 90, Bulbus Lilii 120, Radix Trichosanthis 120, the Radix Astragali 120, Radix Salviae Miltiorrhizae 150, Semen Coicis 150, Rhizoma Dioscoreae 90, Fructus Lycii 90, Rhizoma Pinelliae Preparatum 90, Herba Hedyotidis Diffusae 120, Herba Scutellariae Barbatae 120, Herba Taraxaci 120.
Improve the manufacture method of the Chinese medicine preparation of malignant tumor patients with terminal life quality:
According to embodiment 1, embodiment 2 or embodiment 3 described weight ratios; get Radix Glehniae, Radix Ophiopogonis, Bulbus Lilii, Radix Trichosanthis, the Radix Astragali, Rhizoma Dioscoreae, Fructus Lycii, Herba Hedyotidis Diffusae, Herba Taraxaci; add 10 times of water gagings and decoct 2 times; each 1.5 hours; filter; merging filtrate; being evaporated to relative density is 1.05～1.10 (60 ℃ of surveys), lets cool, add ethanol and reach 70% to containing the alcohol amount; place and spend the night; filter, decompression recycling ethanol, and continue to be concentrated into the thick paste that relative density is 1.25～1.30 (60 ℃ of surveys); drying under reduced pressure, and get final product.Get again Radix Puerariae, Radix Salviae Miltiorrhizae, Plumula Nelumbinis, Semen Coicis, Rhizoma Pinelliae Preparatum, Herba Scutellariae Barbatae, add 6 times of amount 80% alcohol reflux 2 times, each 1.5 hours, filter, merging filtrate, decompression recycling ethanol to nothing alcohol is distinguished the flavor of, and continues to be concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃ of surveys), drying under reduced pressure, and get final product.Then get above-mentioned dried cream, pulverize, cross 80 mesh sieves, add microcrystalline Cellulose 50g, silica 1 0g adds starch to total amount 450g, mixing, and with 90% alcohol granulation, drying is pressed into 1000, film coating, and get final product.
For showing the therapeutic effect of medicine of the present invention, carry out following comparative illustration:
1, clinical data
Case choice criteria inclusive criteria: (1) age was at 18～65 years old sex; (2) meet the late malignant tumour diagnostic criteria, it drafts standard with reference to " CHINESE JOURNAL OF INTERNAL MEDICINE " editorial board oncosis special interest group.1. diagnosis of malignant tumor standard; 2. malignant tumor clinical stages standard; 3. TCM syndrome diagosis is with reference to the standard of " guideline of clinical investigations of new Chinese medicine treatment malignant tumor ".(3) differential diagnosis in tcm belongs to reference to " new Chinese medicine guideline of clinical investigations " and the prescription of yin nourishing tonic anticancer granule, deficiency of YIN Tianjin wound, deficiency of the liver and kindey, the spleen insufficiency that function cures mainly formulation, knot pattern of syndrome in poison is evil.Exclusion standard: (1) is diagnosed as benign tumor patient and other malignant tumor patients; (2) gestation or preparation gestation and age of sucking are women; (3) merge to have the inclination, the serious diseases such as brain, lung, liver, hemopoietic system, or the patient of the wasting diseasess such as active tuberculosis is arranged, hepatitis B inspection prompting e antigen positive person, or the renal transplantation latter; (4) psychotic, can not the partner.
2, physical data is observed case and is in November, 2009 to 2010 year First People's Hospital, economic and technological development zone, 09 month Qingdao and is in hospital and the out-patient, complete case-data is arranged, totally 130 examples.Adopt the completely randomized design scheme, use the table of random number method, the sequencing of going to a doctor by the patient is divided into granule therapy group 80 examples at random with it, man's 48 examples, woman's 32 examples, 32～70 years old age, on average (52.2 ± 10.8) year, matched group 50 examples, male 28 examples are injected in the Conair, woman's 22 examples, 33～69 years old age, average (51.4 ± 12.6) year, each organizes Alb, Hb before patient's physical data and the treatment, RBC, WBC, PLT and related neoplasms mark through harmony relatively, difference there are no significant meaning (P＞0.05) has comparability.
3, all patients of Therapeutic Method all adopt nutrition dietary, in conjunction with controlling blood pressure, correct acidosis according to the state of an illness, and anemia is corrected the anti symptom treatment such as calcium and phosphorus metabolism disorder.On above-mentioned treatment basis, treatment group gives yin nourishing tonic anticancer granule, and warm water is taken after mixing it with water, every day 3 times.The matched group Experimental Study on Shenkang Injection in Treating, 5% glucose injection 250ml+ Kang ' ai injection 80ml intravenous drip, every day 1 time.2 months is a course for the treatment of.
4, observation index clinical symptoms and sign: anemia, weak, inappetence, dim complexion, tongue fur and pulse condition, and limds edema etc., laboratory checking index as: the treatment before and after serum albumin (Alb), hemoglobin (Hb), red blood cell count(RBC) (RBC), numeration of leukocyte (WBC), platelet count (PLT) and related neoplasms mark.
5, therapeutic evaluation is drafted efficacy assessment standard with reference to new Chinese medicine treatment malignant tumor guideline of clinical investigations in " new Chinese medicine guideline of clinical investigations " and in conjunction with clinical experience.Clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and main physical and chemical index is normal; Produce effects: clinical symptoms, sign are obviously improved, main physical and chemical index normal; Effectively: clinical symptoms, sign all take a favorable turn, main physical and chemical index normal; Invalid: clinical symptoms, sign are all without obviously improving, even increase the weight of.
