CN105769762A - Ampicillin suspension injection and preparation method thereof - Google Patents
Ampicillin suspension injection and preparation method thereof Download PDFInfo
- Publication number
- CN105769762A CN105769762A CN201610303791.4A CN201610303791A CN105769762A CN 105769762 A CN105769762 A CN 105769762A CN 201610303791 A CN201610303791 A CN 201610303791A CN 105769762 A CN105769762 A CN 105769762A
- Authority
- CN
- China
- Prior art keywords
- ampicillin
- injection
- oil
- suspension
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an ampicillin suspension injection and a preparation method thereof. The 100ml of injection is prepared from the following components: 0.5 to 10.0g of ampicillin, 0.1 to 5.0g of suspending agent, 0.05 to 0.5g of antioxidant, 1.0 to 3.0g of wetting agent, 0.2 to 2.0g of flocculating agent and the balance of oil for injection. A special veterinary preparation for veterinarians is provided by using the ampicillin suspension injection prepared by the preparation method disclosed by the invention; the preparation method of the ampicillin suspension injection has the advantages of simplicity, high stability, better effect and high bioavailability; the effective shelf life reaches two years or over two years. By using a modern production process and equipment, scale and industrial production is facilitated.
Description
Technical field
The invention belongs to veterinary drug pharmaceutical technology field, be specifically related to a kind of ampicillin suspension injection and preparation method thereof.
Background technology
Ampicillin (English name: AmpiciLLin), another name: ampicillin, Ampicillin.This product is white crystalline powder；Mildly bitter flavor.This product is slightly soluble in water, insoluble in chloroform, ethanol, ether or expressed oi；Dilute acid soln or dilute alkaline soln dissolve.For semisynthetic penbritin, its free acid is containing 3 molecular crystalline water.
To gram-negative bacteria, as Bacillus typhi, escherichia coli etc. effectively but are easily generated drug resistance.Gram positive bacteria effect is similar to benzylpenicillin, viridans streptococci and enterococcal effect is more excellent, the effect of other bacterium is poor.The S. aureus L-forms of penicillin resistant G is invalid.Urinary system caused by sensitive organism, respiratory system, biliary tract, intestinal infection and meningitis, endocarditis etc..
At present, on China veterinary drug market, the veterinary drug preparation that raw material is made based on ampicillin has: the products such as ampicillin soluble powder, ampicillin soluble powder of sodium, Ampicillin Sodium For Injection, Ampicillin Sodium For Injection cloxacillin sodium, and corresponding veterinary medical quality standard, on people's medicine, preparation also has: ampicillin sheet, ampicillin granule, Ampicillin Capsule, ampicillin dry suspension, has corresponding medicine national quality quality.And for the research of ampicillin suspension injection, it does not have corresponding report and production.
When ampicillin is taken orally, nonruminant can absorb 30%-55%, and gastrointestinal content can reduce bioavailability, and ruminant absorbs worse, and the bioavailability that sheep is taken orally is only 2.1%.Intramuscular injection good absorbing, bioavailability is more than 80%.Can be widely distributed to various tissues after absorption, reach therapeutic effect.
Due to ampicillin slightly soluble in water, running into acid, alkali or oxidant etc. and namely lost efficacy rapidly, aqueous solution is placed in room temperature and was easily lost efficacy, and its aqueous solution is unstable, when not easily preparing into aqueous injection.Therefore, do not see corresponding patent and product for ampicillin suspension injection, not yet issue quality standard.
Summary of the invention
During for overcoming ampicillin as oral formulations, absorbance is relatively low, during as aqueous injection, aqueous stability is poor, the technical problem to be solved in the present invention is to provide the formula of a kind of ampicillin suspension injection for animals, the preparation method that a kind of veterinary drug ampicillin suspension injection is provided simultaneously, its preparation method is simple, stability is strong, effect is better, bioavailability is high, is suitable for poultry and uses.
