CN105287389A - Amoxicillin soluble powder and preparation method thereof - Google Patents
Amoxicillin soluble powder and preparation method thereof Download PDFInfo
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- CN105287389A CN105287389A CN201510715068.2A CN201510715068A CN105287389A CN 105287389 A CN105287389 A CN 105287389A CN 201510715068 A CN201510715068 A CN 201510715068A CN 105287389 A CN105287389 A CN 105287389A
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- amoxicillin
- soluble powder
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- polyethylene glycol
- amoxicillin soluble
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Abstract
The invention discloses amoxicillin soluble powder and a preparation method thereof. Every 100 parts of the amoxicillin soluble powder contain, by weight, 10-20 parts of amoxicillin, 20-40 parts of polyethylene glycol and the balance anhydrous dextrose. The preparation method of the amoxicillin soluble powder comprises the following steps: 1, weighing amoxicillin and polyethylene glycol; 2, uniformly mixing the materials which are weighed ready, placing the materials into a stainless steel drying pan, using a thermal circulating type drying oven for conducting fusion, controlling the temperature within the range from 60 DEG to 80 DEG C, conducting stirring in the material fusion process, and taking the materials out; 3, cooling fusant rapidly, conducting collection, adopting an ultralow temperature pulverizer for pulverizing collected coagula, sieving the coagula with a 80-mesh sieve, and obtaining solid dispersed substances; 4, compounding the solid dispersed substances and anhydrous dextrose, and adopting a three-dimensional motion mixing machine for conducting mixing, wherein the mixing time is 20-30 minutes. According to the amoxicillin soluble powder and the preparation method thereof, the amoxicillin soluble powder is prepared through a solid dispersion technique (a fusion method), solubility of amoxicillin in water is improved, and stability of amoxicillin is enhanced.
Description
Technical field
The present invention relates to a kind of amoxicillin soluble powder and preparation method thereof, belong to veterinary drug preparing technical field.
Background technology
Amoxicillin is semi-synthetic penbritin class medicine, antimicrobial spectrum and antibacterial activity substantially identical with ampicillin, but its acid resistance comparatively ampicillin is strong, its bactericidal action comparatively the latter is strong and rapidly, but can not be used for meningitic treatment.Half-life is about 61.3 minutes.Amoxicillin is stablized in acid condition, and gastrointestinal absorption rate reaches 90%, and comparatively ampicillin absorbs more rapidly completely, and except to shigella dysenteriae effect, comparatively ampicillin differs from, all the other effects are similar.
Amoxicillin bactericidal action is strong, and the ability of penetration cell wall is also strong.Lactam group in drug after oral administration molecule is hydrolyzed generation peptide bond immediately, rapid and endobacillary transpeptidase combines and makes it inactivation, having cut off thalline relies on transpeptidase synthesis glycopeptide to be used for building the unique channel of cell wall, bacterial cell is made to become spheroplast rapidly and dissolving of breaking, thalline is finally because of cell wall loss, and moisture content constantly permeates and spalling is dead.The G+ bacterium of cause a disease to great majority and G-bacterium (comprising coccus and bacillus) all have powerful antibacterial and bactericidal action.Wherein to the Streptococcus such as streptococcus pneumoniae, Hemolytic streptococcus, do not produce the aerobic gram positive coccus such as penicillinase staphylococcus, enterococcus faecalis, the aerobic gram-negative bacteria such as escherichia coli, proteus mirabilis, Salmonella, hemophilus influenza, Diplococcus gonorrhoeae do not produce beta lactamase bacterial strain and helicobacter pylori has good antibacterial activity.The sensitive organism that can be widely used in urethra, respiratory tract and the skin for the treatment of various animal infects.
In " People's Republic of China's veterinary drug allusion quotation ", amoxicillin soluble powder is the preparation mixed with amoxicillin and adjuvant, and the preparation water solublity that the method is made is poor.A lot of producer is by adding soda at present, and the Acidity of Aikalinity changing solution improves the dissolubility of amoxicillin, can reduce curative effect of medication like this.
Summary of the invention
The object of this invention is to provide that a kind of dissolubility is higher, the preparation method of the amoxicillin soluble powder of better efficacy, take solid dispersion technology, solve the water solublity of amoxicillin, in turn ensure that curative effect of medication.
Object of the present invention can be achieved through the following technical solutions: a kind of amoxicillin soluble powder, and containing amoxicillin 10-20, Polyethylene Glycol 20-40 in the amoxicillin soluble powder of every 100 weight portions, surplus is anhydrous glucose.
