CN102824600B - Pure traditional Chinese medicine preparation for nourishing liver, protecting liver, softening liver and shrinking spleen and preparation method thereof - Google Patents
Pure traditional Chinese medicine preparation for nourishing liver, protecting liver, softening liver and shrinking spleen and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine for treating liver diseases, and especially relates to a pure traditional Chinese medicine preparation for nourishing liver, protecting liver, softening liver and shrinking spleen and a preparation method thereof. In the formula, bear gall is used for clearing heat, cooling liver, and promoting choleresis; Sichuan coptis chinensis is used for clearing heat with bitter-cold, and eliminating damp phlegm; indigo naturalis is used for clearing heat, and removing jaundice; and ground beetle, radix curcumae, and safflower are used for eliminating blood stasis and dredging collaterals. Tortoise plastron, pangolin, and turtle shell are used for nourishing yin, promoting diuresis, and assisting stasis removal; American ginseng, donkey-hide gelatin, and cordyceps sinensis are used for supporting right, securing root, moving qi, invigorating spleen, eliminating blood stasis and resolving dampness; polyporus, couch grass roots, pericarpium arecae, and the like are used for treating internal retention of water, invigorating spleen, and disinhibiting dampness; bighead atractylodes rhizome, and Chinese yam are combined for clearing heat, cooling liver, activating blood, dissolving stasis, replenishing qi, invigorating spleen, soothing liver, moving qi, promoting diuresis, and eliminating edema. The prescription has the effect of nourishing liver, protecting liver, softening liver and shrinking spleen after long-term administration, and has optimal treatment efficacy on treating hepatic fibrosis, liver ascites, cirrhotic ascites by traditional Chinese medicine.
Description
Technical field
The present invention relates to treat the field of Chinese medicines of hepatopathy, relate in particular to pure Chinese medicinal preparation of a kind of nourishing the liver hepatoprotective, Softing liver and contracting spleen and preparation method thereof.
Background technology
There is ascites in active liver cirrhosis, Chang Rongyi; Show as abdominal distention and oliguria.Ascites is roughly to be caused by portal hypertension, hypoproteinemia, endocrine disturbance, lymphostasis factor.
The essence of liver cirrhosis is a large amount of hypertrophy of collagen fiber in liver, and " workshop " of manufacturing collagen fiber is fibroblasts, this cell, under hepatitis virus, ethanol, organophosphor etc. stimulate, can generate tropocollagen molecule secretion and discharge and be deposited on liver, finally causes in liver extensively fibrosis.
Summary of the invention
The object of invention: in order to provide one can effectively suppress liver cirrhosis, the effectively pure Chinese medicinal preparation of nourishing the liver hepatoprotective, Softing liver and contracting spleen.
Another object of the present invention is to provide the preparation method of this Chinese medicine preparation based on this composition of raw materials.
In order to reach as above object, the present invention takes following technical scheme: the pure Chinese medicinal preparation of a kind of nourishing the liver hepatoprotective, Softing liver and contracting spleen, it is characterized in that, it is prepared by the raw material that comprises following weight portion: processed with vinegar Carapax et Plastrum Testudinis 10-15 part, stir-baked SQUAMA MANITIS 10-15 part, Radix Panacis Quinquefolii 10-15 part, 3 parts of Fel Ursis, Cordyceps 2-5 part, Rhizoma Coptidis 3-6 part, Eupolyphaga Seu Steleophaga 10-15 part, Radix Curcumae 6-10 part, Colla Corii Asini 9-15 part, Polyporus 10-15 part, Rhizoma Atractylodis Macrocephalae (parched) 10-15 part, Rhizoma dioscoreae (parched) 10-15 part.
The further technical scheme of the present invention is, its raw material also comprises following component: Carapax Trionycis (processed with vinegar) 10-15 part, Stigma Croci 2-5 part, 3 parts of Indigo Naturaliss, Fructus Amomi 6-12 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Imperatae 6-12 part, Folium Eriobotryae 3-6 part, Pericarpium Arecae 3-6 part, Poria 10-15 part, Rhizoma Alismatis 10-15 part, Herba Taraxaci 10-15 part, Herba Violae 10-15 part.
The further technical scheme of the present invention is, described components by weight percent is 12 parts of processed with vinegar Carapax et Plastrum Testudiniss, 12 parts of stir-baked SQUAMA MANITISs, 12 parts of Carapax Trionycis (processed with vinegar), 3 parts of Stigma Crocis, 12 parts of Radix Panacis Quinquefoliis, 3 parts of Fel Ursis, 3 parts of Cordyceps, 5 parts of Rhizoma Coptidis, 12 parts of Eupolyphaga Seu Steleophagas, 3 parts of Indigo Naturaliss, 9 parts of Fructus Amomis, 9 parts of Radix Curcumaes, 12 parts, Colla Corii Asini, 12 parts of Polyporus, 12 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 12 parts of Rhizoma dioscoreae (parched)s, 9 parts of Rhizoma Imperataes, 5 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 12 parts, Poria, 12 parts of Rhizoma Alismatis, 12 parts of Herba Taraxacis, 12 parts of Herba Violaes.
