CN102824533B

CN102824533B - Antioxidant traditional Chinese medicine composition and preparation method thereof

Info

Publication number: CN102824533B
Application number: CN201210371849.0A
Authority: CN
Inventors: 刘永平
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-09-29
Filing date: 2012-09-29
Publication date: 2014-06-25
Anticipated expiration: 2032-09-29
Also published as: CN102824533A

Abstract

The invention aims to provide an antioxidant composition which consists of the following raw materials in parts by weight or takes the water and/or alcohol extracts of the following raw materials as active ingredients: 10-60 parts of herba cistanches, 10-55 parts of cortex eucommiae, 10-55 parts of semen astragali complanati, 8-40 parts of fructus psoraleae, 10-55 parts of herba epimedii, 5-20 parts of rhizoma polygonati, 30-120 parts of radix polygoni multiflori and 15-55 parts of swimming bladder. One or any combination of the following materials in parts by weight can be added into the composition provided by the invention: 10-50 parts of lotus seed, 10-50 parts of semen cuscutae, 5-30 parts of poria cocos, 5-30 parts of fructus lycii, 10-50 parts of Chinese angelica, 8-40 parts of fructus ligustri lucidi, 10-50 parts of radix rehmanniae preparata, 5-18 parts of radix morindae officinalis, 10-50 parts of radix astragali, 8-30 parts of caulis spatholobi, 8-35 parts of black sesame, 8-30 parts of radix polygalae, 8-35 parts of eclipta alba, 10-50 parts of rhizoma dioscoreae, 10-40 parts of semen platycladi, 10-50 parts of fructus mori, 10-50 parts of radix glehniae, 10-50 parts of rhizoma atractylodis macrocephalae, 10-40 parts of fructus corni, 10-30 parts of radix aucklandiae, 8-28 parts of fructus broussonetiae, 10-25 parts of radix salviae miltiorrhizae and 10-40 parts of rosa davurica.

Description

A kind of Anti-oxidation teaditional Chinese medicine composition and method of making the same

Technical field

The present invention relates to a kind of Anti-oxidation teaditional Chinese medicine composition and method of making the same.

Background technology

Aging is the inexorable law of life process, old and feeble inevitable, but slow down aging is possible.At all times, people are finding method and the antiaging agent of various life lengthening always, to delay senility in the life time that can define on hereditism or raising quality of life.Basic Theories of Chinese Medicine to the understanding of Aging mechanism taking internal organs as core, its middle kidney occupies an important position in traditional Chinese medical science Aging mechanism, Chinese medicine slow down aging Main Function shows as adjusting body's immunity, remove free radical, antioxidation, nervous system regulation and hormonal system function, regulate organismic internal environment, thereby extend cell survival and extend organism life-span, reach antidotal object; Modern medicine has free radical theory and mitochondrial DNA damage theory about the representative theory of Aging mechanism, and developing rapidly of the subjects such as cytobiology, molecular biology promoted the further investigation of Aging mechanism; Antiaging agent has chemicals (antioxidant, antiaging hormone, nutrient, oxidase inhibitor, immunomodulator, biochemical preparation, brain function promote medicine etc.) and Chinese medicine (comprising single medicinal material, compound preparation and Chinese medicine extract), due to Western medicine erious adverse reaction, Chinese medicine occupies more and more consequence with its unique curative effect in antidotal research.

Summary of the invention

The object of this invention is to provide a kind of antioxidation, have no side effect, the Chinese medicine composition of life lengthening, another object of the present invention has been to provide the preparation method of said composition.

The present composition uses China's Traditional Chinese medical theory, " from QI invigorating enrich blood, spleen invigorating, the kidney invigorating, the lung that relaxes reach liver, adjusting and runing yang, raising immunity, defying age " start with, make full use of China's traditional Chinese medical science treasure-house resource, by regulating entirety to make equilibrium between yin and yang, obtain two-ways regulation good result.

Compositions of the present invention selects Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser to combine, make each efficacy of drugs produce synergism this drug regimen, thereby can effectively reach antidotal effect, wherein select Herba Cistanches, feeble QI, sweet, the micro-hardship of taste, return through sweet, enter kidney, large intestine channel, there is kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation; The Cortex Eucommiae, enter liver, kidney channel, kidney invigorating and YANG supporting expelling wind and removing dampness, is the conventional invigorating the liver and kidney of the traditional Chinese medical science, strengthening bone and muscle, antiabortive, antasthenic; Semen Astragali Complanati, sweet in the mouth, micro-hardship, warm in nature, return liver, kidney channel, matter lubricant nature and, temperature compensation Liver and kidney, has the kidney invigorating bone essence, effect of nourishing the liver to improve visual acuity; Fructus Psoraleae, acrid in the mouth; Bitter; Warm in nature, enter kidney channel, kidney invigorating and YANG supporting, spleen reinforcing antidiarrheal; Herba Epimedii, abnormal smells from the patient are pungent, cold, enter liver, kidney channel, kidney invigorating and YANG supporting, expelling wind and removing dampness; Rhizoma Polygonati, sweet is flat.Return lung, spleen, kidney, benefiting essence-blood relieving constipation, separates sore; Air Bladder pseudosciaenae seu Acipenser, sweet in the mouth, property are put down, and enter liver, kidney channel, have the kidney invigorating and essence nourishing hemostasis dissipating blood stasis, detumescence, nourishing kidney lung moistening, invigorating the spleen and replenishing QI; Radix Polygoni Multiflori, bitter in the mouth, sweet; Puckery, slightly warm in nature.Return liver, kidney channel, effect of tonifying liver benefit, Erythroculter ilishaeformis fat is rich in macromolecular collagen protein.

