CN102846656A - Skin mucosa disinfecting liquid and preparation method thereof - Google Patents
Skin mucosa disinfecting liquid and preparation method thereof Download PDFInfo
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- CN102846656A CN102846656A CN2011101842709A CN201110184270A CN102846656A CN 102846656 A CN102846656 A CN 102846656A CN 2011101842709 A CN2011101842709 A CN 2011101842709A CN 201110184270 A CN201110184270 A CN 201110184270A CN 102846656 A CN102846656 A CN 102846656A
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- skin mucosa
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- disinfectant solution
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Abstract
The invention discloses skin mucosa disinfecting liquid and preparation method thereof. The skin mucosa disinfecting liquid contains (by weight ratio) chlorhexidine acetate 0.25% plus or minus 0.02%, benzalkonium bromide 0.0125%, sodium nitrite 0.015%, glutaraldehyde 0.02%, octyl phenoxy poly ethoxy 0.05%, and residual amount of distilled water. Using octyl phenoxy poly ethoxy for assisting dissolution and containing no alcohol substances such as glycerol, the invention has little irritation on skin mucosa. The invention has wide application scope, and can be used for sterilization of oral mucosa, pudendum, skin mucosa and damaged skin and for mucosa sterilization in medical institution.
Description
Technical field
The present invention relates to a kind of disinfectant solution and preparation method thereof, be specifically related to a kind of skin mucosa disinfectant solution and preparation method thereof.
Background technology
At present, disinfectant solution on the market is of a great variety, mainly comprise oxidation class, aldehydes, alcohols, salt, halogen, surfactant-based by mechanism of action, the formaldehyde such as aldehydes, the glutaraldehyde comparatively commonly used, surfactant-based benzalkonium bromide (bromogeramine).Chlorhexidine acetate is the biguanides middle effect disinfectants, it spills cellular content by the permeability that changes antibacterial endochylema film and plays bactericidal action, part staphylococcus, Streptococcus mutans, streptococcus salivarius, escherichia coli, propionibacterium and Candida albicans Dichlorodiphenyl Acetate chlorhexidine are responsive, bloodthirsty streptococcus is medium sensitivity, and chlorhexidine acetate is faint to effects such as Proteus, Rhodopseudomonas, Klebsiella and Grain-negative coccuses.
Chlorhexidine acetate is easily molten in alcohol, thereby usually adds the alcohols such as ethanol, glycerol as cosolvent when preparation, discloses " skin sterilizing agent before operation " such as Chinese invention patent ZL02126050.8, contains glycerol in this product.And the alcohols high volatilities such as ethanol, glycerol when being used for skin, can not cause drying and excitement, and are non-stimulated during especially for mucosa.
Summary of the invention
Technical problem to be solved by this invention provides a kind of skin mucosa disinfectant solution and preparation method thereof, and, nothing even, nontoxic, non-stimulated by the disinfectant solution dissolving of the method preparation corroded and toxic and side effects.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
A kind of skin mucosa disinfectant solution comprises the component of following percentage by weight:
As this bright further improvement, the percentage by weight of above-mentioned chlorhexidine acetate is 0.25%.
The invention provides a kind of preparation method of skin mucosa disinfectant solution, comprise the steps:
(1) accurately take by weighing in proportion chlorhexidine acetate, benzalkonium bromide, sodium nitrite, measuring cup measures glutaraldehyde and Triton X-100, puts into agitator;
(2) above-mentioned agitator adds distilled water, stirs 20～30 minutes, and it is 6.8～8.3 that pH meter records pH value;
(3) filling machine fill, sealing obtain finished product.
A kind of skin mucosa disinfectant solution of the present invention can be killed pathogenic entero becteria, pyococcus, saccharomytes, hospital's common pathogen, is applicable to oral mucosa, pudendum, skin mucosa sterilization, damaged skin sterilization and medical institutions' mucosa sterilization.When being used for oral mucosa, pudendum, skin mucosa sterilization, directly use stock solution to spray or stock solution oral cavity rinsing the mouth, act on 1-3 minute; 3-5 is sprayed, acted on to direct stock solution when being used for the damaged skin sterilization
Compared with prior art, the beneficial effect that has of the present invention is:
1, a kind of skin mucosa disinfectant solution of the present invention is with non-ionic surface active agent Triton X-100 hydrotropy, Triton X-100 has emulsification, not only the dissolving of chlorhexidine acetate and benzalkonium bromide is even, and owing to not containing the alcohols material such as glycerol in the prescription, thereby very little to Mucocutaneous zest when using, better tolerance.
