CN102908577A - Chinese and western compound medicine for treating respiratory system infection - Google Patents
Chinese and western compound medicine for treating respiratory system infection Download PDFInfo
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Abstract
The invention relates to a Chinese and western compound medicine for treating respiratory system infection. The Chinese and western compound medicine is formed by mixing western medicine components and Chinese medicine components, wherein the Chinese medicine components comprise the 10 ml/g of antivirus oral liquid, 20 g of rhizoma polygonati and 10 g of lucid ganoderma; and the western medicine components comprise two roxithromycin dispersible tablets, 125 mg/table, 250 mg in total, two cefaclor dispersible tablets, 0.25 mg/tablet, 0.5 g in total, two amoxil capsules, 0.25 g/grain, 0.5 g in total, two vitamin C tablets, 0.1 g/tablet, 0.2 g in total, two vitamin B6 tablets, 10 mg/tablet, 20 mg in total and five vitamin E tables, 100 mg/grains, 500 mg in total, wherein the Chinese and western medicines of the components are combined to form a prescription. By combining modern Chinese and western medicine, a successfully researched compound medicine is used for treating the respiratory system infection, particularly upper and lower respiratory infection and lung infection. Sputum can be reduced, the bacteria, the viruses and the fungi of the sputum and pus produced in human respiratory tracts are killed off, snuffle, sneeze, throat abscess, pneumonia and cough are reduced, headache is effectively inhibited, and the probability of fever illness is reduced.
Description
Technical field
The present invention relates to a kind of Chinese-western composite medicine thing for the treatment of respiratory system infection, relate in particular to the Chinese-western composite medicine thing of a kind of suitable treatment respiratory tract and pulmonary infection.
Background technology
Respiratory system disease is commonly encountered diseases and the frequently-occurring disease of harm people ' s health and life.China's population findings of the survey show, the prevalence of respiratory system disease is: chronic bronchitis more than 3.82%, 50 years old the patient up to 15%; About bronchial asthma 2%, the child morbidity rate is up to 5%; Acute upper respiratory tract infection and acute bronchitis still are the main illness of each hospital outpatient treatment; It is the first that pneumonia and various pulmonary infection occupy old people's infectious disease, also is seriously disease patient's main complication, and pulmonary tuberculosis on its is still very severe.
At present the main medicine for the treatment of respiratory system disease has: 1, antibiotic, antibiotic are the Common drugs for the treatment of respiratory tract and pulmonary infection.The respiratory tract infection of community's property is mainly gram positive bacteria, mostly selects oral during treatment or intramuscular injection dosage form antibiotic; Hospital acquired or in, Severe Respiratory Infection is then take gram-negative bacteria as main, mostly selects intravenous administration, after sb.'s illness took a favorable turn, changes intramuscular injection or oral medication into again.Antibiosis commonly used have penicillins, Macrolide, quinolones, cephalosporins, aminoglycoside etc.2, antifungal drug, in the patient of nosocomial infection, the sickness rate that merges fungal infection is very high, and common drug has ketoconazole, amphotericin B etc.3, antisussive and expectorant agent is one of medicine of commonly using in outpatient service, and compound Radix Glycyrrhizae mixture, anticol, MEIKE TANGJIANG etc. are arranged.4, the anti-asthmatic chronic obstructive pulmonary disease is irreversible disease, and asthma is a kind of disease that there is no at present the radical cure method, and anti-asthmatic has theophylline class, anticholinergic agent etc. clinically at present.5, anti-tuberculosis drugs is commonly used First Line medicine isoniazid, rifampicin, kanamycin etc.The chemotherapeutics that 6 antitumor drug are used for lung cancer therapy has cyclophosphamide, 5-fluorouracil etc.
Summary of the invention
Purpose of the present invention is to provide that a kind of determined curative effect, safe ready, effect are lasting, toxic and side effects is very little, is applicable to treat the Chinese-western composite medicine thing of respiratory system infection.
Medicine of the present invention is achieved through the following technical solutions.
A kind of Chinese-western composite medicine thing for the treatment of respiratory system infection, relate in particular to the Chinese-western composite medicine thing of a kind of suitable treatment respiratory tract and pulmonary infection, it is characterized in that: formed by western medicine composition and Chinese medicine ingredients mixing, Chinese medicine ingredients comprises that antivirus oral liquid 10ml/ props up, Rhizoma Polygonati 20 grams, Ganoderma 10 grams, western medicine composition comprises roxithromycin dispersing tablet 150mg/ sheet, totally 2, meter 300mg, Cefaclor 0.25g/ sheet, totally 2, meter 0.5g, Amoxicillin Capsules 0.25g/ grain, totally 2, meter 0.5g, vitamin C 0.1g/ sheet, totally 2, meter 0.2g, vitamin B6 10mg/ sheet, totally 2, meter 20mg, vitamin e1 00mg/ grain, totally 5, meter 500mg., in above composition, western drug carries out compatibility, forms a prescription.
