CN101601657A - A kind of amoxicillin soluble powder and preparation method thereof - Google Patents
A kind of amoxicillin soluble powder and preparation method thereof Download PDFInfo
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- CN101601657A CN101601657A CNA2009100547099A CN200910054709A CN101601657A CN 101601657 A CN101601657 A CN 101601657A CN A2009100547099 A CNA2009100547099 A CN A2009100547099A CN 200910054709 A CN200910054709 A CN 200910054709A CN 101601657 A CN101601657 A CN 101601657A
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- amoxicillin
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- soluble powder
- natrium carbonicum
- carbonicum calcinatum
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Abstract
The present invention relates to a kind of amoxicillin soluble powder and preparation method thereof, particularly relate to a kind of with natrium carbonicum calcinatum as amoxicillin soluble powder of cosolvent and preparation method thereof.A kind of amoxicillin soluble powder, the composition of described amoxicillin soluble powder comprises amoxicillin and natrium carbonicum calcinatum, and the ratio of the weight of amoxicillin and natrium carbonicum calcinatum is 5～10: 1.A kind of preparation method of amoxicillin soluble powder may further comprise the steps: pulverize (1); (2) mix, amoxicillin powder and natrium carbonicum calcinatum powder ratio 5～10: 1 uniform mixing by weight after pulverizing; (3) packing.The invention solves the insoluble problem in amoxicillin, remedied the deficiency of the amoxicillin unsatisfactory curative effect of prior art.
Description
Technical field
The present invention relates to a kind of amoxicillin soluble powder and preparation method thereof, particularly relate to a kind of with natrium carbonicum calcinatum as amoxicillin soluble powder of cosolvent and preparation method thereof.
Background technology
The amoxicillin is semi-synthetic penbritin class medicine, and antimicrobial spectrum and antibacterial activity and ampicillin are basic identical, but its acid resistance is strong than the ampicillin, and its bactericidal action is better than the ampicillin, but can not be used for meningitic treatment.Half-life is about 61.3 minutes.The amoxicillin is stable under acid condition, and the gastrointestinal absorption rate reaches 90%, than the ampicillin absorb rapider fully, except that to the shigella dysenteriae effect than the ampicillin poor, all the other effects are similar.
The amoxicillin bactericidal action is strong, and the ability of penetration cell wall is also strong.Lactam group hydrolysis immediately in the drug molecule of oral back generates peptide bond, rapid and endobacillary transpeptidase is in conjunction with making it inactivation, cut off the unique channel that thalline relies on the synthetic glycopeptide of transpeptidase to be used for building cell wall, make bacterial cell become spheroplast and the dissolving of breaking rapidly, thalline decreases constantly infiltration spalling death of moisture content because of cell wall finally.Most of morbific G+ bacterium and G-bacterium (comprising coccus and bacillus) all there is powerful antibacterial and bactericidal action.Wherein to Hemolytic streptococcus, Brucella, moderate or slight sensitives such as Salmonella and enterococcus.Hemodialysis can be removed the part medicine, but peritoneal dialysis does not have the effect of removing this product.
Sensitive organism: streptococcus A, B, C, F, G and non-grouping type, listerisa monocytogenes in mjme, diphtheria corynebacterium, Neisser meningococcus, bordetella pertussis, bacillus perfringens genus, propionibacterium, peptostreptococcus, bargen's streptococcus, salmonella, Eubacterium, actinomycetes, leptospira, treponema pallidum.
Unstability sensitive organism: penicillin sensitivity or drug resistance streptococcus pneumoniae, intestinal streptococcus faecalis, escherichia coli, proteus mirabilis, shigella dysenteriae, vibrio cholera, Haemophilus influenzae, Neisseria gonorrhoeae, bacillus fusiformis.
Fastbacteria: staphylococcus, mucositis Pseudomonas, produce sour klebsiella bacillus, bacillus canalis capsulatus, proteus vulgaris, Pseudomonas, acinetobacter calcoaceticus, Campylobacter, Veillonella, mycoplasma, rickettsia, Legionnella, mycobacterium, bacillus fragilis.
Owing to the amoxicillin is insoluble in water, its dissolubility only is 0.1 gram in 100ml water, and therefore amoxicillin use at present all is powder, is unfavorable for mobile and absorption in animal body, has had a strong impact on the curative effect of amoxicillin.