The present composition contains following raw material or is made up of as active ingredient water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser.

The present composition can also add following raw material or make active ingredient by water and/or the alcohol extract of following raw material: the one in Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip or combination in any.

The preferred following raw material of the present composition or make active ingredient by water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali.

The preferred following raw material of the present composition or make active ingredient by water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip.

The present composition preferably contains the raw material of following weight parts or is made up of as active ingredient water and/or the alcohol extract of following raw material:

Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part.

The preferably raw material of following weight parts or formed as active ingredient by water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts, Air Bladder pseudosciaenae seu Acipenser.

The present composition can also add the raw material of following weight parts or make active ingredient by water and/or the alcohol extract of following raw material:

Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi

One or combination in any in sub-8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part, Caulis Spatholobi 8-30 part, Semen Sesami Nigrum 8-35 part, Radix Polygalae 8-30 part, Herba Ecliptae 8-35 part, Rhizoma Dioscoreae 10-50 part, Semen Platycladi 10-40 part, Fructus Mori 10-50 part, Radix Glehniae 10-50 part, Rhizoma Atractylodis Macrocephalae 10-50 part, Fructus Corni 10-40 part, Radix Aucklandiae 10-30 part, Fructus Broussonetiae 8-28 part, Radix Salviae Miltiorrhizae 10-25 part, rose hip 10-40 part.

The preferably raw material of following weight parts or make active ingredient by water and/or the alcohol extract of following raw material:

One or combination in any in 30 parts, 40 parts, Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts, Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts, Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 30 parts of Semen Sesami Nigrums, 15 parts of Radix Polygalaes, 20 parts of Herba Ecliptaes, 35 parts of Rhizoma Dioscoreaes, 20 parts of Semen Platycladi, 30 parts, Fructus Mori, 30 parts of Radix Glehniaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Corni, 12 parts of the Radix Aucklandiae, 20 parts of Fructus Broussonetiaes, 20 parts of Radix Salviae Miltiorrhizaes, rose hip.

More preferably the raw material of following weight parts or water and/or alcohol extract by following raw material are made active ingredient:

Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part, Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part.

40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts, Air Bladder pseudosciaenae seu Acipenser, 40 parts, Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts, Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts, Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali.

Most preferably the raw material of following weight parts or water and/or alcohol extract by following raw material are made active ingredient:

Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part, Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part, Caulis Spatholobi 8-30 part, Semen Sesami Nigrum 8-35 part, Radix Polygalae 8-30 part, Herba Ecliptae 8-35 part, Rhizoma Dioscoreae 10-50 part, Semen Platycladi 10-40 part, Fructus Mori 10-50 part, Radix Glehniae 10-50 part, Rhizoma Atractylodis Macrocephalae 10-50 part, Fructus Corni 10-40 part, Radix Aucklandiae 10-30 part, Fructus Broussonetiae 8-28 part, Radix Salviae Miltiorrhizae 10-25 part, rose hip 10-40 part.

40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts, Air Bladder pseudosciaenae seu Acipenser, 40 parts, Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts, Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts, Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 30 parts of Semen Sesami Nigrums, 15 parts of Radix Polygalaes, 20 parts of Herba Ecliptaes, 35 parts of Rhizoma Dioscoreaes, 20 parts of Semen Platycladi, 30 parts, Fructus Mori, 30 parts of Radix Glehniaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Corni, 12 parts of the Radix Aucklandiae, 20 parts of Fructus Broussonetiaes, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of rose hips.

