CN105560187A - Preparation method of amoxicillin soluble powder - Google Patents
Preparation method of amoxicillin soluble powder Download PDFInfo
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- CN105560187A CN105560187A CN201410629714.9A CN201410629714A CN105560187A CN 105560187 A CN105560187 A CN 105560187A CN 201410629714 A CN201410629714 A CN 201410629714A CN 105560187 A CN105560187 A CN 105560187A
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Abstract
The invention relates to a preparation method of amoxicillin soluble powder. The amoxicillin soluble powder comprises the following components in parts by weight: 30-70 parts of amoxicillin, 10-30 parts of maltodextrin, 1-2 parts of ethylenediaminetetraacetic acid disodium salt, and 5-10 parts of purified water. According to the dissolution acceleration process, provided by the invention, the compatibility is scientific, the process is simple, the use is convenient, the cost is relatively low, amoxicillin detection is not affected, drug residue and toxic and side effects are avoided, the difficulty in dissolution of amoxicillin in water is effectively resolved, the dosage of amoxicillin in breeding is increased, amoxicillin can serve as soluble powder in livestock breeding, domestic animals and fowls can freely drink water, the solubility of amoxicillin in water is greatly improved, and the usage of raising households is facilitated.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of preparation method of amoxicillin soluble powder.
Background technology
Amoxicillin (Amoxicillin), has another name called amoxicillin, amoxicillin or Amoxicillin, and be a kind of the most frequently used penicillins wide spectrum beta-lactam antibiotic, be a kind of white powder, the half-life is about 61.3 minutes.Stablize in acid condition, gastrointestinal absorption rate reaches 90.Amoxicillin bactericidal action is strong, and the ability of permeates cell membranes is also strong.Be one of current widely used oral penicillin, be mainly used in the gram negative bacteria of penicillin-susceptible, gram positive bacteria, the infection such as coccus, staphylococcus aureus, dysentery bacterium, escherichia coli as to streptococcus pneumoniae infection.Because amoxicillin is poorly soluble, so occur that minority drugmaker occurs using cosolvent and solubilizing agent to solve the molten water problem in amoxicillin on the market, but there is dissolubility looks into, unstable, occurs precipitation, the side effect such as toxicity or zest increasing.Finally cause medication artifact availability low, so be necessary that a kind of novel hydrotropy technology of development solves molten water problem, this is a difficult problem of current pharmaceutical arts.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of amoxicillin soluble powder, be intended to overcome the deficiencies in the prior art, there is provided a kind of technique simple, easy to use, cost is lower, drug residue free and toxic and side effects, effectively can solve the problem of amoxicillin dissolubility, improves the application of amoxicillin in livestock and poultry cultivation.
The present invention is achieved by the following technical solutions:
A kind of amoxicillin soluble powder, component and the ratio of weight and number thereof of its soluble powder are respectively:
And component and the optimum ratio of weight and number thereof of this soluble powder are:
A preparation method for amoxicillin soluble powder, the step of its preparation method is as follows:
(1) take amoxicillin, maltodextrin, disodiumedetate whole mistake 80 mesh sieve respectively according to weight proportion, pulverize, be placed in three-dimensional stereo mixing machines mixing 25 minutes, detect mixing homogeneity, obtain mixture A, for subsequent use;
(2) take purified water according to weight proportion fully to mix with step (1) gained mixture A, be placed in duster and dust, namely obtain amoxicillin soluble powder finished product.
Advantage of the present invention and beneficial effect are:
1, the present invention can improve the value of amoxicillin, solves the difficulty of indissoluble water, increases operation rate low, and amoxicillin hydrotropy technique solves group solvent micropowder in the past, molten water speed is slow, and dissolution is little, can not meet the difficulties such as the demand of preparation.
2, the present invention can make amoxicillin be fully used in the cultivation of poultry, the impact do not affected by water temperature, acid-base value, absorb rapidly, its bioavailability can be improved, and the hydrotropy Technology of uniqueness makes amoxicillin not produce drug resistance, can the regulating and controlling effect of pathway to inflammatory signal, to gastric acid quite stable, just can reach blood peak concentration of drug at extremely low concentration and in the short period simultaneously.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Amoxicillin involved in the present invention, maltodextrin, disodiumedetate all commercially can be bought and obtain.
