CN102861180A - Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition - Google Patents
Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition Download PDFInfo
- Publication number
- CN102861180A CN102861180A CN2012103688457A CN201210368845A CN102861180A CN 102861180 A CN102861180 A CN 102861180A CN 2012103688457 A CN2012103688457 A CN 2012103688457A CN 201210368845 A CN201210368845 A CN 201210368845A CN 102861180 A CN102861180 A CN 102861180A
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- vitamin
- extracts
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases. The composition comprises, by weight, from 1000 to 2000 parts of hawthorn extracts, from 600 to 1800 parts of bitter gourd extracts, from 500 to 1500 parts of ginkgo leaf extracts, from 500 to 1500 parts of grape seed extracts, from 400 to 1500 parts of ganoderma lucidum extracts, from 400 to 1500 parts of polygonum multiflorum extracts, from 300 to 1000 parts of American ginseng extracts, from 500 to 1000 parts of L-arginine, from 500 to 1000 parts of vitamin C, from 100 to 600 parts of L-histidine, from 100 to 500 parts of taurine, from 50 to 200 parts of vitamin E, from 10 to 100 parts of L-citrulline and from 2 to 8 parts of folic acid. The plant extracts are obtained by extracting plants which are food and healthcare products, the components are simple and are free of toxic and side effects, the amino-acid-containing composition can be used for a long time, and disease prevention and healthcare effects of the composition are sufficiently realized. Besides, a finished product prepared by the formula has effects of obviously improving immunological regulation of a human body and improving the conditions of the patients with the cardiovascular and cerebrovascular diseases, and is applicable to middle aged and elderly people and people in a sub-health state.
Description
Technical field
The present invention relates to a kind ofly contain amino acid whose compositions be used to improving cardiovascular and cerebrovascular disease, be specifically related to the several plant extract and be added with amino acid whose compositions and the application in preparation health food or medicine thereof.
Background technology
Cardiovascular and cerebrovascular disease is that a kind of serious threat is human, the commonly encountered diseases of middle-aged and elderly people health more than 50 years old particularly, even use most advanced, perfect at present treatment means, still can there be the cerebrovascular accident survivor life more than 50% not take care of oneself fully, every year is died from the number of cardiovascular and cerebrovascular disease up to 1,500 ten thousand people in the whole world, and it is the first to occupy the various causes of the death.Cardiovascular and cerebrovascular disease has become the highest No.1 killer of human Death causes, also is " the noiseless demon " of health of people.Although aspect the control cardiovascular and cerebrovascular disease many chemical drugss and many traditional prescriptions and Chinese patent medicine are being arranged at present, but toxic and side effects is in various degree arranged, and similarly health product be not composition single be exactly to be added with a large amount of chemical drugs compositions, life-time service is unprofitable to the health of health.
Summary of the invention
The object of the invention is to: a kind of compositions that can improve cardiovascular and cerebrovascular disease is provided, and it is raw material by the several plant extract and adds aminoacid and make.Wherein, the raw material that plant extract obtains by the plant extract that belongs to food and health care products, prescription simply has no side effect, but life-time service has demonstrated fully the effect of disease-prevention health function.
The invention provides a kind of cardiovascular and cerebrovascular disease that can improve and contain amino acid whose compositions, the raw material of described compositions and parts by weight thereof are: Fructus Crataegi extract 1000～2000; Fructus Momordicae charantiae extract 600～1800; Folium Ginkgo extract 500～1500; Semen Vitis viniferae extract 500～1500; Ganoderma extract 400～1500; Radix Polygoni Multiflori extract 400～1500; Radix Panacis Quinquefolii extract 300～1000; L-arginine 500～1000; vitamin C 500～1000; L-Histidine 100～600; taurine 100～500; vitamin E 50～200; Cit 10～100; folic acid 2～8.
Preferred, the raw material of described compositions and parts by weight thereof are: Fructus Crataegi extract 1500, Fructus Momordicae charantiae extract 1000, Folium Ginkgo extract 800, Semen Vitis viniferae extract 800, Ganoderma extract 700, Radix Polygoni Multiflori extract 700, Radix Panacis Quinquefolii extract 700, L-arginine 700, vitamin C 600, L-Histidine 400, taurine 300, vitamin E 100, Cit 50, folic acid 5.
By weight percentage, general flavone content 〉=10% in the described Fructus Crataegi extract; Charantin content 〉=10% in the Fructus Momordicae charantiae extract; Ginkgo total flavones content 〉=24% in the Folium Ginkgo extract; Semen Vitis viniferae extract contains procyanidin (OPC) content 〉=95%; Lecithin content in the Radix Polygoni Multiflori extract 〉=3.7%; Ganoderma polyoses content in the Ganoderma extract 〉=10%; Radix Panacis Quinquefolii saponin content 〉=20% in the Radix Panacis Quinquefolii extract.
The present invention also provides described and has contained amino acid whose compositions in the application of preparation health food or medicine.