1, the preparation method of Chinese-western composite medicine of the present invention is as follows.
1) at first, the configuration of raw material and utensil is as follows: concentration is 1 bottle of the sodium chloride injection of 250ml: 2.25g, each 2 of the dispensing injector with pins of 1ml, 5ml and 10ml, 1 of the marmite of 500ml, 1 in the measuring cup of 200ml, 1 in medicine spoon, 10ml is with 3 of the vials of rubber closure, cold water 1000ml, 40ml's pounds one of medicinal cupping, 1 of 10ml polyethylene bottle.
2) rinse, put into Rhizoma Polygonati 20 grams and Ganoderma 10 grams well marmite with cold water, add the 300ml cold water, soak after 12 hours, be heated to boiling 10 minutes with slow fire, leach medicinal liquid 150ml, reduced concentration cools in the 50ml vial of packing into for subsequent use to 30ml again.
3) get 2 of roxithromycin dispersing tablets with wood spoon, 2 of Cefaclors are successively placed on and pound in the medicinal cupping, with wooden stick tablet are pulverized, and pour in 2 10ml vials, get 2 of Amoxicillin Capsules medicated powder is directly poured in the 10ml vial.Divide with the 5ml syringe and respectively draw for 3 times in 3 10ml vials of 3ml sodium chloride injection injection, firmly shook 5 minutes, placed 10 minutes, have precipitate to separate out, percent concentration is respectively 15%, 25%, 25%, and suspended emulsion is for subsequent use.
4) draw the 2ml antivirus oral liquid with the 10ml syringe and inject in the 10ml polyethylene bottle, and clean syringe.
5) draw 3 with the 5ml syringe) in the suspended emulsion of roxithromycin dispersing tablet and Cefaclor respectively get 1ml and inject 4) in the polyethylene bottle, drawing 3 with the 1ml syringe) in the suspended emulsion of Amoxicillin Capsules get 0.5ml, injection 4) in the polyethylene bottle, and shook 5 minutes, place.
6) with 5ml syringe absorption 2) bottle interior medicinal liquid 1ml injection 4) bottle is interior and shook placement 5 minutes.
7) get 2 of vitamin Cs, 2 of vitamin Bies with wood spoon, put into successively and pound medicinal cupping; With wooden stick tablet is pulverized, pour in 2 10ml vials.Divide with the 5ml syringe and respectively draw for 2 times in 2 10ml vials of 3ml sodium chloride injection injection, firmly shook 5 minutes, placed 10 minutes, have precipitate to separate out, the percent concentration of suspended emulsion is respectively 30%, 10%; Draw respectively 1ml with the 5ml syringe and inject 4) in the polyethylene bottle, shook 5 minutes.
8) get 5 of vitamin Es with wood spoon and be placed on the blank sheet of paper, left hand clips the powder middle part with tweezers; The right hand thrusts with the 5ml syringe needle point, and the sucking-off medicinal liquid injects 4) in the polyethylene bottle, then shook 10 minutes, place 30 days for subsequent use.
2, above-mentioned " roxithromycin dispersing tablet " is that the market is bought, and produced by the Tai Huatang of Sichuan Province pharmaceutical Co. Ltd; " Cefaclor " is that the market is bought, and produced by Zhejiang Jing Xin pharmaceutical Co. Ltd; " vitamin C " is that the market is bought, and produced by northeast province Dongbei Pharmaceutical General Factory; " vitamin B6 " is that market pharmacy buys, and produced by Shanghai Xin Pasi pharmaceutical Co. Ltd; " vitamin E " is that the market is bought, and produced by White Cloud Mountain, Guangdong Province Pharmacy stock Co., Ltd; " amoxicillin " is that the market is bought, and federal pharmaceutical Co. Ltd produces by Zhuhai, Sichuan Province; " antivirus oral liquid " bought by the market, and Pharmaceutical limited company produces by the north, Shijiazhuang City, Hebei Province city,
3, Chinese medicine ingredients antivirus oral liquid composition of the present invention: formed by Radix Isatidis, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Radix Curcumae, the Rhizoma Anemarrhenae, Rhizoma Acori Graminei, Fructus Forsythiae, Herba Pogostemonis and sucrose.Pharmacological action: be used for clearing heat and expelling damp, influenza is controlled in removing pathogenic heat from blood and toxic substance from the body.
The chemical composition of Fructus Forsythiae in the antivirus oral liquid composition: fruit contains forsythol, sterol compound, Saponin (without hemolytic) and Flavonoids, horse tongue resinol glycoside etc.Pharmacological action: 1. antibacterial action Fructus Forsythiae concentrated decotion has an antibacterial action external, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.Effective ingredient research antibiotic in the Fructus Forsythiae is few, and forsythol Mlc to staphylococcus aureus in test tube is 1: 5120; It is 1: 1280 to dysentery bacterium; Be 1: 640 to diphtheria corynebacterium and paratyphoid fever (first) bacillus, may be antibiotic effective ingredient.