The Cortex Eucommiae of the present invention is the dry bark of Eucommiaceae plant Du kind of Eucommia ulmoides oliv, enters liver, kidney channel, kidney invigorating and YANG supporting expelling wind and removing dampness; Herba Cistanches is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C. Ma; Semen Astragali Complanati is the dry mature seed of leguminous plant astragatus complanatus Astragalus complanatusR. Br, enters liver, kidney channel, temperature compensation Liver and kidney, bone essence, reducing urination, improving eyesight; Fructus Psoraleae is the dry mature fruit of legumes psoraleae Psoralea corylifolia L., enters kidney, spleen channel, warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal; Herba Epimedii is Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium sagittatum(Sieb. et Zucc.) dry aerial parts of Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T. S. Ying or Herba Epimedii Epimedium koreaum Nakai, enter liver, kidney channel, kidney invigorating and YANG supporting, bone and muscle strengthening, expelling wind and removing dampness; Rhizoma Polygonati is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll. et Hemsl.), Rhizoma Polygonati (Polygonatum sibiricum Red.) or Polygonatum cyrtonema Hua (Polygonatum cyrtonema Hua.), enter lung, spleen, kidney channel, QI invigorating, yin nourishing, spleen reinforcing, lung moistening; Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., enters liver, kidney channel, the liver and the kidney tonifying, and benefiting essence-blood relieving constipation, separates sore; Air Bladder pseudosciaenae seu Acipenser enters liver, kidney channel for the Air Bladder pseudosciaenae seu Acipenser Pseudosciaene erocea (Rich) of Sciaenidae animal Carnis Pseudosciaenae, Carnis Pseudosciaenae or Acipenseridae animal mandarin sturgeon, sturgeon etc., the kidney invigorating and essence nourishing hemostasis; Semen Nelumbinis are the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn., enter spleen, kidney, heart channel, nourishing the heart and kidney, the solid intestinal of spleen reinforcing; Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant Cusouta chinensis Lam., enters liver,kidney,spleen warp, invigorating the liver and kidney benefit marrow; Poria is the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf, enters the heart, lung, spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L., enters liver, kidney channel, nourishing the liver and kidney, replenishing vital essence to improve eyesight; When being classified as the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels, enter spleen, liver, kidney channel, tonifying blood and arresting bleeding, menstruction regulating and pain relieving, nourishing is moisturized; The dry mature fruit of Fructus Ligustri Lucidi Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait., enters liver, kidney channel, nourishing kidney the liver benefiting, the improving eyesight of crow palpus; Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), enters the heart, liver, kidney channel, the YIN nourishing of enriching blood; Radix Morindae Officinalis is the dry root of Maguireothamnus speciosus Radix Morindae Officinalis Morinda officinalis How, enters kidney channel, kidney invigorating and YANG supporting, bone and muscle strengthening; The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch) Bge.var.mongholicus (Bge) Hsiao or Radix Astragali Astragalus membranaceus (Fisch) Bge., enter spleen, lung meridian, effect that benefiting QI for strengthening the superficies, arresting sweating admittedly take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema; Rose hip is that Rosa davurica Pall. enters liver, spleen, stomach, urinary bladder channel warp, promoting QI circulation for relieving depression, and dispersing the stagnated liver-QI for regulating the stomach nourishes blood, promoting blood circulation and stopping pain; Radix Salviae Miltiorrhizae for these product be dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae salvia miltiorrhizabge. dry root and rhizome, enters the heart, Liver Channel, stasis-dispelling and pain-killing, and promoting blood flow to regulate menstruation, clearing away heat from blood, except stuffy sensation with restlessness; Fructus Corni is cornws offieinalis sied et zucc, enters liver, kidney channel, liver and kidney tonifying, consolidating semen hidroschesis; Fructus Broussonetiae is the dry mature fruit of Moraceae Broussonetia papyrifera Broussonetia papyrifera (L.) Vent., enters liver, kidney channel, the kidney invigorating liver heat removing, and improving eyesight is supporing yang, diuresis parasite killing; Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L., enters the heart, liver, kidney channel, and nourishing YIN and supplementing blood, promotes the production of body fluid and moisturize; Semen Sesami Nigrum is the dry mature seed of Pedaliaceae plant sesame Sesamum indicum L., enters liver, kidney, large intestine channel, and nourishing the liver and kidney, moisturizes laxation; Radix Polygalae is the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L., enters lung, the heart, kidney channel, eliminate the phlegm, and detumescence, the Fructus Alpiniae Oxyphyllae of calming the nerves; The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz., enters spleen, stomach warp, invigorating the spleen and replenishing QI, dampness diuretic bone table hidroschesis; Caulis Spatholobi is Spatholobus sunerecfus Dunn, enters liver, kidney channel, the promoting the circulation of blood of enriching blood, relaxing muscles and tendons and activating QI and blood in the collateral; The dry aerial parts of Herba Ecliptae feverfew Eclipta prostrata Eclipta prostrata L., enter liver, kidney channel, liver and kidney tonifying, cooling blood for hemostasis; Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb., enters lung, spleen, kidney channel, tonifying the spleen and stomach, lung benefiting kidney; Semen Platycladi is the dry mature kernal of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco, enters the heart, kidney large intestine channel, tranquilizing by nourishing the heart, hidroschesis, intestine moistening; The Radix Aucklandiae is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne., enters spleen, stomach, large intestine, three warmers, gallbladder meridian, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Radix Glehniae is the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq., enters spleen, stomach warp, nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.

