CN102824600A - Pure traditional Chinese medicine preparation for nourishing liver, protecting liver, softening liver and shrinking spleen and preparation method thereof - Google Patents
Pure traditional Chinese medicine preparation for nourishing liver, protecting liver, softening liver and shrinking spleen and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine for treating liver diseases, and especially relates to a pure traditional Chinese medicine preparation for nourishing liver, protecting liver, softening liver and shrinking spleen and a preparation method thereof. In the formula, bear gall is used for clearing heat, cooling liver, and promoting choleresis; Sichuan coptis chinensis is used for clearing heat with bitter-cold, and eliminating damp phlegm; indigo naturalis is used for clearing heat, and removing jaundice; and ground beetle, radix curcumae, and safflower are used for eliminating blood stasis and dredging collaterals. Tortoise plastron, pangolin, and turtle shell are used for nourishing yin, promoting diuresis, and assisting stasis removal; American ginseng, donkey-hide gelatin, and cordyceps sinensis are used for supporting right, securing root, moving qi, invigorating spleen, eliminating blood stasis and resolving dampness; polyporus, couch grass roots, pericarpium arecae, and the like are used for treating internal retention of water, invigorating spleen, and disinhibiting dampness; bighead atractylodes rhizome, and Chinese yam are combined for clearing heat, cooling liver, activating blood, dissolving stasis, replenishing qi, invigorating spleen, soothing liver, moving qi, promoting diuresis, and eliminating edema. The prescription has the effect of nourishing liver, protecting liver, softening liver and shrinking spleen after long-term administration, and has optimal treatment efficacy on treating hepatic fibrosis, liver ascites, cirrhotic ascites by traditional Chinese medicine.
Description
Technical field
The present invention relates to treat the field of Chinese medicines of hepatopathy, relate in particular to pure Chinese medicinal preparation of a kind of nourishing the liver hepatoprotective, Softing liver and contracting spleen and preparation method thereof.
Background technology
Ascites appears in active liver cirrhosis, Chang Rongyi; Show as abdominal distention and oliguria.Ascites roughly is to be caused by portal hypertension, hypoproteinemia, endocrine disturbance, lymphatic return barrier factors.
The essence of liver cirrhosis is a large amount of hypertrophy of collagen fiber in the liver; And " workshop " of making collagen fiber is fibroblasts; This cell can generate the discharge of tropocollagen molecule justacrine and be deposited on liver under hepatitis virus, ethanol, organophosphor etc. stimulate, and causes extensive fibrosis in the liver at last.
Summary of the invention
The purpose of invention: can effectively suppress liver cirrhosis in order to provide a kind of, effectively the pure Chinese medicinal preparation of nourishing the liver hepatoprotective, Softing liver and contracting spleen.
Another object of the present invention provides the method for preparing based on this Chinese medicine preparation of this composition of raw materials.
In order to reach as above purpose; The present invention takes following technical scheme: the pure Chinese medicinal preparation of a kind of nourishing the liver hepatoprotective, Softing liver and contracting spleen; It is characterized in that it is by the feedstock production that comprises following weight portion: Carapax et Plastrum Testudinis (processed with vinegar) 10-15 part, stir-baked SQUAMA MANITIS 10-15 part, Radix Panacis Quinquefolii 10-15 part, 3 parts of Fel Ursis, Cordyceps 2-5 part, Rhizoma Coptidis 3-6 part, Eupolyphaga Seu Steleophaga 10-15 part, Radix Curcumae 6-10 part, Colla Corii Asini 9-15 part, Polyporus 10-15 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 10-15 part, Rhizoma Dioscoreae (stir-fry) 10-15 part.
The further technical scheme of the present invention is that its raw material also comprises following component: Carapax Trionycis (processed with vinegar) 10-15 part, Stigma Croci 2-5 part, 3 parts of Indigo Naturaliss, Fructus Amomi 6-12 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Imperatae 6-12 part, Folium Eriobotryae 3-6 part, Pericarpium Arecae 3-6 part, Poria 10-15 part, Rhizoma Alismatis 10-15 part, Herba Taraxaci 10-15 part, Herba Violae 10-15 part.
