CN102846578A - Fenbendazole effervescence particle for livestock and poultry and preparation method thereof - Google Patents
Fenbendazole effervescence particle for livestock and poultry and preparation method thereof Download PDFInfo
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- CN102846578A CN102846578A CN2012103187523A CN201210318752A CN102846578A CN 102846578 A CN102846578 A CN 102846578A CN 2012103187523 A CN2012103187523 A CN 2012103187523A CN 201210318752 A CN201210318752 A CN 201210318752A CN 102846578 A CN102846578 A CN 102846578A
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Abstract
The invention relates to a fenbendazole effervescence particle for livestock and poultry and a preparation method thereof. The fenbendazole effervescence particle comprises the following raw materials and accessories expressed in weight parts: 30 to 80 parts of fenbendazole, 100 to 140 parts of citric acid, 120 to 170 parts of sodium bicarbonate, 20 to 60 parts of polyethylene glycol 6000, 190 to 260 parts of dextrin and 310 to 390 parts of cane sugar. The preparation method comprises the following steps: respective crushing of the raw materials and the accessories; mixing; granulation; drying; size finishing; and subpackage. The effervescence particle provided by the invention is developed and prepared by using modern detection means and modern pharmaceutical equipment according to GMP standard for veterinary drugs and has the advantages of good curative effects, safety and reliability; the accessories and an effervescent disintegrating agent are added into the raw materials so as to prepare an effervescent granule, and livestock and poultry with diseases take the effervescent granule through oral administration, and good taste, stable quality and improved bioavailability of drugs are realized.
Description
Technical field
The invention belongs to the veterinary drug preparation field, especially a kind of poultry fenbendazole effervescent granule and preparation method thereof.
Background technology
In the whole veterinary drug pharmaceutical industry of China, veterinary drug preparation is a weak link, existing veterinary drug dosage form comprises tablet, oral liquid, injection etc., these far can not adapt to the needs of absorption and the drug action of the some drugs on the veterinary clinic, therefore, strengthening research and exploitation novel form are by the characteristics of timing, location, constant speed and the continuous action of different requirements realization medicines, improve constantly the curative effect of medicine, reducing toxic and side effects is that we are from now in dosage form research and the striving direction of developing.Benzimidazole is a class anthelmintic medicine that is widely used as control poultry nematicide and taeniasis, and tablet and the injections of using have caused the deficiencies such as the poultry administration is inconvenient, assimilation effect is low more at present.
And effervescent granule is a kind of novel dosage form, the difference of it and plain particles agent is that it contains gas-producing disintegrant, after effervescent granule is put into drinking-water, under the effect of gas-producing disintegrant, at once produce a large amount of bubbles (carbon dioxide), make the rapid disintegrate of granule and thawing, the bubble that disintegrate produces also can make medicine up and down rolling in water, accelerate its disintegrate and thawing, increased dissolving and the action time of medicine.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art part, provide a kind of good effect, instant effect, safe and reliable a kind of poultry with fenbendazole effervescent granule and preparation method thereof, this effervescent granule can effectively be treated poultry nematicide and taeniasis.
Of the present invention by technical scheme realization once:
A kind of poultry fenbendazole effervescent granule comprises that the parts by weight of following former, adjuvant and each raw material are as follows:
Fenbendazole: 30 ~ 80 parts; Citric acid: 100-140 part; Sodium bicarbonate: 120-180 part; Polyethylene glycol 6000: 20-60 part; Dextrin: 190-260 part; Sucrose: 310-390 part.
Further preferably, above-mentioned poultry fenbendazole effervescent granule comprises that former, adjuvant and each parts by weight former, adjuvant are as follows:
Fenbendazole: 50 parts; Citric acid: 130 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 50 parts; Dextrin: 240 parts; Sucrose: 370 parts.
Simultaneously the present invention also provides the preparation method of a kind of above-mentioned poultry with the fenbendazole effervescent granule, and its preparation process is:
⑴ former with all, the equal grinding particle size of adjuvant is to the 80-120 order, for subsequent use;
⑵ take by weighing by weight fenbendazole, the citric acid after the pulverizing and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
⑶ take by weighing by weight the sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, adds purified water and make soft material, granulation, drying, granulate;
⑷ enter three-dimensional mixer mix homogeneously, packing with the dried particles of above-mentioned ⑵, ⑶.
Advantage of the present invention and beneficial effect are:
1, this effervescent granule is according to veterinary drug GMP standard, adopt a kind of good effect that modern detection means and modern pharmaceutical equipment develop, safe and reliable effervescent granule, the present invention adds adjuvant and gas-producing disintegrant in raw material, make effervescent granule, ill poultry pass through oral administration, mouthfeel is good, and steady quality has improved the bioavailability of medicine.
2, the preparation method among the present invention prepares disintegrating agent and adjuvant at twice, effective medicinal ingredient can be wrapped in the inside, has effectively increased the rapid release effect of medicine, makes medicine in the situation that same amount, and therapeutic effect is faster.
3, the present invention is prepared into fenbendazole kind of an effervescent granule first, has overcome that existing similar products rate of release is slow, the shortcoming of absorption difference, and is obvious to the prevention effect of poultry nematicide and taeniasis.