Chinese medicine compositions of the present invention can add pharmaceutically acceptable adjuvant to be prepared into any dosage form.

Dosage form of the present invention can be any one in tablet, granule, capsule, oral liquid, powder, soft extract, drop pill, pill, the watered pill, honeyed pill, powder, lozenge, fluid extract, extractum, injection, syrup.

The water of the raw material of Chinese medicine composition of the present invention and/or the preparation technology of alcohol extract, comprise the following steps:

1) take traditional Chinese medicinal material raw materials;

2) with alcohol or water to above-mentioned medical material reflux, extract,, obtain extracting solution and do active ingredient, add additives, make various dosage forms.

The water of the raw material of Chinese medicine composition of the present invention and/or the preparation technology of alcohol extract, can also comprise the following steps:

1) raw material is prepared: take traditional Chinese medicinal material raw materials;

2) extract and concentrate: after the raw material of handling well in step 1 is soaked, heating decocts repeatedly, and merge extractive liquid, filters, and filtrate is concentrated in right amount, and concentrated solution lets cool rear high speed centrifugation remove impurity, for subsequent use;

3) prepare preparation: by the concentrated solution of gained in step 2 separately or add pharmaceutically acceptable adjuvant, technique is made required preparation routinely.

By step 2) in soak time be 20 minutes-120 minutes, post-heating decoct 1～3 time, each 1～2 hour;

Alcohol of the present invention is methanol or ethanol; Methanol concentration is 5%-95%, and concentration of alcohol is 5-95%.

Present composition pill preparation technology, comprises the following steps:

1), take traditional Chinese medicinal material raw materials;

2), 80～105 DEG C dry medical materials, make moisture ± 8%, pulverized 200 mesh sieves;

3), smalls adds Mel and is in harmonious proportion as pill.

The compositions that the present invention relates to be made up of Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser is in the purposes of preparing in antioxidant health-care product or medicine or product.

The present invention relates to by Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, the compositions of Air Bladder pseudosciaenae seu Acipenser composition adds Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, the compositions of a kind of or any composition composition in rose hip is in the purposes of preparing in antioxidant health-care product or medicine or product.

The compositions that the present invention relates to be made up of Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali is in the purposes of preparing in antioxidant health-care product or medicine or product.

The compositions that the present invention relates to be made up of Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip is in the purposes of preparing in antioxidant health-care product or medicine or product.

In order to understand better essence of the present invention, the zoopery of the compositions being made up of Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser with embodiment 1 and result are illustrated to it has antioxidative effect below.

The compositions being similarly made up of Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser adds the compositions a kind of or that combination in any forms in Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip all can reach to have the same antioxidative effect that has, and difference is use amount difference.

Chinese medicine composition I of the present invention (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip) proves through animal experiment, there is the mice of raising anti-oxidation function, and have no side effect, Report on Animal is described as follows:

1. materials and methods

1.1sample source and processing: Chinese medicine composition I (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati,

Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip) composite powder, sample is that brown solid is Powdered, before test, be mixed with desired concn with distilled water, mouse stomach gives.

laboratory animal and environment: SPF level Kunming kind male 11 the monthly age 40 of mices, male 1 the monthly age 10 of mices, animal feeding room temperature is 21-26 DEG C, humidity is 40-70%.

1.3 dosage grouping

By 11 the monthly age 40 of mices be divided at random four groups by malonaldehyde in blood (MDA) level, be respectively aged matched group and basic, normal, high dosage group.Basic, normal, high dosage group is raised 30 days continuously with 1.429g crude drug/kg BW, 2.857g crude drug/kg BW, 5.714g crude drug/kg BW respectively, is equivalent to crowd and recommends daily intaking amount 20g crude drug/70kgBW) 5,10,20 times.Aged matched group gives not add the feedstuff of Chinese medicine.

Sample preparation: accurately take given the test agent and quantitatively make feedstuff, make basic, normal, high dosage group mouse feed.Each dosage group is all being eaten up the normal feedstuff of taking food again after adding Chinese medicine fodder.

1.4 experimental technique

The continuous gavage of tested material animal, after 30 days, increases less Mus matched group in age, and each treated animal selects endocanthion to get blood, and the hemolysate of preparation 2%, 1% detects respectively malonaldehyde (MDA) content and glutathion peroxidase (GSH-PX) vigor.Put to death animal, get liver and do homogenate, the liver homogenate of preparation 1% is made superoxide dismutase (SOD) vitality test.

2 result

2.1chinese medicine composition I on the impact of aged mouse body weight

From table 1, each dosage treated animal give tested material after 30 days body weight and aged matched group comparing difference without significance (p>0.05), illustrate this sample on aged mouse body weight without impact.