Embodiment 1
A preparation method for amoxicillin soluble powder, component and the weight thereof of its soluble powder are respectively: amoxicillin 30g, maltodextrin 10g, disodiumedetate 1g, purified water 5g.
A preparation method for amoxicillin soluble powder, the step of its preparation method is as follows:
(1) take amoxicillin, maltodextrin, disodiumedetate whole mistake 80 mesh sieve respectively according to weight proportion, pulverize, be placed in three-dimensional stereo mixing machines mixing 25 minutes, detect mixing homogeneity, obtain mixture A, for subsequent use;
(2) take purified water according to weight proportion fully to mix with step (1) gained mixture A, be placed in duster and dust, namely obtain amoxicillin soluble powder finished product.
Embodiment 2
A preparation method for amoxicillin soluble powder, component and the weight thereof of its soluble powder are respectively: amoxicillin 70g, maltodextrin 30g, disodiumedetate 2g, purified water 10g.
The step of its preparation method is with embodiment 1.
Embodiment 3
A preparation method for amoxicillin soluble powder, component and the weight thereof of its soluble powder are respectively: amoxicillin 50g, maltodextrin 20g, disodiumedetate 1g, purified water 8g.
The step of its preparation method is with embodiment 1.
Contrast test
Different group has carried out dissolubility to it and efficient liquid phase detection experiment proves that the ratio of hydrotropy technology of the present invention is best.
Test tools and method
1.1 test tool
Purified water, beaker, test tube, electronic balance, Glass rod, thermometer, high performance liquid chromatograph
1.2 test method
1.2.1 solubization: get the water solublity amoxicillin of 1.0g the present invention and market selling respectively and carry out solubization contrast.
Table 1 water solublity comparative result
1.2.2 efficient Liquid Detection the present invention and amoxicillin reference substance contrast:
Chromatographic condition and system suitability octadecylsilane chemically bonded silica are filler; With
0.05mol/L potassium dihydrogen phosphate (by 2mol/L potassium hydroxide solution adjust ph to 5.0)-acetonitrile (97.5:2.5) is mobile phase; Determined wavelength is 254nm.Get amoxicillin system suitability reference substance and be about 25mg, put in 50ml measuring bottle, dissolve and be diluted to scale, shake up with mobile phase, get 20 μ l injection liquid chromatographies, the chromatogram of record should be consistent with standard diagram.
It is appropriate, accurately weighed that algoscopy gets this product, adds mobile phase and dissolve and be diluted to scale, shake up, and make the solution about containing 0.5mg in every 1ml, filter, precision measures subsequent filtrate 20 μ l, injection liquid chromatography, record chromatogram; Separately get amoxicillin reference substance appropriate, be measured in the same method.By external standard method with calculated by peak area, to obtain final product.
Experimental condition Cometro (U.S. Kang Nuo) highly effective liquid phase chromatographic system;
Cometro (U.S. Kang Nuo) 6000PVWUV detector, wavelength=254nm;
Cometro (U.S. Kang Nuo) 6000LDIPump;
Scienhome (Tianjin treasure boat) KromasilC18250*4.6mm color
Spectrum post;
Sample size: 10ul.Reference substance content 96.1%, buyer: middle prison institute
Reference substance liquid chromatogram is shown in accompanying drawing 1
Amoxicillin soluble powder sample liquid chromatogram is shown in accompanying drawing 2
More than check and detect according to Chinese veterinary pharmacopoeia 2010 editions standards.
Conclusion: the present invention and dissolubility by force, do not affect product quality again.
