CN102824620A - Composition suitable for yang-deficiency physique and its preparation method and use - Google Patents
Composition suitable for yang-deficiency physique and its preparation method and use Download PDFInfo
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- CN102824620A CN102824620A CN2012102999355A CN201210299935A CN102824620A CN 102824620 A CN102824620 A CN 102824620A CN 2012102999355 A CN2012102999355 A CN 2012102999355A CN 201210299935 A CN201210299935 A CN 201210299935A CN 102824620 A CN102824620 A CN 102824620A
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Abstract
The invention relates to a composition suitable for yang-deficiency physique and its preparation method and use. The preparation method comprises that through a semi-bionic extraction method and an ultrasonic method, medicinal materials are subjected to extraction and purification so that the composition suitable for yang-deficiency physique is prepared. The composition suitable for yang-deficiency physique effectively retains active ingredients, has effects of warming and invigorating kidney yang and dispelling cold-evil and also has unique curative effects on yang-deficiency symptoms.
Description
One, technical field
The present invention relates to a kind of composition and method of making the same and application, particularly a kind of employing is the compositions of raw material production with Cortex Cinnamomi, Poria, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Colla Corii Asini.
Two, background technology
Subhealth state is a kind of critical state, is in the people of sub-health state, though there is not clear and definite disease; Body does not have organic disease; But the decline of spiritual vigor and adaptive capacity occurs,, be very easy to cause psychosomatic disease if this state can not be corrected timely.Now people's health care consciousness strengthens gradually, and much human is understood the discomfort of self, but definite symptom is can not check in the doctor trained in Western medicine inspection, and the doctor can't be with targetedly medicine and treat.Like yang deficiency body constitution, the crowd of yang deficiency body constitution is general, and fear is cold, and limb is cool, tastelessness and no thirst, or desire for hot drinks, or spontaneous perspiration, and clear urine in large amounts or oliguria are unfavorable, and it is thin to defecate, and complexion light is white, hyposexuality, light red tongue is fat, white, slippery and moist fur, deep-slow pulse is unable.Similarly symptom does not have clear and definite definition in doctor trained in Western medicine, can only open Chinese medicine by the traditional Chinese medical science and nurse one's health.The Chinese medicine conditioning then need be taken Chinese medicine for a long time, but boiling of Chinese medicine is more time-consuming, and mouthfeel is bad, is unfavorable for that people conveniently take.In addition, Subhealth treating is a very long relatively process, and secular conditioning process is good with dietetic therapy; Through inquiry, there is not commercially available similar conditioning products, the listing of this product at present; Filled up the market vacancy of this series products, adopted the integration of edible and medicinal herbs raw material to process, can take for a long time; Reach the effect of conditioning health, make body constitution recover normal.
Three, summary of the invention
The purpose of this invention is to provide a kind of compositions, method for preparing and application of nursing one's health yang deficiency body constitution.
Compositions provided by the invention realizes through following technical scheme:
A kind of compositions of treating yang deficiency body constitution is characterized in that comprising the raw material of following weight portion: Cortex Cinnamomi 1-5 part, Poria 3-9 part, Rhizoma Zingiberis 1-5 part, Pericarpium Citri Reticulatae 3-8 part, Colla Corii Asini 6-12 part.Parts by weight of raw materials is preferably: 3 parts of Cortex Cinnamomis, 6 parts in Poria, 3 parts of Rhizoma Zingiberiss, 5 parts of Pericarpium Citri Reticulataes, 9 parts in Colla Corii Asini.Can also be by Cortex Cinnamomi 1-5 part, Poria 3-9 part, Rhizoma Zingiberis 1-5 part, Pericarpium Citri Reticulatae 3-8 part, Colla Corii Asini 6-12 part, crystal sugar 1-5 part, Fructus Citri Limoniae powder 3-9 part are prepared from.Weight portion is preferably 3 parts of Cortex Cinnamomis, 6 parts in Poria, 3 parts of Rhizoma Zingiberiss, 5 parts of Pericarpium Citri Reticulataes, 9 parts in Colla Corii Asini, 3 parts in crystal sugar, 6 parts of Fructus Citri Limoniae powder.