The pharmacological effect of each component is as follows in the above compositions:
1) Fructus Crataegi extract:This product is dry mature fruit (the containing nuclear) extract of Rosaceae (Rosaceae) plant Fructus Crataegi (Crataegus pinnatifida Bge.) or Fructus Pyri Pashiae (C.pinnatifidaBge.Var.major N.E.Br.), Crataegi cuneatae (C.cuneata S.et Z.).The increase myocardial contraction is arranged, increase cardiac output, the effect of decreasing heart rate; The increase coronary flow is arranged, reduce the effect of myocardial oxygen consumption and myocardium coefficient of oxygen utilization; The Nutritional myocardium blood flow amount is had certain increasing action, and Fructus Crataegi is to the increasing action of Nutritional myocardium blood flow amount, may be with the dilating coronary blood vessel bed, to improve coronary circulation relevant; Cavia porcellus is had protective effect by isoproterenol sulfate induced Acute myocardial ischemia, prevention is arranged or alleviate isoproterenol to cause myocardial ischemia or downright bad effect; More lasting hypotensive effect is arranged; The various hyperlipidemia models that different animals is caused have more sure effect for reducing fat, can short of moneyly do serum cholesterol and content of triglyceride rising that high lipid food causes.
) Fructus Momordicae charantiae extract:The fruit that belongs to the Cucurbitaceae Fructus Momordicae charantiae, Fructus Momordicae charantiae extract (Momordica Charantia Linn.) is the annual herbaceous plant that overgrows of Cucurbitaceae Momordica.It has following effect:
1. antidiabetic effect contains steroid saponin such as Charantin in the Fructus Momordicae charantiae extract, para-insulin peptide class and alkaloid, and these materials are given the balsam pear hypoglycemic activity.Charantin stimulates the release of insulin and hinders the formation of glucose in the blood flow, and this function may particularly play huge effect in the non-insulin-dependent diabetes mellitus treatment in diabetes.This function of blood sugar reduction is given the credit to two kinds of materials: the crystalline material that obtains in the ethanol extraction of (1) Charantin-a kind of Fructus Momordicae charantiae.Charantin has reduced blood glucose in the body of testing rabbit sum 42% in the situation of control dosage 50mg/kg.Charantin demonstrates pancreas and outer pancreas effect, and slight spasmolytic and cholinolytic effect are arranged.(2) P-insulin (or v-insulin, because it is glucokinin).It structurally is macromole polypeptide configuration, and the pharmacology is upper close with bovine insulin.The P-insulin is comprised of two polypeptide chains that connect by disulfide bond.The subcutaneous administration with muscle to the P-insulin of diabetics has hypoglycemic activity, and is different after 2 hours of its effect peak period and bovine insulin, appear at 4-8 hour after.2. antiviral functions and other.Fructus Momordicae charantiae extract has been proved for psoriasis, susceptible due to the cancer, nerve complication are pain caused effectively, and may delay the outbreak of cataract or retinopathy and suppress HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) by destroying filterability toadstool DNA, suppress lymphocytosis and macrophage and lymphocyte activity.3. good effect of weight reducing.The bioactive ingredients high energy fat eliminating element that extracts from Fructus Momordicae charantiae extract has good antiobesity action.Take high energy fat eliminating element 2mg-4mg every day through test, can organize the fat absorption about 6-12kg, have approximately 3-7kg to be decomposed and be stored in the fat that waist, abdomen, buttocks, thigh etc. locate.
) Folium Ginkgo extract: this product is the dried leaves extract of Ginkgoaceae plant Ginkgo biloba (Ginkgo biloba L.).Has the increase cerebrovascular flow; reduce cerebral vascular resistance, improve the cerebrovascular circulatory function, the protection brain cell; avoid ischemic damage; coronary artery dilator prevents angina pectoris and myocardial infarction, anticoagulant; prevent thrombosis; remove harmful oxyradical, improve immunocompetence, have the anti-cancer anti-aging function.Sick effective in cure to treatment coronary heart diseases and angina pectoris, cerebral arteriosclerosis, alzheimer disease, hypertension etc.
Semen Vitis viniferae extract: this product is the seed extract of vitaceae Fructus Vitis viniferae (Vitis vinifera L.).It is the new and effective Natural antioxidant material that can not synthesize in a kind of human body.Its effect is: 1, anti-oxidation function: it is antioxidation, the strongest material of removing free radical ability that present occurring in nature is found, its antioxidant activity is 50 times, ascorbic 20 times of the plain E of dimension, it can effectively remove unnecessary free radical in the human body, has the effect of superpower slow down aging and enhancing immunity.Antioxidation, antiallergic, resisting fatigue health invigorating, improve the sub-health state slow down aging, improve irritated irritability, the symptoms such as dizzy weak, hypomnesis.2, protection cardiovascular and prophylaxis of hypertension.3, antitumor action.4, radiation resistance.5, antimutagenic effect 6, skin care and beautification function, 7, antiallergic and antiinflammatory action.8, improve visual performance.
) Ganoderma extract:This product is that the sporophore of basidiomycetes Polyporaceae Ganoderma plant Ganoderma (Ganoderma Lucidum (Leyss.ex Fr) Karst.) or Ganoderma (G.Japonicum (Fr.) Lloyd) is through fermented extracted, main component is ganoderma lucidum triterpene compounds and ganoderan, the ganoderan compounds is the contained important physiologically active ingredient of Ganoderma, deeply be subjected to medical sci-tech worker's attention, but unlimited, the quick splitting ability of ganoderan inhibition tumor cell, at present, ganoderan has been used as one of medicine for the treatment of tumor.Now prove: ganoderan also has the raising immunity of organisms, improves body's hypoxia tolerance, hypoglycemic activity, effect for reducing blood fat, anti-radiation and anti-aging effects.
