CN109419781A - A kind of water soluble Florfenicol effervescent agent and preparation method thereof - Google Patents
A kind of water soluble Florfenicol effervescent agent and preparation method thereof Download PDFInfo
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- CN109419781A CN109419781A CN201710735933.9A CN201710735933A CN109419781A CN 109419781 A CN109419781 A CN 109419781A CN 201710735933 A CN201710735933 A CN 201710735933A CN 109419781 A CN109419781 A CN 109419781A
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- florfenicol
- parts
- water soluble
- powder
- effervescent agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to veterinary drug field of antibiotics, it is a kind of water soluble Florfenicol effervescent agent and preparation method thereof, including following components and parts by weight are as follows: 1-20 parts of Ultramicro-powder Florfenicol, 0.2-5 parts of cosolvent, 3-5 parts of organic acid (sour agent), 1-11 parts of inorganic salts (alkaline agent), filler adds to 100 parts；Supplementary material ingredient of the present invention is easy to get safely, and commercially available cheap, simple process, strong operability, production cost is low, and preparation time is short, and production energy consumption is small, is suitable for large-scale production and promotional value.
Description
Technical field
The present invention relates to veterinary drug field of antibiotics, specifically a kind of water soluble Florfenicol effervescent agent and its preparation side
Method.
Background technique
Florfenicol (Florfenicol) Chinese: Fluprofen, Florfenicol, Florfenicol are in the eighties
The broad spectrum antibiotic of the new dedicated chloromycetin of animal doctor of one kind that later period successfully develops has has a broad antifungal spectrum, good absorbing, divides in vivo
The features such as cloth is wide, highly effective and safe, it is significant for bacterial disease of fowl therapeutic effect caused by sensitive bacteria, to gram-positive bacteria
There is effect with negative bacterium, is the drug of first choice of various infection caused by typhoid bacillus, paratyphosum Bacterium, Salmonella.1990
Year for the first time Japan list, Norway in 1993 ratify the medicine treatment salmon dothienesis, nineteen ninety-five France, Britain, Austria, Mexico
And Spain's approval is for treating ox respiratory system bacteriosis.Also ratify the feed addition as pig in Japan and Mexico
Agent prevents and treats the bacteriosis (Qiu Yinsheng etc., 1996) of pig, and China has passed through the examination & approval of the medicine at present.In animal
In disease prevention and cure, especially food animal, Florfenicol have broad application prospects.
It is water-insoluble powder, absorption and biological utilisation in animal body but since florfenicol solubility is low
It spends low, is administered often by being mixed into feed when administration, limit giving full play to for drug effect, and when occurring than more serious
Infection when, often due to animal feed intake degradation even appetite abolish, it is poor by mixed feeding drug treatment effect.But this
When animal amount of drinking water it is normal, drinking water administration can guarantee curative effect, therefore develop the drinking agent for being suitble to poultry administration, will significantly
Improve application effect of the Florfenicol in terms of poultry treating bacteriosis.
The technology of China's florfenicol water soluble is mainly by flux method, solid dispersion method, ultra micro etc. at present, but these sides
The solubilization-aid effect of method is undesirable, and solution rate is slow, inconvenient to use.
Summary of the invention
Undesirable present invention aim to solve existing flux method solubilization-aid effect, solution rate is slow, using not
Convenient problem provides a kind of water soluble Florfenicol effervescent agent and preparation method thereof.
A kind of water soluble Florfenicol effervescent agent of the invention includes following components and parts by weight are as follows: Ultramicro-powder fluorobenzene
Buddhist nun examines 1-20 parts, 0.2-5 parts of cosolvent, 3-5 parts of organic acid (sour agent), 1-11 parts of inorganic salts (alkaline agent), and filler adds to 100
Part.
Heretofore described cosolvent is lauryl sodium sulfate, poloxamer, PVP K30 or its is any
Combination.
Heretofore described organic acid (sour agent) is citric acid, malic acid, tartaric acid, fumaric acid or any combination thereof.