The above preparation of compositions method is:
A. choose Cortex Cinnamomi, Rhizoma Zingiberis, the Pericarpium Citri Reticulatae of above weight portion, at first, adding pH value is the water of 3.0-5.0, and amount of water is 8-10 a times of medical material weight, and behind supersound process 20-30min, heating extraction 2 hours filters; Then, add the water that pH value is 5.5-7.0, amount of water is 8-10 a times of medical material weight, heating extraction 1-1.5 hour, filters; Add the water that pH value is 7.5-9.0 again, amount of water be medical material weight 8-10 doubly, heating extraction 1-1.5 hour, filter merging filtrate, and to become relative density in 55 ℃ of concentrating under reduced pressure be that the clear paste of 1.20-1.30 is subsequent use;
B. Poria, the Colla Corii Asini of getting said weight portion are ground into fine powder, and the clear paste that makes with above-mentioned A step mixes, and add crystal sugar, Fruit powder, process granule, tablet, capsule or oral liquid.
Said compositions is used for the application of yang deficiency body constitution medicine in preparation, it is characterized in that having the improvement effect for yang deficiency body constitution, and the sign performance is mainly: fear cold; Limb is cool, tastelessness and no thirst, or desire for hot drinks, or spontaneous perspiration; clear urine in large amounts or oliguria are unfavorable, and it is thin to defecate, and complexion light is white, hyposexuality; light red tongue is fat, white, slippery and moist fur, deep-slow pulse is unable.
3.1 nursing one's health the compositions of yang deficiency body constitution, the present invention mainly has following creationary useful technique effect:
3.1.1. the extraction of medical material and purification aspect:
Raw material of the present invention is made up of Cortex Cinnamomi, Poria, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Colla Corii Asini, and its prescription is simplified proper, and effect significantly.Cortex Cinnamomi acrid in the mouth in the side and sweet, pure sun hot in nature, gas is fragrant and scurry, and it is supporing yang that function is mended fire, helps monarch fire, warm public region, kidney-Yang invigorating is the meaning monarch drug; Rhizoma Zingiberis is hot, returns spleen, stomach, the heart, lung meridian, function warming YANG gas, and the cold expelling heresy is a ministerial drug; The monarch and his subjects' mutual reinforcement between compatibility then has the effect of warming YANG to expel cold.After the yang deficiency, gas must be not enough, and after the deficiency of vital energy, gas must stasis, so be equipped with Poria spleen invigorating QI invigorating, the Pericarpium Citri Reticulatae promoting the circulation of QI to alleviate the stagnation in middle-JIAO is adjuvant drug; Colla Corii Asini is longer than nourishing YIN and is nourished blood, and can prevent that the monarch and his subjects' medicine is too hot, and can be used as excipient again is messenger drug.All same usefulness of medicine is played warming and recuperating the kidney-YANG, the merit of the cold expelling heresy of dispelling altogether.Our research is on the basis that prescription is confirmed; Extraction and purification process to medical material is completely newly groped; Factors such as medical material physical property, effective ingredient characteristic and production cost have been taken all factors into consideration; Concrete improve be mainly reflected in following some: (1) for the effective ingredient in better utilization Poria, the Colla Corii Asini, with two flavor pulverizing medicinal materials to best particle diameter; (2) other three flavor medical materials, the effect characteristics of Chinese medicine preparation and combine modern biopharmaceutical new technique according to the present invention, we adopt semi-bionic extraction, creationary it have been carried out the extraction purification, have kept active component effectively.Semi-biomimetic method is a kind of Chinese medicine extraction new technique that the imitation oral drugs propose at the gastrointestinal transport process, and it adopts the acid water of selected pH value and alkaline water to extract continuously successively, its objective is to extract to contain index components high " active mixture ".This method is adhered to the viewpoint of " the composition opinion is arranged, not only the composition opinion focusing on the reaction of body pharmacodynamics " in the design of extraction process; Do index with one or more effective ingredient, total extractives and opposed polarity part or main pharmacological; Multifactorial evaluation, the theoretical principle of preferred extraction process can be given full play to the comprehensive function characteristics of mix ingredients like this; Help again controlling the quality of the pharmaceutical preparations, finally obtain being fit to the active ingredient of absorption of human body with monomer component.In the present invention, we are through unremitting effort, through a large amount of experimentatioies; Final also is to have obtained the technical scheme described in the present invention accidentally: promptly extract 3 pH value and be respectively: 3.0-5.0,5.5-7.0,7.5-9.0; Wherein pH value is preferably 4.0,6.0 and 8.0; (3) will extract medical material and pass through ultrasonic pretreatment in advance after; Its extraction ratio of effective constituents significantly improves; Mainly be because through cavitation effect of ultrasonic waves, vibration effect and heating effect, can make the destruction of crude drug cell, thereby quicken the release and the stripping of effective ingredient; To be a very big saving to production cost and production capacity like this, finally be of value to the popularization of industrialization.