Preparation is the method for the pure Chinese medicinal preparation of any described a kind of nourishing the liver hepatoprotective, Softing liver and contracting spleen as above, it is characterized in that, comprises following steps:
Preliminary powder process: get Stigma Croci, Fel Ursi, Cordyceps, Indigo Naturalis, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves for subsequent use;
Decoct and filter: processed with vinegar Carapax et Plastrum Testudinis, stir-baked SQUAMA MANITIS, Carapax Trionycis (processed with vinegar) are put into water and soaked 30 minutes post-heating to boiling, decoct after 30 minutes, add Radix Panacis Quinquefolii, Rhizoma Coptidis, Eupolyphaga Seu Steleophaga, Fructus Amomi, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma dioscoreae (parched), Rhizoma Imperatae, Folium Eriobotryae, Pericarpium Arecae, Poria, Rhizoma Alismatis, Herba Taraxaci, Herba Violae, first pass adds pentaploid accumulated amount water to be heated to boiling, decoct 1.5 hours, emit filtrate; Add triploid accumulated amount water for second time, be heated to boiling, decoct 1 hour, emit filtrate; Add triploid accumulated amount water the 3rd time, be heated to boiling, decoct 1 hour, emit filtrate;
Concentrated and finished product preparation: above filtrate is merged, leave standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned fine powder for subsequent use to mix and point turn.
Adopt as above the present invention of technical scheme, there is following beneficial effect: Fang Zhong, the cool liver function of gallbladder promoting of Fel Ursi heat clearing away, Rhizoma Coptidis clearing up internal heat by using drugs of bitter in taste and cold in nature, dampness expectorant, Indigo Naturalis can heat clearing away jaundice eliminating, and eupolyphaga, Radix Curcumae, Flos Carthami, row scattered silt hinder in network.Processed with vinegar Carapax et Plastrum Testudinis, Squama Manis, Carapax Trionycis (processed with vinegar), yin nourishing diuretic, assistant is with blood stasis dispelling, and treatment retention of water-damp in the body, invigorating spleen to remove dampness, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma dioscoreae (parched), all medicines such as the logical silt of Radix Panacis Quinquefolii, Colla Corii Asini, Cordyceps, strengthening the body resistance circulation of qi promoting spleen invigorating, removing dampness, Polyporus, Rhizoma Imperatae, large abdomen share altogether and play, the cool liver of heat clearing away, blood circulation promoting and blood stasis dispelling, replenishing QI to invigorate the spleen, soothing the liver circulation of qi promoting, inducing diuresis to remove edema.
This prescription life-time service can reach nourishing the liver hepatoprotective, and the effect of Softing liver and contracting spleen, in Chinese traditional treatment hepatic fibrosis, hepatic ascites, cirrhotic ascites, reach optimal treatment special effect.
Detailed description of the invention
Below embodiments of the invention are described, embodiment is not construed as limiting the invention:
The applicant thinks:
Liver cirrhosis mainly can be divided into aspect dialectical:
(1) deficiency of spleen-YANG and kidneyYANG, stagnation of QI and blood, retention of water-damp in the body.
(2) stagnation of QI congestion, retention of water-damp in the body.
(3) hepatic and renal YIN deficiency, damp and hot stagnation, retention of water-damp in the body.
(4) stagnation of QI due to depression of the liver, phlegm-damp resistance network cause.
The commitment forming at collagen fiber, microfibre can be dissolved by weak acid, and this is the opportune moment of reversing liver cirrhosis, and the collagen fiber in liver cirrhosis later stage are also non-iron-plated, still may cut off and open this helical structure by the interior protease of body.The a large amount of clinical experiences of method by traditional Chinese medical herbal treatment show, if dialectical accurately, conditioning appropriateness, treatment do in the proper way, in liver fibrous scar voluntarily gradually degraded, fiber from the coarse to fine, by thick attenuation, by longly shortening, these broken fubrils are engulfed, remove by defense cell in liver again.Meanwhile, liver is brought into play powerful regeneration capacity, rebuilds normal hepatocytes leaflet structure, finally all replaces pseudolobuli, recovers normal hepatocytes function.
