CN102846708A - Injection for treating urinary system and intestinal canal infections of livestock and preparation method thereof - Google Patents
Injection for treating urinary system and intestinal canal infections of livestock and preparation method thereof Download PDFInfo
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- CN102846708A CN102846708A CN2012102740228A CN201210274022A CN102846708A CN 102846708 A CN102846708 A CN 102846708A CN 2012102740228 A CN2012102740228 A CN 2012102740228A CN 201210274022 A CN201210274022 A CN 201210274022A CN 102846708 A CN102846708 A CN 102846708A
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Abstract
The invention discloses an injection for treating urinary system and intestinal canal infections of the livestock and a preparation method thereof. The injection is prepared through active constituents extracted from populus pseudo-simonii bark, birch bark and scutellaria baicalensis. The preparation method includes boiling the three materials into an immersion-boiled solution by adding water and raising the temperature and concentrating the immersion-boiled solution; adding ethanol to dissolve the concentrated solution, and subjecting a filtrate to ethanol recovery till no ethanol exists; and adding injection water into a concentrate, heating and boiling the concentrate to obtain a supernate for precipitation, refeeding the injection water into liquid medicine and adding tween-80, evenly stirring the mixture, and subjecting the mixture to refined filtration to obtain the injection. According to the injection for treating urinary system and intestinal canal infections of the livestock and the preparation method thereof, the injection can be used for treating urinary tract infection, acute pyelonephritis, bacillary enteritis and the like of the livestock. Clinical effects are apparent, drug resistance is difficult for pathogenic bacteria to produce, and drug residues and public nuisances are effectively prevented. The raw material cost is low, the preparation process is simple, the use effect is good, and the use cost is low.
Description
Technical field
The invention belongs to the veterinary drug technical field, especially a kind of injection and preparation method for the treatment of domestic animal urinary system and intestinal infection.
Background technology
At present, various countries generally adopt antibiotic, such as the urinary system infection of the treatment such as oxytetracycline, penicillin, streptomycin, chloromycetin poultry etc., the diseases such as acute/chronic gastroenteritis.Because long-term and abuse of antibiotics are easily developed immunity to drugs poultry, reduced curative effect, and the antibiotic price are higher.In the prior art, China also someone adopts the Chinese medicine preparation such as Herba Andrographis, berberine, Radix Bupleuri, but its therapeutic effect is undesirable, and the composite Chinese herbal injection is still nervous, can not meet the need of market.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of injection for the treatment of domestic animal urinary system and intestinal infection is provided, this injection is evident in efficacy, production cost is low, do not develop immunity to drugs, have no side effect, drug residue free.
Another object of the present invention is to provide a kind of preparation method for the treatment of the injection of domestic animal urinary system and intestinal infection.
The object of the present invention is achieved like this: a kind of injection for the treatment of domestic animal urinary system and intestinal infection, it is characterized in that: it by Cortex Populi Pseudo-simonii bark, Cortex Betulae Luminiferae and three kinds of raw materials of Radix Scutellariae through the effective ingredient system extracted, the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: 5～7 parts on Cortex Populi Pseudo-simonii bark, 2～4 parts of Cortex Betulae Luminiferaes, 1～3 part of Radix Scutellariae.
Preferred version of the present invention, the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: 5.5～6.5 parts on Cortex Populi Pseudo-simonii bark, 2.5～3.5 parts of Cortex Betulae Luminiferaes, 1.5～2.5 parts of Radix Scutellariaes.
More preferably scheme of the present invention, the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: 6 parts on Cortex Populi Pseudo-simonii bark, 3 parts of Cortex Betulae Luminiferaes, 2 parts of Radix Scutellariaes.
