CN102824533A

CN102824533A - Antioxidant traditional Chinese medicine composition and preparation method thereof

Info

Publication number: CN102824533A
Application number: CN2012103718490A
Authority: CN
Inventors: 刘永平
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-09-29
Filing date: 2012-09-29
Publication date: 2012-12-19
Anticipated expiration: 2032-09-29
Also published as: CN102824533B

Abstract

The invention aims to provide an antioxidant composition which consists of the following raw materials in parts by weight or takes the water and/or alcohol extracts of the following raw materials as active ingredients: 10-60 parts of herba cistanches, 10-55 parts of cortex eucommiae, 10-55 parts of semen astragali complanati, 8-40 parts of fructus psoraleae, 10-55 parts of herba epimedii, 5-20 parts of rhizoma polygonati, 30-120 parts of radix polygoni multiflori and 15-55 parts of swimming bladder. One or any combination of the following materials in parts by weight can be added into the composition provided by the invention: 10-50 parts of lotus seed, 10-50 parts of semen cuscutae, 5-30 parts of poria cocos, 5-30 parts of fructus lycii, 10-50 parts of Chinese angelica, 8-40 parts of fructus ligustri lucidi, 10-50 parts of radix rehmanniae preparata, 5-18 parts of radix morindae officinalis, 10-50 parts of radix astragali, 8-30 parts of caulis spatholobi, 8-35 parts of black sesame, 8-30 parts of radix polygalae, 8-35 parts of eclipta alba, 10-50 parts of rhizoma dioscoreae, 10-40 parts of semen platycladi, 10-50 parts of fructus mori, 10-50 parts of radix glehniae, 10-50 parts of rhizoma atractylodis macrocephalae, 10-40 parts of fructus corni, 10-30 parts of radix aucklandiae, 8-28 parts of fructus broussonetiae, 10-25 parts of radix salviae miltiorrhizae and 10-40 parts of rosa davurica.

Description

A kind of antioxidation Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to a kind of antioxidation Chinese medicine composition and preparation method thereof.

Background technology

Aging is the inexorable law of life process, and is old and feeble inevitable, but slow down aging is possible.At all times, people are seeking the method and the antiaging agent of various life lengthening always, in the hope of delay senility in the life time that can on the hereditism, be defined or raising quality of life.Basic Theories of Chinese Medicine is core with internal organs to the understanding of old and feeble mechanism, and its middle kidney occupies an important position in the old and feeble mechanism of the traditional Chinese medical science, and the Chinese medicine slow down aging mainly acts on and shows as the adjusting body's immunity; Remove free radical; Antioxidation, nervous system regulation and hormonal system function are regulated organismic internal environment; Thereby prolong cell survival and prolong organism life-span, reach antidotal purpose; Modern medicine has free radical theory and mitochondrial DNA damage theory about the representative theory of old and feeble mechanism, and developing rapidly of subjects such as cytobiology, molecular biology promoted the further investigation of old and feeble mechanism; Antiaging agent has chemicals (antioxidant, antiaging hormone, nutrient, oxidase inhibitor, immunomodulator, biochemical preparation, brain function promote medicine etc.) and Chinese medicine (comprising single medicinal material, compound preparation and Chinese medicine extract); Because the Western medicine erious adverse reaction, Chinese medicine occupies more and more important position with its unique curative effect in antidotal research.

Summary of the invention

The purpose of this invention is to provide a kind of antioxidation, have no side effect, the Chinese medicine composition of life lengthening, another object of the present invention has provided the method for preparing of said composition.

Present composition utilization China Traditional Chinese medical theory; " from QI invigorating enrich blood, spleen invigorating, the kidney invigorating, the lung that relaxes reach liver, adjusting and runing yang, raising immunity, defying age " start with; Make full use of China's traditional Chinese medical science treasure-house resource, make equilibrium between yin and yang, obtain the two-ways regulation good result through regulating integral body.