) Radix Polygoni Multiflori extract:Chocolate brown powder shape extract for the tuber of polygonum multiflorum thunb (Polygonum multiflorumThunb.).The major function composition is lecithin, emodin, chrysophanic acid and other composition.Main Function: anti-aging effects, on immune impact, blood fat reducing and study of anti-atherogenic effect, myocardium protecting action, hepatoprotective effect, neuroprotective, antibacterial action.
) Radix Panacis Quinquefolii extract:The extract of the dry root of Araliaceae Radix Panacis Quinquefolii (Panax quinque folium L.).Radix Panacis Quinquefolii is a kind of benefit and high-class healthy product dry, not sutable for men, women, and children.Radix Panacis Quinquefolii has the effects such as benefiting qi and nourishing blood, enriching yin and nourishing kidney, the nourishing the stomach of key spleen, slow down aging and skin care.Modern medicine study proves that Radix Panacis Quinquefolii has resisting fatigue, defying age, shock, raising thinking, improves memory and endocrine regulation, enhancing body immunity and improves the effects such as cardiovascular function.
) vitamin C:Vitamin C (Vitamin C, Ascorbic Acid) be again L-AA, is a kind of water soluble vitamins.In fact ascorbic effect mainly can be divided into following some: 1. synthetic 2. treatment vitamin C deficiency, the 3. prevention gingival atrophyes of collagen protein, the dental beds of hemorrhage health tightly encase each tooth.Gingiva is soft tissue, easily produces gingival atrophy, hemorrhage when lacking protein, calcium, VC.4. the prevention of arterial sclerosis can promote the drainage of cholesterol, prevents that cholesterol from depositing at Wall of Artery, even can make the atheromatous plaque dissolving of deposition.5. antioxidant can be protected other antioxidant, such as VitAVitE, unsaturated fatty acid, prevents the injury of radical pair human body.6. the treatment anemia makes the ferric iron that is difficult to absorb be reduced into ferrous iron, promotes intestinal to the absorption of ferrum, improves liver to the utilization rate of ferrum, helps to treat iron deficiency anemia.7. the collagen protein that anti-cancer is abundant helps to prevent the diffusion of cancerous cell; The injury that the antioxidation of VC can be resisted the radical pair cell prevents the variation of cell; Blocking-up nitrite and secondary amine form the strong carcinogen nitrosamine.Once had the people to because of the VC content in the cancer mortality patient anatomy Discover the patients body almost nil.8. Cell protection, detoxifcation, the immunity leukocyte that the liver protecting 9. improves human body contains abundant VC, and intraleukocytic VC sharply reduces when organism infection.VC can strengthen chemotaxis and the deformability of neutrophilic granulocyte, improves sterilizing ability.10. improve the emergency capability of body, human body is subject to unusual stimulation, such as severe pain, cold, anoxia, spiritual strong stimulation, can cause the tense situation of resisting abnormal stimulation.This state comprises sympathetic activation, adrenal medulla and 17-hydroxy-11-dehydrocorticosterone secretion increasing with a series of healths.The epinephrine that adrenal medulla is secreted and norepinephrine are to have tyrosine to be transformed, in the participation of this process need VC.
) L-arginine:(Arginine) being a kind of alpha amino acid, also is one of 20 kinds of general natural aminoacid.It act as: 1, arginine is a constituent in the ornithine cycle, has extremely important physiological function.Eat arginine more, can increase the activity of arginase in the liver, help to change the ammonia in the blood into carbamide and excrete out.So arginine quite produces effect to diseases such as hyperammonemia, liver malfunctions.2, arginine is a kind of double-basis aminoacid, although concerning the adult, or not essential amino acids, in some situation such as body development is immature or under serious stressed condition, if lack arginine, just body can not be kept positive nitrogen balance and normal physiological function.If lacking arginine, patient can cause blood ammonia too high, even stupor.If some enzyme of baby's congenital deficiency ornithine cycle, arginine also are essential to it, otherwise can not keep its normal growth and grow.3, arginic important metabolic function is the Healing that promotes wound, and it can promote the synthetic of collagen tissue, so can repair wound.Can be observed the rising of arginase activity in the wound juice, this shows that also near the arginine requirement the wound increases.Arginine can promote the microcirculation of wound circumference and impel wound to fully recover early.4, arginic immunoloregulation function can prevent the degeneration (degeneration after especially injured) of thymus, and additional arginine can increase the weight of thymus, promotes the growth of thymus medium-sized lymphocyte.5, replenish the volume that arginine can also reduce tumor-bearing animal, reduce the rate of transform of tumor, improve time-to-live and the survival rate of animal.6, in immune system, except lymphocyte, cytophagous vigor is also relevant with arginine.After adding arginine, can activate its enzyme system, making it more can the kill tumor cell or the target cell such as antibacterial.7, arginine is the same with glutamine, just needs when human body is under the immense pressure.Just often be in this state as body-builders, so need to replenish arginine.Replenish just before going to bed 10～20 grams, can improve the level of tumor growth hormone.