Described Polyethylene Glycol is solid at normal temperatures, is one or more in Macrogol 4000, polyethylene glycol 6000, PEG 8000.
The preparation method of amoxicillin soluble powder, comprises the following steps:
1. according to amoxicillin: Polyethylene Glycol=1:1-1:4 takes amoxicillin and Polyethylene Glycol; 2. load weighted mixing of materials is even, put into rustless steel drip pan, carry out melting with heat-circulation type baking oven, temperature controls at 60-80 DEG C, stirs during material melting, takes out; 3. fused mass is cooled rapidly, collect, adopt super-low temperature pulverizator to pulverize the coagulum of collection, cross 80 mesh sieves, obtain solid dispersion; 4. solid dispersion and anhydrous glucose are prepared burden, adopt three-dimensional motion mixer mixing, incorporation time is 20-30min.
Step 3. middle fused mass is collected in rustless steel container.
Step 4. middle anhydrous glucose pulverized 100 mesh sieves.
The amoxicillin soluble powder that preparation method disclosed by the invention obtains not only increases the dissolubility of amoxicillin in water, and enhances the stability of amoxicillin.
Detailed description of the invention
Embodiment 1
The preparation method of amoxicillin soluble powder, comprises the following steps:
1. amoxicillin 10g and polyethylene glycol 6000 40g is taken; 2. load weighted mixing of materials is even, put into rustless steel drip pan, carry out melting with heat-circulation type baking oven, temperature controls, at 60 DEG C, to stir during material melting, takes out; 3. fused mass is cooled rapidly, collect in rustless steel container, adopt super-low temperature pulverizator to pulverize the coagulum of collection, cross 80 mesh sieves, obtain solid dispersion; 4. anhydrous glucose pulverized 100 mesh sieves, took anhydrous glucose, supplied 100g with solid dispersion, and adopt three-dimensional motion mixer mixing, incorporation time is 20min, obtains amoxicillin soluble powder.
Embodiment 2
The preparation method of amoxicillin soluble powder, comprises the following steps:
1. amoxicillin 10g and PEG 8000 30g is taken; 2. load weighted mixing of materials is even, put into rustless steel drip pan, carry out melting with heat-circulation type baking oven, temperature controls, at 80 DEG C, to stir during material melting, takes out; 3. fused mass is cooled rapidly, collect in rustless steel container, adopt super-low temperature pulverizator to pulverize the coagulum of collection, cross 80 mesh sieves, obtain solid dispersion; 4. anhydrous glucose pulverized 100 mesh sieves, took anhydrous glucose, supplied 100g with solid dispersion, and adopt three-dimensional motion mixer mixing, incorporation time is 30min, obtains amoxicillin soluble powder.
Embodiment 3
The preparation method of amoxicillin soluble powder, comprises the following steps:
1. amoxicillin 20g and Macrogol 4000 20g is taken; 2. load weighted mixing of materials is even, put into rustless steel drip pan, carry out melting with heat-circulation type baking oven, temperature controls, at 70 DEG C, to stir during material melting, takes out; 3. fused mass is cooled rapidly, collect in rustless steel container, adopt super-low temperature pulverizator to pulverize the coagulum of collection, cross 80 mesh sieves, obtain solid dispersion; 4. anhydrous glucose pulverized 100 mesh sieves, took anhydrous glucose, supplied 100g with solid dispersion, and adopt three-dimensional motion mixer mixing, incorporation time is 25min, obtains amoxicillin soluble powder.
Embodiment 4-embodiment 14
In embodiment 4-embodiment 14, variable is as following table, and all the other preparation processes are with embodiment 1.
Claims (5)
1. an amoxicillin soluble powder, is characterized in that: containing amoxicillin 10-20, Polyethylene Glycol 20-40 in the amoxicillin soluble powder of every 100 weight portions, surplus is anhydrous glucose.
2. a kind of amoxicillin soluble powder according to claim 1, is characterized in that: described Polyethylene Glycol is solid at normal temperatures, is one or more in Macrogol 4000, polyethylene glycol 6000, PEG 8000.