The chemical composition of Herba Pogostemonis in the antivirus oral liquid composition: from Herba Pogostemonis, isolate flavone compound 4',5,7-trihydroxyflavone, rhamnocitrin and ombuin.Pharmacological action: antifungal, leptospira, isolate flavone compound ombuin and 4',5,7-trihydroxyflavone in the Herba Pogostemonis and have antivirus action, can suppress digestive tract and upper respiratory tract pathogen-rhinoviral breeding.
Radix Rehmanniae, Rhizoma Phragmitis, Gypsum Fibrosum, the Rhizoma Anemarrhenae are heat removing and blood cooling medicine in the antivirus oral liquid composition, and the effect of YIN nourishing and the production of body fluid promoting is arranged.
The chemical composition of Radix Isatidis in the antivirus oral liquid composition: Radix Isatidis contains indigo, indirubin, Anthraquinones, cupreol, clionasterol and several amino acids.Also contain potassium myronate, the indigo glycoside.Pharmacological action:. antibiosis and antiviral functions. anti-leptospira effect, Detoxication, raising immunologic function.Radix Isatidis, antibiotic, the antiviral effective ingredient of Folium Isatidis, someone thinks indigo glycoside, indirubin. antitumor action has the effect that destroys the leukaemia.
The chemical composition of Chinese medicine Rhizoma Polygonati: the rhizome of Rhizoma Polygonati contains azetidine-2-carboxylic acid, aspartic acid, homoserine, DAB, digitalis glucoside and multiple anthraquinone analog compound.Pharmacological action: Rhizoma Polygonati has blood vessel dilating, blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, slow down aging and the effect such as antibiotic, and polygonatum polysaccharide has Immunestimulatory effect.
The chemical composition of Chinese medicine Ganoderma: the Ganoderma chemical composition mainly contains ergosterol 0.3%～0.4%, fungal lysozyme and acid protease, L-mannitol, Xi pure and mild several amino acids, polypeptide and polysaccharide.Pharmacological action: cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc. animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, respiratory system there is phlegm-dispelling functions, in addition, also have hepatoprotective, improve immunologic function, effect such as antibiotic grade.
4, the Western medicine Amoxicillin Capsules is one of semi-synthetic beta-lactam enzyme antibiotic.Be multiplication stage bactericide, its antibacterial action mechanism is identical with penicillin, and is all effective to gram-positive bacteria and gram-negative bacteria.The oral rear absorption of this medicine is rapid, and approximately 75%-90% can be from gastrointestinal absorption.Clinical practice: be applicable to respiratory tract infection, urinary tract infection, biliary tract infection, typhoid fever and gonorrhea etc. due to the various sensitive bacterials such as streptococcus, streptococcus pneumoniae, non-product enzyme staphylococcus and escherichia coli.Untoward reaction: the anaphylaxiss such as nausea,vomiting,diarrhea and pseudomembranous enterocolitis, erythra, asthma and drug fever are arranged after taking medicine.
Cephalosporin and penicillins belong to beta-lactam antibiotic.Western medicine Cefaclor has a broad antifungal spectrum, antibacterial activity is strong.This product has antibacterial activity to escherichia coli, Klebsiella Pneumoniae, hemophilus influenza, product enzyme staphylococcus aureus, A group Hemolytic streptococcus and Streptococcus viridans. clinical practice; Cefaclor is multiplication stage bactericide, and complete, oral this product 500mg absorbance is 52%-95% rapidly in oral rear absorption.Cefaclor is applicable to treat respiratory tract infection, otitis media, urinary tract infection and the soft tissue infection due to the sensitive bacterial.The untoward reaction of Cefaclor: nausea,vomiting,diarrhea and giddy, headache, drowsiness etc. are arranged after taking medicine.
Roxithromycin dispersing tablet is the derivant of Erythromycin A, and novel 14 membered macrolide antibiotic are antibacterial.Penetration power is strong, and biological half-life is longer, and is effective to staphylococcus aureus, streptococcus, moraxelle catarrhalis, meninges coccus, chlamydia, mycoplasma and infection with legionella.Clinical practice: roxithromycin dispersing tablet is mainly used in treating the respiratory system infection that sensitive bacterial causes, urinary system infection, ear,nose ﹠ throat infection etc.Untoward reaction: feel sick, stomachache, diarrhoea, constipation, headache, pruritus etc.
5, vitamin is requisite organic compound in the body metabolism, and vitamin is the important substance of keeping and regulating the body homergy.Respiratory system particularly, malnutrition can weaken respiratory muscule strength, changes ventilation capacity and infringement immunologic function, causes decline in pulmonary function; The recovery of nutriture can improve impaired pulmonary function, can improve curative effect.
It has the functions such as the vomiting of inhibition, promotion growth vitamin B6, lacks the symptoms such as it can cause vomiting, cramp.Vitamin B6 is combined into pyridoxal 5-phosphate or phosphopyridoxamine with phosphoric acid in vivo.They are coenzyme of the relevant amino acid metabolism enzyme of many kinds, therefore very important to amino acid metabolism.