6, meter is learned method statistic and is processed use SPSS13.0 statistical package, and all continuous datas carry out first the homogeneity of variance analysis, confirms neat rear employing of variance
The t check is relatively used in expression in the group, ranked data adopt Ridit to analyze, and P＜0.05 has been considered as statistical significance.
Therapeutic evaluation
According to certain the standard of curative effect evaluation, Estimating curative effect is: granule therapy group 0 example of fully recovering, produce effects 41 examples, effective 30 examples, no effect 9; Matched group 0 example of fully recovering, produce effects 21 examples, effective 22 examples, invalid 7 examples.Comparing difference sees Table 1 without significance (P＞0.05) between two groups.
Table 1 liang group curative effect relatively
Annotate: compare P＞0.05 with matched group.
Table 2 is taken clinical drug symptom of the present invention, sign curative effect relatively
(annotate: treatment group and matched group comparison total effective rate there were significant differences P＜0.05)
Table 3 is taken Drug therapy of the present invention front and back leukocyte, platelet and alpha-fetoprotein and is changed relatively
(annotate: before two groups of treatments with treatment after between leukocyte, platelet and alpha-fetoprotein Quantitative Comparison there were significant differences P＜0.01, two group after the treatment result relatively, no significant difference (P＞0.05)
Table 4 is taken Drug therapy of the present invention front and back albumin, hemoglobin and red blood cell count(RBC) and is changed relatively
(annotate: before two groups of treatments with treatment postalbumin, hemoglobin and red blood cell count(RBC) Quantitative Comparison there were significant differences P＜0.01, two group between after the treatment result relatively, no significant difference (P＞0.05)
Untoward reaction
After observation period endoparticle treatment group has some cases to take medicine the reactions such as slight stomach discomfort, times of defecation increase are arranged, suitably reduce dosage or the rear most elimination of taking medicine after meal, can proceed to observe; Matched group, idol has hypercalcemia to occur, suitably reduce the intake of vitamin D after, can eliminate symptom, proceed to observe.Groups of grains is 11.25% (9/80); Conair 14.00% (7/50), adverse reaction rate compares difference not statistically significant (P＞0.05) between each group.
In sum, more than use medicine of the present invention 80 routine patients with advanced malignant tumors are done the treatment observation, obtain significant curative effect, and Liver and kidney cardiac function and blood biochemical, defecation check before and after the treatment, all do not find obvious toxic-side effects, drug administration safety of the present invention is described, to human body nonhazardous effect.
Claims (2)
1. improve the Chinese medicine preparation of malignant tumor patients with terminal life quality, it is characterized in that this Chinese medicine preparation is made by the raw material of following weight parts: Radix Glehniae 100-140, Radix Ophiopogonis 100-140, Radix Puerariae 100-160, Plumula Nelumbinis 60-120, Bulbus Lilii 50-150, Radix Trichosanthis 110-130, Radix Astragali 100-150, Radix Salviae Miltiorrhizae 100-180, Semen Coicis 100-160, Rhizoma Dioscoreae 60-100, Fructus Lycii 80-100, Rhizoma Pinelliae Preparatum 80-100, Herba Hedyotidis Diffusae 100-150, Herba Scutellariae Barbatae 100-150, Herba Taraxaci 80-160.
2. the Chinese medicine preparation that improves malignant tumor patients with terminal life quality according to claim 1, it is characterized in that this Chinese medicine preparation is made by the raw material of following weight parts: Radix Glehniae 120, Radix Ophiopogonis 120, Radix Puerariae 150, Plumula Nelumbinis 90, Bulbus Lilii 120, Radix Trichosanthis 120, the Radix Astragali 120, Radix Salviae Miltiorrhizae 150, Semen Coicis 150, Rhizoma Dioscoreae 90, Fructus Lycii 90, Rhizoma Pinelliae Preparatum 90, Herba Hedyotidis Diffusae 120, Herba Scutellariae Barbatae 120, Herba Taraxaci 120.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107459333A (en) * | 2017-08-18 | 2017-12-12 | 广东康世泰新材料科技股份有限公司 | A kind of ceramic of aspergillus flavus resisting and preparation method thereof |
| CN107555972A (en) * | 2017-08-18 | 2018-01-09 | 广东康世泰新材料科技股份有限公司 | A kind of ceramic for improving human malignant tumor and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1088100A (en) * | 1992-12-17 | 1994-06-22 | 何承恕 | Be used for giving protection against cancer, controlling the processing technology of cancer herb liquid " true man of Xingan soup " |
| CN1141784A (en) * | 1995-07-28 | 1997-02-05 | 皮敦厚 | Anti-cancer medicine and preparation method thereof |
-
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- 2012-08-18 CN CN 201210305168 patent/CN102861261B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088100A (en) * | 1992-12-17 | 1994-06-22 | 何承恕 | Be used for giving protection against cancer, controlling the processing technology of cancer herb liquid " true man of Xingan soup " |
| CN1141784A (en) * | 1995-07-28 | 1997-02-05 | 皮敦厚 | Anti-cancer medicine and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107459333A (en) * | 2017-08-18 | 2017-12-12 | 广东康世泰新材料科技股份有限公司 | A kind of ceramic of aspergillus flavus resisting and preparation method thereof |
| CN107555972A (en) * | 2017-08-18 | 2018-01-09 | 广东康世泰新材料科技股份有限公司 | A kind of ceramic for improving human malignant tumor and preparation method thereof |
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