The further technical scheme of the present invention is, described components by weight percent be 12 parts of Carapax et Plastrum Testudiniss (processed with vinegar), 12 parts of stir-baked SQUAMA MANITISs, 12 parts of Carapax Trionycis (processed with vinegar), 3 parts of Stigma Crocis, 12 parts of Radix Panacis Quinquefoliis, 3 parts of Fel Ursis, 3 parts of Cordyceps, 5 parts of Rhizoma Coptidis, 12 parts of Eupolyphaga Seu Steleophagas, 3 parts of Indigo Naturaliss, Fructus Amomi 9-part, 9 parts of Radix Curcumaes, 12 parts in Colla Corii Asini, 12 parts of Polyporus, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 12 parts of Rhizoma Dioscoreaes (stir-fry),, 9 parts of Rhizoma Imperataes, 5 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 12 parts in Poria, 12 parts of Rhizoma Alismatis, 12 parts of Herba Taraxacis, 12 parts of Herba Violaes.
The method of the pure Chinese medicinal preparation of the as above any described a kind of nourishing the liver hepatoprotective of preparation, Softing liver and contracting spleen is characterized in that, comprises following steps:
Preliminary powder process: get Stigma Croci, Fel Ursi, Cordyceps, Indigo Naturalis, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves subsequent use;
Decoct and filter: medical material Carapax et Plastrum Testudinis, stir-baked SQUAMA MANITIS, Carapax Trionycis are put into water and are soaked 30 minutes post-heating to boiling; After decocting 30 minutes; Add Radix Panacis Quinquefolii, Rhizoma Coptidis, Eupolyphaga Seu Steleophaga, Fructus Amomi, Radix Curcumae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Rhizoma Imperatae, Folium Eriobotryae, Pericarpium Arecae, Poria, Rhizoma Alismatis, Herba Taraxaci, Herba Violae; First pass adds the long-pending water gaging of pentaploid and is heated to boiling, decocts 1.5 hours, emits filtrating; Add the long-pending water gaging of triploid for second time, be heated to boiling, decocted 1 hour, emit filtrating; Add the long-pending water gaging of triploid for the 3rd time, be heated to boiling, decocted 1 hour, emit filtrating;
Concentrated and finished product prepares: above filtrating is merged, left standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned subsequent use fine powder mixing and divide commentaries on classics to get final product.
Adopt as above the present invention of technical scheme, have following beneficial effect: in the side, the cool liver function of gallbladder promoting of Fel Ursi heat clearing away, the Rhizoma Coptidis clearing up internal heat by using drugs of bitter in taste and cold in nature, dampness expectorant, Indigo Naturalis can the heat clearing away jaundice eliminating, and eupolyphaga, Radix Curcumae, Flos Carthami, row loose to become silted up and hinder in network.Carapax et Plastrum Testudinis, Squama Manis, Carapax Trionycis, yin nourishing diuretic; Assistant is with blood stasis dispelling, and treatment retention of water-damp in the bodys, invigorating spleen to remove dampness, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, all medicines such as Radix Panacis Quinquefolii, Colla Corii Asini, Cordyceps, the logical silt of strengthening the body resistance circulation of qi promoting spleen invigorating, removing dampness, Polyporus, Rhizoma Imperatae, big abdomen share altogether and play, heat clearing away cold liver, blood circulation promoting and blood stasis dispelling, replenishing QI to invigorate the spleen, soothing the liver circulation of qi promoting, inducing diuresis to remove edema.
This prescription life-time service can reach the nourishing the liver hepatoprotective, and the effect of Softing liver and contracting spleen is in Chinese traditional treatment hepatic fibrosis, hepatic ascites, cirrhotic ascites, reach the optimal treatment special effect.
The specific embodiment
Describe in the face of embodiments of the invention down, embodiment is not construed as limiting the invention:
The applicant thinks:
Liver cirrhosis mainly can be divided into aspect dialectical:
(1) deficiency of spleen-YANG and kidneyYANG, stagnation of QI and blood, retention of water-damp in the body.
(2) stagnation of QI congestion, retention of water-damp in the body.
(3) hepatic and renal YIN deficiency, damp and hot stagnation, retention of water-damp in the body.