It can treat vitamin C vitamin C deficiency and have acidity, so be called ascorbic acid.Ascorbic major function is to help human body to finish redox reaction, improves human body sterilization ability and detoxification ability.
Vitamin E soft gelatin capsule 100mg/ grain, (indication): be used for cardiovascular and cerebrovascular disease and habitual abortion.Vitamin E also has keeps normal reproductive performance and muscle homergy; Keep the complete of nervus centralis and vascular system.Vitamin E is easy to oxidation, thus can protect other easily oxidized material (such as vitamin A and unsaturated fatty acid etc.) be not destroyed, amyotrophy, anemia, cerebral malacia and other neurodegenerative pathological changes also may occur in the animal E that is deficient in vitamin.
6, the anthraquinone analog compound of Amoxicillin Capsules, Cefaclor, roxithromycin dispersing tablet and Chinese medicine Rhizoma Polygonati, indigo, the indirubin of Radix Isatidis, Anthraquinones; The forsythol of Fructus Forsythiae, sterol compound, Flavonoids etc. are collaborative to reach quick kill bacteria, chlamydia, mycoplasma and infection with legionella effect; Isolate flavone compound in the fungal lysozyme of Ganoderma, the Herba Pogostemonis and have antifungic action; Isolate the flavone compound ombuin in the indigo glycoside of Radix Isatidis and the Herba Pogostemonis and 4',5,7-trihydroxyflavone has antivirus action; The absorption of vitamin E soft gelatin capsule, vitamin C, vitamin B6, Rhizoma Polygonati and the favourable aminoglycoside of Ganoderma has the adjusting immunization; Organic acid in the Chinese medicine reduces the pharmacology toxicity of Western medicine, and digestive enzyme decomposes large drug molecule in the Chinese medicine; Vitamin E can increase polysaccharide and generate, and makes medicine become sweet taste by bitterness, and the rear mouthfeel of taking medicine is good; Thereby reach antibacterium antiviral, antifungic action, reduce the generation of pus, sputum, stop the appearance of fever and headache; Be suitable for the treatment of the infection of nasopharynx larynx, pulmonary infection, bronchial infection.
Implementation
The upper respiratory tract infection viral infection has adenovirus, rhinovirus, echovirus, Coxsackie virus, Measles virus, rubella virus.Antibacterial infects and can directly or after viral infection occur, and take Hemolytic streptococcus as common, is hemophilus influenza, streptococcus pneumoniae and staphylococcus etc. secondly.Accidental gram negative bacilli.The main manifestations of its infection is rhinitis, pharyngolaryngitis or tonsillitis. antibacterial infects, and onset is more anxious, and General Symptoms and local symptom are all heavier, fear of cold is arranged, shivers, generates heat, headache, extremity and aching pain in waist and back, pharyngalgia, weak etc.; Pharyngeal obvious hyperemia, antiadoncus is often with cervical lymph node enlargement and tenderness.
Lower respiratory tract and pulmonary infection are caused by microorganisms such as virus, antibacterial, mycoplasma, chlamydia, legionella.Show as acute tracheitis, acute episode of chronic bronchitis, bronchiectasis accompanying infection, bronchopneumonia, lobar pneumonia and pulmonary abscess.This class disease incidence is high, and the crowd generally easily dyes, children's, old man, malnutrition and to suffer from the chronic disease patient easier to be ill.Main manifestations is asthma, cough, network expectorant etc.
The present invention adopts the form of therapy respiratory system infection disease of drug combination, the condition of drug combination, 1, the out of contior aerobe of single antibacterials and anaerobe mixed infection, pathogenic bacterial infection more than 2 kinds or 3 kinds: 2, need long-term treatment, but pathogen easily produces the infection of drug resistance to some antibacterials, such as tuberculosis, deep mycosis.The purpose of drug combination is the appropriate to the occasion drug combination with collaborative or additive action of selecting of medication, weakens the toxic and side effects of Western medicine, increases Chinese Herbs.
The preparation method of Chinese-western composite medicine of the present invention is as follows.
A, at first, the configuration of raw material and utensil is as follows: concentration is 1 bottle of the sodium chloride injection of 250ml: 2.25g, each 2 of the dispensing injector with pins of 5ml and 10ml, 1 of the marmite of 500ml, 1 in the measuring cup of 200ml, 1 in medicine spoon, 10ml is with 3 of the vials of rubber closure, cold water 1000ml, 40ml's pounds one of medicinal cupping, 1 of 10ml polyethylene bottle.
B, rinse, put into Rhizoma Polygonati 20 gram and Ganoderma 10 grams well marmite with cold water, add the 300ml cold water, soaks after 12 hours, be heated to boiling 10 minutes with slow fire, leach medicinal liquid 150ml, reduced concentration cools the 50ml vial of packing into interior for subsequent use to 30ml again.