Heretofore described inorganic salts (alkaline agent) are that one or several kinds of acid of meeting can produce the inorganic salts of CO2, Carbon Dioxide
Sodium, anhydrous sodium bicarbonate or any combination thereof.
Heretofore described filler is DEXTROSE ANHYDROUS, lactose, mannitol or any combination thereof object.
Heretofore described Ultramicro-powder Florfenicol preparation method is that florfenicol powder is continuously added to micronizer, into
Row crushes, and powder diameter 100% is at 10 μm or less after control crushes.
A kind of preparation method of water soluble Florfenicol effervescent agent in the present invention, including following preparation step:
(1), it by Ultramicro-powder Florfenicol, cosolvent and filler, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), inorganic salts (alkaline agent) and 3 parts of organic acid (sour agent) are uniformly mixed, are coated with Macrogol 4000,
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
The invention has the following advantages that
1. the present invention for the first time can water-soluble Florfenicol and effervescent agent technical tie-up use, be disintegrated by sour agent and alkaline agent structure
At calving disaggregation is powerful, drug can be made to be disintegrated into fine particle rapidly and dissolve rapidly；Obtained can water-soluble Florfenicol bubble
The molten accurate measurement of agent is risen, solution rate is fast, and without powder bitter taste when dissolution, automatic dissolving immediately, is convenient for drinking water administration into the water；
2. preparation method of the present invention is compared with existing florfenicol soluble powder preparation method, supplementary material ingredient is easy safely
, commercially available cheap, simple process, operability is stronger, and production cost is lower, and preparation time is shorter, and production energy consumption is smaller,
It is more advantageous to large-scale production and popularization.
Specific embodiment
Embodiment 1
A kind of preparation step of water soluble Florfenicol effervescent agent:
(1), 100kg Ultramicro-powder Florfenicol is produced, Ultramicro-powder Florfenicol 20kg, lauryl sodium sulfate 0.2kg and nothing are claimed
Water glucose 26.8kg, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), by natrium carbonicum calcinatum 10kg and there is citric acid 3kg to be uniformly mixed, be coated with Macrogol 4000 40kg；
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
Embodiment 2
A kind of preparation step of water soluble Florfenicol effervescent agent:
(1), 100kg Ultramicro-powder Florfenicol is produced, Ultramicro-powder Florfenicol 20kg, poloxamer 0.2kg and anhydrous grape are claimed
Sugared 26kg, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), by natrium carbonicum calcinatum 10kg and there is citric acid 3kg to be uniformly mixed, be coated with Macrogol 4000 40kg；
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
Embodiment 3
A kind of preparation step of water soluble Florfenicol effervescent agent:
(1), 100kg Ultramicro-powder Florfenicol is produced, Ultramicro-powder Florfenicol 20kg, polyvinylpyrrolidone K are claimed30 1kg and nothing
Water glucose 26.8kg, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), by natrium carbonicum calcinatum 10kg and there is citric acid 3kg to be uniformly mixed, be coated with Macrogol 4000 40kg；
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
Embodiment 4
A kind of preparation step of water soluble Florfenicol effervescent agent:
(1), 100kg Ultramicro-powder Florfenicol is produced, Ultramicro-powder Florfenicol 10kg, lauryl sodium sulfate 0.2kg and nothing are claimed
Water glucose 36.8kg, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), by natrium carbonicum calcinatum 10kg and there is citric acid 3kg to be uniformly mixed, be coated with Macrogol 4000 40kg；
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
Embodiment 5
A kind of preparation step of water soluble Florfenicol effervescent agent:
(1), 100kg Ultramicro-powder Florfenicol is produced, Ultramicro-powder Florfenicol 15kg, lauryl sodium sulfate 0.2kg and nothing are claimed
Water glucose 31.8kg, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), by natrium carbonicum calcinatum 10kg and there is citric acid 3kg to be uniformly mixed, be coated with Macrogol 4000 40kg；
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
Embodiment 6
A kind of preparation step of water soluble Florfenicol effervescent agent:
(1), 100kg Ultramicro-powder Florfenicol is produced, Ultramicro-powder Florfenicol 10kg, poloxamer 0.2kg and anhydrous grape are claimed
Sugared 36kg, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), by natrium carbonicum calcinatum 10kg and there is citric acid 3kg to be uniformly mixed, be coated with Macrogol 4000 40kg；
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
Claims (7)
1. a kind of water soluble Florfenicol effervescent agent, it is characterised in that including following components and parts by weight are as follows: Ultramicro-powder fluorine
Benzene Buddhist nun examines 1-20 parts, 0.2-5 parts of cosolvent, 3-5 parts of organic acid (sour agent), 1-11 parts of inorganic salts (alkaline agent), and filler adds to
100 parts.