Three embodiment of the special proposition of the applicant, are described in detail specific embodiment of the invention:
Embodiment 1:
Preliminary powder process: get 9 parts of 2 parts of Stigma Crocis, 3 parts of Fel Ursis, 2 parts of Cordyceps, 3 parts of Indigo Naturaliss, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves for subsequent use;
Decoct and filter: 10 parts of 10 parts of processed with vinegar Carapax et Plastrum Testudiniss, 10 parts of stir-baked SQUAMA MANITISs, Carapax Trionycis (processed with vinegar) are put into water and soaked 30 minutes post-heating to boiling, decoct after 30 minutes, add 10 parts of Radix Panacis Quinquefoliis, 3 parts of Rhizoma Coptidis, 10 parts of Eupolyphaga Seu Steleophagas, 6 parts of Radix Curcumaes, 9 parts, Colla Corii Asini, 10 parts of Polyporus, 10 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 10 parts of Rhizoma dioscoreae (parched)s.6 parts of Fructus Amomis, 10 parts of Radix Angelicae Sinensis, 6 parts of Rhizoma Imperataes, 3 parts of Folium Eriobotryaes, 3 parts of Pericarpium Arecae, 10 parts, Poria, 10 parts of Rhizoma Alismatis, 10 parts of Herba Taraxacis, 10 parts of Herba Violaes, first pass adds pentaploid accumulated amount water to be heated to boiling, decocts 1.5 hours, emits filtrate; Add triploid accumulated amount water for second time, be heated to boiling, decoct 1 hour, emit filtrate; Add triploid accumulated amount water the 3rd time, be heated to boiling, decoct 1 hour, emit filtrate;
Concentrated and finished product preparation: above filtrate is merged, leave standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned fine powder for subsequent use to mix and point turn.
Embodiment 2;
Preliminary powder process: get 15 parts of 5 parts of Stigma Crocis, 3 parts of Fel Ursis, 5 parts of Cordyceps, 3 parts of Indigo Naturaliss, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves for subsequent use;
Decoct and filter: 15 parts of 15 parts of processed with vinegar Carapax et Plastrum Testudiniss, 15 parts of stir-baked SQUAMA MANITISs, Carapax Trionycis (processed with vinegar) are put into water and soaked 30 minutes post-heating to boiling, decoct after 30 minutes, add 15 parts of Radix Panacis Quinquefoliis, 6 parts of Rhizoma Coptidis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Radix Curcumaes, 15 parts, Colla Corii Asini, 15 parts of Polyporus, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 15 parts of Rhizoma dioscoreae (parched)s.12 parts of Fructus Amomis, 15 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Imperataes, 6 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 15 parts, Poria, 15 parts of Rhizoma Alismatis, 15 parts of Herba Taraxacis, 15 parts of Herba Violaes, first pass adds pentaploid accumulated amount water to be heated to boiling, decocts 1.5 hours, emits filtrate; Add triploid accumulated amount water for second time, be heated to boiling, decoct 1 hour, emit filtrate; Add triploid accumulated amount water the 3rd time, be heated to boiling, decoct 1 hour, emit filtrate;
Concentrated and finished product preparation: above filtrate is merged, leave standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned fine powder for subsequent use to mix and point turn.
Embodiment 3;
Preliminary powder process: get 12 parts of 3 parts of Stigma Crocis, 3 parts of Fel Ursis, 3 parts of Cordyceps, 3 parts of Indigo Naturaliss, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves for subsequent use;
Decoct and filter: 12 parts of 12 parts of processed with vinegar Carapax et Plastrum Testudiniss, 12 parts of stir-baked SQUAMA MANITISs, Carapax Trionycis (processed with vinegar) are put into water and soaked 30 minutes post-heating to boiling, decoct after 30 minutes, add 12 parts of Radix Panacis Quinquefoliis, 5 parts of Rhizoma Coptidis, 12 parts of Eupolyphaga Seu Steleophagas, Fructus Amomi 9-part, 9 parts of Radix Curcumaes, 12 parts, Colla Corii Asini, 12 parts of Polyporus, 12 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 12 parts of Rhizoma dioscoreae (parched)s, 9 parts of Rhizoma Imperataes, 5 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 12 parts, Poria, 12 parts of Rhizoma Alismatis, 12 parts of Herba Taraxacis, 12 parts of Herba Violaes, first pass adds pentaploid accumulated amount water to be heated to boiling, decoct 1.5 hours, emit filtrate; Add triploid accumulated amount water for second time, be heated to boiling, decoct 1 hour, emit filtrate; Add triploid accumulated amount water the 3rd time, be heated to boiling, decoct 1 hour, emit filtrate;
Concentrated and finished product preparation: above filtrate is merged, leave standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned fine powder for subsequent use to mix and point turn.Function: heat clearing away, blood circulation promoting and blood stasis dispelling, replenishing QI to invigorate the spleen, soothing the liver circulation of qi promoting, inducing diuresis to remove edema.