Summary of the invention
The purpose of this invention is to provide a kind of amoxicillin soluble powder and preparation method thereof, a kind of usefulness natrium carbonicum calcinatum amoxicillin soluble powder as cosolvent and preparation method thereof just is provided, the invention solves the insoluble problem in amoxicillin, remedied the deficiency of the amoxicillin unsatisfactory curative effect of prior art.
A kind of amoxicillin soluble powder of the present invention, the composition of described amoxicillin soluble powder comprises amoxicillin and natrium carbonicum calcinatum, and the ratio of the weight of amoxicillin and natrium carbonicum calcinatum is 5～10: 1.
As optimized technical scheme:
Aforesaid a kind of amoxicillin soluble powder, wherein, the mixture that described amoxicillin soluble powder is made up of amoxicillin powder and natrium carbonicum calcinatum powder.
Aforesaid a kind of amoxicillin soluble powder, wherein, the purity of described amoxicillin powder is 90～100%, the purity of described natrium carbonicum calcinatum powder is 90～100%.
Aforesaid a kind of amoxicillin soluble powder, wherein, described amoxicillin powder grain diameter is less than 80 orders, and described natrium carbonicum calcinatum powder particles particle diameter is less than 80 orders.
Aforesaid a kind of amoxicillin soluble powder, wherein, the ratio of the weight of described amoxicillin and natrium carbonicum calcinatum is 5: 1.
The present invention also provides a kind of preparation method of amoxicillin soluble powder, may further comprise the steps:
(1) pulverizes, amoxicillin raw material and Carbon Dioxide sodium raw materials are pulverized respectively;
(2) mix, amoxicillin powder and natrium carbonicum calcinatum powder ratio 5～10: 1 uniform mixing by weight after pulverizing;
(3) packing.
Wherein, the preparation method of aforesaid a kind of amoxicillin soluble powder, 80 mesh sieves are adopted in described pulverizing.
The preparation method of aforesaid a kind of amoxicillin soluble powder, the ratio of the weight of described amoxicillin powder and natrium carbonicum calcinatum powder is 5: 1.
The preparation method of aforesaid a kind of amoxicillin soluble powder, the purity of described amoxicillin powder are 90～100%, and the purity of described natrium carbonicum calcinatum powder is 90～100%.
The invention has the beneficial effects as follows:
A kind of amoxicillin soluble powder of the present invention, the soluble powder good stability, dissolution velocity is fast.The preparation method of a kind of amoxicillin soluble powder of the present invention, production technology is simple.
The specific embodiment
Below in conjunction with the specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
A kind of amoxicillin soluble powder of the present invention, the composition of described amoxicillin soluble powder comprises amoxicillin and natrium carbonicum calcinatum, and the ratio of the weight of amoxicillin and natrium carbonicum calcinatum is 5～10: 1.
Wherein, the mixture formed by amoxicillin powder and natrium carbonicum calcinatum powder of described amoxicillin soluble powder.
The purity of described amoxicillin powder is 90～100%, and the purity of described natrium carbonicum calcinatum powder is 90～100%.
Described amoxicillin powder grain diameter is less than 80 orders, and described natrium carbonicum calcinatum powder particles particle diameter is less than 80 orders.
The ratio of the weight of described amoxicillin and natrium carbonicum calcinatum is 5: 1.
The present invention also provides a kind of preparation method of amoxicillin soluble powder, may further comprise the steps:
(1) pulverizes, amoxicillin raw material and Carbon Dioxide sodium raw materials are pulverized respectively;
(2) mix, amoxicillin powder and natrium carbonicum calcinatum powder ratio 5～10: 1 uniform mixing by weight after pulverizing;
(3) packing.
Wherein, 80 mesh sieves are adopted in described pulverizing.
The ratio of the weight of described amoxicillin powder and natrium carbonicum calcinatum powder is 5: 1.
The purity of described amoxicillin powder is 90～100%, and the purity of described natrium carbonicum calcinatum powder is 90～100%.
Claims (9)
1. amoxicillin soluble powder, it is characterized in that: the composition of described amoxicillin soluble powder comprises amoxicillin and natrium carbonicum calcinatum, and the ratio of the weight of amoxicillin and natrium carbonicum calcinatum is 5～10: 1.
2. a kind of amoxicillin soluble powder as claimed in claim 1 is characterized in that, the mixture that described amoxicillin soluble powder is made up of amoxicillin powder and natrium carbonicum calcinatum powder.