2. a kind of water soluble Florfenicol effervescent agent according to claim 1, it is characterized in that: the cosolvent is 12
Sodium alkyl sulfate, poloxamer, PVP K30 or any combination thereof.
3. a kind of water soluble Florfenicol effervescent agent according to claim 1, it is characterized in that: the organic acid (sour agent)
For citric acid, malic acid, tartaric acid, fumaric acid or any combination thereof.
4. a kind of water soluble Florfenicol effervescent agent according to claim 1, it is characterized in that: the inorganic salts (alkaline agent)
It is that one or several kinds of acid of meeting can produce the inorganic salts of CO2, natrium carbonicum calcinatum, anhydrous sodium bicarbonate or any combination thereof.
5. a kind of water soluble Florfenicol effervescent agent according to claim 1, it is characterized in that: the filler is anhydrous
Glucose, lactose, mannitol or any combination thereof object.
6. a kind of water soluble Florfenicol effervescent agent according to claim 1, it is characterized in that: the Ultramicro-powder fluorobenzene Buddhist nun
Examining preparation method is that florfenicol powder is continuously added to micronizer, is crushed, and powder diameter 100% exists after control crushes
10 μm or less.
7. a kind of preparation method of water soluble Florfenicol effervescent agent according to claim 1, it is characterised in that including
Following preparation step:
(1), it by Ultramicro-powder Florfenicol, cosolvent and filler, pours into mixing machine, is uniformly mixed；
(2), (1) mixture is poured into pulverizer and pulverizes and sieves 120；
(3), inorganic salts (alkaline agent) and 3 parts of organic acid (sour agent) are uniformly mixed, are coated with Macrogol 4000,
(4), (2) and (3) are poured into mixing machine to be uniformly mixed, direct tablet compressing can obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710735933.9A CN109419781A (en) | 2017-08-24 | 2017-08-24 | A kind of water soluble Florfenicol effervescent agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710735933.9A CN109419781A (en) | 2017-08-24 | 2017-08-24 | A kind of water soluble Florfenicol effervescent agent and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN109419781A true CN109419781A (en) | 2019-03-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710735933.9A Pending CN109419781A (en) | 2017-08-24 | 2017-08-24 | A kind of water soluble Florfenicol effervescent agent and preparation method thereof |
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| CN (1) | CN109419781A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302163A (en) * | 2019-07-23 | 2019-10-08 | 东莞正大康地饲料有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
| CN115300461A (en) * | 2021-05-06 | 2022-11-08 | 江苏恒丰强生物技术有限公司 | Florfenicol soluble powder and preparation method thereof |
-
2017
- 2017-08-24 CN CN201710735933.9A patent/CN109419781A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302163A (en) * | 2019-07-23 | 2019-10-08 | 东莞正大康地饲料有限公司 | A kind of florfenicol soluble powder and preparation method thereof |
| CN115300461A (en) * | 2021-05-06 | 2022-11-08 | 江苏恒丰强生物技术有限公司 | Florfenicol soluble powder and preparation method thereof |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190305 |
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| WD01 | Invention patent application deemed withdrawn after publication |