CN102860995A - Enrofloxacin effervescent granule for livestock and preparation method thereof - Google Patents
Enrofloxacin effervescent granule for livestock and preparation method thereof Download PDFInfo
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- CN102860995A CN102860995A CN2012103197169A CN201210319716A CN102860995A CN 102860995 A CN102860995 A CN 102860995A CN 2012103197169 A CN2012103197169 A CN 2012103197169A CN 201210319716 A CN201210319716 A CN 201210319716A CN 102860995 A CN102860995 A CN 102860995A
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Abstract
The invention relates to an enrofloxacin effervescent granule for livestock and a preparation method of the enrofloxacin effervescent granule. The enrofloxacin effervescent granule comprises the following raw materials and auxiliary materials in parts by weight: 80-120 parts of enrofloxacin, 100-140 parts of citric acid, 150-170 parts of sodium bicarbonate, 20-40 parts of polyethylene glycol 6000, 190-260 parts of dextrin and 310-390 parts of cane sugar. The preparation method comprises the steps of respectively crushing the raw materials and the auxiliary materials, mixing, pelletizing, drying, granulating, and finally subpackaging. The enrofloxacin effervescent granule is developed according to veterinary drug GMP (Good Manufacturing Practice) standards by using modern detection means and pharmaceutical equipment, and is good in curative effect and is safe and reliable; the auxiliary materials and an effervescent disintegrating agent are added to the raw materials to prepare the effervescent granule; and the sick livestock administrates orally, the enrofloxacin effervescent granule is good in mouth feel and stable in quality, and the bioavailability of medicine is improved.
Description
Technical field
The invention belongs to the veterinary drug preparation field, especially relate to a kind of poultry enrofloxacin effervescent granule and preparation method thereof.
Background technology
In the whole veterinary drug pharmaceutical industry of China, veterinary drug preparation is a weak link, existing veterinary drug dosage form comprises tablet, oral liquid, injection etc., these far can not adapt to the needs of absorption and the drug action of the some drugs on the veterinary clinic, therefore, strengthening research and exploitation novel form are by the characteristics of timing, location, constant speed and the continuous action of different requirements realization medicines, improve constantly the curative effect of medicine, reducing toxic and side effects is that we are from now in dosage form research and the striving direction of developing.
Enrofloxacin has another name called ENR, it is the third generation Development of Fluoroquinolone Antibacterials for animal specific, can reach antibacterial effect by anti-bacteria DNA helicase, to resting stage and trophophase antibacterial good antibacterial action being arranged all, have that fungicidal spectrum is wide, bactericidal activity is strong, widely distributed in the body, with other drug without cross resistance, the characteristics such as tissue concentration is high, toxic and side effects is little, therefore the application in veterinary clinic is more extensive.
At present the dosage form of enrofloxacin commonly used is mainly powder, injection and suspensoid, but because the water-soluble of enrofloxacin own is poor, bitter in the mouth, the administering mode of animal is had very large restriction, and be unfavorable for that animal body absorbs.It is oral that powder is not easy to animal; Injection in vivo action time short, need repeatedly animal drug administration by injection is repeatedly caused stronger stress stimulation to animal individual, time-consuming trouble is unfavorable for colony's administration; Outstanding mixture also exists above defective to be unfavorable for colony's administration, increases feeding cost.
Effervescent granule is a kind of novel dosage form, the difference of it and plain particles agent is that it contains gas-producing disintegrant, after effervescent granule is put into drinking-water, under the effect of gas-producing disintegrant, at once produce a large amount of bubbles (carbon dioxide), make the rapid disintegrate of granule and thawing, the bubble that disintegrate produces also can make medicine up and down rolling in water, accelerate its disintegrate and thawing, increased dissolving and the action time of medicine.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art part, provide a kind of good effect, instant effect, safe and reliable a kind of poultry with enrofloxacin effervescent granule and preparation method thereof, this effervescent granule can effectively be treated fowl bacterial disease and mycoplasma infection.
Of the present invention being achieved through the following technical solutions:
A kind of poultry enrofloxacin effervescent granule comprises that the parts by weight of following former, adjuvant and each raw material are as follows:
Enrofloxacin: 80 ~ 120 parts; Citric acid: 100-140 part; Sodium bicarbonate: 150-170 part; Polyethylene glycol 6000: 20-40 part; Dextrin: 190-260 part; Sucrose: 310-390 part.
Further preferably, above-mentioned enrofloxacin effervescent granule comprises that following former, adjuvant and each optimum weight umber former, adjuvant are as follows:
Enrofloxacin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 230 parts; Sucrose: 360 parts.
The preparation method of above-mentioned poultry with the enrofloxacin effervescent granule is provided simultaneously, the steps include:
(1) all are former, the equal grinding particle size of adjuvant is to the 80-120 order, and is for subsequent use;
(2) take by weighing by weight enrofloxacin, citric acid after the pulverizing, and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(3) take by weighing by weight sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(4) dried particles with above-mentioned (2), (3) enters three-dimensional mixer mix homogeneously, packing.
Advantage of the present invention and beneficial effect are:
1, this effervescent granule is according to veterinary drug GMP standard, adopt a kind of good effect that modern detection means and modern pharmaceutical equipment develop, safe and reliable effervescent granule, the present invention adds adjuvant and gas-producing disintegrant in raw material, make effervescent granule, ill poultry pass through oral administration, mouthfeel is good, and steady quality has improved the bioavailability of medicine.