) L-Histidine:(L-Histidine) L-Histidine be to the adult for nonessential propylhomoserin, but be essential amino acids to the child.Add a small amount of histidine in chronic uremia patient's meals, aminoacid increases in conjunction with the speed that enters hemoglobin, and kidney originality anemia alleviates, so histidine also is the essential amino acids of uremic patient.The imidazole radicals of histidine can form coordination compound with Fe2+ or other metal ions, promotes the absorption of ferrum, thereby can be used for preventing and treating anemia.Histidine can reduce gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates trimester of pregnancy vomiting and scorching hot sense, suppresses nervous by vegetative nerve and digestive tract that cause festers, and is to anaphylactic disease, also powerful such as asthma etc.In addition, the expansible blood vessel of histidine reduces blood pressure, and is used for clinically angina pectoris, the treatment of the diseases such as cardiac insufficiency.Histidine content significantly reduces in the patient with rheumatoid arthritis blood, finds its grip after using histidine, walks and all take a favorable turn with the index such as erythrocyte sedimentation rate.Under the effect of histidine decarboxylase, the histidine decarboxylation forms histamine.Histamine has very strong vasorelaxation action, and relevant with multiple allergy and inflammation.In addition, histamine can stimulate pepsin and gastric acid.For nonessential propylhomoserin, but be essential amino acids to the child to the adult.Add a small amount of histidine in chronic uremia patient's meals, aminoacid increases in conjunction with the speed that enters hemoglobin, and kidney originality anemia alleviates, so histidine also is the essential amino acids of uremic patient.
) taurine:Taurine (Taurine) claim again the beta-amino ethyl sulfonic acid, the earliest by separating in the Calculus Bovis, so gain the name.Show that from relevant pharmacology data taurine has: 1. strong liver choleretic effect: the Cavia porcellus experiment shows that taurine can be removed cholestasis, is choleretic effect.2. analgesic and antiinflammatory action: this product may reduce body temperature by the effect to maincenter 5-hydroxy tryptamine (5-HT) system or catecholamine system.3. hypotensive effect.4. heart tonifying and antiarrhythmic effect.5. hypoglycemic activity.6. taurine has lax skeletal muscle and the myotonic effect of antagonism.
) vitamin E:Vitamin E (Vitamin E) is a kind of fatsoluble vitamin, claims again tocopherol, is one of topmost antioxidant.Tocopherol can promote sex hormones secretion, and man's motility of sperm and quantity are increased; Make woman's estrogen Enrichment, improve fertility, prevention of miscarriage also can be used for preventing and treating the aspects such as male infertility, burn, cold injury, capillary hemorrhage, climacteric syndrome, beauty treatment.Recently find also that vitamin E can suppress the lipid peroxidation reaction in the eye lens, make slightly vasodilation of end, improve blood circulation, pre-myopia prevention occurs and development.
) Cit:Cit (L-Citrulline) is a kind of alpha amino acid, and name is by the Citrullus vulgaris that at first extracts citrulline.Citrulline is to generate ornithine cycle from ornithine and amido first vinegar phosphate, or seeing through nitricoxide synthase (NOS) catalysis generates arginic by-product.At first arginine can be oxidized to N-hydroxyl-arginine, and row is oxidized to citrulline and disengages nitric oxide again.It is lax that citrulline can make people's blood vessel obtain, be used for strengthening male's sexual, and the treatment of sexual dysfunction.Safeguard the pulmonary function in Jiankang, improve mental definition, helpful cranial nerve cell tool storage and the function of recalling to message.
) folic acid:One of folic acid (Folic acid) vitamin B complex is equivalent to pteroylglutamic acid (pteroylglutamic acid, PGA), is that Michele (H.K.Mitchell, 1941) extracts purification from the leaf of spinach, so called after folic acid.The effect that promotes juvenile cell maturation in the bone marrow is arranged, and human as shortage folic acid can cause megaloblastic anemia and leukopenia, and the anemia of pregnant woman is even more important.
Remarkable advantage of the present invention: prescription of the present invention has been given full play to Fructus Crataegi extract, Fructus Momordicae charantiae extract, Folium Ginkgo extract, Semen Vitis viniferae extract, Ganoderma extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract in the mutual supplement with each other's advantages that the work of human body is used, remedied the limitation of folk prescription medication effect, reach the effect that improves cardiovascular and cerebrovascular disease with rational prescription and consumption, the drug effect of prescription is much better than the monotaste plant extract.Wherein, L-arginine; Cit and taurine are the basic substances that generates NO; with high-strength antioxidant content vitamin C; the vitamin E combination; synthetic NO under the catalytic action of cell nitricoxide synthase (NOS); and maintenance NO's is stable; prevent from being destroyed by oxygen-derived free radicals; treat that its transhipment enters in the cell; nitric oxide stimulates the messenger molecule that produces a kind of cyclic guanosine monophosphate (GMP) to make papaverine and expansion; blood flow is accelerated; significantly reduce blood pressure, stop the formation of blood clotting and speckle, thereby prevention and treatment atherosclerosis are arranged; improve the heart oxygen-supplying amount; the generation of prevention myocardial infarction and apoplexy, allevating angina pectoris; repair the damage of vascular endothelial function etc., reach treatment and maintenance to whole bodies such as human central nervous and immunity systems.Compositions of the present invention in conjunction with modern medical theory so that prescription more rationally, effect is more outstanding.The present invention has significant raising human immunity and regulates, and improves the effect of cardiovascular and cerebrovascular disease, and prescription simply has no side effect, but life-time service is fit to middle-aged and elderly people and sub-health population.In addition, the present invention makes the granule form with finished product, brings great convenience to user.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention, but do not limit in any form the present invention.