Compositions of the present invention selects Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser to make up, and makes each efficacy of drugs produce synergism this drug regimen, thereby can effectively reach antidotal effect; Wherein select Herba Cistanches, feeble QI; Sweet, little hardship of distinguishing the flavor of, return through sweet, go into kidney, large intestine channel, have kidney-replenishing; Benefiting essence-blood, the effect of loosening bowel to relieve constipation; The Cortex Eucommiae, go into liver, kidney channel, the kidney invigorating and YANG supporting expelling wind and removing dampness is traditional Chinese medical science invigorating the liver and kidney commonly used, strengthening bone and muscle, antiabortive, antasthenic; Semen Astragali Complanati, sweet in the mouth, little hardship, warm in nature, return liver, kidney channel, matter lubricant nature and, the temperature compensation Liver and kidney, it is smart to have a kidney invigorating bone, the effect of nourishing the liver to improve visual acuity; Fructus Psoraleae, acrid in the mouth; Bitter; Warm in nature, go into kidney channel, kidney invigorating and YANG supporting, spleen reinforcing antidiarrheal; Herba Epimedii, abnormal smells from the patient suffering, cold are gone into liver, kidney channel, kidney invigorating and YANG supporting, expelling wind and removing dampness; Rhizoma Polygonati, sweet is flat.Return lung, spleen, kidney, sore is separated in the benefiting essence-blood relieving constipation; Air Bladder pseudosciaenae seu Acipenser, sweet in the mouth, property are put down, and go into liver, kidney channel, have the kidney invigorating and essence nourishing hemostasis dissipating blood stasis, detumescence, nourishing kidney lung moistening, invigorating the spleen and replenishing QI; Radix Polygoni Multiflori, bitter in the mouth, sweet; Puckery, slightly warm in nature.Return liver, kidney channel, the effect of tonifying liver benefit, the Erythroculter ilishaeformis fat is rich in macromolecular collagen protein.

The present composition contains following raw material or is made up of as active ingredient the water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser.

The present composition can also add following raw material or make active ingredient by the water and/or the alcohol extract of following raw material: a kind of or combination in any in Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, the rose hip.

The preferred following raw material of the present composition is perhaps made active ingredient by the water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali.

The preferred following raw material of the present composition is perhaps made active ingredient by the water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip.

The present composition preferably contains the raw material of following weight parts or is made up of as active ingredient the water and/or the alcohol extract of following raw material:

Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part.

The raw material of preferred following weight parts perhaps is made up of as active ingredient the water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts in Air Bladder pseudosciaenae seu Acipenser.

The present composition can also add the raw material of following weight parts or make active ingredient by the water and/or the alcohol extract of following raw material:

Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi

A kind of or combination in any in sub-8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part, Caulis Spatholobi 8-30 part, Semen Sesami Nigrum 8-35 part, Radix Polygalae 8-30 part, Herba Ecliptae 8-35 part, Rhizoma Dioscoreae 10-50 part, Semen Platycladi 10-40 part, Fructus Mori 10-50 part, Radix Glehniae 10-50 part, Rhizoma Atractylodis Macrocephalae 10-50 part, Fructus Corni 10-40 part, Radix Aucklandiae 10-30 part, Fructus Broussonetiae 8-28 part, Radix Salviae Miltiorrhizae 10-25 part, rose hip 10-40 part.

The raw material of preferred following weight parts is perhaps made active ingredient by the water and/or the alcohol extract of following raw material:

A kind of or combination in any in 30 parts in 40 parts in the Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts in Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts in Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 30 parts of Semen Sesami Nigrums, 15 parts of Radix Polygalaes, 20 parts of Herba Ecliptaes, 35 parts of Rhizoma Dioscoreaes, 20 parts of Semen Platycladi, 30 parts in Fructus Mori, 30 parts of Radix Glehniaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Corni, 12 parts of the Radix Aucklandiae, 20 parts of Fructus Broussonetiaes, 20 parts of Radix Salviae Miltiorrhizaes, rose hip.

More preferably the raw material of following weight parts is perhaps made active ingredient by the water and/or the alcohol extract of following raw material:

Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part, Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part.

40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts in Air Bladder pseudosciaenae seu Acipenser, 40 parts in Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts in Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts in Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali.

Most preferably the raw material of following weight parts is perhaps made active ingredient by the water and/or the alcohol extract of following raw material:

Herba Cistanches 10-60 part; Cortex Eucommiae 10-55 part; Semen Astragali Complanati 10-55 part; Fructus Psoraleae 8-40 part; Herba Epimedii 10-55 part; Rhizoma Polygonati 5-20 part; Radix Polygoni Multiflori 30-120 part; Air Bladder pseudosciaenae seu Acipenser 15-55 part; Semen Nelumbinis 10-50 part; Semen Cuscutae 10-50 part; Poria 5-30 part; Fructus Lycii 5-30 part; Radix Angelicae Sinensis 10-50 part; Fructus Ligustri Lucidi 8-40 part; Radix Rehmanniae Preparata 10-50 part; Radix Morindae Officinalis 5-18 part; Radix Astragali 10-50 part; Caulis Spatholobi 8-30 part; Semen Sesami Nigrum 8-35 part; Radix Polygalae 8-30 part; Herba Ecliptae 8-35 part; Rhizoma Dioscoreae 10-50 part; Semen Platycladi 10-40 part; Fructus Mori 10-50 part; Radix Glehniae 10-50 part; Rhizoma Atractylodis Macrocephalae 10-50 part; Fructus Corni 10-40 part; Radix Aucklandiae 10-30 part; Fructus Broussonetiae 8-28 part; Radix Salviae Miltiorrhizae 10-25 part; Rose hip 10-40 part.