For achieving the above object, the present invention can take following technical proposals:
A kind of ampicillin suspension injection of the present invention and preparation method, it is characterized by containing principal agent ampicillin, suspending agent, wetting agent, flocculant, antioxidant one-tenth be grouped into.
Described a kind of ampicillin suspension injection, this 100mL injection includes following component ampicillin 0.5～10.0g, suspending agent 0.1～5.0g, antioxidant 0.05～0.5g, wetting agent 1.0～3.0g, flocculant 0.2～2.0g, and surplus is oil for injection.
Described antioxidant is vitamin E or 2,6-di-tert-butyl-4-methy phenols (BHT).
Described wetting agent is Arlacel-60 or Arlacel-80.
Described suspending agent is one or both materials composition of sodium alginate, polyvinylpyrrolidone K17, PVP K30, aluminium stearate.
Described flocculant is citric acid or sodium citrate.
Described oil for injection is one or both materials composition of ethyl oleate, 10# white oil, oil with hydrogenated soybean and castor oil hydrogenated.
Present invention simultaneously provides the preparation technology of a kind of above-mentioned ampicillin suspension injection, its step is as follows:
The first step: take oil for injection and heat to 115～125 DEG C, be incubated 1～2 hour, add suspending agent, stirring and dissolving, cool to less than 50 DEG C, standby；
Second step: by the material of the first step as, in colloid mills, adding ampicillin, with the speed of 4000r/min, high speed shear 30min, make suspension, standby；
3rd step: by second step liquid, is sequentially added into antioxidant, flocculant, wetting agent, stirring while adding, until completely uniform, then continuously grinding 10min, standby；
4th step: the liquid after the 3rd step being ground, as in high pressure homogenizer, with pressure 50-55 MPa, carries out high pressure homogenize, then, and filling and sealing,.
A kind of ampicillin provided by the invention suspension injection and preparation method thereof, it has the advantages of: employ existing new equipment, new technology, improves existing traditional processing technology, makes production process more efficiently, fast；Production efficiency improves, and energy consumption reduces；Improve the dosage form of ampicillin, add the novel form of the ampicillin suspension injection of animal specific；Safety is high, good effect, and during intramuscular injection, zest is little；Stability is relatively strong, and in storage period, drug effect is not easily lost.
Detailed description of the invention
For making the present invention easier to understand, below in conjunction with specific embodiment, the present invention is expanded on further.Should be understood that these embodiments are merely to illustrate the present invention rather than restriction the scope of the present invention, NM specific experiment method in the following example, generally conventionally experimental technique carries out.
Embodiment 11% (g/mL) ampicillin suspension injection and preparation method thereof
Ampicillin 1g, vitamin E 0.05g, polyvinylpyrrolidone K170.25g, sodium alginate 0.25g, sodium citrate 0.5g, Arlacel-80 1g, oil with hydrogenated soybean 40g, 10# white oil are added to 100mL.
Preparation technology:
The first step: take oil with hydrogenated soybean and 10# white oil, after mixing, heating, to 115～125 DEG C, is incubated 1～2 hour, adds polyvinylpyrrolidone K17, sodium alginate, stirring and dissolving, cools to less than 50 DEG C, standby；
Second step: by the material of the first step as, in colloid mills, adding ampicillin, with the speed of 4000r/min, high speed shear 30min, make suspension, standby；
3rd step: by second step liquid, is sequentially added into vitamin E, sodium citrate, Arlacel-80, stirring while adding, until completely uniform, then continuously grinding 10min, standby；
4th step: the liquid after the 3rd step is ground, as, in high pressure homogenizer, with pressure 50 MPas, carrying out high pressure homogenize, then, filling and sealing,.
Embodiment 22% (g/mL) ampicillin suspension injection and preparation method thereof
Ampicillin 2g, BHT0.1g, PVP K30 0.4g, aluminium stearate 0.4g, citric acid 0.8g, Arlacel-80 1.5g, 10# white oil 40g, castor oil hydrogenated are added to 100mL.