C, get 2 of roxithromycin dispersing tablets with wood spoon, 2 of Cefaclors are successively placed on and pound in the medicinal cupping, with wooden stick tablet are pulverized, and pour in 2 10ml vials, get 2 of Amoxicillin Capsules medicated powder is directly poured in the 10ml vial.Divide with the 5ml syringe and respectively draw for 3 times in 3 10ml vials of 3ml sodium chloride injection injection, firmly shook 5 minutes, placed 10 minutes, have precipitate to separate out, percent concentration is respectively 15%, 25%, 25%, and suspended emulsion is for subsequent use.
D, usefulness 10ml syringe are drawn the 2ml antivirus oral liquid and are injected in the 10ml polyethylene bottle, and clean syringe.
E, draw 3 with the 5ml syringe) in the suspended emulsion of roxithromycin dispersing tablet and Cefaclor respectively get 1ml and inject 4) in the polyethylene bottle, drawing 3 with the 1ml syringe) in the suspended emulsion of Amoxicillin Capsules get 0.5ml, injection 4) in the polyethylene bottle, and shook 5 minutes, place.
F, draw 2 with the 5ml syringe) a medicinal liquid 1ml in the bottle injects 4) in the bottle and shook 5 minutes, place.
G, get 2 of vitamin Cs, 2 of vitamin Bies with wood spoon, put into successively and pound medicinal cupping; With wooden stick tablet is pulverized, pour in 2 10ml vials.Divide with the 5ml syringe and respectively draw for 2 times in 2 10ml vials of 3ml sodium chloride injection injection, firmly shook 5 minutes, placed 10 minutes, have precipitate to separate out, the percent concentration of suspended emulsion is respectively 30%, 10%; Draw respectively 1ml with the 5ml syringe and inject 4) in the polyethylene bottle, shook 5 minutes
H gets 5 of vitamin Es with wood spoon and is placed on the blank sheet of paper, and left hand clips the powder middle part with tweezers.The right hand thrusts with the 5ml syringe needle point, and the sucking-off medicinal liquid injects 4) in the polyethylene bottle, then shook 10 minutes, place 30 days for subsequent use.
The medicine pharmacological verification of i, invention: when edible contain pathogen food after, when causing respiratory tract infection, have sticking expectorant or thick sputum to discharge from the oral cavity; Medicinal liquid is splashed into oral cavity 2-4 drip, 3-4 hour transference cure.
Use this medicine should observe the taboo that Chinese medicine is taken: cigarette, wine, milk, egg, meat, pungent, greasy food etc.
The case history that clinical drug of the present invention is applied to upper respiratory tract infection is as follows:
Wang Wusang, man, 12 years old; The consultation of doctors on April 13rd, 2009.
Main suit: cough, expectoration, pant.
Medical history: May 21 cough, expectoration, pant and increase the weight of suddenly, this symptom continues 3 years.
Lab testing: 1.Respiratory function test is early stage without unusual.During if any SAO, Maximal expiratory flow volume curves is 75% with during 50% lung capacity, and flow obviously reduces.
2.。The blood test antibacterial can total white blood cells occur by chance when infecting and/or neutrophilic granulocyte increases.
3.。Sputum examination can be turned out pathogenic bacterium.Smear can be found gram positive bacteria or gram-negative bacteria, or the goblet cell of the leukocyte of considerable damage and destroyed.
Diagnosis: according to cough, expectoration, or with panting, annual morbidity continues 3 months, and continuous more than 2 years or 2 years, and gets rid of other chronic airway disorders, is diagnosed as chronic bronchitis.
Treatment: oral cavity booty or saliva are cleaned up, medicinal liquid (a kind of Chinese-western composite medicine thing for the treatment of respiratory tract infection) is splashed into; Every day 1 time, used for 1 week, this medicine can suppress pathogen, improves immunity of organisms, eliminates disease.
Zhang Haijun, man, 32 years old; The consultation of doctors on May 8th, 2009.
Main suit: flow clear nasal mucus, fever and headache 2 days.
Medical history: May 6 occurred the poisoning symptoms such as fear of cold, high heat, headache, dizziness, systemic pain, power on.
Blood test:, virus is separated inspection: nasopharyngeal secretions or oral cavity contain transfusion and isolate influenza virus.Serological testing: the disease initial stage and convalescent period paired sera antibodies against influenza virus titre 4 times or above rising are arranged, help retrospective diagnosis.The patient respiratory tract epithelial cell is looked into the influenza antigen positive; Be diagnosed as influenza.
The side of controlling: available a kind of upper respiratory tract and encephalitis b virus for the treatment of causes that the combination drug (200910143582.1) of fever and headache alleviates heating and headache symptom, suppress copying of influenza virus with this medicine, reduce pathogenic, alleviate flu-like symptom, shorten the course of disease, complication, strengthen immunocompetence, accelerate physical rehabilitation.