A kind of method for the treatment of the injection of domestic animal urinary system and intestinal infection comprises the following steps:
(1), take by weighing Cortex Populi Pseudo-simonii bark, Cortex Betulae Luminiferae and three kinds of crude drug of Radix Scutellariae by above-mentioned formula proportion, its chopping is mixed, soaked 12～24 hours;
(2) will shred the crude drug that mixes and decoct secondary, add water to submerge crude drug for the first time, decoct 0.5～1.5 hour, and pour out digestion liquid and deposit separately; For the second time add water to submerge crude drug, decocted 0.3～1.0 hour, pour out digestion liquid; Merge digestion liquid twice, heating is concentrated into 1/3～1/2 of digestion liquid and gets the digestion concentrated solution;
(3) the digestion concentrated solution being added concentration is 75～96% ethanol, makes ethanol content reach 55～65%, and static placement was got supernatant liquid filtering more than 48 hours, and decompression recycling ethanol is to distinguishing the flavor of without pure supernatant without alcohol; Add for the second time concentration in the digestion concentrated solution after taking out supernatant and be 85～96% ethanol, make ethanol content reach 60～70%, static placement was got supernatant liquid filtering more than 48 hours, and decompression recycling ethanol is extremely distinguished the flavor of without pure supernatant without alcohol;
(4) step (3) is merged without pure supernatant for twice after, amount by 2～3 times of three kinds of crude drug weight adds water for injection, the post-heating that stirs boiled 20～30 minutes, cooling, quiescent setting, get supernatant and go precipitation, filter, 0.1%～1% of adding solution total amount injection is removed thermal source and impurity with activated carbon when boiling;
(5) the prepared medicinal liquid of step (4) is added the amount of 2～3 times of water for injection to three kind of crude drug weight, added 1%～2% tween 80 again, the rear fine straining that stirs obtains the injection for the treatment of domestic animal urinary system of the present invention and intestinal infection.
The injection intramuscular injection for the treatment of domestic animal urinary system and intestinal infection is once measured: 60～80 milliliters of horse, cattle, 10～20 milliliters of sheep, 20～30 milliliters of pigs; One twice-daily, but have no side effect for consolidating the curative effect continuous use.
Advantage of the present invention and beneficial effect are:
(1) injection of the present invention is a kind of antibacterials, and staphylococcus aureus, escherichia coli, bacillus pyocyaneus and Brucella etc. are had significant inhibitory action.
(2) injection of the present invention can be used for treating domestic animal urinary tract infection, acute pyelonephritis, bacterial enteritis etc.
(3) clinical effectiveness of the present invention is remarkable, and makes pathogenic bacterium be difficult to produce drug resistance, has and puts the generation of having avoided drug residue and social effects of pollution.
(4) crude drug of the present invention source is abundant, and with low cost, preparation technology is simple, and result of use is good, and use cost is low.
The specific embodiment
Embodiment 1: a kind of injection for the treatment of domestic animal urinary system and intestinal infection, it by Cortex Populi Pseudo-simonii bark, Cortex Betulae Luminiferae and three kinds of raw materials of Radix Scutellariae through the effective ingredient system extracted, the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: Cortex Populi Pseudo-simonii bark 6000 grams, Cortex Betulae Luminiferae 3000 grams, Radix Scutellariae 2000 grams.
A kind of method for the treatment of the injection of domestic animal urinary system and intestinal infection comprises the following steps:
(1) takes by weighing respectively Cortex Populi Pseudo-simonii bark 6000 grams, Cortex Betulae Luminiferae 3000 grams and Radix Scutellariae 2000 grams, its chopping is mixed, soaked 24 hours;
(2) will shred the crude drug that mixes and decoct secondary, add water to submerge crude drug for the first time, decoct 1 hour, and pour out digestion liquid and deposit separately; For the second time add water to submerge crude drug, decocted 0.8 hour, pour out digestion liquid; Merge digestion liquid twice, heating is concentrated into 1/2 of digestion liquid and gets the digestion concentrated solution;
(3) the digestion concentrated solution being added concentration is 96% ethanol, makes ethanol content reach 60%, and supernatant liquid filtering is got in static placement 48 hours, and decompression recycling ethanol is to distinguishing the flavor of without pure supernatant without alcohol; Add for the second time concentration in the digestion concentrated solution after taking out supernatant and be 96% ethanol, make ethanol content reach 65%, supernatant liquid filtering is got in static placement 60 hours, and decompression recycling ethanol is extremely distinguished the flavor of without pure supernatant without alcohol;
(4) step (3) is merged without pure supernatant for twice after, add 15000 milliliters of waters for injection, the post-heating that stirs boiled 25 minutes, cooling, quiescent setting is got supernatant and is gone precipitation, filter, 0.2% of adding solution total amount injection is removed thermal source and impurity with activated carbon when boiling;
(5) the prepared medicinal liquid of step (4) is added water for injection to 15000 milliliter, added 1% tween 80 again, the rear fine straining that stirs obtains the injection for the treatment of domestic animal urinary system of the present invention and intestinal infection.
Embodiment 2: a kind of injection for the treatment of domestic animal urinary system and intestinal infection, it by Cortex Populi Pseudo-simonii bark, Cortex Betulae Luminiferae and three kinds of raw materials of Radix Scutellariae through the effective ingredient system extracted, the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: Cortex Populi Pseudo-simonii bark 5000 grams, Cortex Betulae Luminiferae 3500 grams, Radix Scutellariae 1500 grams.