Preparation technology:
The first step: take 10# white oil and castor oil hydrogenated, after mixing, heating, to 115～125 DEG C, is incubated 1～2 hour, adds PVP K30, aluminium stearate, stirring and dissolving, cools to less than 50 DEG C, standby；
Second step: by the material of the first step as, in colloid mills, adding ampicillin, with the speed of 4000r/min, high speed shear 30min, make suspension, standby；
3rd step: by second step liquid, is sequentially added into BHT, citric acid, Arlacel-80, stirring while adding, until completely uniform, then continuously grinding 10min, standby；
4th step: the liquid after the 3rd step is ground, as, in high pressure homogenizer, with pressure 50 MPas, carrying out high pressure homogenize, then, filling and sealing,.
Embodiment 35% (g/mL) ampicillin suspension injection and preparation method thereof
Ampicillin 5g, vitamin E 0.2g, polyvinylpyrrolidone K171g, sodium alginate 0.5g, sodium citrate 1g, Arlacel-80 1g, oil with hydrogenated soybean 50g, 10# white oil are added to 100mL.
Preparation technology:
The first step: take oil with hydrogenated soybean and 10# white oil, after mixing, heating, to 115～125 DEG C, is incubated 1～2 hour, adds polyvinylpyrrolidone K17, sodium alginate, stirring and dissolving, cools to less than 50 DEG C, standby；
Second step: by the material of the first step as, in colloid mills, adding ampicillin, with the speed of 4000r/min, high speed shear 30min, make suspension, standby；
3rd step: by second step liquid, is sequentially added into vitamin E, sodium citrate, Arlacel-80, stirring while adding, until completely uniform, then continuously grinding 10min, standby；
4th step: the liquid after the 3rd step is ground, as, in high pressure homogenizer, with pressure 50 MPas, carrying out high pressure homogenize, then, filling and sealing,.
Embodiment 410% (g/mL) ampicillin suspension injection and preparation method thereof
Ampicillin 10g, BHT1g, polyvinylpyrrolidone K172g, aluminium stearate 1g, citric acid 1g, Arlacel-60 2g, ethyl oleate 40g, castor oil hydrogenated are added to 100mL.
Preparation technology:
The first step: take ethyl oleate and castor oil hydrogenated, after mixing, heating, to 115～125 DEG C, is incubated 1～2 hour, adds polyvinylpyrrolidone K17, aluminium stearate, stirring and dissolving, cools to less than 50 DEG C, standby；
Second step: by the material of the first step as, in colloid mills, adding ampicillin, with the speed of 4000r/min, high speed shear 30min, make suspension, standby；
3rd step: by second step liquid, is sequentially added into BHT, citric acid, Arlacel-60, stirring while adding, until completely uniform, then continuously grinding 10min, standby；
4th step: the liquid after the 3rd step is ground, as, in high pressure homogenizer, with pressure 50 MPas, carrying out high pressure homogenize, then, filling and sealing,.
Each embodiment is all further illustrating the present invention above, in practice process, it is not limited solely to above opereating specification, based on each composition shown in the content of weight of the present invention, a kind of ampicillin suspension injection of preparation and preparation method thereof, all should calculate as the scope of the invention.
Experiment and research
One. adopt the present invention to prepare the stability test of ampicillin suspension injection
1. instrument and reagent
1.1 instruments
YJQ-2 water circulation constant temperature formula heater (Shanghai analytical tool factory), BCD-182W refrigerator (Hua Ling refrigerator factory), P3000 type high performance liquid chromatograph (Beijing innovation Tong Heng precision instrument company limited), RC-1 type dissolution tester (Shanghai Lu Si precision instrument company limited), water isolation type electro-heating standing-temperature cultivator (Tianjin precision instrument factory).