2, the preparation method among the present invention prepares disintegrating agent and adjuvant at twice, effective medicinal ingredient can be wrapped in the inside, has effectively increased the rapid release effect of medicine, makes medicine in the situation that same amount, and therapeutic effect is faster.
3, the present invention is prepared into enrofloxacin kind of an effervescent granule first, has overcome that existing similar products rate of release is slow, the shortcoming of absorption difference, and is obvious to the prevention effect of fowl bacterial disease and mycoplasma infection.
The specific embodiment
The invention will be further described below by specific embodiment, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
A kind of poultry enrofloxacin effervescent granule, each is former, adjuvant and parts by weight thereof are respectively:
Enrofloxacin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 230 parts; Sucrose: 360 parts.
Above-mentioned poultry with the preparation method of enrofloxacin effervescent granule are:
(1) equal grinding particle size to 100 order of all are former, adjuvant is for subsequent use;
(2) take by weighing by weight enrofloxacin, citric acid after the pulverizing, and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(3) take by weighing by weight sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(4) dried particles with above-mentioned (2), (3) enters three-dimensional mixer mix homogeneously, packing.
Using method: in enrofloxacin.For oral administration, once measure every 1kg body weight, dog, cat 1-2mg; Fowl 2-4mg.2 times on the one, be used in conjunction 3-5 day.
Embodiment 2:
A kind of poultry enrofloxacin effervescent granule, each is former, adjuvant and parts by weight thereof are respectively:
Enrofloxacin: 80 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 40 parts; Dextrin: 230 parts; Sucrose: 370 parts.
Above-mentioned poultry with the preparation method of enrofloxacin effervescent granule are:
(1) equal grinding particle size to 100 order of all are former, adjuvant is for subsequent use;
(2) take by weighing by weight enrofloxacin, citric acid after the pulverizing, and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(3) take by weighing by weight sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(4) dried particles with above-mentioned (2), (3) enters three-dimensional mixer mix homogeneously, packing.
Using method: in enrofloxacin.For oral administration, once measure every 1kg body weight, dog, cat 1-2mg; Fowl 2-4mg.2 times on the one, be used in conjunction 3-5 day.
The detection method of determining enrofloxacin content:
Enrofloxacin: according to determined by ultraviolet spectrophotometry, above-mentioned poultry must not be less than 10% with containing enrofloxacin in the enrofloxacin effervescent granule.
Claims (3)
1. poultry enrofloxacin effervescent granule is characterized in that: the parts by weight that comprise following former, adjuvant and each raw material are as follows:
Enrofloxacin: 80 ~ 120 parts; Citric acid: 100-140 part; Sodium bicarbonate: 150-170 part; Polyethylene glycol 6000: 20-40 part; Dextrin: 190-260 part; Sucrose: 310-390 part.
2. poultry according to claim 1 enrofloxacin effervescent granule is characterized in that: comprise that former, adjuvant and each parts by weight former, adjuvant are as follows:
Enrofloxacin: 100 parts; Citric acid: 120 parts; Sodium bicarbonate: 160 parts; Polyethylene glycol 6000: 30 parts; Dextrin: 230 parts; Sucrose: 360 parts.
3. poultry as claimed in claim 1 are with the preparation method of enrofloxacin effervescent granule, and it is characterized in that: the step of preparation method is:
(1) all are former, the equal grinding particle size of adjuvant is to the 80-120 order, and is for subsequent use;
(2) take by weighing by weight enrofloxacin, citric acid after the pulverizing, and account for half polyethylene glycol 6000, dextrin, sucrose of parts by weight total amount separately, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(3) take by weighing by weight sodium bicarbonate after the pulverizing, and remaining polyethylene glycol 6000, dextrin, sucrose, with above-mentioned former, adjuvant slot-in type mixer mix homogeneously, add purified water and make soft material, granulation, drying, granulate;
(4) dried particles with above-mentioned (2), (3) enters three-dimensional mixer mix homogeneously, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103197169A CN102860995A (en) | 2012-08-31 | 2012-08-31 | Enrofloxacin effervescent granule for livestock and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103197169A CN102860995A (en) | 2012-08-31 | 2012-08-31 | Enrofloxacin effervescent granule for livestock and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102860995A true CN102860995A (en) | 2013-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012103197169A Pending CN102860995A (en) | 2012-08-31 | 2012-08-31 | Enrofloxacin effervescent granule for livestock and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897679A (en) * | 2010-07-07 | 2010-12-01 | 施瑞客（天津）生物技术有限公司 | Method for preparing tiamulin fumarate effervescent granules for livestock and poultry |
| CN102397552A (en) * | 2010-09-10 | 2012-04-04 | 广州自远生物科技有限公司 | Medicinal composite preparation containing quinolones, preparation method thereof and application thereof |
-
2012
- 2012-08-31 CN CN2012103197169A patent/CN102860995A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897679A (en) * | 2010-07-07 | 2010-12-01 | 施瑞客（天津）生物技术有限公司 | Method for preparing tiamulin fumarate effervescent granules for livestock and poultry |
| CN102397552A (en) * | 2010-09-10 | 2012-04-04 | 广州自远生物科技有限公司 | Medicinal composite preparation containing quinolones, preparation method thereof and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵存梅等: "《药物泡腾剂技术》", 31 January 2007, article "泡腾剂的赋形剂" * |
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Application publication date: 20130109 |