A kind of method for the treatment of the injection of domestic animal urinary system and intestinal infection comprises the following steps:
(1) takes by weighing respectively Cortex Populi Pseudo-simonii bark 5000 grams, Cortex Betulae Luminiferae 3500 grams and Radix Scutellariae 1500 grams, its chopping is mixed, soaked 12 hours;
(2) will shred the crude drug that mixes and decoct secondary, add water to submerge crude drug for the first time, decoct 1.2 hours, and pour out digestion liquid and deposit separately; For the second time add water to submerge crude drug, decocted 0.5 hour, pour out digestion liquid; Merge digestion liquid twice, heating is concentrated into 1/3 of digestion liquid and gets the digestion concentrated solution;
(3) the digestion concentrated solution being added concentration is 90% ethanol, makes ethanol content reach 58%, and supernatant liquid filtering is got in static placement 50 hours, and decompression recycling ethanol is to distinguishing the flavor of without pure supernatant without alcohol; Add for the second time concentration in the digestion concentrated solution after taking out supernatant and be 90% ethanol, make ethanol content reach 62%, supernatant liquid filtering is got in static placement 48 hours, and decompression recycling ethanol is extremely distinguished the flavor of without pure supernatant without alcohol;
(4) step (3) is merged without pure supernatant for twice after, add 12000 milliliters of waters for injection, the post-heating that stirs boiled 20 minutes, cooling, quiescent setting is got supernatant and is gone precipitation, filter, 0.3% of adding solution total amount injection is removed thermal source and impurity with activated carbon when boiling;
(5) the prepared medicinal liquid of step (4) is added water for injection to 12000 milliliter, added 2% tween 80 again, the rear fine straining that stirs obtains the injection for the treatment of domestic animal urinary system of the present invention and intestinal infection.
Embodiment 3: a kind of injection for the treatment of domestic animal urinary system and intestinal infection, it by Cortex Populi Pseudo-simonii bark, Cortex Betulae Luminiferae and three kinds of raw materials of Radix Scutellariae through the effective ingredient system extracted, the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: Cortex Populi Pseudo-simonii bark 7000 grams, Cortex Betulae Luminiferae 2500 grams, Radix Scutellariae 2500 grams.
A kind of method for the treatment of the injection of domestic animal urinary system and intestinal infection comprises the following steps:
(1) takes by weighing respectively Cortex Populi Pseudo-simonii bark 7000 grams, Cortex Betulae Luminiferae 2500 grams and Radix Scutellariae 2500 grams, its chopping is mixed, soaked 18 hours;
(2) will shred the crude drug that mixes and decoct secondary, add water to submerge crude drug for the first time, decoct 0.8 hour, and pour out digestion liquid and deposit separately; For the second time add water to submerge crude drug, decocted 0.6 hour, pour out digestion liquid; Merge digestion liquid twice, heating is concentrated into 1/2 of digestion liquid and gets the digestion concentrated solution;
(3) the digestion concentrated solution being added concentration is 80% ethanol, makes ethanol content reach 62%, and supernatant liquid filtering is got in static placement 60 hours, and decompression recycling ethanol is to distinguishing the flavor of without pure supernatant without alcohol; Add for the second time concentration in the digestion concentrated solution after taking out supernatant and be 85% ethanol, make ethanol content reach 68%, supernatant liquid filtering is got in static placement 50 hours, and decompression recycling ethanol is extremely distinguished the flavor of without pure supernatant without alcohol;
(4) step (3) is merged without pure supernatant for twice after, add 20000 milliliters of waters for injection, the post-heating that stirs boiled 30 minutes, cooling, quiescent setting is got supernatant and is gone precipitation, filter, 0.1% of adding solution total amount injection is removed thermal source and impurity with activated carbon when boiling;
(5) the prepared medicinal liquid of step (4) is added water for injection to 20000 milliliter, added 1.5% tween 80 again, the rear fine straining that stirs obtains the injection for the treatment of domestic animal urinary system of the present invention and intestinal infection.
Clinical trial: the clinical test of pesticide effectiveness of injection of the present invention has been carried out on 5 pig farms such as pig farm, land owned by officials on Chifeng City's agriculture and animal husbandry research institute pig farm, Songshan District in by the end of October, 2011 in first arrival in April, 2011.Result of the test is as follows:
This test amount to 328 cases carried out adopting embodiment 1 system injection carry out medication test, each 25 milliliters of intramuscular injection; One twice-daily.Swine enteritis 260 examples wherein, total effective rate 93.1%, pig urinary system infection 68 examples, the total effective rate 93.6% of 95.6%, two kind of disease of total effective rate.