40 parts of Herba Cistanches; 40 parts of the Cortexs Eucommiae; 40 parts of Semen Astragali Complanatis; 30 parts of Fructus Psoraleaes; 40 parts of Herba Epimedii; 15 parts of Rhizoma Polygonatis; 90 parts of Radix Polygoni Multiflori; 50 parts in Air Bladder pseudosciaenae seu Acipenser; 40 parts in Semen Nelumbinis; 40 parts of Semen Cuscutae; 20 parts in Poria; 20 parts of Fructus Lycii; 40 parts of Radix Angelicae Sinensis; 20 parts of Fructus Ligustri Lucidi; 30 parts in Radix Rehmanniae Preparata; 10 parts of Radix Morindae Officinaliss; 30 parts of the Radixs Astragali; 15 parts of Caulis Spatholobis; 30 parts of Semen Sesami Nigrums; 15 parts of Radix Polygalaes; 20 parts of Herba Ecliptaes; 35 parts of Rhizoma Dioscoreaes; 20 parts of Semen Platycladi; 30 parts in Fructus Mori; 30 parts of Radix Glehniaes; 25 parts of the Rhizoma Atractylodis Macrocephalaes; 30 parts of Fructus Corni; 12 parts of the Radix Aucklandiae; 20 parts of Fructus Broussonetiaes; 20 parts of Radix Salviae Miltiorrhizaes; 30 parts of rose hips.