Claims (3)
1. an amoxicillin soluble powder, is characterized in that: the component of this soluble powder and ratio of weight and number thereof are:
2. a kind of amoxicillin soluble powder according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of this soluble powder are:
3. the preparation method of a kind of amoxicillin soluble powder as claimed in claim 1, is characterized in that: the step of this preparation method is as follows:
(1) take amoxicillin, maltodextrin, disodiumedetate whole mistake 80 mesh sieve respectively according to weight proportion, pulverize, be placed in three-dimensional stereo mixing machines mixing 25 minutes, detect mixing homogeneity, obtain mixture A, for subsequent use;
(2) take purified water according to weight proportion fully to mix with step (1) gained mixture A, be placed in duster and dust, namely obtain amoxicillin soluble powder finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410629714.9A CN105560187A (en) | 2014-11-11 | 2014-11-11 | Preparation method of amoxicillin soluble powder |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410629714.9A CN105560187A (en) | 2014-11-11 | 2014-11-11 | Preparation method of amoxicillin soluble powder |
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| CN105560187A true CN105560187A (en) | 2016-05-11 |
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| CN201410629714.9A Pending CN105560187A (en) | 2014-11-11 | 2014-11-11 | Preparation method of amoxicillin soluble powder |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308116A (en) * | 2017-07-06 | 2017-11-03 | 山东中牧兽药有限公司 | A kind of amoxicillin soluble powder for animals and preparation method thereof |
| CN108159729A (en) * | 2017-12-31 | 2018-06-15 | 天津赫莱恩特生物科技有限公司 | A kind of recrystallization composition is turning brilliant technologic application |
| CN108670956A (en) * | 2018-07-04 | 2018-10-19 | 河南牧翔动物药业有限公司 | A kind of amoxicillin soluble powder and preparation method thereof |
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| EP1602361A2 (en) * | 2004-06-01 | 2005-12-07 | Vaccifar BV | Antibiotic in the form of a water-soluble powder for veterinary and human use |
| CN101601657A (en) * | 2009-07-13 | 2009-12-16 | 上海恒丰强动物药业有限公司 | A kind of amoxicillin soluble powder and preparation method thereof |
| CN102816251A (en) * | 2012-06-18 | 2012-12-12 | 北京生泰尔生物科技有限公司 | High-activity astragalus polysaccharide and preparation method of pharmaceutical composition of high-activity astragalus polysaccharide |
| CN103948722A (en) * | 2014-04-30 | 2014-07-30 | 武汉华扬动物药业有限责任公司 | Traditional Chinese medicinal composition for preventing and treating animal heat stress and preparation method thereof |
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2014
- 2014-11-11 CN CN201410629714.9A patent/CN105560187A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1602361A2 (en) * | 2004-06-01 | 2005-12-07 | Vaccifar BV | Antibiotic in the form of a water-soluble powder for veterinary and human use |
| CN101601657A (en) * | 2009-07-13 | 2009-12-16 | 上海恒丰强动物药业有限公司 | A kind of amoxicillin soluble powder and preparation method thereof |
| CN102816251A (en) * | 2012-06-18 | 2012-12-12 | 北京生泰尔生物科技有限公司 | High-activity astragalus polysaccharide and preparation method of pharmaceutical composition of high-activity astragalus polysaccharide |
| CN103948722A (en) * | 2014-04-30 | 2014-07-30 | 武汉华扬动物药业有限责任公司 | Traditional Chinese medicinal composition for preventing and treating animal heat stress and preparation method thereof |
Non-Patent Citations (1)
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| 浙江省农科生物技术有限公司: "阿莫西林可溶性粉", 《HTTPS://WENKU.BAIDU.COM/VIEW/01C789A7AEAAD1F346933F5B.HTML?FROM=SEARCH》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308116A (en) * | 2017-07-06 | 2017-11-03 | 山东中牧兽药有限公司 | A kind of amoxicillin soluble powder for animals and preparation method thereof |
| CN108159729A (en) * | 2017-12-31 | 2018-06-15 | 天津赫莱恩特生物科技有限公司 | A kind of recrystallization composition is turning brilliant technologic application |
| CN108670956A (en) * | 2018-07-04 | 2018-10-19 | 河南牧翔动物药业有限公司 | A kind of amoxicillin soluble powder and preparation method thereof |
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Application publication date: 20160511 |
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