1.2 reagents
Ampicillin suspension injection (according to embodiment 1, embodiment 2, embodiment 3 method prepare)
2. test method and result
2.1 detection methods (described " annex " means one annex of " Chinese veterinary pharmacopoeia " version in 2010)
2.1.1 character this product is the suspension of subparticle, and after standing, subparticle sinks, uniformly milky suspension after jolting.
2.1.2 dispersibility takes this product 1 bottle, and firmly jolting 30 seconds, is transferred in glass container by test sample, must not observe caking or precipitate
2.1.3 sedimentation takes this product 1 bottle, and firmly jolting 30 seconds, takes test sample 10mL and put (internal diameter 1.0-1.5cm) in scale test tube, must not precipitate in 10 minutes.
2.1.4 granularity takes this product, shakes up, and measures according to granularity and particle size distribution method (annex 98 pages, the first method), must not less than 90% containing 15 μm of particles below, and 20 μm of particles below less than 95%, must not must not have the granule of more than 50 μm.
2.1.5 assay
Ampicillin measures according to high performance liquid chromatography (annex 36 pages).
Chromatographic condition and system suitability octadecylsilane chemically bonded silica are filler；Water-acetonitrile-1moL/L potassium dihydrogen phosphate-1moL/L acetum (909: 80: 10: 1) is mobile phase；Flow velocity is 1mL per minute；Column temperature 30 DEG C；Detection wavelength 254nm.Number of theoretical plate calculates by peak, ampicillin and is not less than 1000.
It is appropriate that algoscopy precision measures this product after shaking up, (1moL/L potassium dihydrogen phosphate 10mL and 1moL/L acetum 1mL is taken with diluent, it is diluted with water to 1000mL, shake up) dissolve and make in every 1mL the solution containing about ampicillin 1mg, precision measures 20 μ L, inject chromatograph of liquid, record chromatogram；Separately take ampicillin reference substance appropriate, be measured in the same method.And get final product with calculated by peak area by external standard method.
2.2 accelerated tests
2.2.1 temperature accelerated test
Homemade for difference lot number ampicillin suspension injection (ampoule is bottled) is placed on holding saturated nacl aqueous solution (temperature 40 ± 2 DEG C, relative humidity is 75 ± 5%) close drying device in, exsiccator is put in 40 DEG C of water isolation type electro-heating standing-temperature cultivators, places six months.Detect by injection stability high spot reviews project, result of the test following (see table 1, table 2, table 3).
Table 1 temperature accelerated test result (lot number: 20130301)
Table 2 temperature accelerated test result (lot number: 20130302)
Table 3 temperature accelerated test result (lot number: 20130303)
Showing from table 1, table 2, table 3 result: three batch samples, after the temperature accelerated test of 6 months, its character, dispersibility, sedimentation, granularity and content, all in acceptability limit, illustrate the stable in properties under temperature accelerated test of product.
2.3 humidity accelerated tests
Three batch samples are placed on and fill NaCL saturated solution (relative humidity 75 ± 1%, 25 DEG C) hermetic container in place 10 days, in the 5th day, 10 days separately sampled, by injection stability high spot reviews project, testing result following (see table 4, table 5, table 6):
Table 4 humidity accelerated test result (lot number: 20130301)
Table 5 humidity accelerated test result (lot number: 20130302)
Table 6 humidity accelerated test result (lot number: 20130303)
From table 4, table 5, table 6 result it can be seen that three batch samples, after the humidity accelerated test of 10 days, its character, dispersibility, sedimentation, granularity and content, all in acceptability limit, illustrate the stable in properties under humidity accelerated test of product.