3. a kind of amoxicillin soluble powder as claimed in claim 2 is characterized in that, the purity of described amoxicillin powder is 90～100%, and the purity of described natrium carbonicum calcinatum powder is 90～100%.
4. a kind of amoxicillin soluble powder as claimed in claim 2 is characterized in that, described amoxicillin powder grain diameter is less than 80 orders, and described natrium carbonicum calcinatum powder particles particle diameter is less than 80 orders.
5. a kind of amoxicillin soluble powder as claimed in claim 1 or 2 is characterized in that, the ratio of the weight of described amoxicillin and natrium carbonicum calcinatum is 5: 1.
6. the preparation method of an amoxicillin soluble powder is characterized in that may further comprise the steps:
(1) pulverizes, amoxicillin raw material and Carbon Dioxide sodium raw materials are pulverized respectively;
(2) mix, amoxicillin powder and natrium carbonicum calcinatum powder ratio 5～10: 1 uniform mixing by weight after pulverizing;
(3) packing.
7. the preparation method of a kind of amoxicillin soluble powder as claimed in claim 6 is characterized in that, 80 mesh sieves are adopted in described pulverizing.
8. the preparation method of a kind of amoxicillin soluble powder as claimed in claim 6 is characterized in that, the ratio of the weight of described amoxicillin powder and natrium carbonicum calcinatum powder is 5: 1.
9. the preparation method of a kind of amoxicillin soluble powder as claimed in claim 6 is characterized in that, the purity of described amoxicillin powder is 90～100%, and the purity of described natrium carbonicum calcinatum powder is 90～100%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100547099A CN101601657A (en) | 2009-07-13 | 2009-07-13 | A kind of amoxicillin soluble powder and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2009100547099A CN101601657A (en) | 2009-07-13 | 2009-07-13 | A kind of amoxicillin soluble powder and preparation method thereof |
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| CN101601657A true CN101601657A (en) | 2009-12-16 |
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| CNA2009100547099A Pending CN101601657A (en) | 2009-07-13 | 2009-07-13 | A kind of amoxicillin soluble powder and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560187A (en) * | 2014-11-11 | 2016-05-11 | 天津嘉创生物科技有限公司 | Preparation method of amoxicillin soluble powder |
| CN106176617A (en) * | 2016-08-31 | 2016-12-07 | 中牧南京动物药业有限公司 | Amoxicillin soluble powder and preparation method thereof |
| CN106344522A (en) * | 2016-11-11 | 2017-01-25 | 河北利华药业有限公司 | Amoxicillin granule for livestock and preparation method thereof |
| CN113679672A (en) * | 2021-09-17 | 2021-11-23 | 江西成必信生物科技有限公司 | Preparation method of high-water-solubility amoxicillin soluble powder |
| CN114869884A (en) * | 2021-07-30 | 2022-08-09 | 江苏恒丰强生物技术有限公司 | Compound amoxicillin powder for porcine respiratory diseases and preparation method thereof |
-
2009
- 2009-07-13 CN CNA2009100547099A patent/CN101601657A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560187A (en) * | 2014-11-11 | 2016-05-11 | 天津嘉创生物科技有限公司 | Preparation method of amoxicillin soluble powder |
| CN106176617A (en) * | 2016-08-31 | 2016-12-07 | 中牧南京动物药业有限公司 | Amoxicillin soluble powder and preparation method thereof |
| CN106176617B (en) * | 2016-08-31 | 2018-02-13 | 中牧南京动物药业有限公司 | Amoxicillin soluble powder and preparation method thereof |
| CN106344522A (en) * | 2016-11-11 | 2017-01-25 | 河北利华药业有限公司 | Amoxicillin granule for livestock and preparation method thereof |
| CN106344522B (en) * | 2016-11-11 | 2019-04-09 | 河北利华药业有限公司 | A kind of amoxicillin granules for animals and preparation method thereof |
| CN114869884A (en) * | 2021-07-30 | 2022-08-09 | 江苏恒丰强生物技术有限公司 | Compound amoxicillin powder for porcine respiratory diseases and preparation method thereof |
| CN113679672A (en) * | 2021-09-17 | 2021-11-23 | 江西成必信生物科技有限公司 | Preparation method of high-water-solubility amoxicillin soluble powder |
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Open date: 20091216 |