Because the finished product made of this compositions needs the storage life more than 2 years, and because of this compositions moisture absorption very easily, bitter and puckery flavor, mouthfeel are not good, so on the make can add as required pharmacy acceptable adjuvant.Consider end user's character, the granule that preferred low-sugar type or Sugarless type are made.Fully satisfying the preparation process requirement, guaranteeing to reduce as far as possible the consumption of adjuvant under the prerequisite of product quality.The adjuvant that this product is selected and parts by weight thereof are: dextrin 2000-8000, lactose 1000-4000, steviosin 50-250.
The preparation method of compositions among the present invention: (relative humidity of following steps preferably is controlled at below 40%, temperature is below 25 ℃; Below among each embodiment vitamin E be pulverulence)
1) takes by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) Fructus Crataegi extract of formula ratio, Fructus Momordicae charantiae extract, Folium Ginkgo extract, Semen Vitis viniferae extract, Ganoderma extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract mix homogeneously, pulverizing is crossed 80 orders-100 mesh sieve and is got extract mixtures;
2) take by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) L-arginine of formula ratio, vitamin C, L-Histidine, taurine, vitamin E, Cit, folic acid adopt equivalent incremental method mix homogeneously, and pulverizing is crossed 80 orders-100 mesh sieve and got the amino acid, vitamine mixture;
3) take by weighing dextrin, lactose, the steviosin of (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) formula ratio, mix homogeneously, pulverizing are crossed 30 mesh sieves and are got the adjuvant mixture;
4) with 1), 2), 3) each mixture of preparation evenly mixes again, adding 85%-95%(mass percent) ethanol is as wetting agent, consumption is the 30%(percentage by weight of total mixture weight) make soft material, crossing 14 mesh sieves granulates, wet granular is in 55 ℃ of oven dry, dried granule is crossed 14 mesh sieve granulate, with bag packing and get final product.
Embodiment 1:
A kind of cardiovascular and cerebrovascular disease that can improve contains amino acid whose compositions, and the raw material of described compositions and weight portion thereof are: Fructus Crataegi extract 1500g, Fructus Momordicae charantiae extract 1000g, Folium Ginkgo extract 800g, Semen Vitis viniferae extract 800g, Ganoderma extract 700g, Radix Polygoni Multiflori extract 700g, Radix Panacis Quinquefolii extract 700g, L-arginine 700g, vitamin C 600g, L-Histidine 400g, taurine 300g, vitamin e1 00g, Cit 50g, folic acid 5g.
Adjuvant: dextrin 2800g, lactose 1400g, steviosin 150g.
Preparation technology comprises the steps: (relative humidity of following steps preferably is controlled at below 40%, temperature below 25 ℃)
1) takes by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) Fructus Crataegi extract of formula ratio, Fructus Momordicae charantiae extract, Folium Ginkgo extract, Semen Vitis viniferae extract, Ganoderma extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract mix homogeneously, pulverizing is crossed 80 mesh sieves and is got extract mixtures;
2) take by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) L-arginine of formula ratio, vitamin C, L-Histidine, taurine, vitamin E, Cit, folic acid adopt equivalent incremental method mix homogeneously, and pulverizing is crossed 80 mesh sieves and got the amino acid, vitamine mixture;
3) take by weighing dextrin, lactose, the steviosin of (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) formula ratio.Mix homogeneously, pulverizing are crossed 30 mesh sieves and are got the adjuvant mixture;
4) with 1), 2), 3) each mixture of preparation evenly mixes again, add 90% ethanol as wetting agent, consumption is the 30%(percentage by weight of total mixture weight) make soft material, crossing 14 mesh sieves granulates, wet granular is in 55 ℃ of oven dry, and dried granule is crossed 14 mesh sieve granulate, with the bag packing, every bag of 25g, and get final product.
Embodiment 2:
A kind of cardiovascular and cerebrovascular disease that can improve contains amino acid whose compositions, and the raw material of described compositions and weight portion thereof are: Fructus Crataegi extract 1800g, Fructus Momordicae charantiae extract 800g, Folium Ginkgo extract 600g, Semen Vitis viniferae extract 600g, Ganoderma extract 800g, Radix Polygoni Multiflori extract 500g, Radix Panacis Quinquefolii extract 600g, L-arginine 800g, vitamin C 700g, L-Histidine 300g, taurine 400g, vitamin E 120g, Cit 60g, folic acid 8g,
Adjuvant: dextrin 2200g, lactose 1200g, steviosin 200g.
Preparation technology comprises the steps: (relative humidity of following steps preferably is controlled at below 40%, temperature below 25 ℃)
1) takes by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) Fructus Crataegi extract of formula ratio, Fructus Momordicae charantiae extract, Folium Ginkgo extract, Semen Vitis viniferae extract, Ganoderma extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract mix homogeneously, pulverizing is crossed 90 mesh sieves and is got extract mixtures;
2) take by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) L-arginine of formula ratio, vitamin C, L-Histidine, taurine, vitamin E, Cit, folic acid adopt equivalent incremental method mix homogeneously, and pulverizing is crossed 90 mesh sieves and got the amino acid, vitamine mixture;
3) with embodiment 1 3)
4) with 1), 2), 3) each mixture of preparation evenly mixes again, add 85% ethanol as wetting agent, consumption is the 30%(percentage by weight of total mixture weight) make soft material, crossing 14 mesh sieves granulates, wet granular is in 55 ℃ of oven dry, and dried granule is crossed 14 mesh sieve granulate, with the bag packing, every bag of 20g, and get final product.