2.4 acceleration by light tests
By three batch samples, being placed in the container that intensity of illumination is 4500 ± 500LX, in 5 days, sample was taken out in timing in 10 days, by injection stability high spot reviews project, testing result following (see table 7, table 8, table 9)
Table 7 acceleration by light result of the test (lot number: 20130301)
Table 8 acceleration by light result of the test (lot number: 20130302)
Table 9 acceleration by light result of the test (lot number: 20130303)
From table 7, table 8, table 9 result it can be seen that three batch samples, after the Illumination test of 10 days, the equal conformance with standard regulation of the dispersibility of its sample, sedimentation, granularity and content, but the character of injection deepens, the content of principal agent declines very fast, it sees that light is susceptible to oxidation, therefore this product needs shading to preserve.
Comprehensive above result of the test, ampicillin suspension injection is under temperature, humidity, acceleration by light test, and the stability of injection is relatively strong, and by the standard of Xi Nianzhu, the injection of this test is in shading, airtight preservation.
2.5 keep sample test for a long time
According to the ampicillin suspension injection (ampoule is bottled) that above-mentioned example produces, it is placed on room temperature and keeps sample in room, place 24 months.And in 3 months, 6 months, 9 months, 18 months, 24 months, be sampled respectively, detect by stability high spot reviews project, result of the test following (see table 10, table 11, table 12).
Table 10 keeps sample result of the test (lot number: 20130301) for a long time
Table 11 keeps sample result of the test (lot number: 20130302) for a long time
Table 12 keeps sample result of the test (lot number: 20130303) for a long time
From table 10, table 11, table 12 result it can be seen that three samples, after the test that keeps sample for a long time, the equal conformance with standard of the character of its sample, dispersibility, sedimentation, granularity and content specifies, and all in acceptability limit.
Comprehensive above result of the test, ampicillin suspension injection is in accelerated test and keeps sample under test for a long time, and stability is relatively strong, meets the requirements, and by the stability test standard of Xi Nianzhu, this test products shelf-life at normal temperatures is more than 2 years.
Two. ampicillin suspension injection prepared by the employing present invention pharmacokinetics research in pig body
1. materials and methods
1.1 medicines
Ampicillin suspension injection: adopt the present invention to prepare.
Ampicillin Sodium For Injection (powder pin): lot number is 20150526, Chuzhou City Chun Mudongbao Science and Technology Ltd. produces.
Ampicillin reference substance: content is 85.7%, and lot number is 130410-200706, Nat'l Pharmaceutical & Biological Products Control Institute provide.
Ampicillin (raw material): content is 98.6%, lot number is 31015055162, and Zhuhai United Laboratories Ltd produces.
1.2 test solution methods
HPLC method.Mobile phase: glacial acetic acid-acetonitrile-methanol solution.
1.3 experimental animals
Health pig 12, body weight 25kg ± 4.0kg, purchased from pig farm, Zhenyang, Henan.
1.4 administration and blood specimen collections
12 pigs being randomly divided into 2 groups, uses ampicillin suspension injection for the 1st group, the 2nd group, with Ampicillin Sodium For Injection (powder pin), carries out intramuscular injection by 20mg/kg dosage respectively.
Primary blank blood sample is adopted before administration, after administration respectively at the 0.25th, 0.50,0.75,1.00,2.00,3.00,5.00,9.00,12.00,24.00,36.00,48.00,72.00,96.00,108.00,120.00h takes a blood sample 5mL from vena cava anterior, it is placed in the centrifuge tube containing heparin, mixing, 3000r/min is centrifuged 10min, separated plasma, carries out HPLC mensuration.
1.5 data process
Adopt " MCPKP " pharmacokinetics calculation procedure that data are processed.
Result of the test
Result shows: the 1st group of elimination half-life (t1/2 β) respectively 12.45h ± 5.18h and 1.96h ± 1.03h with the 2nd group；(tmax) respectively 2.15h ± 0.37h and 0.78h ± 0.35h during peak；Peak concentration (Cmax) respectively 19.40 μ g/mL ± 2.09 μ g/mL and 21.90 μ g/mL ± 2.32 μ g/mL；Area under curve (AUC) respectively 629.43 μ g/ (mL h) ± 31.82 μ g/ (mL h) and 210.32 μ g/ (mL h) ± 10.28 μ g/ (mL h)；Valid density is held time tcp (ther) respectively 21.90h ± 10.36h and 1.92h ± 1.06h, and in blood, minimum active drug concentration is 0.8 μ g/mL.