Claims (7)
1. Chinese-western composite medicine thing for the treatment of respiratory system infection, relate in particular to the Chinese-western composite medicine thing of a kind of suitable treatment respiratory tract and pulmonary infection, it is characterized in that: formed by western medicine composition and Chinese medicine ingredients mixing, Chinese medicine ingredients comprises that antivirus oral liquid 10ml/ props up, Rhizoma Polygonati 20 grams, Ganoderma 10 grams, western medicine composition comprises roxithromycin dispersing tablet 150mg/ sheet, totally 2, meter 300mg, Cefaclor 0.25g/ sheet, totally 2, meter 0.5g, Amoxicillin Capsules 0.25g/ grain, totally 2, meter 0.5g, vitamin C 0.1g/ sheet, totally 2, meter 0.2g, vitamin B6 10mg/ sheet, totally 2, meter 20mg, vitamin E 100mg/ grain, totally 5, meter 500mg., in above composition, western drug carries out compatibility, forms a prescription.
2. the Chinese-western composite medicine thing for the treatment of respiratory system infection according to claim 1, it is characterized in that: the preparation method of this medicine is as follows:
1) at first, the configuration of raw material and utensil is as follows: concentration is 1 bottle of the sodium chloride injection of 250ml: 2.25g, each 2 of the dispensing injector with pins of 1ml, 5ml and 10ml, 1 of the marmite of 500ml, 1 in the measuring cup of 200ml, 1 in medicine spoon, 10ml is with 3 of the vials of rubber closure, cold water 1000ml, 40ml's pounds one of medicinal cupping, 1 of 10ml polyethylene bottle.
2) rinse, put into Rhizoma Polygonati 20 grams and Ganoderma 10 grams well marmite with cold water, add the 300ml cold water, soak after 12 hours, be heated to boiling 10 minutes with slow fire, leach medicinal liquid 150ml, reduced concentration cools in the 50ml vial of packing into for subsequent use to 30ml again.
3) get 2 of roxithromycin dispersing tablets with wood spoon, 2 of Cefaclors are successively placed on and pound in the medicinal cupping, with wooden stick tablet are pulverized, and pour in 2 10ml vials, get 2 of Amoxicillin Capsules medicated powder is directly poured in the 10ml vial.Divide with the 5ml syringe and respectively draw for 3 times in 3 10ml vials of 3ml sodium chloride injection injection, firmly shook 5 minutes, placed 10 minutes, have precipitate to separate out, percent concentration is respectively 15%, 25%, 25%, and suspended emulsion is for subsequent use.
4) draw the 2ml antivirus oral liquid with the 10ml syringe and inject in the 10ml polyethylene bottle, and clean syringe.
5) draw 3 with the 5ml syringe) in the suspended emulsion of roxithromycin dispersing tablet and Cefaclor respectively get 1ml and inject 4) in the polyethylene bottle, drawing 3 with the 1ml syringe) in the Amoxicillin Capsules suspended emulsion get 0.5ml, injection 4) in the polyethylene bottle, and shook 5 minutes, place.
6) with 5ml syringe absorption 2) bottle interior medicinal liquid 1ml injection 4) bottle is interior and shook placement 5 minutes.
7) get 2 of vitamin Cs, 2 of vitamin Bies with wood spoon, put into successively and pound medicinal cupping; With wooden stick tablet is pulverized, pour in 2 10ml vials.Divide with the 5ml syringe and respectively draw for 2 times in 2 10ml vials of 3ml sodium chloride injection injection, firmly shook 5 minutes, placed 10 minutes, have precipitate to separate out, the percent concentration of suspended emulsion is respectively 30%, 10%; Draw respectively 1ml with the 5ml syringe and inject 4) in the polyethylene bottle, shook 5 minutes.
8) get 5 of vitamin Es with wood spoon and be placed on the blank sheet of paper, left hand clips the powder middle part with tweezers; The right hand thrusts with the 5ml syringe needle point, and the sucking-off medicinal liquid injects 4) in the polyethylene bottle, then shook 10 minutes, place 30 days for subsequent use.
3. the Chinese-western composite medicine thing for the treatment of respiratory system infection according to claim 1 is characterized in that: described " roxithromycin dispersing tablet " is that the market is bought, and produced by the Tai Huatang of Sichuan Province pharmaceutical Co. Ltd; " Cefaclor " is that the market is bought, and produced by Zhejiang Jing Xin pharmaceutical Co. Ltd; " vitamin C " is that the market is bought, and produced by northeast province Dongbei Pharmaceutical General Factory; " vitamin B6 " is that market pharmacy buys, and produced by Shanghai Xin Pasi pharmaceutical Co. Ltd; " vitamin E " is that the market is bought, and produced by White Cloud Mountain, Guangdong Province Pharmacy stock Co., Ltd; " amoxicillin " is that the market is bought, and federal pharmaceutical Co. Ltd produces by Zhuhai, Sichuan Province; " antivirus oral liquid " bought by the market, and Pharmaceutical limited company produces by the north, Shijiazhuang City, Hebei Province city.