Embodiment 3:
A kind of cardiovascular and cerebrovascular disease that can improve contains amino acid whose compositions, and the raw material of described compositions and weight portion thereof are: Fructus Crataegi extract 1300g, Fructus Momordicae charantiae extract 1200g, Folium Ginkgo extract 1000g, Semen Vitis viniferae extract 1000g, Ganoderma extract 600g, Radix Polygoni Multiflori extract 900g, Radix Panacis Quinquefolii extract 500g, L-arginine 900g, vitamin C 800g, L-Histidine 500g, taurine 200g, vitamin E 150g, Cit 90g, folic acid 6g,
Adjuvant: dextrin 3000g, lactose 1300g, steviosin 180g.
Preparation technology comprises the steps: (relative humidity of following steps preferably is controlled at below 40%, temperature below 25 ℃)
1) takes by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) Fructus Crataegi extract of formula ratio, Fructus Momordicae charantiae extract, Folium Ginkgo extract, Semen Vitis viniferae extract, Ganoderma extract, Radix Polygoni Multiflori extract, Radix Panacis Quinquefolii extract mix homogeneously, pulverizing is crossed 100 mesh sieves and is got extract mixtures;
2) take by weighing (after 60 ℃ of dryings, moisture≤1.5% percentage by weight) L-arginine of formula ratio, vitamin C, L-Histidine, taurine, vitamin E, Cit, folic acid adopt equivalent incremental method mix homogeneously, and pulverizing is crossed 100 mesh sieves and got the amino acid, vitamine mixture;
3) with embodiment 1 3)
4) with 1), 2), 3) each mixture of preparation evenly mixes again, add 95% ethanol as wetting agent, consumption is the 30%(percentage by weight of total mixture weight) make soft material, crossing 14 mesh sieves granulates, wet granular is in 55 ℃ of oven dry, and dried granule is crossed 14 mesh sieve granulate, with the bag packing, every bag of 15g, and get final product.
Embodiment 4:
A kind of cardiovascular and cerebrovascular disease that can improve contains amino acid whose compositions, and the raw material of described compositions and weight portion thereof are: Fructus Crataegi extract 1000g, Fructus Momordicae charantiae extract 600g, Folium Ginkgo extract 500g, Semen Vitis viniferae extract 500g, Ganoderma extract 400g, Radix Polygoni Multiflori extract 400g, Radix Panacis Quinquefolii extract 300g, L-arginine 500 g, vitamin C 500 g, L-Histidine 100g, taurine 100g, vitamin E 50g, Cit 10g, folic acid 2g.
Adjuvant: dextrin 2000g, lactose 1000g, steviosin 50g.
Preparation technology uses a bag packing at last with embodiment 1, every bag of 30g, and get final product.
Embodiment 5:
A kind of cardiovascular and cerebrovascular disease that can improve contains amino acid whose compositions, and the raw material of described compositions and weight portion thereof are: Fructus Crataegi extract 2000g, Fructus Momordicae charantiae extract 1800g, Folium Ginkgo extract 1500g, Semen Vitis viniferae extract 1500g, Ganoderma extract 1500g, Radix Polygoni Multiflori extract 1500g, Radix Panacis Quinquefolii extract 1000g, L-arginine 1000g, vitamin C 1000g, L-Histidine 600g, taurine 500g, vitamin E 200g, Cit 100g, folic acid 8g.
Adjuvant: dextrin 8000g, lactose 4000g, steviosin 250g.
Preparation technology uses a bag packing at last with embodiment 3, every bag of 15g, and get final product.
Embodiment 6:
This compositions has good functions of prevention and health care to cardiovascular and cerebrovascular disease, and the granule of making take this compositions embodiment 1 is as example (embodiment 1 is preferred embodiment).The granule specification is: the 25g/ bag, and using method is: each 1-2 bag, one after each meal, warm boiled water, every day three times, 30 days is a course for the treatment of.
Take effect: patient's 48 examples of cardiovascular and cerebrovascular disease are suffered to diagnosis by certain hospital, are divided into two groups, every group of 24 examples, and two groups of Genders, age, the state of an illness are balanced, without significant difference.In the situation of normal ethical goods treatment, wherein one group adds the granule (experimental group) that this compositions is made by taking requirement, another group does not add this product (matched group), through observing three courses for the treatment of, the matched group effective percentage that nothing adds this composition granule is 72.5%, and the experimental group effective percentage that adds composition granule is 93.5%.(criterion of therapeutical effect is: produce effects: coronary heart diseases and angina pectoris and heart infarction symptom disappear substantially; Effectively: coronary heart diseases and angina pectoris and heart infarction symptom have clear improvement, invalid: unchanged before and after coronary heart diseases and angina pectoris and the heart infarction symptom treatment)
Embodiment 7:Model case:
1, Wu so-and-so, man, 75 years old, former Foochow retired employees of pharmaceutical factory, consultation time: on March 10th, 2012, suffer from for many years hypertension, blood pressure 180/95mm/hg, cerebral ischemia, high, high, the sensation of oppression over the chest with shortness of breath of blood fat of blood viscosity are kept by taking many medicines, and effect is all bad, since the granule that adds this compositions after two courses for the treatment of, blood pressure has just dropped to 135/85mm/hg,, have not a particle of the sensation of headache and dizzy.