The Cortex Eucommiae of the present invention is gone into liver, kidney channel, the kidney invigorating and YANG supporting expelling wind and removing dampness for the dry bark of Eucommiaceae plant Du kind of Eucommia ulmoides oliv; Herba Cistanches is the chylocaulous of the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C. Ma; Semen Astragali Complanati is the dry mature seed of leguminous plant astragatus complanatus Astragalus complanatusR. Br, goes into liver, kidney channel, the temperature compensation Liver and kidney, and bone is smart, and reducing urination makes eye bright; Fructus Psoraleae is the dry mature fruit of legumes psoraleae Psoralea corylifolia L., goes into kidney, spleen channel, warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal; Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium sagittatum (Sieb. et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T. S. Ying or Herba Epimedii Epimedium koreaum Nakai; Go into liver, kidney channel; Kidney invigorating and YANG supporting; Bone and muscle strengthening, expelling wind and removing dampness; Rhizoma Polygonati is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll. et Hemsl.), Rhizoma Polygonati (Polygonatum sibiricum Red.) or Polygonatum cyrtonema Hua (Polygonatum cyrtonema Hua.); Go into lung, spleen, kidney channel; QI invigorating; Yin nourishing, spleen reinforcing, lung moistening; Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., goes into liver, kidney channel, the liver and the kidney tonifying, and sore is separated in the benefiting essence-blood relieving constipation; Air Bladder pseudosciaenae seu Acipenser is for the Air Bladder pseudosciaenae seu Acipenser Pseudosciaene erocea (Rich) of Sciaenidae animal Carnis Pseudosciaenae, Carnis Pseudosciaenae or sturgeon section animal mandarin sturgeon, sturgeon etc. goes into liver, kidney channel, the kidney invigorating and essence nourishing hemostasis; Semen Nelumbinis are the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn., go into spleen, kidney, heart channel, nourishing the heart and kidney, the solid intestinal of spleen reinforcing; Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant Cusouta chinensis Lam., goes into the liver,kidney,spleen warp, invigorating the liver and kidney benefit marrow; Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf, goes into the heart, lung, spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L., goes into liver, kidney channel, nourishing the liver and kidney, replenishing vital essence to improve eyesight; When the dry root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels, go into spleen, liver, kidney channel, tonifying blood and arresting bleeding, menstruction regulating and pain relieving, nourishing is moisturized; The dry mature fruit of Fructus Ligustri Lucidi Oleaceae plant Fructus Ligustri Lucidi Ligustrum lucidum Ait. is gone into liver, kidney channel, the nourishing kidney the liver benefiting, and crow must make eye bright; Radix Rehmanniae Preparata be scrophulariaceae rehmannia glutinosa plant (formal name used at school: tuber Rehmannia glutinosa), go into the heart, liver, kidney channel, the YIN nourishing of enriching blood; Radix Morindae Officinalis is the dry root of Maguireothamnus speciosus Radix Morindae Officinalis Morinda officinalis How, goes into kidney channel, kidney invigorating and YANG supporting, bone and muscle strengthening; The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch) Bge.var.mongholicus (Bge) Hsiao or Radix Astragali Astragalus membranaceus (Fisch) Bge.; Go into spleen, lung meridian, benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly; Rose hip is that Rosa davurica Pall. goes into liver, spleen, stomach, urinary bladder channel warp, promoting QI circulation for relieving depression, and dispersing the stagnated liver-QI for regulating the stomach nourishes blood, promoting blood circulation and stopping pain; Radix Salviae Miltiorrhizae is a dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae for these article Salvia miltiorrhizaBge. dry root and rhizome is gone into the heart, Liver Channel, stasis-dispelling and pain-killing, and promoting blood flow to regulate menstruation, clearing away heat from blood removes stuffy sensation with restlessness; Fructus Corni is cornws offieinalis sied et zucc, goes into liver, kidney channel, liver and kidney tonifying, consolidating semen hidroschesis; Fructus Broussonetiae is the dry mature fruit of Moraceae Broussonetia papyrifera Broussonetia papyrifera (L.) Vent., goes into liver, kidney channel, the kidney invigorating liver heat removing, and it is supporing yang to make eye bright, the diuresis parasite killing; Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L., goes into the heart, liver, kidney channel, and nourishing YIN and supplementing blood promotes the production of body fluid and moisturizes; Semen Sesami Nigrum is the dry mature seed of Pedaliaceae plant sesame Sesamum indicum L., goes into liver, kidney, large intestine channel, and nourishing the liver and kidney is moisturized laxation; Radix Polygalae is the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L., goes into lung, the heart, kidney channel, eliminates the phlegm detumescence, the Fructus Alpiniae Oxyphyllae of calming the nerves; The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz., goes into spleen, stomach warp, invigorating the spleen and replenishing QI, dampness diuretic bone table hidroschesis; Caulis Spatholobi is Spatholobus sunerecfus Dunn, goes into liver, kidney channel, the promoting the circulation of blood of enriching blood, relaxing muscles and tendons and activating QI and blood in the collateral; The dry aerial parts of Herba Ecliptae feverfew Eclipta prostrata Eclipta prostrata L. are gone into liver, kidney channel, liver and kidney tonifying, cooling blood for hemostasis; Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb., goes into lung, spleen, kidney channel, tonifying the spleen and stomach, lung benefiting kidney; Semen Platycladi is the dry mature kernal of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco, goes into the heart, kidney large intestine channel, tranquilizing by nourishing the heart, hidroschesis, intestine moistening; The Radix Aucklandiae is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne., goes into spleen, stomach, large intestine, three warmers, gallbladder meridian, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Radix Glehniae is the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq., goes into spleen, stomach warp, nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.

Chinese medicine compositions of the present invention can add acceptable accessories and be prepared into any dosage form.

Dosage form of the present invention can be any one in tablet, granule, capsule, oral liquid, powder, soft extract, drop pill, pill, the watered pill, honeyed pill, powder, lozenge, fluid extract, extractum, injection, the syrup.

The water of the raw material of Chinese medicine composition according to the invention and/or the preparation technology of alcohol extract may further comprise the steps:

1) takes by weighing the Chinese crude drug raw material;

2) with alcohol or water to above-mentioned medical material reflux, extract,, obtain extracting solution and do active ingredient, add additives, process various dosage forms.

The water of the raw material of Chinese medicine composition according to the invention and/or the preparation technology of alcohol extract can also may further comprise the steps:

1) raw material is prepared: take by weighing the Chinese crude drug raw material;

2) extraction is concentrated: after the raw material of handling well in the step 1 was soaked, heating decocted repeatedly, and merge extractive liquid, filters, and filtrating is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, and is subsequent use;

3) preparation preparation: the independent or adding acceptable accessories with the concentrated solution of gained in the step 2, process required preparation by common process.

