CN101897679A - Method for preparing tiamulin fumarate effervescent granules for livestock and poultry - Google Patents
Method for preparing tiamulin fumarate effervescent granules for livestock and poultry Download PDFInfo
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- CN101897679A CN101897679A CN 201010219798 CN201010219798A CN101897679A CN 101897679 A CN101897679 A CN 101897679A CN 201010219798 CN201010219798 CN 201010219798 CN 201010219798 A CN201010219798 A CN 201010219798A CN 101897679 A CN101897679 A CN 101897679A
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- tiamulin
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Abstract
The invention relates to a method for preparing tiamulin fumarate effervescent granules for livestock and poultry, which comprises the following steps of: taking raw and auxiliary materials in part by weight for later use; mixing the weighed and crushed tiamulin fumarate, citric acid, polyethylene glycol 6000 in an amount which is one second of the total amount, dextrin and sucrose uniformly in a groove-shaped mixer, adding purified water into the mixture to prepare a soft material, granulating and drying the soft material, and settling the granules; weighing crushed sodium bicarbonate, mixing the reset auxiliary materials in the groove-shaped mixer uniformly, adding purified water into the mixture to prepare a soft material, granulating and drying the soft material, and settling the granules; and mixing the two kinds of dried granules uniformly in a three-dimensional mixer, and packing the mixed granules. The prepared tiamulin fumarate effervescent granules have the advantages of good mouthfeel and stable quality after oral administration of sick livestock and poultry, and are an ideal preparation for treating mycoplasma pneumonia, actinomycetic pleuropneumonia and treponema dysentery at present.
Description
Technical field
The invention belongs to the veterinary drug preparation field, especially a kind of preparation method of tiamulin fumarate effervescent granules for livestock and poultry.
Background technology
In the whole veterinary drug pharmaceutical industry of China, veterinary drug preparation is a weak link, existing veterinary drug dosage form comprises tablet, oral liquid, powder etc., these far can not adapt to the needs of the absorption and the drug action of the some drugs on the veterinary clinic, therefore, strengthen the research and development novel form, realize the characteristics of timing, location, constant speed and the continuous action of medicine by different requirements, improve constantly the curative effect of medicine, reducing toxic and side effects is that we are from now in dosage form research and the striving direction of developing.
Effervescent granule is a kind of novel dosage form, the difference of it and plain particles agent, just be that it contains gas-producing disintegrant, after effervescent granule is put into drinking-water, under the effect of gas-producing disintegrant, produce a large amount of bubbles (carbon dioxide) at once, make rapid disintegrate of tablet and thawing, the bubble that disintegrate produces also can make tablet roll up and down in water, quickens its disintegrate and thawing.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, the preparation method of the tiamulin fumarate effervescent granules for livestock and poultry that a kind of preparation method is simple, equipment is cheap is provided.
The objective of the invention is to be achieved through the following technical solutions:
A kind of preparation method of tiamulin fumarate effervescent granules for livestock and poultry, the step of preparation method is:
(1) will get former, adjuvant according to parts by weight, and be crushed to 100-150 purpose granularity, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into the three-dimensional mixer mix homogeneously, packing,
Its Central Plains, adjuvant and each raw materials in part by weight are as follows:
Fumaric acid tiamulin: 80～120 parts; Citric acid: 100-140 part; Sodium bicarbonate: 150-170 part; Polyethylene glycol 6000: 20-40 part; Dextrin: 190-230 part; Sucrose: 360-400 part.
And the optimum weight umber of described raw material is as follows:
Fumaric acid tiamulin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 210 parts; Sucrose: 380 parts.
Advantage of the present invention and beneficial effect are:
1, the effervescent granule of the present invention's preparation is according to veterinary drug GMP standard, according to pharmacodynamics, pharmacokinetics and effervescence granular preparation theory, scientific preparation process, and the utilization modern means of science and technology are carried out detection by quantitative to the effective ingredient of key component, through the clinical verification determined curative effect, be a kind of safe and reliable, veterinary drug that bioavailability is high.
2, the preparation method among the present invention prepares disintegrating agent and adjuvant at twice, effective medicinal ingredient can be wrapped in the inside, has effectively increased the rapid release effect of medicine, makes medicine under the situation of same amount, and the time that plays a role is longer.
3, the tiamulin fumarate effervescent granules disintegrate of the present invention preparation fast, taking convenience, onset be rapid, overcome that existing similar products mouthfeel is poor, rate of release is slow, the shortcoming of bioavailability difference, ill poultry pass through oral administration, it is good to have mouthfeel, stay-in-grade advantage is the current desirable preparation that is used for the treatment of livestock and poultry mycoplasma pneumonia, actinomycetes property pleuropneumonia, treponema dysentery.
The specific embodiment
The invention will be further described below by specific embodiment, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
A kind of preparation method of tiamulin fumarate effervescent granules for livestock and poultry: step is:
(1) all supplementary materials all are crushed to 100 purpose granularities, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
Each raw material and parts by weight thereof are respectively:
Fumaric acid tiamulin: 80 parts; Citric acid: 100 parts; Sodium bicarbonate: 150 parts; Polyethylene glycol 6000: 20 parts; Dextrin: 190 parts; Sucrose: 360 parts.
Detection method
Fumaric acid tiamulin: measure according to antibiosis prime implicant below method, contain taimulin (C
28H
47NO
4S) must not be less than 9.5%.