(4) stagnation of QI due to depression of the liver, phlegm-damp resistance network cause.
At the commitment that collagen fiber form, microfibre can be dissolved by weak acid, and this is the opportune moment of reversing liver cirrhosis, and the collagen fiber in liver cirrhosis later stage are also non-iron-plated, still possibly cut off and open this helical structure by some protease in the body.Show through a large amount of clinical experiences of the method for traditional Chinese medical herbal treatment, if dialectical accurately, conditioning appropriateness, treatment do in the proper way, in the liver fibrous scar voluntarily gradually degraded, fiber from the coarse to fine, by thick attenuation, by longly shorten, these broken fubrils are engulfed, remove by defense cell in the liver again.Meanwhile, liver is brought into play powerful regeneration capacity, rebuilds the normal hepatocytes leaflet structure, all replaces pseudolobuli finally, recovers the normal hepatocytes function.
Three embodiment of the special proposition of the applicant, do to specify practical implementation of the present invention:
Embodiment 1:
Preliminary powder process: get 9 parts of 2 parts of Stigma Crocis, 3 parts of Fel Ursis, 2 parts of Cordyceps, 3 parts of Indigo Naturaliss, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves subsequent use;
Decoct and filter: 10 parts of medical material Carapax et Plastrum Testudiniss (processed with vinegar), 10 parts of stir-baked SQUAMA MANITISs, Carapax Trionycis (processed with vinegar) are put into water for 10 parts and are soaked 30 minutes post-heating to boiling; After decocting 30 minutes, add 10 parts of Radix Panacis Quinquefoliis, 3 parts of Rhizoma Coptidis, 10 parts of Eupolyphaga Seu Steleophagas, 6 parts of Radix Curcumaes, 9 parts in Colla Corii Asini, 10 parts of Polyporus, 10 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 10 parts of Rhizoma Dioscoreaes (stir-fry).6 parts of Fructus Amomis, 10 parts of Radix Angelicae Sinensis, 6 parts of Rhizoma Imperataes, 3 parts of Folium Eriobotryaes, 3 parts of Pericarpium Arecae, 10 parts in Poria, 10 parts of Rhizoma Alismatis, 10 parts of Herba Taraxacis, 10 parts of Herba Violaes, first pass add the long-pending water gaging of pentaploid and are heated to boiling, decoct 1.5 hours, emit filtrating; Add the long-pending water gaging of triploid for second time, be heated to boiling, decocted 1 hour, emit filtrating; Add the long-pending water gaging of triploid for the 3rd time, be heated to boiling, decocted 1 hour, emit filtrating;
Concentrated and finished product prepares: above filtrating is merged, left standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned subsequent use fine powder mixing and divide commentaries on classics to get final product.
Embodiment 2;
Preliminary powder process: get 15 parts of 5 parts of Stigma Crocis, 3 parts of Fel Ursis, 5 parts of Cordyceps, 3 parts of Indigo Naturaliss, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves subsequent use;
Decoct and filter: 15 parts of medical material Carapax et Plastrum Testudiniss (processed with vinegar), 15 parts of stir-baked SQUAMA MANITISs, Carapax Trionycis (processed with vinegar) are put into water for 15 parts and are soaked 30 minutes post-heating to boiling; After decocting 30 minutes, add 15 parts of Radix Panacis Quinquefoliis, 6 parts of Rhizoma Coptidis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Radix Curcumaes, 15 parts in Colla Corii Asini, 15 parts of Polyporus, 15 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 15 parts of Rhizoma Dioscoreaes (stir-fry).12 parts of Fructus Amomis, 15 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Imperataes, 6 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 15 parts in Poria, 15 parts of Rhizoma Alismatis, 15 parts of Herba Taraxacis, 15 parts of Herba Violaes, first pass add the long-pending water gaging of pentaploid and are heated to boiling, decoct 1.5 hours, emit filtrating; Add the long-pending water gaging of triploid for second time, be heated to boiling, decocted 1 hour, emit filtrating; Add the long-pending water gaging of triploid for the 3rd time, be heated to boiling, decocted 1 hour, emit filtrating;
Concentrated and finished product prepares: above filtrating is merged, left standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned subsequent use fine powder mixing and divide commentaries on classics to get final product.