4. the Chinese-western composite medicine thing for the treatment of respiratory system infection according to claim 1, it is characterized in that: Chinese medicine ingredients and the pharmacological action of using among the present invention are as follows:
1), antivirus oral liquid composition: formed by Radix Isatidis, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Radix Curcumae, the Rhizoma Anemarrhenae, Rhizoma Acori Graminei, Fructus Forsythiae, Herba Pogostemonis and sucrose.Pharmacological action; Be used for clearing heat and expelling damp, influenza is controlled in removing pathogenic heat from blood and toxic substance from the body.
The chemical composition of Fructus Forsythiae in the antivirus oral liquid composition; Fruit contains forsythol, sterol compound, Saponin (without hemolytic) and Flavonoids, horse tongue resinol glycoside etc.Pharmacological action: 1. antibacterial action Fructus Forsythiae concentrated decotion has an antibacterial action external, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.Effective ingredient research antibiotic in the Fructus Forsythiae is few, and forsythol Mlc to staphylococcus aureus in test tube is 1: 5120; It is 1: 1280 to dysentery bacterium; Be 1: 640 to diphtheria corynebacterium and paratyphoid fever (first) bacillus, may be antibiotic effective ingredient.
The chemical composition of Herba Pogostemonis in the antivirus oral liquid composition: from Herba Pogostemonis, isolate flavone compound 4',5,7-trihydroxyflavone, rhamnocitrin and ombuin.Pharmacological action: antifungal, leptospira, isolate flavone compound ombuin and 4',5,7-trihydroxyflavone in the Herba Pogostemonis and have antivirus action, can suppress digestive tract and upper respiratory tract pathogen-rhinoviral breeding.
Radix Rehmanniae, Rhizoma Phragmitis, Gypsum Fibrosum, the Rhizoma Anemarrhenae are heat removing and blood cooling medicine in the antivirus oral liquid composition, and the effect of YIN nourishing and the production of body fluid promoting is arranged.
The chemical composition of Radix Isatidis in the antivirus oral liquid composition: Radix Isatidis contains indigo, indirubin, Anthraquinones, cupreol, clionasterol and several amino acids.Also contain potassium myronate, the indigo glycoside.Pharmacological action:. antibiosis and antiviral functions. anti-leptospira effect, Detoxication, raising immunologic function.Radix Isatidis, antibiotic, the antiviral effective ingredient of Folium Isatidis, someone thinks indigo glycoside, indirubin. antitumor action has the effect that destroys the leukaemia.
2), the chemical composition of Chinese medicine Rhizoma Polygonati: the rhizome of Rhizoma Polygonati contains azetidine-2-carboxylic acid, aspartic acid, homoserine, DAB, digitalis glucoside and multiple anthraquinone analog compound.Pharmacological action: Rhizoma Polygonati has blood vessel dilating, blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, slow down aging and the effect such as antibiotic, and polygonatum polysaccharide has Immunestimulatory effect.
3), the chemical composition of Chinese medicine Ganoderma: the Ganoderma chemical composition mainly contains ergosterol 0.3%～0.4%, fungal lysozyme and acid protease, L-mannitol, Xi pure and mild several amino acids, polypeptide and polysaccharide.Pharmacological action: cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibioticly waits effect.
5. the Chinese-western composite medicine thing for the treatment of respiratory system infection according to claim 1, it is characterized in that: Western medicine pharmacological action and the untoward reaction of using among the present invention are as follows:
1), the Western medicine Amoxicillin Capsules is one of semi-synthetic beta-lactam enzyme antibiotic.Be multiplication stage bactericide, its antibacterial action mechanism is identical with penicillin, and is all effective to gram-positive bacteria and gram-negative bacteria.The oral rear absorption of this medicine is rapid, and approximately 75%-90 is from gastrointestinal absorption.Clinical practice: be applicable to respiratory tract infection, urinary tract infection, biliary tract infection, typhoid fever and gonorrhea etc. due to the various sensitive bacterials such as streptococcus, streptococcus pneumoniae, non-product enzyme staphylococcus and escherichia coli.Untoward reaction: nausea,vomiting,diarrhea and pseudomembranous enterocolitis are arranged after taking medicine; The anaphylaxiss such as erythra, asthma and drug fever.
2), cephalosporin and penicillins belong to beta-lactam antibiotic.Western medicine Cefaclor has a broad antifungal spectrum, antibacterial activity is strong.This product has antibacterial activity to escherichia coli, Klebsiella Pneumoniae, hemophilus influenza, product enzyme staphylococcus aureus, A group Hemolytic streptococcus and Streptococcus viridans.Clinical practice: cefaclor is multiplication stage bactericide, oral rear absorption rapidly and fully, oral this product 500mg absorbance is that the 52%-95%. Cefaclor is applicable to treat respiratory tract infection, otitis media, urinary tract infection and the soft tissue infection due to the sensitive bacterial.The untoward reaction of Cefaclor: nausea,vomiting,diarrhea and giddy, headache, drowsiness etc. are arranged after taking medicine.