2, Wang, the man, 72 years old, former certain retired cadre of city light industrial bureau, consultation time: on April 15th, 2012, poor sleeping quality, hypertension, deficiency myocardial blood supply causes nervous agitation, has a pain in the leg, after taking conventional medicine, added the granule of this compositions after course for the treatment of, nervous, irritated sx↓ many, sleep also obtained very large improvement, walks also feeling relaxed of lower limb.
3, in so-and-so, the woman, 78 years old, former Foochow middle school retired professor, consultation time: suffered from the severe coronary artery disease angina pectoris on February 1st, 2012, hurt like hell during morbidity, the Multiple Hospitalization treatment can not be cured exactly, carries the emergency medicine throughout the year.Granule through adding this compositions is after three courses for the treatment of, and it is just much unobstructed to breathe, and relaxation is also arranged with it, and the state of an illness is controlled.
4, Lin, the woman, 75 years old, former Foochow retired employees of textile mills, consultation time: suffered from shock property heart disease more than 20 year on March 10th, 2012, almost all fall ill every day, emotion is very easily exciting.Conventional medicine can not be cured, and carries always with oneself SUXIAO JIUXIN WAN and provides against any misfortune, and the granule by adding this compositions is after three courses for the treatment of, and incidence obviously reduces, and it is optimistic that emotion is tending towards, symptom be improved significantly.
5, Wu, the man, 48 years old, certain employee of insurance company, consultation time: on March 18th, 2012, since in February, 2012 sensation sleep bad, easily perspire at ordinary times, fatigue, weak, sensation of oppression over the chest with shortness of breath in the time of was upstairs taken the granule of this compositions less than one month, felt that the mental status takes a turn for the better, health is easily many, also in continuing use.
Claims (4)
1.
OneKind can be improved cardiovascular and cerebrovascular disease and contain amino acid whose compositions, and it is characterized in that: the raw material of described compositions and parts by weight thereof are: Fructus Crataegi extract 1000～2000; Fructus Momordicae charantiae extract 600～1800; Folium Ginkgo extract 500～1500; Semen Vitis viniferae extract 500～1500; Ganoderma extract 400～1500; Radix Polygoni Multiflori extract 400～1500; Radix Panacis Quinquefolii extract 300～1000; L-arginine 500～1000; vitamin C 500～1000; L-Histidine 100～600; taurine 100～500; vitamin E 50～200; Cit 10～100; folic acid 2～8.
2. according to claim 1
OneKind can be improved cardiovascular and cerebrovascular disease and contain amino acid whose compositions, and it is characterized in that: the raw material of described compositions and parts by weight thereof are: Fructus Crataegi extract 1500, Fructus Momordicae charantiae extract 1000, Folium Ginkgo extract 800, Semen Vitis viniferae extract 800, Ganoderma extract 700, Radix Polygoni Multiflori extract 700, Radix Panacis Quinquefolii extract 700, L-arginine 700, vitamin C 600, L-Histidine 400, taurine 300, vitamin E 100, Cit 50, folic acid 5.
3. according to claim 1 and 2ly contain amino acid whose compositions, it is characterized in that: by weight percentage, general flavone content in the described Fructus Crataegi extract 〉=10%; Charantin content 〉=10% in the Fructus Momordicae charantiae extract; Ginkgo total flavones content 〉=24% in the Folium Ginkgo extract; Semen Vitis viniferae extract contains procyanidin content 〉=95%; Lecithin content in the Radix Polygoni Multiflori extract 〉=3.7%; Ganoderma polyoses content in the Ganoderma extract 〉=10%; Radix Panacis Quinquefolii saponin content 〉=20% in the Radix Panacis Quinquefolii extract.
4. as claimed in claim 1 or 2
OneKind can be improved cardiovascular and cerebrovascular disease and contain the application of amino acid whose compositions in preparation health food or medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103688457A CN102861180A (en) | 2012-09-27 | 2012-09-27 | Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103688457A CN102861180A (en) | 2012-09-27 | 2012-09-27 | Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102861180A true CN102861180A (en) | 2013-01-09 |
Family
ID=47440495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012103688457A Pending CN102861180A (en) | 2012-09-27 | 2012-09-27 | Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102861180A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263018A (en) * | 2013-04-27 | 2013-08-28 | 北京中国科学院老专家技术中心 | Nitric oxide functional beverage and preparation method thereof |
| CN105878282A (en) * | 2016-05-14 | 2016-08-24 | 张恒洲 | Health care product with compatibility of bezoar and nitric oxide, and preparation method thereof |
| CN106334098A (en) * | 2016-08-29 | 2017-01-18 | 姚新亮 | Alkaline plant salt for relieving cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN107836622A (en) * | 2017-11-30 | 2018-03-27 | 孔国东 | A kind of sub-health population conditioning solid beverage and preparation method thereof |
| CN108685971A (en) * | 2018-06-12 | 2018-10-23 | 泓博元生命科技（深圳）有限公司 | A kind of Weight reducing compound and its preparation method and application |
| CN109645494A (en) * | 2019-01-23 | 2019-04-19 | 四川治宇东盟贸易有限责任公司 | Improve function of human body and prevents the composition and preparation method of cardiovascular and cerebrovascular disease |