3.1.2 pharmacodynamics aspect:
The medicine that has conditioning yang deficiency body constitution in the prior art has much the ginseng antler pill that the product Beijing TongrenTang Pharmaceutical Co., Ltd of good drug efficacy produces.In order to embody the compositions that the present invention prepares the yang deficiency symptom had unforeseeable technique effect; Utilize hydrocortisone intramuscular injection rat to obtain model of yang asthenia; The product and the above product that then the present invention are prepared have carried out contrast experiment's research; In order to illustrate the significant curative effect of product of the present invention, the remarkable useful technique effect that the present invention reaches is described.The concrete experiment as follows:
(1) material and method
1, laboratory animal
The SD rat, male, body weight 180 ± 10g is provided by Shandong University's Experimental Animal Center, production licence number (SCXK (Shandong) 20090001).
2, compositions
The compositions for preparing through the application embodiment 2.
3, main agents
Hydrocortisone, Tianjin gold credit aminoacid company limited, lot number 1007301; Ginseng antler pill, the Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory produces, lot number 1031769.
4, method
4.1 modeling
Rat intramuscular injection every day hydrocortisone 25mg/kg, successive administration 10 days, preparation yang deficiency rat model; The performances such as rat occurs successively that hair color is withered, the mental status is dispirited, moves less, likes flocking together after 10 days, soft stool, counteragent weaken of model group rat intramuscular injection hydrocortisone show the modeling success.
4.2 experiment is divided into groups
Be divided into six groups according to randomization; Normal group, model of yang asthenia group, positive controls and the high, medium and low dose groups of the application's compositions; Every group 10; The high, medium and low dose groups of model of yang asthenia group, positive controls and the present composition, rat every morning gives intramuscular injection hydrocortisone 25mg/kg, and the normal control group gives intramuscular injection equivalent normal saline; From modeling beginning in the 8th day; Every afternoon, positive controls was irritated clothes ginseng antler pill suspension (concentration is 0.6g/kg); The high, medium and low dosage of side of the present invention irritate respectively clothes the application Chinese medicine composition suspension (concentration is 1.2g/kg, 0.6g/kg, 0.3g/kg); The normal control group is irritated clothes equivalent normal saline, continuous 30 days.
4.3 method
(1) level of serum testosterone and SOD, MDA: after last gives the application's compositions filling stomach; All animal subjects are gathered animal blood with a strand arteriovenous blood collection method; Adopt non-anticoagulant blood-collecting pipe to collect, 3000r/min is centrifugal, separates upper serum; A part adopts the radioimmunoassay method to measure serum testosterone content, and all the other measure serum superoxide dismutases SOD and malonaldehyde MDA content; (2) organ coefficient is measured: separation and collection heart, liver, spleen, thymic tissue; (3) genitals's coefficient determination: testis, epididymis, prostate and seminal vesicle, penis and preputial glands tissue.(design factor=organ weights/body weight * 100%)
4.4 result
(1) to the influence of level of serum testosterone.Compare with the normal control group, the level of serum testosterone that gives the animal of hydrocortisone modeling all reduces than the blank group, and significant difference (P＜0.05) is arranged.Prompting; Adopt the obvious decline of intramuscular injection hydrocortisone modeling can causing rat blood serum testosterone levels; High, medium and low dose groups of the present invention and ginseng antler pill positive controls can improve the level of serum testosterone to a certain extent, and the present invention is high, middle dose groups effect is particularly evident.Referring to table 1.
(2) to the influence of SOD, MDA level.Compare with model control group, ginseng antler pill positive controls, the high, medium and low dose groups SOD level of the present composition all have significance rising (p＜0.01 or p＜0.05); Above-mentioned four groups of MDA levels have significance to reduce (p＜0.01 or p＜0.05) than model control group.The result shows that the present composition all has the improvement effect to SOD and the MDA of yang deficiency rat.Referring to table 2.