Embodiment 3;
Preliminary powder process: get 12 parts of 3 parts of Stigma Crocis, 3 parts of Fel Ursis, 3 parts of Cordyceps, 3 parts of Indigo Naturaliss, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves subsequent use;
Decoct and filter: 12 parts of medical material Carapax et Plastrum Testudiniss (processed with vinegar), 12 parts of stir-baked SQUAMA MANITISs, Carapax Trionycis (processed with vinegar) are put into water for 12 parts and are soaked 30 minutes post-heating to boiling; After decocting 30 minutes; Add 12 parts of Radix Panacis Quinquefoliis, 5 parts of Rhizoma Coptidis, 12 parts of Eupolyphaga Seu Steleophagas, Fructus Amomi 9-part, 9 parts of Radix Curcumaes, 12 parts in Colla Corii Asini, 12 parts of Polyporus, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 12 parts of Rhizoma Dioscoreaes (stir-fry),, 9 parts of Rhizoma Imperataes, 5 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 12 parts in Poria, 12 parts of Rhizoma Alismatis, 12 parts of Herba Taraxacis, 12 parts of Herba Violaes; First pass adds the long-pending water gaging of pentaploid and is heated to boiling; Decocted 1.5 hours, and emitted filtrating; Add the long-pending water gaging of triploid for second time, be heated to boiling, decocted 1 hour, emit filtrating; Add the long-pending water gaging of triploid for the 3rd time, be heated to boiling, decocted 1 hour, emit filtrating;
Concentrated and finished product prepares: above filtrating is merged, left standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned subsequent use fine powder mixing and divide commentaries on classics to get final product.Function: heat clearing away, blood circulation promoting and blood stasis dispelling, replenishing QI to invigorate the spleen, soothing the liver circulation of qi promoting, inducing diuresis to remove edema.
Cure mainly: cause hepatic fibrosis, liver cirrhosis, ascites by a variety of causes.
Usage and dosage: be decocted in water for oral dose every day 2 times, a 200ml.
To take 30 days continuously is a course of treatment.
The preferred decoction of the present invention, but dosage form does not produce restriction to other dosage form mutation that the present invention can adopt, and takes appropriate process, and the present invention can make other dosage forms.
Adopt " Softing liver and contracting spleen soup " preparation of as above technical scheme and preparation method thereof; Discovery can generate the protease cut-out when having degraded liver collagen fiber, open its helical structure of liver collagen fiber in clinical practice is used; Thereby reach degraded Kupffer Cell and endotheliocyte; Stop, suppress even reverse the process of liver fiber, thereby reach the effect of the liver fiber of healing.
Hypersplenism phenomenon liver cirrhosis later stage patient usually takes place with ascites in liver cirrhosis patient, thereby this programme has easing the affected liver, function of gallbladder promoting, antiinflammatory, eliminating dampness by diuresis, invigorates blood circulation, circulation of qi promoting reaches the effect that soft liver contracts.
Enclose clinical experiment report:
Clinical experiment report
can be known through above analysis, and drug effect of the present invention is outstanding, has the splendid effect of curing the disease.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.Those skilled in the art should understand the present invention and not be restricted to the described embodiments; That describes in the foregoing description and the description just explains principle of the present invention; Under the prerequisite that does not break away from spirit and scope of the invention; The present invention also has various changes and modifications, and these variations and improvement all fall in the scope that requires protection.
Claims (4)
1. the pure Chinese medicinal preparation of a nourishing the liver hepatoprotective, Softing liver and contracting spleen; It is characterized in that it is by the feedstock production that comprises following weight portion: Carapax et Plastrum Testudinis (processed with vinegar) 10-15 part, stir-baked SQUAMA MANITIS 10-15 part, Radix Panacis Quinquefolii 10-15 part, 3 parts of Fel Ursis, Cordyceps 2-5 part, Rhizoma Coptidis 3-6 part, Eupolyphaga Seu Steleophaga 10-15 part, Radix Curcumae 6-10 part, Colla Corii Asini 9-15 part, Polyporus 10-15 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 10-15 part, Rhizoma Dioscoreae (stir-fry) 10-15 part.