3 discuss
This result of the test shows: adopting ampicillin suspension injection prepared by the present invention with after 20mg/kg body weight intramuscular injection, the elimination half-life is 12.45h ± 5.18h, hence it is evident that be longer than Ampicillin Sodium For Injection (powder pin).
Pharmacokinetics is analyzed result and is shown: ampicillin suspension injection and the Ampicillin Sodium For Injection (powder pin) pharmacokinetics in pig body meet two-compartment model.When eliminating half-life, peak, peak concentration, valid density hold time and the parameter such as area under curve there were significant differences (P < 0.05).
Blood drug level testing result shows: the valid density of the ampicillin suspension injection of the present invention is held time for 12.45h ± 5.18h, and Ampicillin Sodium For Injection (powder pin) is only 1.96h ± 1.03h；The former is considerably longer than the latter.This illustrates that the ampicillin suspension injection of the present invention eliminates relatively slow than Ampicillin Sodium For Injection (powder pin), and the time maintaining blood drug level in vivo is long.
Claims (2)
1. an ampicillin suspension injection, it is characterised in that: by ampicillin, suspending agent, antioxidant, wetting agent, flocculant, oil for injection forms, and described antioxidant is vitamin E or 2,6-di-tert-butyl-4-methy phenols (BHT)；Described wetting agent is Arlacel-60 or Arlacel-80；Described suspending agent is one or both materials composition of sodium alginate, polyvinylpyrrolidone K17, PVP K30, aluminium stearate；Described flocculant is citric acid or sodium citrate；Described oil for injection is one or both materials composition of ethyl oleate, 10# white oil, oil with hydrogenated soybean and castor oil hydrogenated.
Above-mentioned each component every 100mL injection includes following component: ampicillin 0.5～10.0g, suspending agent 0.1～5.0g, antioxidant 0.05～0.5g, wetting agent 1.0～3.0g, flocculant 0.2～2.0g, and surplus is oil for injection.
2. the preparation method of a kind of ampicillin according to claim 1 suspension injection, it comprises the steps:
The first step: take oil for injection and heat to 115～125 DEG C, be incubated 1～2 hour, add suspending agent, stirring and dissolving, cool to less than 50 DEG C, standby；
Second step: by the material of the first step as, in colloid mills, adding ampicillin, with the speed of 4000r/min, high speed shear 30min, make suspension, standby；
3rd step: by second step liquid, is sequentially added into antioxidant, flocculant, wetting agent, stirring while adding, until completely uniform, then continuously grinding 10min, standby；
4th step: the liquid after the 3rd step being ground, as in high pressure homogenizer, with pressure 50-55 MPa, carries out high pressure homogenize, then, and filling and sealing,.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610303791.4A CN105769762A (en) | 2016-05-11 | 2016-05-11 | Ampicillin suspension injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610303791.4A CN105769762A (en) | 2016-05-11 | 2016-05-11 | Ampicillin suspension injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105769762A true CN105769762A (en) | 2016-07-20 |
Family
ID=56401173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610303791.4A Pending CN105769762A (en) | 2016-05-11 | 2016-05-11 | Ampicillin suspension injection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105769762A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377499A (en) * | 2016-10-13 | 2017-02-08 | 成都乾坤动物药业股份有限公司 | Ampicillin oil suspension and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406450A (en) * | 2007-10-12 | 2009-04-15 | 河南农业大学 | Technique for preparing compound amoxicillin oil suspension injection |