Embodiment 2:
A kind of preparation method of tiamulin fumarate effervescent granules for livestock and poultry, step is:
(1) all supplementary materials all are crushed to 110 purpose granularities, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
Each raw material and parts by weight thereof are respectively:
Fumaric acid tiamulin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 200 parts; Sucrose: 380 parts.
Embodiment 3:
A kind of preparation method of tiamulin fumarate effervescent granules for livestock and poultry, step is:
(1) all supplementary materials all are crushed to 120 purpose granularities, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into three-dimensional mixer mix homogeneously, packing.
Each raw material and parts by weight thereof are respectively:
Fumaric acid tiamulin: 120 parts; Citric acid: 140 parts; Sodium bicarbonate: 170 parts; Polyethylene glycol 6000: 40 parts; Dextrin: 230 parts; Sucrose: 400 parts.
Claims (2)
1. the preparation method of a tiamulin fumarate effervescent granules for livestock and poultry, it is characterized in that: the step of preparation method is:
(1) will get former, adjuvant according to parts by weight, and be crushed to 100-150 purpose granularity, standby;
(2) take by weighing fumaric acid tiamulin after the pulverizing, citric acid, the polyethylene glycol 6000 of total amount 1/2, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(3) take by weighing sodium bicarbonate after the pulverizing, remaining polyethylene glycol 6000, dextrin, sucrose elder generation slot-in type mixer mix homogeneously add purified water and make soft material, granulate, drying granulate;
(4) dried particles of above-mentioned (2), (3) is gone into the three-dimensional mixer mix homogeneously, packing,
Its Central Plains, adjuvant and each raw materials in part by weight are as follows:
Fumaric acid tiamulin: 80～120 parts; Citric acid: 100-140 part; Sodium bicarbonate: 150-170 part; Polyethylene glycol 6000: 20-40 part; Dextrin: 190-230 part; Sucrose: 360-400 part.
2. the preparation method of tiamulin fumarate effervescent granules for livestock and poultry according to claim 1, it is characterized in that: the optimum weight umber of described raw material is as follows:
Fumaric acid tiamulin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 210 parts; Sucrose: 380 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010219798 CN101897679A (en) | 2010-07-07 | 2010-07-07 | Method for preparing tiamulin fumarate effervescent granules for livestock and poultry |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010219798 CN101897679A (en) | 2010-07-07 | 2010-07-07 | Method for preparing tiamulin fumarate effervescent granules for livestock and poultry |
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| Publication Number | Publication Date |
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| CN101897679A true CN101897679A (en) | 2010-12-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201010219798 Pending CN101897679A (en) | 2010-07-07 | 2010-07-07 | Method for preparing tiamulin fumarate effervescent granules for livestock and poultry |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727461A (en) * | 2012-07-17 | 2012-10-17 | 宁夏泰瑞制药股份有限公司 | Method for preparing tilmicosin phosphate effervescent granules |
| CN102860995A (en) * | 2012-08-31 | 2013-01-09 | 格特生物制药（天津）有限公司 | Enrofloxacin effervescent granule for livestock and preparation method thereof |
| CN102895377A (en) * | 2012-11-09 | 2013-01-30 | 挑战（天津）动物药业有限公司 | Pharmaceutical composition for treating livestock respiratory diseases and method for preparing pharmaceutical composition for treating livestock respiratory diseases |
| CN114366732A (en) * | 2022-02-23 | 2022-04-19 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | Application of tiamulin in preparing medicine for treating psoriasis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642438A (en) * | 2009-08-17 | 2010-02-10 | 扬州市三药制药有限公司 | Tramadol hydrochloride effervescent granule and production method thereof |
| CN101664425A (en) * | 2009-08-20 | 2010-03-10 | 天津生机集团股份有限公司 | Poplar flower effervescent granules for treating avian colibacillosis and preparation method thereof |
-
2010
- 2010-07-07 CN CN 201010219798 patent/CN101897679A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642438A (en) * | 2009-08-17 | 2010-02-10 | 扬州市三药制药有限公司 | Tramadol hydrochloride effervescent granule and production method thereof |
| CN101664425A (en) * | 2009-08-20 | 2010-03-10 | 天津生机集团股份有限公司 | Poplar flower effervescent granules for treating avian colibacillosis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《药物泡腾剂技术》 20070131 赵存梅、朱世斌 其他泡腾剂和酸碱系统等 化学工业出版社生物医药出版分社 第11-17、22、39、56-59页 1-2 , 1 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727461A (en) * | 2012-07-17 | 2012-10-17 | 宁夏泰瑞制药股份有限公司 | Method for preparing tilmicosin phosphate effervescent granules |
| CN102860995A (en) * | 2012-08-31 | 2013-01-09 | 格特生物制药（天津）有限公司 | Enrofloxacin effervescent granule for livestock and preparation method thereof |
| CN102895377A (en) * | 2012-11-09 | 2013-01-30 | 挑战（天津）动物药业有限公司 | Pharmaceutical composition for treating livestock respiratory diseases and method for preparing pharmaceutical composition for treating livestock respiratory diseases |
| CN102895377B (en) * | 2012-11-09 | 2015-03-11 | 挑战（天津）动物药业有限公司 | Pharmaceutical composition for treating livestock respiratory diseases and method for preparing pharmaceutical composition for treating livestock respiratory diseases |
| CN114366732A (en) * | 2022-02-23 | 2022-04-19 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | Application of tiamulin in preparing medicine for treating psoriasis |
| CN114366732B (en) * | 2022-02-23 | 2023-08-18 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | Application of tiamulin in preparation of medicine for treating psoriasis |
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Open date: 20101201 |