With step 2) in soak time be 20 minutes-120 minutes, post-heating decocts 1～3 time, each 1～2 hour;

Alcohol of the present invention is methanol or ethanol; Methanol concentration is 5%-95%, and concentration of alcohol is 5-95%.

Present composition pill preparation technology may further comprise the steps:

1), takes by weighing the Chinese crude drug raw material;

2), 80～105 ℃ the oven dry medical materials, make moisture ± 8%, pulverized 200 mesh sieves;

3), smalls adds Mel and is in harmonious proportion and is pill.

The purposes of the compositions that the present invention relates to form in preparation anti-oxidation health article or medicine or product by Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser.

The present invention relates to by Herba Cistanches; The Cortex Eucommiae; Semen Astragali Complanati; Fructus Psoraleae; Herba Epimedii; Rhizoma Polygonati; Radix Polygoni Multiflori; The compositions that Air Bladder pseudosciaenae seu Acipenser is formed adds Semen Nelumbinis; Semen Cuscutae; Poria; Fructus Lycii; Radix Angelicae Sinensis; Fructus Ligustri Lucidi; Radix Rehmanniae Preparata; Radix Morindae Officinalis; The Radix Astragali; Caulis Spatholobi; Semen Sesami Nigrum; Radix Polygalae; Herba Ecliptae; Rhizoma Dioscoreae; Semen Platycladi; Fructus Mori; Radix Glehniae; The Rhizoma Atractylodis Macrocephalae; Fructus Corni; The Radix Aucklandiae; Fructus Broussonetiae; Radix Salviae Miltiorrhizae; The purposes of compositions in preparation anti-oxidation health article or medicine or product that a kind of or any composition in the rose hip is formed.

The purposes of the compositions that the present invention relates to form in preparation anti-oxidation health article or medicine or product by Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali.

The purposes of the compositions that the present invention relates to form in preparation anti-oxidation health article or medicine or product by Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip.

In order to understand essence of the present invention better, will explain that it has the antioxidative effect with the zoopery and the result of the compositions of forming by Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser of embodiment 1 below.

The compositions of likewise being made up of Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser adds compositions a kind of or that combination in any is formed in Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, the rose hip and all can reach the same antioxidative effect that has is arranged, and difference is the use amount difference.

Chinese medicine composition I of the present invention (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip) proves through animal experiment; Has the mouse anti of raising oxidative function; And have no side effect, the zoopery report is explained as follows:

1. materials and methods

1.1Sample source and processing: the Chinese medicine composition I (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati,

Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip) composite powder; Sample is that brown solid is Powdered; Be mixed with desired concn with distilled water before the test, mouse stomach gives.

laboratory animal and environment: SPF level Kunming kind male 11 the monthly age 40 of mices; Male 1 the monthly age 10 of mices; The animal feeding room temperature is 21-26 ℃, and humidity is 40-70%.

1.3 Dosage divides into groups

With 11 the monthly age 40 of mices be divided into four groups at random by malonaldehyde in the blood (MDA) level, be respectively aged matched group and basic, normal, high dose groups.Basic, normal, high dose groups was raised 30 days with 1.429g crude drug/kg BW, 2.857g crude drug/kg BW, 5.714g crude drug/kg BW respectively continuously, was equivalent to the crowd and recommended 5,10,20 times of daily intaking amount 20g crude drug/70kgBW).Aged matched group gives not add the feedstuff of Chinese medicine.

Sample preparation: accurately take by weighing given the test agent and quantitatively process feedstuff, process basic, normal, high dose groups mouse feed.Each dose groups is all being eaten up the normal feedstuff of taking food again after adding Chinese medicine fodder.

1.4 Experimental technique

Tried thing animal continuous irrigation stomach after 30 days, increase and lack Mus matched group in age, each treated animal selects endocanthion to get blood, and the hemolysate of preparation 2%, 1% detects malonaldehyde (MDA) content and glutathion peroxidase (GSH-PX) vigor respectively.Put to death animal, get liver and do homogenate, the LH of preparation 1% is made superoxide dismutase (SOD) vitality test.

2 The result

2.1The Chinese medicine composition I Influence to the aged mouse body weight

Visible by table 1, each dose groups animal tried thing after 30 days body weight and aged matched group comparing difference do not have significance (p>0.05), explain that this sample does not have influence to the aged mouse body weight.