| CN101721366A (en) * | 2010-01-13 | 2010-06-09 | 洛阳惠中兽药有限公司 | Components and preparation method of beta-lactam injection |
| CN101822637A (en) * | 2009-12-31 | 2010-09-08 | 天津瑞普生物技术股份有限公司 | Beta-lactam antibiotics-containing suspension injection |
-
2016
- 2016-05-11 CN CN201610303791.4A patent/CN105769762A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406450A (en) * | 2007-10-12 | 2009-04-15 | 河南农业大学 | Technique for preparing compound amoxicillin oil suspension injection |
| CN101822637A (en) * | 2009-12-31 | 2010-09-08 | 天津瑞普生物技术股份有限公司 | Beta-lactam antibiotics-containing suspension injection |
| CN101721366A (en) * | 2010-01-13 | 2010-06-09 | 洛阳惠中兽药有限公司 | Components and preparation method of beta-lactam injection |
Non-Patent Citations (3)
| Title |
|---|
| 吴正红: "《纳米药剂学》", 31 July 2011, 南京：江苏美术出版社 * |
| 孟胜男: "《药剂学》", 30 September 2011, 上海：上海科学技术出版社 * |
| 王晓君等: "阿莫西林油混悬液的工艺改进", 《黑龙江畜牧兽医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377499A (en) * | 2016-10-13 | 2017-02-08 | 成都乾坤动物药业股份有限公司 | Ampicillin oil suspension and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103751103A (en) | Long-acting cefquinome sulfate injection and preparation method thereof | |
| CN101721366A (en) | Components and preparation method of beta-lactam injection | |
| CN101401787B (en) | Ceftiofur long-acting injection and preparation method thereof | |
| CN101926840B (en) | Ultrafine powder of echinacea and preparation method and application thereof | |
| CN108815123A (en) | A kind of curcumin solid dispersion and its preparation method and application | |
| CN102525963B (en) | Netilmicin sulfate lyophiled powder injection and preparation method thereof | |
| CN105616383A (en) | Acetylisovaleryl tylosion tartrate enteric pellet and preparation method thereof | |
| CN101982173B (en) | Danofloxacin mesylate-amoxicillin suspension injection applicable to livestock and poultry as well as preparation and application thereof | |
| CN108670956A (en) | A kind of amoxicillin soluble powder and preparation method thereof | |
| CN103142515B (en) | Asarone injection and preparation method thereof | |
| CN101627967B (en) | Ambroxol hydrochloride liquid preparation and preparation method thereof | |
| CN105769762A (en) | Ampicillin suspension injection and preparation method thereof | |
| CN103705447B (en) | A kind of long-acting ceftiofur hydrochloride injection and preparation method thereof | |
| Tang et al. | Preparation of a newly formulated long‐acting ceftiofur hydrochloride suspension and evaluation of its pharmacokinetics in pigs | |
| CN101606950A (en) | A kind of pediatric paracetamol,atificial cowbezoar and chlorphenamine maleate granule and method of quality control | |
| EP3040067A1 (en) | Chlorogenic acid powder-injection and preparation method thereof | |
| CN105232450A (en) | Rifaximin-containing in-situ gel for breast injection and preparation method of rifaximin-containing in-situ gel | |
| CN113350297B (en) | Tilmicosin dry suspension and preparation method thereof | |
| CN105640881A (en) | Cefquinome sulfate muscle injection and preparation method thereof | |
| CN102397282A (en) | Long-acting compound ceftiofur suspension injection and its preparation method | |
| CN108210452B (en) | Veterinary cyadox nano suspension and preparation method thereof | |
| CN102614294A (en) | Compound amoxicillin suspension injection and preparation method thereof | |
| CN102552160B (en) | Veterinary danofloxacin mesylate slow-release microsphere preparation as well as preparation method and application of veterinary danofloxacin mesylate slow-release microsphere preparation | |
| CN102440998A (en) | Compound doxycycline hyclate suspension injection and preparation method thereof | |
| CN102125583A (en) | Pediatric paracetamol, cow-bezoar and chlorphenamine maleate granules and quality control method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160720 |