| CN109892599A (en) * | 2019-04-15 | 2019-06-18 | 吉林省九圣源生物科技有限公司 | A kind of herbal cuisine eaten for coronary heart disease crowd |
| CN113383950A (en) * | 2021-05-17 | 2021-09-14 | 李红光 | Bitter gourd health food |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129514A (en) * | 2007-08-20 | 2008-02-27 | 戴晓平 | Fat-benefiting health care composition capsule and its preparing method |
| CN101322780A (en) * | 2008-07-21 | 2008-12-17 | 陈红春 | Formulation for delaying aging, improving cardiovascular and cerebrovascular condition, and prolonging life and preparation thereof |
| CN101780181A (en) * | 2009-01-16 | 2010-07-21 | 陈祥槐 | Nitric oxide free radical health care product |
-
2012
- 2012-09-27 CN CN2012103688457A patent/CN102861180A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129514A (en) * | 2007-08-20 | 2008-02-27 | 戴晓平 | Fat-benefiting health care composition capsule and its preparing method |
| CN101322780A (en) * | 2008-07-21 | 2008-12-17 | 陈红春 | Formulation for delaying aging, improving cardiovascular and cerebrovascular condition, and prolonging life and preparation thereof |
| CN101780181A (en) * | 2009-01-16 | 2010-07-21 | 陈祥槐 | Nitric oxide free radical health care product |
Non-Patent Citations (2)
| Title |
|---|
| 东浩: "一氧化氮引爆营养保健新浪潮", 《知识经济》, no. 3, 31 March 2007 (2007-03-31), pages 18 - 19 * |
| 王先科等: "植物皂甙降低机体胆固醇的作用及其机理研究进展", 《江西农业学报》, vol. 22, no. 1, 31 January 2010 (2010-01-31), pages 132 - 135 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263018A (en) * | 2013-04-27 | 2013-08-28 | 北京中国科学院老专家技术中心 | Nitric oxide functional beverage and preparation method thereof |
| CN105878282A (en) * | 2016-05-14 | 2016-08-24 | 张恒洲 | Health care product with compatibility of bezoar and nitric oxide, and preparation method thereof |
| CN106334098A (en) * | 2016-08-29 | 2017-01-18 | 姚新亮 | Alkaline plant salt for relieving cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN107836622A (en) * | 2017-11-30 | 2018-03-27 | 孔国东 | A kind of sub-health population conditioning solid beverage and preparation method thereof |
| CN108685971A (en) * | 2018-06-12 | 2018-10-23 | 泓博元生命科技（深圳）有限公司 | A kind of Weight reducing compound and its preparation method and application |
| CN109645494A (en) * | 2019-01-23 | 2019-04-19 | 四川治宇东盟贸易有限责任公司 | Improve function of human body and prevents the composition and preparation method of cardiovascular and cerebrovascular disease |
| CN109892599A (en) * | 2019-04-15 | 2019-06-18 | 吉林省九圣源生物科技有限公司 | A kind of herbal cuisine eaten for coronary heart disease crowd |
| CN113383950A (en) * | 2021-05-17 | 2021-09-14 | 李红光 | Bitter gourd health food |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102861180A (en) | Amino-acid-containing composition capable of improving conditions of patients with cardiovascular and cerebrovascular diseases and application of amino-acid-containing composition | |
| CN101982082B (en) | Aizoon compound health tea | |
| CN103877263B (en) | A kind of antifatigue health preparation of the compound Chinese medicine such as red ginseng, maca, green-tea extract (theanine) | |
| CN102742840A (en) | Maca Cordyceps buccal tablet and preparation method thereof | |
| CN100394859C (en) | Health tea | |
| CN105695258A (en) | Female health wine containing lychee seed saponin | |
| CN102940801A (en) | Traditional Chinese medicine composition for treating hypertension | |
| CN103099833A (en) | Soft capsule helpful for relieving sports fatigue and delaying aging and preparation method thereof | |
| CN108671002A (en) | A kind of composition of the extract containing Saussurea involucrata culture and its application | |
| CN1109554C (en) | Medicine for treating allergic purpura | |
| CN107006856A (en) | One kind enhancing endurance, raising anti anoxia tolerance nutritional agents and preparation method thereof | |
| CN104758353B (en) | A kind of pharmaceutical composition and its preparation method and application for treating angiocardiopathy | |
| CN104225417A (en) | Traditional Chinese medicine composition with function of assisting improvement of memory and preparation method thereof | |
| CN103479754B (en) | Hypotensive drug and preparation method thereof | |
| KR101456937B1 (en) | Composition comprising the extracts of natural material for controling or treating obesity | |
| CN103142848B (en) | Anti-aging Chinese medicine preparation and preparation method thereof | |
| CN101099775B (en) | Cardiac and cerebral vascular disease treating medicine | |
| RU2485965C2 (en) | Compartment-specific dual combination of herbal extracts of ginkgo biloba and ginseng | |
| CN108186966A (en) | A kind of composition for preventing or improving senile dementia and its application | |
| CN104256821B (en) | A kind of agate coffee compound oral liquid and preparation method thereof | |
| EP2508084A1 (en) | Biologically active food additive for preventing cardiovascular diseases and enhancing the cardiovascular system | |
| CN102973687B (en) | Oral liquid for regulating female hormonal balance | |
| CN103933282B (en) | A kind of Chinese medicinal capsule for treating diabetes | |
| CN102784230A (en) | Pharmaceutical composition preparation for treating nutritional anemia | |
| KR101113593B1 (en) | A pharmaceutical comprising the extract of red panax ginseng, gastrodia rhizoma and polygoni multiflori radix for treating or preventing erectile dysfunction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130109 |