The impact of table 1 Chinese medicine composition I on aged mouse body weight (

± s)

。

2.2 Chinese medicine composition I on the impact of MDA content in aged mouse 2% haemolysis

Middle dosage group can obviously reduce MDA content in aged mouse 2% hemolysate, has significance (p<0.05) with aged matched group comparing difference.In table 2:

The impact of table 2 Chinese medicine composition I on MDA content in aged mouse 2% hemolysate (

± s)

。

2.3 Chinese medicine composition I on the impact of aged mouse liver homogenate SOD, serum SOD-PX

The middle dosage group SOD activity in aged mouse 1% liver homogenate that can obviously raise, has significance (p<0.05) with aged matched group comparing difference; The middle dosage group aged mouse 1% hemolysate GSH-PX activity that can obviously raise, has significance (p<0.05) with aged matched group comparing difference.In table 3:

The impact of table 3 Chinese medicine composition I on aged mouse liver homogenate SOD, serum SOD-PX (

± s)

。

3 brief summary

The test of Chinese medicine composition I anti-oxidation function, adopt SPF level Kunming kind aged mouse as experimental system, recommend 5,10,20 times of daily intaking amount 20g crude drug/70kg BW to be equivalent to crowd, be low dose group, middle dosage group, high dose group, raise 30 days continuously, result of the test shows: each dosage group Mouse Weight and aged matched group relatively do not have significant difference (p>0.05); Middle dosage group can obviously reduce aged mouse 2% hemolysate MDA content, has significance (p<0.05) with aged matched group comparing difference; The middle dosage group SOD activity in aged mouse 1% liver homogenate that can raise, has significance (p<0.05) with aged matched group comparing difference; The middle dosage group aged mouse 1% hemolysate GSH-PX activity that obviously raises, has significance (p<0.05) with aged matched group comparing difference, according to above result, judges that this tested material anti-oxidation function animal test results is positive.

Chinese medicine composition II of the present invention (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser) proves to have the mice of raising anti-oxidation function, and have no side effect through animal experiment, Report on Animal is described as follows:

1. materials and methods

1.1sample source and processing: Chinese medicine composition II (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati,

Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser) composite powder, sample is that brown solid is Powdered, before test, is mixed with desired concn with distilled water, mouse stomach gives.

1.2 laboratory animals and environment: SPF level Kunming kind male 11 the monthly age 40 of mices, male 1 the monthly age 10 of mices, animal feeding room temperature is 21-26 DEG C, humidity is 40-70%.

1.3 dosage grouping

By 11 the monthly age 40 of mices be divided at random four groups by malonaldehyde in blood (MDA) level, be respectively aged matched group and basic, normal, high dosage group.Basic, normal, high dosage group is raised 30 days continuously with 1.143g crude drug/kg BW, 2.286g crude drug/kg BW, 4.571g crude drug/kg BW respectively, is equivalent to crowd and recommends daily intaking amount 16g crude drug/70kgBW) 5,10,20 times.Aged matched group gives not add the feedstuff of Chinese medicine.

1.4 experimental technique

3 result

2.1chinese medicine composition II on the impact of aged mouse body weight

The impact of table 4 Chinese medicine composition II on aged mouse body weight ( ± s)

。

2.2 Chinese medicine composition II on the impact of MDA content in aged mouse 2% haemolysis

The impact of table 5 Chinese medicine composition II on MDA content in aged mouse 2% hemolysate ( ± s)

。

3.3 Chinese medicine composition II on the impact of aged mouse liver homogenate SOD, serum SOD-PX

The impact of table 6 Chinese medicine composition II on aged mouse liver homogenate SOD, serum SOD-PX ( ± s)

。

3 brief summary

The test of Chinese medicine composition II anti-oxidation function, adopt SPF level Kunming kind aged mouse as experimental system, recommend 5,10,20 times of daily intaking amount 16g crude drug/70kg BW to be equivalent to crowd, be low dose group, middle dosage group, high dose group, raise 30 days continuously, result of the test shows: each dosage group Mouse Weight and aged matched group relatively do not have significant difference (p>0.05); Middle dosage group can obviously reduce aged mouse 2% hemolysate MDA content, has significance (p<0.05) with aged matched group comparing difference; The middle dosage group SOD activity in aged mouse 1% liver homogenate that can raise, has significance (p<0.05) with aged matched group comparing difference; The middle dosage group aged mouse 1% hemolysate GSH-PX activity that obviously raises, has significance (p<0.05) with aged matched group comparing difference, according to above result, judges that this tested material anti-oxidation function animal test results is positive.