2. the pure Chinese medicinal preparation of a kind of nourishing the liver hepatoprotective as claimed in claim 1, Softing liver and contracting spleen; It is characterized in that its raw material also comprises following component: Carapax Trionycis (processed with vinegar) 10-15 part, Stigma Croci 2-5 part, 3 parts of Indigo Naturaliss, Fructus Amomi 6-12 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Imperatae 6-12 part, Folium Eriobotryae 3-6 part, Pericarpium Arecae 3-6 part, Poria 10-15 part, Rhizoma Alismatis 10-15 part, Herba Taraxaci 10-15 part, Herba Violae 10-15 part.
3. the pure Chinese medicinal preparation of a kind of nourishing the liver hepatoprotective as claimed in claim 2, Softing liver and contracting spleen; It is characterized in that, described components by weight percent be 12 parts of Carapax et Plastrum Testudiniss (processed with vinegar), 12 parts of stir-baked SQUAMA MANITISs, 12 parts of Carapax Trionycis (processed with vinegar), 3 parts of Stigma Crocis, 12 parts of Radix Panacis Quinquefoliis, 3 parts of Fel Ursis, 3 parts of Cordyceps, 5 parts of Rhizoma Coptidis, 12 parts of Eupolyphaga Seu Steleophagas, 3 parts of Indigo Naturaliss, Fructus Amomi 9-part, 9 parts of Radix Curcumaes, 12 parts in Colla Corii Asini, 12 parts of Polyporus, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 12 parts of Rhizoma Dioscoreaes (stir-fry),, 9 parts of Rhizoma Imperataes, 5 parts of Folium Eriobotryaes, 6 parts of Pericarpium Arecae, 12 parts in Poria, 12 parts of Rhizoma Alismatis, 12 parts of Herba Taraxacis, 12 parts of Herba Violaes.
4. preparation is characterized in that like the method for the pure Chinese medicinal preparation of any described a kind of nourishing the liver hepatoprotective of claim 1-3, Softing liver and contracting spleen, comprises following steps:
● preliminary powder process: get Stigma Croci, Fel Ursi, Cordyceps, Indigo Naturalis, Colla Corii Asini and be ground into fine powder to cross 100 mesh sieves subsequent use;
● decoct and filter: medical material Carapax et Plastrum Testudinis, stir-baked SQUAMA MANITIS, Carapax Trionycis are put into water and are soaked 30 minutes post-heating to boiling; After decocting 30 minutes; Add Radix Panacis Quinquefolii, Rhizoma Coptidis, Eupolyphaga Seu Steleophaga, Fructus Amomi, Radix Curcumae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Rhizoma Imperatae, Folium Eriobotryae, Pericarpium Arecae, Poria, Rhizoma Alismatis, Herba Taraxaci, Herba Violae; First pass adds the long-pending water gaging of pentaploid and is heated to boiling, decocts 1.5 hours, emits filtrating; Add the long-pending water gaging of triploid for second time, be heated to boiling, decocted 1 hour, emit filtrating; Add the long-pending water gaging of triploid for the 3rd time, be heated to boiling, decocted 1 hour, emit filtrating;
● concentrated and finished product preparation: above filtrating is merged, left standstill 24 hours, leach supernatant, be concentrated into 560ml, add above-mentioned subsequent use fine powder mixing and divide commentaries on classics to get final product.
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| CN105056101A (en) * | 2015-07-16 | 2015-11-18 | 陆开云 | Liver-nourishing-and-protecting traditional Chinese medicine |
| CN106963916A (en) * | 2016-12-31 | 2017-07-21 | 麻凯 | Softing liver and contracting spleen decocts tea |
| US20190038710A1 (en) * | 2016-01-29 | 2019-02-07 | Shandong Zhonghai Pharmaceutical CO. LTD | Medicament used for treating hypertension |
| US11000569B2 (en) * | 2016-01-29 | 2021-05-11 | Shandong Zhonghai Pharmaceutical CO. LTD | Medicament for use in treating fatty liver, hepatitis and cirrhosis |
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| CN102824600B (en) | 2014-07-23 |
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