(3) to the influence of internal organs.With respect to model group, ginseng antler pill positive controls, the high, medium and low dose groups organ coefficient of the present composition all have significant increase (p＜0.01 or p＜0.05).The result shows that the present composition all can increase the organ coefficient of yang deficiency rat, improves its immunity.Referring to table 3.
(4) to genitals's influence.With respect to model group, ginseng antler pill positive controls, the high, medium and low dose groups organ coefficient of the present composition all have significant increase (p＜0.01 or p＜0.05).But signify hydrogen modeling as a result can activate the thing genital atrophy, and coefficient reduces, and the present composition all can improve genitals's coefficient of yang deficiency rat, improves its physiological function.Participate in table 4.
Table 1 couple yang deficiency animal model protective effect serum testosterone level result
Annotate: compare Δ P＜0.05, Δ Δ P＜0.01 with the normal control group; Compare * P＜0.05, * * P＜0.01 with the yang deficiency group
The influence of table 2 couple yang deficiency animal model SOD and MDA
Annotate: compare Δ P＜0.05, Δ Δ P＜0.01 with the normal control group; Compare * P＜0.05, * * P＜0.01 with the yang deficiency group
The influence of table 3 pair yang deficiency animal model organ weights
Annotate: compare Δ P＜0.05, Δ Δ P＜0.01 with the normal control group; Compare * P＜0.05, * * PP＜0.01 with the yang deficiency group
The influence of table 4 pair yang deficiency animal model weight of reproductive organs
Annotate: compare Δ P＜0.05, Δ Δ P＜0.01 with the normal control group; Compare * P＜0..5, * * P＜0.01 with the yang deficiency group
Four, specific embodiment
Embodiment 1
A, choose Cortex Cinnamomi 100g, Rhizoma Zingiberis 100g, Pericarpium Citri Reticulatae 300g, at first, add pH value and be 3.0 water, amount of water is 8 times of medical material weight, and behind supersound process 20min, heating extraction 2 hours filters; Then, add pH value and be 5.5 water, amount of water is 8 times of medical material weight, and heating extraction 1 hour filters; Add pH value again and be 7.5 water, amount of water is 8 times of medical material weight, and heating extraction 1 hour filters, merging filtrate, and to become relative density in 55 ℃ of concentrating under reduced pressure be that 1.20 clear paste is subsequent use;
B. get Poria 300g, Colla Corii Asini 600g is ground into fine powder, the clear paste that makes with above-mentioned A step mixes, and adds crystal sugar 100g, Fructus Citri Limoniae powder 300g, processes granule, tablet, capsule or oral liquid.
Embodiment 2
A, choose Cortex Cinnamomi 300g, Rhizoma Zingiberis 300g, Pericarpium Citri Reticulatae 500g, at first, add pH value and be 4.0 water, amount of water and medical material weight ratio are 9 times, behind supersound process 25min, and heating extraction 2 hours, filtration; Then, add pH value and be 6 water, amount of water is 9 times of medical material weight, and heating extraction 1 hour filters; Add pH value again and be 8 water, amount of water is 9 times of medical material weight, and heating extraction 1 hour filters, merging filtrate, and to become relative density in 55 ℃ of concentrating under reduced pressure be that 1.25 clear paste is subsequent use;
B. get Poria 600g, Colla Corii Asini 900g is ground into fine powder, the clear paste that makes with above-mentioned A step mixes, and adds crystal sugar 300g, Fructus Citri Limoniae powder 600g, processes granule, tablet, capsule or oral liquid.
Embodiment 3
A, choose Cortex Cinnamomi 500g, Rhizoma Zingiberis 500g, Pericarpium Citri Reticulatae 800g, at first, add pH value and be 5.0 water, amount of water and medical material weight ratio are 10 times, behind supersound process 30min, and heating extraction 2 hours, filtration; Then, add pH value and be 7 water, amount of water is 10 times of medical material weight, and heating extraction 1 hour filters; Add pH value again and be 9 water, amount of water is 10 times of medical material weight, and heating extraction 1 hour filters, merging filtrate, and to become relative density in 55 ℃ of concentrating under reduced pressure be that 1.30 clear paste is subsequent use;
B. get Poria 900g, Colla Corii Asini 1200g is ground into fine powder, the clear paste that makes with above-mentioned A step mixes, and adds crystal sugar 500g, Fructus Citri Limoniae powder 900g, processes granule, tablet, capsule or oral liquid.
