CN101889988A - Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry - Google Patents
Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry Download PDFInfo
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- CN101889988A CN101889988A CN 201010219816 CN201010219816A CN101889988A CN 101889988 A CN101889988 A CN 101889988A CN 201010219816 CN201010219816 CN 201010219816 CN 201010219816 A CN201010219816 A CN 201010219816A CN 101889988 A CN101889988 A CN 101889988A
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Abstract
The invention relates to tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry, which comprise the following raw materials and auxiliary materials in part by weight: 80 to 120 parts of tiamulin fumarate, 100 to 140 parts of citric acid, 150 to 170 parts of sodium bicarbonate, 20 to 40 parts of polyethylene glycol 6000, 190 to 230 parts of dextrin and 360 to 400 parts of sucrose. A method for preparing the tiamulin fumarate effervescent granules comprises the following steps of: grinding the raw materials and the auxiliary materials, respectively mixing the ground raw materials and the ground auxiliary materials, drying the mixture, pelletizing the dried mixture and sufficiently mixing the products. The tiamulin fumarate effervescent granules prepared by the method are used for diseased livestock and poultry in an oral administration mode, have the advantages of good taste and stable quality and are an ideal preparation for treating mycoplasma pneumonia, actinomycotic pleuropneumonia and treponema dysentery of the livestock and poultry currently.
Description
Technical field
The invention belongs to the veterinary drug preparation field, especially a kind of tiamulin fumarate effervescent granules for livestock and poultry.
Background technology
In the whole veterinary drug pharmaceutical industry of China, veterinary drug preparation is a weak link, existing veterinary drug dosage form comprises tablet, oral liquid, powder etc., these far can not adapt to the needs of the absorption and the drug action of the some drugs on the veterinary clinic, therefore, strengthen the research and development novel form, realize the characteristics of timing, location, constant speed and the continuous action of medicine by different requirements, improve constantly the curative effect of medicine, reducing toxic and side effects is that we are from now in dosage form research and the striving direction of developing.
Effervescent granule is a kind of novel dosage form, the difference of it and plain particles agent, just be that it contains gas-producing disintegrant, after effervescent granule is put into drinking-water, under the effect of gas-producing disintegrant, produce a large amount of bubbles (carbon dioxide) at once, make rapid disintegrate of tablet and thawing, the bubble that disintegrate produces also can make tablet roll up and down in water, quickens its disintegrate and thawing.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, the treatment pneumonia of a kind of good effect, instant effect, green safety, the tiamulin fumarate effervescent granules for livestock and poultry of dysentery are provided.
The objective of the invention is to be achieved through the following technical solutions:
A kind of tiamulin fumarate effervescent granules for livestock and poultry for the treatment of pneumonia, dysentery comprises that following former, adjuvant and each parts by weight former, adjuvant are as follows:
Fumaric acid tiamulin: 80～120 parts; Citric acid: 100-140 part; Sodium bicarbonate: 150-170 part; Polyethylene glycol 6000: 20-40 part; Dextrin: 190-230 part; Sucrose: 360-400 part.
The step of preparation method is:
(1) will get former, adjuvant according to parts by weight, and be crushed to 100-150 purpose granularity, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
And described optimum weight umber former, adjuvant is as follows:
Fumaric acid tiamulin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 210 parts; Sucrose: 380 parts.
Advantage of the present invention and beneficial effect are:
1, the effervescent granule of the present invention's preparation is according to veterinary drug GMP standard, according to pharmacodynamics, pharmacokinetics and effervescence granular preparation theory, scientific preparation process, and the utilization modern means of science and technology are carried out detection by quantitative to the effective ingredient of key component, through the clinical verification determined curative effect, be a kind of safe and reliable, veterinary drug that bioavailability is high.
2, the tiamulin fumarate effervescent granules disintegrate of the present invention preparation fast, taking convenience, onset be rapid, overcome that existing similar products mouthfeel is poor, rate of release is slow, the shortcoming of bioavailability difference, ill poultry pass through oral administration, it is good to have mouthfeel, stay-in-grade advantage is the current desirable preparation that is used for the treatment of livestock and poultry mycoplasma pneumonia, actinomycetes property pleuropneumonia, treponema dysentery.