Claims (4)
1. injection for the treatment of domestic animal urinary system and intestinal infection, it is characterized in that: it by Cortex Populi Pseudo-simonii bark, Cortex Betulae Luminiferae and three kinds of raw materials of Radix Scutellariae through the effective ingredient system extracted, the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: 5～7 parts on Cortex Populi Pseudo-simonii bark, 2～4 parts of Cortex Betulae Luminiferaes, 1～3 part of Radix Scutellariae.
2. the injection for the treatment of according to claim 1 domestic animal urinary system and intestinal infection, it is characterized in that: the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: 5.5～6.5 parts on Cortex Populi Pseudo-simonii bark, 2.5～3.5 parts of Cortex Betulae Luminiferaes, 1.5～2.5 parts of Radix Scutellariaes.
3. the injection for the treatment of according to claim 2 domestic animal urinary system and intestinal infection, it is characterized in that: the weight portion proportioning of the used three kinds of raw materials of effective component extracting is: 6 parts on Cortex Populi Pseudo-simonii bark, 3 parts of Cortex Betulae Luminiferaes, 2 parts of Radix Scutellariaes.
4. a method for the treatment of the injection of domestic animal urinary system and intestinal infection comprises the following steps:
(1) takes by weighing Cortex Populi Pseudo-simonii bark, Cortex Betulae Luminiferae and three kinds of crude drug of Radix Scutellariae by claim 1, the described weight portion proportioning of 2 or 3 any one, its chopping is mixed, soaked 12～24 hours;
(2) will shred the crude drug that mixes and decoct secondary, add water to submerge crude drug for the first time, decoct 0.5～1.5 hour, and pour out digestion liquid and deposit separately; For the second time add water to submerge crude drug, decocted 0.3～1.0 hour, pour out digestion liquid; Merge digestion liquid twice, heating is concentrated into 1/3～1/2 of digestion liquid and gets the digestion concentrated solution;
(3) the digestion concentrated solution being added concentration is 75～96% ethanol, makes ethanol content reach 55～65%, and static placement was got supernatant liquid filtering more than 48 hours, and decompression recycling ethanol is to distinguishing the flavor of without pure supernatant without alcohol; Add for the second time concentration in the digestion concentrated solution after taking out supernatant and be 85～96% ethanol, make ethanol content reach 60～70%, static placement was got supernatant liquid filtering more than 48 hours, and decompression recycling ethanol is extremely distinguished the flavor of without pure supernatant without alcohol;
(4) step (3) is merged without pure supernatant for twice after, amount by 2～3 times of three kinds of crude drug weight adds water for injection, the post-heating that stirs boiled 20～30 minutes, cooling, quiescent setting, get supernatant and go precipitation, filter, 0.1%～1% of adding solution total amount injection is removed thermal source and impurity with activated carbon when boiling;
(5) the prepared medicinal liquid of step (4) is added the amount of 2～3 times of water for injection to three kind of crude drug weight, added 1%～2% tween 80 again, the rear fine straining that stirs obtains the injection for the treatment of domestic animal urinary system of the present invention and intestinal infection.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102740228A CN102846708A (en) | 2012-07-25 | 2012-07-25 | Injection for treating urinary system and intestinal canal infections of livestock and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102740228A CN102846708A (en) | 2012-07-25 | 2012-07-25 | Injection for treating urinary system and intestinal canal infections of livestock and preparation method thereof |
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| CN102846708A true CN102846708A (en) | 2013-01-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012102740228A Pending CN102846708A (en) | 2012-07-25 | 2012-07-25 | Injection for treating urinary system and intestinal canal infections of livestock and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096446A (en) * | 1993-06-16 | 1994-12-21 | 河北省怀来县新保安畜牧兽医站 | Compound flavescent sophora root injection for animals |
| CN101396509A (en) * | 2007-09-28 | 2009-04-01 | 天津生机集团有限公司 | Chinese veterinary drug for treating livestock and poultry intestinal tract disease |
-
2012
- 2012-07-25 CN CN2012102740228A patent/CN102846708A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096446A (en) * | 1993-06-16 | 1994-12-21 | 河北省怀来县新保安畜牧兽医站 | Compound flavescent sophora root injection for animals |
| CN101396509A (en) * | 2007-09-28 | 2009-04-01 | 天津生机集团有限公司 | Chinese veterinary drug for treating livestock and poultry intestinal tract disease |
Non-Patent Citations (1)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006 * |
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Application publication date: 20130102 |