Detailed description of the invention

Embodiment 1

Take Herba Cistanches 400g, Cortex Eucommiae 400g, Semen Astragali Complanati 400g, Fructus Psoraleae 300g, Herba Epimedii 400g, Rhizoma Polygonati 150g, Radix Polygoni Multiflori 900g, Air Bladder pseudosciaenae seu Acipenser 500g, above 8 tastes are soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later, add water 10 times at every turn and measure, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution lets cool rear high speed centrifugation remove impurity, add oral liquid to commonly use adjuvant, mix homogeneously, makes 20000ml oral liquid by oral liquid common process.

Embodiment 2

Take traditional Chinese medicinal material raw materials Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, Radix Polygoni Multiflori 300g, Air Bladder pseudosciaenae seu Acipenser 150g, above 8 tastes are soaked 60min, heating decocts 3 times, adds water 10 times at every turn and measures, each 2 hours, merge 3 times extracting liquid filtering, filtrate lets cool rear high speed centrifugation remove impurity, and concentrating under reduced pressure becomes cream or spraying drying powder-forming, adds tablet to commonly use adjuvant, mix homogeneously, makes various tablets by tablet common process.

Embodiment 3

Take traditional Chinese medicinal material raw materials Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, Radix Polygoni Multiflori 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, above 8 tastes are soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later, add water 10 times at every turn and measure, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution lets cool rear high speed centrifugation remove impurity, add syrup to commonly use adjuvant, mix homogeneously, makes syrup by syrup common process.

Embodiment 4

Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, Radix Polygoni Multiflori

300g, Air Bladder pseudosciaenae seu Acipenser 150g, Semen Nelumbinis 100g, Semen Cuscutae 100g, Poria 50g, Fructus Lycii 50g, Radix Angelicae Sinensis 100g, Fructus Ligustri Lucidi 80g, Radix Rehmanniae Preparata 100g, Radix Morindae Officinalis 50g, Radix Astragali 100g, add 95% alcohol reflux 2 hours, after recovery ethanol, obtains alcohol extract; Medicinal residues add water to heat again and decoct 3 times, each 2 hours, merge alcohol extract and aqueous extract, filter, filtrate is concentrated in right amount, and concentrated solution lets cool rear high speed centrifugation remove impurity and filters, add oral liquid to commonly use adjuvant, mix homogeneously, makes 20000ml oral liquid by oral liquid common process.

Embodiment 5

Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, He Shou

Crow 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, Semen Nelumbinis 500g, Semen Cuscutae 500g, Poria 300g, Fructus Lycii 300g, Radix Angelicae Sinensis 500g, Fructus Ligustri Lucidi 400g, Radix Rehmanniae Preparata 500g, Radix Morindae Officinalis 180g, Radix Astragali 500g, above medicine is soaked 1 hour, decoct with water 2-3 time, within each 1-3 hour, filter, merging filtrate, be concentrated into relative density 1.10-1.40(55-60 DEG C), add ethanol to reaching 50% containing alcohol amount, leave standstill 24 hours and filter, filtrate is reclaimed, ethanol is concentrated into relative density 1.35-1.38(55-60 DEG C) thick paste, vacuum drying, be ground into fine powder, add appropriate amount of auxiliary materials, mix, granulate, be pressed into 1000 sugar coatings and obtain tablet.

Embodiment 6

Herba Cistanches 400g, Cortex Eucommiae 400g, Semen Astragali Complanati 400g, Fructus Psoraleae 300g, Herba Epimedii 400g, Rhizoma Polygonati 150g, Radix Polygoni Multiflori 900g, Air Bladder pseudosciaenae seu Acipenser 500g, Semen Nelumbinis 400g, Semen Cuscutae 400g, Poria 200g, Fructus Lycii 200g, Radix Angelicae Sinensis 400g, Fructus Ligustri Lucidi 200g, Radix Rehmanniae Preparata 300g, Radix Morindae Officinalis 100g, Radix Astragali 300g, to remove impurity with medicine-feeding, become 300 mesh sieve smalls with pulverizer powder, add additives starch, dextrin, incapsulate and make capsule.

Embodiment 7

Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, He Shou

Crow 300g, Air Bladder pseudosciaenae seu Acipenser 150g, Semen Nelumbinis 100g, Semen Cuscutae 100g, Poria 50g, Fructus Lycii 50g, Radix Angelicae Sinensis 100g, Fructus Ligustri Lucidi 80g, Radix Rehmanniae Preparata 100g, Radix Morindae Officinalis 50g, Radix Astragali 100g, Caulis Spatholobi 80g, Semen Sesami Nigrum 80g, Radix Polygalae 80g, Herba Ecliptae 80g, Rhizoma Dioscoreae 100g, Semen Platycladi 100g, Fructus Mori 100g, Radix Glehniae 100g, Rhizoma Atractylodis Macrocephalae 100g, Fructus Corni 100g, Radix Aucklandiae 100g, Fructus Broussonetiae 80g, Radix Salviae Miltiorrhizae 100g, rose hip 100g, by above medicine respectively 80-105 DEG C of oven dry, make moisture be less than 8% pulverizing, cross sieve No. one, press solid-liquid ratio 1:5-10, flooding 3-12 hour at temperature 60-98 DEG C, repeat twice, filter and remove residue, get supernatant, merging filtrate, filtrate sucks vacuum concentration pot, under 0.04-0.08MPa vacuum, be concentrated into the 1/2-3/4 that material is heavy, concentrate feed is sprayed dry, spray drying control system inlet temperature 160-180 DEG C, granulation electuary after dry product dextrin, maltodextrin, cyclodextrin, soluble starch.