2, a kind of skin mucosa disinfectant solution of the present invention dissolve complete is dispersed system, no suspended substance and microgranule, thereby good stability, and the resting period is long.
3, a kind of skin mucosa disinfectant solution of the present invention is of many uses, can kill pathogenic entero becteria, pyococcus, saccharomytes, hospital's common pathogen, and fungus and virus are also had stronger inhibitory action.
The specific embodiment
Embodiment 1
A kind of preparation method of skin mucosa disinfectant solution:
(1) accurately take by weighing chlorhexidine acetate 25 grams, benzalkonium bromide 1.25 grams, sodium nitrite 1.5 grams, (relative density is 0.861g/cm to measure 2 milliliters of glutaraldehydes with measuring cup
3), (relative density is 1.0595g/cm for 50 milliliters of Triton X-100s
3), put into agitator;
(2) above-mentioned agitator adds 9948 ml distilled waters, stirs 30 minutes, uses pH meter to record pH value and is 6.8-8.3;
(3) filling machine carries out fill, screws on the bottle cap sealing, stamps the date of manufacture with ink recorder, cases, packs, enters warehouse for finished product.
Embodiment 2
Repeat embodiment 1, difference is for accurately taking by weighing chlorhexidine acetate 25 grams.
Claims (3)
1. skin mucosa disinfectant solution is characterized in that comprising the component of following percentage by weight:
2. according to the described a kind of skin mucosa disinfectant solution of claim 1, it is characterized in that comprising the component of following percentage by weight:
3. according to the preparation method of the described a kind of skin mucosa disinfectant solution of claim 1, it is characterized in that comprising the steps:
(1) accurately take by weighing in proportion chlorhexidine acetate, benzalkonium bromide, sodium nitrite, measuring cup measures glutaraldehyde and Triton X-100, puts into agitator;
(2) above-mentioned agitator adds distilled water, stirs 20～30 minutes;
(3) filling machine fill, sealing obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101842709A CN102846656A (en) | 2011-07-01 | 2011-07-01 | Skin mucosa disinfecting liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101842709A CN102846656A (en) | 2011-07-01 | 2011-07-01 | Skin mucosa disinfecting liquid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102846656A true CN102846656A (en) | 2013-01-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101842709A Pending CN102846656A (en) | 2011-07-01 | 2011-07-01 | Skin mucosa disinfecting liquid and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN102846656A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242418A (en) * | 1998-06-29 | 2000-01-26 | 上海医南药业有限公司 | Sterilizing detergent and method for preparing same |
| US20020037268A1 (en) * | 1999-05-19 | 2002-03-28 | Kevin Stack | Antimicrobial sanitizing lotion with skin protection properties |
| CN1729778A (en) * | 2005-08-18 | 2006-02-08 | 刘震 | Sterilizing agent, preparation method and use thereof |
-
2011
- 2011-07-01 CN CN2011101842709A patent/CN102846656A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242418A (en) * | 1998-06-29 | 2000-01-26 | 上海医南药业有限公司 | Sterilizing detergent and method for preparing same |
| US20020037268A1 (en) * | 1999-05-19 | 2002-03-28 | Kevin Stack | Antimicrobial sanitizing lotion with skin protection properties |
| CN1729778A (en) * | 2005-08-18 | 2006-02-08 | 刘震 | Sterilizing agent, preparation method and use thereof |
Non-Patent Citations (2)
| Title |
|---|
| WANG Y, SHI W, ZHU Y, ET AL.: "resistance of pseudomonas aeruginosa against five antiseptics", 《CHINESE JOURNAL OF NOSOCOMIOLOGY》, vol. 18, no. 12, 31 December 2008 (2008-12-31), pages 1717 - 1719 * |
| 杨萍: "LJ—强化戊二醛消毒液加入亚硝酸钠防锈的效果观察", 《护理学杂志》, 29 August 1991 (1991-08-29), pages 172 - 173 * |
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| C06 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130102 |