The specific embodiment
The invention will be further described below by specific embodiment, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
A kind of poultry fenbendazole effervescent granule, each is former, adjuvant and parts by weight thereof are respectively:
Fenbendazole: 50 parts; Citric acid: 130 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 50 parts; Dextrin: 240 parts; Sucrose: 370 parts.
Above-mentioned poultry with the preparation method of fenbendazole effervescent granule are:
⑴ former with all, equal grinding particle size to 100 order of adjuvant, for subsequent use;
⑵ take by weighing fenbendazole, the citric acid after the pulverizing and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, adds purified water and make soft material, granulates, drying granulate;
⑶ take by weighing by weight the sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, adds purified water and make soft material, granulation, drying, granulate;
⑷ enter three-dimensional mixer mix homogeneously, packing with the dried particles of above-mentioned ⑵, ⑶.
Using method: in fenbendazole.For oral administration, once measure every 1kg body weight, horse, cattle, sheep, pig 2-4mg; Dog, cat 15-25mg; Fowl 5-25mg.2 times on the one, be used in conjunction 3-5 day.
Embodiment 2:
A kind of poultry fenbendazole effervescent granule, each is former, adjuvant and parts by weight thereof are respectively:
Fenbendazole: 40 parts; Citric acid: 130 parts; Sodium bicarbonate: 170 parts; Polyethylene glycol 6000: 50 parts; Dextrin: 250 parts; Sucrose: 370 parts.
Above-mentioned poultry with the preparation method of fenbendazole effervescent granule are:
⑴ former with all, equal grinding particle size to 100 order of adjuvant, for subsequent use;
⑵ take by weighing fenbendazole, the citric acid after the pulverizing and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, adds purified water and make soft material, granulates, drying granulate;
⑶ take by weighing by weight the sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, adds purified water and make soft material, granulation, drying, granulate;
⑷ enter three-dimensional mixer mix homogeneously, packing with the dried particles of above-mentioned ⑵, ⑶.
Using method: in fenbendazole.For oral administration, once measure every 1kg body weight, horse, cattle, sheep, pig 2-4mg; Dog, cat 15-25mg; Fowl 5-25mg.2 times on the one, be used in conjunction 3-5 day.
Detection method
Fenbendazole: according to determined by ultraviolet spectrophotometry, contain fenbendazole and must not be less than 5%.
Claims (3)
1. poultry fenbendazole effervescent granule is characterized in that: the parts by weight that comprise following former, adjuvant and each raw material are as follows:
Fenbendazole: 30 ~ 80 parts; Citric acid: 100-140 part; Sodium bicarbonate: 120-180 part; Polyethylene glycol 6000: 20-60 part; Dextrin: 190-260 part; Sucrose: 310-390 part.
2. poultry according to claim 1 fenbendazole effervescent granule is characterized in that: comprise that former, adjuvant and each parts by weight former, adjuvant are as follows:
Fenbendazole: 50 parts; Citric acid: 130 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 50 parts; Dextrin: 240 parts; Sucrose: 370 parts.
3. poultry as claimed in claim 1 are with the preparation method of fenbendazole effervescent granule, and it is characterized in that: the step of preparation method is:
⑴ former with all, the equal grinding particle size of adjuvant is to the 80-120 order, for subsequent use;
⑵ take by weighing by weight fenbendazole, the citric acid after the pulverizing and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
⑶ take by weighing by weight the sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, adds purified water and make soft material, granulation, drying, granulate;
⑷ enter three-dimensional mixer mix homogeneously, packing with the dried particles of above-mentioned ⑵, ⑶.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103187523A CN102846578A (en) | 2012-08-31 | 2012-08-31 | Fenbendazole effervescence particle for livestock and poultry and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103187523A CN102846578A (en) | 2012-08-31 | 2012-08-31 | Fenbendazole effervescence particle for livestock and poultry and preparation method thereof |
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| CN102846578A true CN102846578A (en) | 2013-01-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012103187523A Pending CN102846578A (en) | 2012-08-31 | 2012-08-31 | Fenbendazole effervescence particle for livestock and poultry and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610647A (en) * | 2013-12-05 | 2014-03-05 | 江苏恒丰强生物技术有限公司 | Fenbendazole pellet pill |
| CN107041373A (en) * | 2017-05-09 | 2017-08-15 | 李洪军 | A kind of crops long-acting fungicide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869571A (en) * | 2010-07-14 | 2010-10-27 | 施瑞客（天津）生物技术有限公司 | Doxycycline hydrochloride and rifampicin effervescent granules for livestock and poultry and preparation method thereof |
| CN101889988A (en) * | 2010-07-07 | 2010-11-24 | 施瑞客（天津）生物技术有限公司 | Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry |
-
2012
- 2012-08-31 CN CN2012103187523A patent/CN102846578A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889988A (en) * | 2010-07-07 | 2010-11-24 | 施瑞客（天津）生物技术有限公司 | Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry |
| CN101869571A (en) * | 2010-07-14 | 2010-10-27 | 施瑞客（天津）生物技术有限公司 | Doxycycline hydrochloride and rifampicin effervescent granules for livestock and poultry and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610647A (en) * | 2013-12-05 | 2014-03-05 | 江苏恒丰强生物技术有限公司 | Fenbendazole pellet pill |
| CN107041373A (en) * | 2017-05-09 | 2017-08-15 | 李洪军 | A kind of crops long-acting fungicide |
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Application publication date: 20130102 |