3), roxithromycin dispersing tablet is the derivant of Erythromycin A, novel 14 membered macrolide antibiotic are antibacterial.Penetration power is strong, and biological half-life is longer, and is effective to staphylococcus aureus, streptococcus, moraxelle catarrhalis, meninges coccus, chlamydia, mycoplasma and infection with legionella.Clinical practice: roxithromycin dispersing tablet is mainly used in treating the respiratory system infection that sensitive bacterial causes, urinary system infection, ear,nose ﹠ throat infection etc.Untoward reaction: feel sick, stomachache, diarrhoea, constipation, headache, pruritus etc.
6. the Chinese-western composite medicine thing for the treatment of respiratory system infection according to claim 1, it is characterized in that: the vitamin pharmacological action of using among the present invention is as follows:
Vitamin is requisite organic compound in the body metabolism, and vitamin is the important substance of keeping and regulating the body homergy.Respiratory system particularly, malnutrition can weaken respiratory muscule strength, changes ventilation capacity and infringement immunologic function, causes decline in pulmonary function; The recovery of nutriture can improve impaired pulmonary function, can improve curative effect.
1), vitamin B6 it have and suppress vomiting, promote the function such as growth, lack the symptoms such as it can cause vomiting, cramp.Vitamin B6 is combined into pyridoxal 5-phosphate or phosphopyridoxamine with phosphoric acid in vivo.They are coenzyme of the relevant amino acid metabolism enzyme of many kinds, therefore very important to amino acid metabolism.
2), vitamin C it can treat vitamin C deficiency and have acidity, so be called ascorbic acid.Ascorbic major function is to help human body to finish redox reaction, improves human body sterilization ability and detoxification ability.
3), vitamin E soft gelatin capsule 100mg/ grain, (indication): be used for cardiovascular and cerebrovascular disease and habitual abortion.Vitamin E also has keeps normal reproductive performance and muscle homergy; Keep the complete of nervus centralis and vascular system.Vitamin E is easy to oxidation, thus can protect other easily oxidized material (such as vitamin A and unsaturated fatty acid etc.) be not destroyed, amyotrophy, anemia, cerebral malacia and other neurodegenerative pathological changes also may occur in the animal E that is deficient in vitamin.
7. the Chinese-western composite medicine thing for the treatment of respiratory system infection according to claim 1, it is characterized in that: pharmacological action of the present invention is as follows:
The anthraquinone analog compound of Amoxicillin Capsules, Cefaclor, roxithromycin dispersing tablet and Chinese medicine Rhizoma Polygonati, indigo, the indirubin of Radix Isatidis, Anthraquinones; The forsythol of Fructus Forsythiae, sterol compound, Flavonoids etc. are collaborative to reach quick kill bacteria, chlamydia, mycoplasma and infection with legionella effect; Isolate flavone compound in the fungal lysozyme of Ganoderma, the Herba Pogostemonis and have antifungic action; Isolate the flavone compound ombuin in the indigo glycoside of Radix Isatidis and the Herba Pogostemonis and 4',5,7-trihydroxyflavone has antivirus action; The absorption of vitamin E soft gelatin capsule, vitamin C, vitamin B6, Rhizoma Polygonati and the favourable aminoglycoside of Ganoderma has the adjusting immunization; Organic acid in the Chinese medicine reduces the pharmacology toxicity of Western medicine, and digestive enzyme decomposes large drug molecule in the Chinese medicine; Vitamin E can increase polysaccharide and generate, and makes medicine become sweet taste by bitterness, and the rear mouthfeel of taking medicine is good; Thereby reach antibacterium antiviral, antifungic action, reduce the generation of pus, sputum, stop the appearance of fever and headache; Be suitable for the treatment of the infection of nasopharynx larynx, pulmonary infection, bronchial infection.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104707008A (en) * | 2015-03-13 | 2015-06-17 | 聊城职业技术学院 | Composite reagent for prevention and treatment of meat chicken respiratory diseases, and preparation method of composite reagent |
| CN107281211A (en) * | 2017-08-01 | 2017-10-24 | 田东雄桂牧业有限公司 | It is a kind of to treat medicine of infectious bronchitis of chicken and preparation method thereof |
-
2011
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| Title |
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| 王淑梅等主编: "《内科学》", 31 July 2004, 人民军医出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104707008A (en) * | 2015-03-13 | 2015-06-17 | 聊城职业技术学院 | Composite reagent for prevention and treatment of meat chicken respiratory diseases, and preparation method of composite reagent |
| CN104707008B (en) * | 2015-03-13 | 2018-05-22 | 聊城职业技术学院 | A kind of composite drug and preparation method for preventing chickens respiratory disease |
| CN107281211A (en) * | 2017-08-01 | 2017-10-24 | 田东雄桂牧业有限公司 | It is a kind of to treat medicine of infectious bronchitis of chicken and preparation method thereof |
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