Embodiment 8

Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, what

Radix Polygoni Multiflori 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, Semen Nelumbinis 500g, Semen Cuscutae 500g, Poria 300g, Fructus Lycii 300g, Radix Angelicae Sinensis 500g, Fructus Ligustri Lucidi 400g, Radix Rehmanniae Preparata 500g, Radix Morindae Officinalis 180g, Radix Astragali 500g, Caulis Spatholobi 300g, Semen Sesami Nigrum 350g, Radix Polygalae 300g, Herba Ecliptae 350g, Rhizoma Dioscoreae 500g, Semen Platycladi 400g, Fructus Mori 500 g, Radix Glehniae 500g, Rhizoma Atractylodis Macrocephalae 500g, Fructus Corni 400g, Radix Aucklandiae 300g, Fructus Broussonetiae 280g, Radix Salviae Miltiorrhizae 250g, rose hip 400g, above medicine is removed to impurity, dry, sterilization, become 200 order dusting cover smalls with pulverizer powder, add additives, as soybean oil, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin, make the watered pill.

Embodiment 9

Herba Cistanches 400g, Cortex Eucommiae 400g, Semen Astragali Complanati 400g, Fructus Psoraleae 300g, Herba Epimedii 400g, Rhizoma Polygonati 150g, Radix Polygoni Multiflori 900g, Air Bladder pseudosciaenae seu Acipenser 500g, Semen Nelumbinis 400g, Semen Cuscutae 400g, Poria 200g, Fructus Lycii 200g, Radix Angelicae Sinensis 400g, Fructus Ligustri Lucidi 200g, Radix Rehmanniae Preparata 300g, Radix Morindae Officinalis 100g, Radix Astragali 300g, Caulis Spatholobi 150g, Semen Sesami Nigrum 300g, Radix Polygalae 150g, Herba Ecliptae 200g, Rhizoma Dioscoreae 350g, Semen Platycladi 200g, Fructus Mori 300g, Radix Glehniae 300g, Rhizoma Atractylodis Macrocephalae 250g, Fructus Corni 300g, Radix Aucklandiae 120g, Fructus Broussonetiae 200g, Radix Salviae Miltiorrhizae 200g, rose hip 300g, above 31 tastes, dry medical material for 80-105 DEG C, make moisture ± 8%, pulverized 200 mesh sieves, smalls adds Mel and is in harmonious proportion as pill.

Embodiment 10

Get Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, Radix Polygoni Multiflori 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, above 8 tastes are soaked 1 hour, and heating decocts 2 times, 2 hours for the first time, each 1 hour later, add water 10 times at every turn and measure, merge 2 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution lets cool rear high speed centrifugation remove impurity, concentrating under reduced pressure becomes clear paste, and spraying drying powder-forming is made composite powder.

Embodiment 11

Get Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, He Shou

Crow 300g, Air Bladder pseudosciaenae seu Acipenser 150g, Semen Nelumbinis 100g, Semen Cuscutae 100g, Poria 50g, Fructus Lycii 50g, Radix Angelicae Sinensis 100g, Fructus Ligustri Lucidi 80g, Radix Rehmanniae Preparata 100g, Radix Morindae Officinalis 50g, Radix Astragali 100g, Caulis Spatholobi 80g, Semen Sesami Nigrum 80g, Radix Polygalae 80g, Herba Ecliptae 80g, Rhizoma Dioscoreae 100g, Semen Platycladi 100g, Fructus Mori 100g, Radix Glehniae 100g, Rhizoma Atractylodis Macrocephalae 100g, Fructus Corni 100g, Radix Aucklandiae 100g, Fructus Broussonetiae 80g, Radix Salviae Miltiorrhizae 100g, rose hip 100g, above 31 tastes are soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later, 8 times of amounts add water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution lets cool rear high speed centrifugation remove impurity, concentrating under reduced pressure becomes clear paste, spraying drying powder-forming, make composite powder.

Claims

1. an antioxidant composition, is characterized in that forming as active component by the raw material of following weight parts or by water and/or the alcohol extract of following raw material: Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part.

2. compositions according to claim 1, is characterized in that forming as active component by the raw material of following weight parts or by water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts, Air Bladder pseudosciaenae seu Acipenser.