The specific embodiment
The invention will be further described below by specific embodiment, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
A kind of tiamulin fumarate effervescent granules for livestock and poultry for the treatment of pneumonia, dysentery, each is former, adjuvant and parts by weight thereof are respectively:
Fumaric acid tiamulin: 80 parts; Citric acid: 100 parts; Sodium bicarbonate: 150 parts; Polyethylene glycol 6000: 20 parts; Dextrin: 190 parts; Sucrose: 360 parts,
Preparation method, step is:
(1) will get former, adjuvant according to parts by weight, and be crushed to 100 purpose granularities, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
Detection method
Fumaric acid tiamulin: measure according to antibiosis prime implicant below method, contain taimulin (C
28H
47NO
4S) must not be less than 9.5%.
Embodiment 2:
A kind of tiamulin fumarate effervescent granules for livestock and poultry for the treatment of pneumonia, dysentery, each is former, adjuvant and parts by weight thereof are respectively:
Fumaric acid tiamulin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 200 parts; Sucrose: 380 parts.
Preparation method, step is:
(1) all supplementary materials all are crushed to 110 purpose granularities, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
Embodiment 3:
A kind of tiamulin fumarate effervescent granules for livestock and poultry for the treatment of pneumonia, dysentery, each raw material and parts by weight thereof are respectively:
Fumaric acid tiamulin: 120 parts: citric acid: 140 parts; Sodium bicarbonate: 170 parts; Polyethylene glycol 6000: 40 parts; Dextrin: 230 parts; Sucrose: 400 parts.
Preparation method, step is:
(1) all supplementary materials all are crushed to 120 purpose granularities, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
Claims (2)
1. tiamulin fumarate effervescent granules for livestock and poultry for the treatment of pneumonia, dysentery is characterized in that: comprise that following former, adjuvant and each parts by weight former, adjuvant are as follows:
Fumaric acid tiamulin: 80～120 parts; Citric acid: 100-140 part; Sodium bicarbonate: 150-170 part; Polyethylene glycol 6000: 20-40 part; Dextrin: 190-230 part; Sucrose: 360-400 part.
The step of preparation method is:
(1) will get former, adjuvant according to parts by weight, and be crushed to 100-150 purpose granularity, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
2. the tiamulin fumarate effervescent granules for livestock and poultry of treatment pneumonia according to claim 1, dysentery is characterized in that: described optimum weight umber former, adjuvant is as follows:
Fumaric acid tiamulin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 210 parts; Sucrose: 380 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010219816 CN101889988A (en) | 2010-07-07 | 2010-07-07 | Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010219816 CN101889988A (en) | 2010-07-07 | 2010-07-07 | Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry |
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| Publication Number | Publication Date |
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| CN101889988A true CN101889988A (en) | 2010-11-24 |
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| CN 201010219816 Pending CN101889988A (en) | 2010-07-07 | 2010-07-07 | Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846578A (en) * | 2012-08-31 | 2013-01-02 | 格特生物制药（天津）有限公司 | Fenbendazole effervescence particle for livestock and poultry and preparation method thereof |
| CN105878228A (en) * | 2016-06-27 | 2016-08-24 | 河北天元药业有限公司 | Soluble powder with tiamulin hydrogen famarate and method for preparing soluble powder |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768736A (en) * | 2005-10-09 | 2006-05-10 | 浙江升华拜克生物股份有限公司 | Solid dispersion containing fumaric acid tiamulin and its preparation method |
| CN101455196A (en) * | 2008-12-23 | 2009-06-17 | 中国人民解放军海军医学研究所 | Pesticide effervescence combination and preparation method thereof |
-
2010
- 2010-07-07 CN CN 201010219816 patent/CN101889988A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768736A (en) * | 2005-10-09 | 2006-05-10 | 浙江升华拜克生物股份有限公司 | Solid dispersion containing fumaric acid tiamulin and its preparation method |
| CN101455196A (en) * | 2008-12-23 | 2009-06-17 | 中国人民解放军海军医学研究所 | Pesticide effervescence combination and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《药物泡腾剂技术》 20070131 赵存梅、朱世斌 其他泡腾剂型和酸碱系统等 化学工业出版社生物医药出版分社 第11-17、22、39、56-59页 1-2 , 1 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846578A (en) * | 2012-08-31 | 2013-01-02 | 格特生物制药（天津）有限公司 | Fenbendazole effervescence particle for livestock and poultry and preparation method thereof |
| CN105878228A (en) * | 2016-06-27 | 2016-08-24 | 河北天元药业有限公司 | Soluble powder with tiamulin hydrogen famarate and method for preparing soluble powder |
| CN105878228B (en) * | 2016-06-27 | 2018-05-18 | 河北天元药业有限公司 | A kind of fumaric acid tiamulin soluble powder and preparation method thereof |
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Open date: 20101124 |