3. a kind of preparation method of amoxicillin soluble powder according to claim 1 or 2, is characterized in that comprising the following steps:
1. according to amoxicillin: Polyethylene Glycol=1:1-1:4 takes amoxicillin and Polyethylene Glycol; 2. load weighted mixing of materials is even, put into rustless steel drip pan, carry out melting with heat-circulation type baking oven, temperature controls at 60-80 DEG C, stirs during material melting, takes out; 3. fused mass is cooled rapidly, collect, adopt super-low temperature pulverizator to pulverize the coagulum of collection, cross 80 mesh sieves, obtain solid dispersion; 4. solid dispersion and anhydrous glucose are prepared burden, adopt three-dimensional motion mixer mixing, incorporation time is 20-30min.
4. the preparation method of a kind of amoxicillin soluble powder according to claim 3, is characterized in that: step 3. in fused mass collect in rustless steel container.
5. the preparation method of a kind of amoxicillin soluble powder according to claim 3, is characterized in that: step 4. in anhydrous glucose pulverized 100 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510715068.2A CN105287389A (en) | 2015-10-29 | 2015-10-29 | Amoxicillin soluble powder and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510715068.2A CN105287389A (en) | 2015-10-29 | 2015-10-29 | Amoxicillin soluble powder and preparation method thereof |
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| CN105287389A true CN105287389A (en) | 2016-02-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510715068.2A Pending CN105287389A (en) | 2015-10-29 | 2015-10-29 | Amoxicillin soluble powder and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108670956A (en) * | 2018-07-04 | 2018-10-19 | 河南牧翔动物药业有限公司 | A kind of amoxicillin soluble powder and preparation method thereof |
| CN112089694A (en) * | 2020-11-04 | 2020-12-18 | 湖北龙翔药业科技股份有限公司 | Amoxicillin soluble powder and preparation method thereof |
| CN113069418A (en) * | 2021-04-21 | 2021-07-06 | 海南通用三洋药业有限公司 | Preparation method of amoxicillin granules |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001045667A2 (en) * | 1999-12-22 | 2001-06-28 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Water-soluble powders for oral solution and use thereof |
| CN102008445A (en) * | 2010-12-10 | 2011-04-13 | 青岛康地恩药业有限公司 | Amoxicillin soluble powder as well as preparation method and application thereof |
| CN102670516A (en) * | 2012-05-29 | 2012-09-19 | 广东大华农动物保健品股份有限公司 | Tilmicosin soluble powder and preparation method thereof |
| CN104983685A (en) * | 2015-06-25 | 2015-10-21 | 四川恒通动物制药有限公司 | Amoxicillin soluble powder and preparation method |
-
2015
- 2015-10-29 CN CN201510715068.2A patent/CN105287389A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001045667A2 (en) * | 1999-12-22 | 2001-06-28 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Water-soluble powders for oral solution and use thereof |
| CN102008445A (en) * | 2010-12-10 | 2011-04-13 | 青岛康地恩药业有限公司 | Amoxicillin soluble powder as well as preparation method and application thereof |
| CN102670516A (en) * | 2012-05-29 | 2012-09-19 | 广东大华农动物保健品股份有限公司 | Tilmicosin soluble powder and preparation method thereof |
| CN104983685A (en) * | 2015-06-25 | 2015-10-21 | 四川恒通动物制药有限公司 | Amoxicillin soluble powder and preparation method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108670956A (en) * | 2018-07-04 | 2018-10-19 | 河南牧翔动物药业有限公司 | A kind of amoxicillin soluble powder and preparation method thereof |
| CN112089694A (en) * | 2020-11-04 | 2020-12-18 | 湖北龙翔药业科技股份有限公司 | Amoxicillin soluble powder and preparation method thereof |
| CN113069418A (en) * | 2021-04-21 | 2021-07-06 | 海南通用三洋药业有限公司 | Preparation method of amoxicillin granules |
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Address after: 456550 Luban Avenue, Linzhou industrial cluster, Henan, Anyang, China, No. 8 Applicant after: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO.,LTD. Address before: 456550 Luban Avenue, Linzhou industrial cluster, Henan, Anyang, China, No. 8 Applicant before: Linzhou middle peasants biological peptide Co.,Ltd. Address after: 456550 Luban Avenue, Linzhou industrial cluster, Henan, Anyang, China, No. 8 Applicant after: Linzhou middle peasants biological peptide Co.,Ltd. Address before: 456550 Luban Avenue, Linzhou industrial cluster, Henan, Anyang, China, No. 8 Applicant before: LINZHOU SINAGRI BIOLOGICAL PEPTIDES TECHNOLOGY Co.,Ltd. |
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Application publication date: 20160203 |
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| RJ01 | Rejection of invention patent application after publication |