3. compositions according to claim 1, it is characterized in that also adding the raw material of following weight parts or the water of following raw material and/or alcohol extract to make active component: Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part, Caulis Spatholobi 8-30 part, Semen Sesami Nigrum 8-35 part, Radix Polygalae 8-30 part, Herba Ecliptae 8-35 part, Rhizoma Dioscoreae 10-50 part, Semen Platycladi 10-40 part, Fructus Mori 10-50 part, Radix Glehniae 10-50 part, Rhizoma Atractylodis Macrocephalae 10-50 part, Fructus Corni 10-40 part, Radix Aucklandiae 10-30 part, Fructus Broussonetiae 8-28 part, Radix Salviae Miltiorrhizae 10-25 part, one or combination in any in thorn nine fruit 10-40 part.

4. compositions according to claim 3, it is characterized in that also adding the raw material of following weight parts or the water of following raw material and/or alcohol extract to make active component: 40 parts, Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts, Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts, Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 30 parts of Semen Sesami Nigrums, 15 parts of Radix Polygalaes, 20 parts of Herba Ecliptaes, 35 parts of Rhizoma Dioscoreaes, 20 parts of Semen Platycladi, 30 parts, Fructus Mori, 30 parts of Radix Glehniaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Corni, 12 parts of the Radix Aucklandiae, 20 parts of Fructus Broussonetiaes, 20 parts of Radix Salviae Miltiorrhizaes, one or the combination in any of thorn nine fruit in 30 parts.

5. compositions according to claim 3, is characterized in that forming as active component by the raw material of following weight parts or by water and/or the alcohol extract of following raw material: Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part, Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part.

6. compositions according to claim 5, is characterized in that forming as active component by the raw material of following weight parts or by water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts, Air Bladder pseudosciaenae seu Acipenser, 40 parts, Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts, Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts, Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali.

7. compositions according to claim 3, it is characterized in that forming as active component by the raw material of following weight parts or by water and/or the alcohol extract of following raw material: Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part, Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part, Caulis Spatholobi 8-30 part, Semen Sesami Nigrum 8-35 part, Radix Polygalae 8-30 part, Herba Ecliptae 8-35 part, Rhizoma Dioscoreae 10-50 part, Semen Platycladi 10-40 part, Fructus Mori 10-50 part, Radix Glehniae 10-50 part, Rhizoma Atractylodis Macrocephalae 10-50 part, Fructus Corni 10-40 part, Radix Aucklandiae 10-30 part, Fructus Broussonetiae 8-28 part, Radix Salviae Miltiorrhizae 10-25 part, thorn nine fruit 10-40 part.

8. compositions according to claim 7, it is characterized in that forming as active component by the raw material of following weight parts or by water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts, Air Bladder pseudosciaenae seu Acipenser, 40 parts, Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts, Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts, Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 30 parts of Semen Sesami Nigrums, 15 parts of Radix Polygalaes, 20 parts of Herba Ecliptaes, 35 parts of Rhizoma Dioscoreaes, 20 parts of Semen Platycladi, 30 parts, Fructus Mori, 30 parts of Radix Glehniaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Corni, 12 parts of the Radix Aucklandiae, 20 parts of Fructus Broussonetiaes, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of thorn nine fruits.

9. according to the arbitrary described compositions of claim 1-8, it is characterized in that: alcohol is methanol or ethanol.

10. compositions according to claim 9, is characterized in that: methanol concentration 5-95%, concentration of alcohol 5-95%.

11. according to the arbitrary described compositions of claim 1-8, it is characterized in that: said composition adds acceptable additives in product to be prepared into any dosage form.

12. compositionss according to claim 11, is characterized in that: this dosage form is any one in tablet, oral liquid, granule, capsule, soft extract, pill, powder, lozenge, extractum, injection, syrup.

13. according to the preparation technology of the arbitrary described compositions of claim 1-8, it is characterized in that comprising the following steps:

1) take traditional Chinese medicinal material raw materials;

2) with alcohol or water to above-mentioned medical material reflux, extract,, obtain extracting solution and do active component, add additives, make various dosage forms.

14. according to the preparation technology of the arbitrary described compositions of claim 1-8, it is characterized in that comprising the following steps:

2) extract and concentrate: after the raw material of handling well is soaked, heating decocts repeatedly, and merge extractive liquid, filters, and filtrate is concentrated in right amount, and concentrated solution lets cool rear high speed centrifugation remove impurity, for subsequent use;

3) prepare preparation: by the concentrated solution of gained separately or add pharmaceutically acceptable adjuvant, technique is made required preparation routinely.

The preparation technology of 15. compositionss according to claim 14, is characterized in that:

Soak time is 20 minutes-120 minutes, and heating decocts 1～3 time, each 1～2 hour.

The arbitrary described compositions of 16. claim 1-8 is in the application of preparing in oxidation resistant product.