Claims (6)
1. compositions of treating yang deficiency body constitution is characterized in that comprising the raw material of following weight portion:
Cortex Cinnamomi 1-5 part, Poria 3-9 part, Rhizoma Zingiberis 1-5 part, Pericarpium Citri Reticulatae 3-8 part, Colla Corii Asini 6-12 part.
2. compositions according to claim 1 is characterized in that comprising the raw material of following weight portion:
3 parts of Cortex Cinnamomis, 6 parts in Poria, 3 parts of Rhizoma Zingiberiss, 5 parts of Pericarpium Citri Reticulataes, 9 parts in Colla Corii Asini.
3. compositions according to claim 1 is characterized in that by Cortex Cinnamomi 1-5 part, Poria 3-9 part, Rhizoma Zingiberis 1-5 part, Pericarpium Citri Reticulatae 3-8 part, Colla Corii Asini 6-12 part, crystal sugar 1-5 part, Fructus Citri Limoniae powder 3-9 part are prepared from.
4. compositions according to claim 3 is characterized in that by 3 parts of Cortex Cinnamomis, 6 parts in Poria, 3 parts of Rhizoma Zingiberiss, 5 parts of Pericarpium Citri Reticulataes, 9 parts in Colla Corii Asini, 3 parts in crystal sugar, Fructus Citri Limoniae powder are prepared from for 6 parts.
5. one of any said preparation of compositions method of a claim 1-4 the steps include:
A. choose Cortex Cinnamomi, Rhizoma Zingiberis, the Pericarpium Citri Reticulatae of said weight portion, at first, adding pH value is the water of 3.0-5.0, and amount of water is 8-10 a times of medical material weight, and behind supersound process 20-30min, heating extraction 2 hours filters; Then, add the water that pH value is 5.5-7.0, amount of water is 8-10 a times of medical material weight, heating extraction 1-1.5 hour, filters; Add the water that pH value is 7.5-9.0 again, amount of water be medical material weight 8-10 doubly, heating extraction 1-1.5 hour, filter merging filtrate, and to become relative density in 55 ℃ of concentrating under reduced pressure be that the clear paste of 1.20-1.30 is subsequent use;
B. Poria, the Colla Corii Asini of getting said weight portion are ground into fine powder, and the clear paste that makes with above-mentioned A step mixes, and add crystal sugar, Fruit powder, process granule, tablet, capsule or oral liquid.
6. be used for the application of yang deficiency body constitution medicine according to one of any said compositions of claim 1-4 in preparation, it is characterized in that having the improvement effect for yang deficiency body constitution, the sign performance is mainly: fear cold; Limb is cool, tastelessness and no thirst, or desire for hot drinks, or spontaneous perspiration; clear urine in large amounts or oliguria are unfavorable, and it is thin to defecate, and complexion light is white, hyposexuality; light red tongue is fat, white, slippery and moist fur, deep-slow pulse is unable.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113304242A (en) * | 2021-07-06 | 2021-08-27 | 河南中医药大学 | Medicinal liquor for tonifying kidney and strengthening yang |
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| CN1279090A (en) * | 1999-06-25 | 2001-01-10 | 刘永香 | Powdered medicine for conditioning viscera and whole body |
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| CN1279090A (en) * | 1999-06-25 | 2001-01-10 | 刘永香 | Powdered medicine for conditioning viscera and whole body |
| CN102008391A (en) * | 2010-09-26 | 2011-04-13 | 江苏省中医院 | Method for solidifying traditional Chinese ointment |
| CN102614356A (en) * | 2012-04-20 | 2012-08-01 | 吕宝俊 | Chinese angelica, Chinese gentian and aloe membrane coat tablet and preparation method thereof |
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| 严石林等: "脾肾阳虚常见假热证辨析", 《中国中医基础医学杂志》, vol. 17, no. 9, 30 September 2011 (2011-09-30), pages 942 - 943 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113304242A (en) * | 2021-07-06 | 2021-08-27 | 河南中医药大学 | Medicinal liquor for tonifying kidney and strengthening yang |
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Application publication date: 20121219 |