Cure mainly: cause hepatic fibrosis, liver cirrhosis, ascites by a variety of causes.
Usage and dosage: be decocted in water for oral dose, every day 2 times, a 200ml.
To take continuously 30 days as a course for the treatment of.
The preferred decoction of the present invention, but other dosage form mutation that dosage form can not adopt the present invention produce restriction, take appropriate process, and the present invention can make other dosage forms.
Adopt " Softing liver and contracting spleen soup " preparation of as above technical scheme and preparation method thereof, in clinical practice application, discovery can generate protease cut-out in having degraded liver collagen fiber, open its helical structure of liver collagen fiber, thereby reach degraded Kupffer Cell and endotheliocyte, stop, suppress even to reverse the process of liver fiber, thereby reach the effect of the liver fiber of healing.
Usually there is hypersplenism phenomenon liver cirrhosis later stage patient with ascites in liver cirrhosis patient, thus effect that this programme has easing the affected liver, function of gallbladder promoting, antiinflammatory, eliminating dampness by diuresis, invigorates blood circulation, circulation of qi promoting reaches soft liver contracting.
Enclose clinical experiment report:
Clinical experiment report
known by above analysis, drug effect of the present invention is outstanding, has the splendid effect of curing the disease.more than show and described ultimate principle of the present invention, principal character and advantage of the present invention.Those skilled in the art should understand the present invention and not be restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in claimed scope.
Claims (2)
1. a nourishing the liver hepatoprotective, the pure Chinese medicinal preparation of Softing liver and contracting spleen, it is characterized in that, its preparation of raw material by following weight portion: processed with vinegar Carapax et Plastrum Testudinis 10-15 part, stir-baked SQUAMA MANITIS 10-15 part, Radix Panacis Quinquefolii 10-15 part, 3 parts of Fel Ursis, Cordyceps 2-5 part, Rhizoma Coptidis 3-6 part, Eupolyphaga Seu Steleophaga 10-15 part, Radix Curcumae 6-10 part, Colla Corii Asini 9-15 part, Polyporus 10-15 part, Rhizoma Atractylodis Macrocephalae (parched) 10-15 part, Rhizoma dioscoreae (parched) 10-15 part, Carapax Trionycis (processed with vinegar) 10-15 part, Stigma Croci 2-5 part, 3 parts of Indigo Naturaliss, Fructus Amomi 6-12 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Imperatae 6-12 part, Folium Eriobotryae 3-6 part, Pericarpium Arecae 3-6 part, Poria 10-15 part, Rhizoma Alismatis 10-15 part, Herba Taraxaci 10-15 part, Herba Violae 10-15 part.
2. a kind of nourishing the liver hepatoprotective as claimed in claim 1, the pure Chinese medicinal preparation of Softing liver and contracting spleen, it is characterized in that, raw material preparation by following weight portion: 12 parts of processed with vinegar Carapax et Plastrum Testudiniss, 12 parts of stir-baked SQUAMA MANITISs, 12 parts of Carapax Trionycis (processed with vinegar), 3 parts of Stigma Crocis, 12 parts of Radix Panacis Quinquefoliis, 3 parts of Fel Ursis, 3 parts of Cordyceps, 5 parts of Rhizoma Coptidis, 12 parts of Eupolyphaga Seu Steleophagas, 3 parts of Indigo Naturaliss, 9 parts of Fructus Amomis, 9 parts of Radix Curcumaes, 12 parts, Colla Corii Asini, 12 parts of Polyporus, 12 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 12 parts of Rhizoma dioscoreae (parched)s, 9 parts of Rhizoma Imperataes, 5 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 12 parts, Poria, 12 parts of Rhizoma Alismatis, 12 parts of Herba Taraxacis, 12 parts of Herba Violaes.
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| CN103071122A (en) * | 2013-02-04 | 2013-05-01 | 上海浦东高星生物技术研究所 | Jiashu swelling eliminating powder |
| CN105056101A (en) * | 2015-07-16 | 2015-11-18 | 陆开云 | Liver-nourishing-and-protecting traditional Chinese medicine |
| CN105597081A (en) * | 2016-01-29 | 2016-05-25 | 程龙 | Medicine for reducing hypertension |
| CN105709206A (en) * | 2016-01-29 | 2016-06-29 | 程潜 | Medicine for treating fatty liver, hepatitis and liver cirrhosis |
| CN106963916A (en) * | 2016-12-31 | 2017-07-21 | 麻凯 | Softing liver and contracting spleen decocts tea |
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