Table 1 Chinese medicine composition I is to the influence ( ± s) of aged mouse body weight

。

2.2 Chinese medicine composition I Influence to MDA content in aged mouse 2% haemolysis

In dose groups can obviously reduce MDA content in aged mouse 2% hemolysate, with aged matched group comparing difference significance (p < 0.05) is arranged.See table 2:

Table 2 Chinese medicine composition I is to the influence ( ± s) of MDA content in aged mouse 2% hemolysate

。

2.3 Chinese medicine composition I Influence to aged mouse LH SOD, whole blood GSH-PX

In the dose groups SOD that can obviously raise in aged mouse 1% LH active, with aged matched group comparing difference significance (p < 0.05) is arranged; In the dose groups aged mouse 1% hemolysate GSH-PX that can obviously raise active, with aged matched group comparing difference significance (p < 0.05) is arranged.See table 3:

Table 3 Chinese medicine composition I is to the influence (

± s) of aged mouse LH SOD, whole blood GSH-PX

。

3 Brief summary

The test of Chinese medicine composition I anti-oxidation function; Adopt SPF level Kunming kind aged mouse as experimental system; Recommend 5,10,20 times of daily intaking amount 20g crude drug/70kg BW to be equivalent to the crowd; Be low dose group, middle dose groups, high dose group, raised continuously 30 days that result of the test shows: each dose groups mice body weight and aged matched group relatively do not have significant difference (p>0.05); In dose groups can obviously reduce aged mouse 2% hemolysate MDA content, with aged matched group comparing difference significance (p < 0.05) is arranged; In the dose groups SOD that can raise in aged mouse 1% LH active, with aged matched group comparing difference significance (p < 0.05) is arranged; In the dose groups aged mouse 1% hemolysate GSH-PX that obviously raises active, with aged matched group comparing difference significance (p < 0.05) is arranged, according to above result, it is positive to judge that this is tried thing anti-oxidation function animal test results.

Chinese medicine composition II of the present invention (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser) proves to have the mouse anti of raising oxidative function, and have no side effect through animal experiment, the zoopery report is explained as follows:

1. materials and methods

1.1Sample source and processing: the Chinese medicine composition II (Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati,

Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser) composite powder, sample is that brown solid is Powdered, is mixed with desired concn with distilled water before the test, mouse stomach gives.

1.2 laboratory animal and environment: SPF level Kunming kind male 11 the monthly age 40 of mices, male 1 the monthly age 10 of mices, the animal feeding room temperature is 21-26 ℃, humidity is 40-70%.

1.3 Dosage divides into groups

With 11 the monthly age 40 of mices be divided into four groups at random by malonaldehyde in the blood (MDA) level, be respectively aged matched group and basic, normal, high dose groups.Basic, normal, high dose groups was raised 30 days with 1.143g crude drug/kg BW, 2.286g crude drug/kg BW, 4.571g crude drug/kg BW respectively continuously, was equivalent to the crowd and recommended 5,10,20 times of daily intaking amount 16g crude drug/70kgBW).Aged matched group gives not add the feedstuff of Chinese medicine.

1.4 Experimental technique

3 The result

2.1The Chinese medicine composition II Influence to the aged mouse body weight

Table 4 Chinese medicine composition II is to the influence (

± s) of aged mouse body weight

。

2.2 Chinese medicine composition II Influence to MDA content in aged mouse 2% haemolysis

Table 5 Chinese medicine composition II is to the influence ( ± s) of MDA content in aged mouse 2% hemolysate

。

3.3 Chinese medicine composition II Influence to aged mouse LH SOD, whole blood GSH-PX

Table 6 Chinese medicine composition II is to the influence ( ± s) of aged mouse LH SOD, whole blood GSH-PX

。

3 Brief summary

The test of Chinese medicine composition II anti-oxidation function; Adopt SPF level Kunming kind aged mouse as experimental system; Recommend 5,10,20 times of daily intaking amount 16g crude drug/70kg BW to be equivalent to the crowd; Be low dose group, middle dose groups, high dose group, raised continuously 30 days that result of the test shows: each dose groups mice body weight and aged matched group relatively do not have significant difference (p>0.05); In dose groups can obviously reduce aged mouse 2% hemolysate MDA content, with aged matched group comparing difference significance (p < 0.05) is arranged; In the dose groups SOD that can raise in aged mouse 1% LH active, with aged matched group comparing difference significance (p < 0.05) is arranged; In the dose groups aged mouse 1% hemolysate GSH-PX that obviously raises active, with aged matched group comparing difference significance (p < 0.05) is arranged, according to above result, it is positive to judge that this is tried thing anti-oxidation function animal test results.

The specific embodiment

Embodiment 1

Take by weighing Herba Cistanches 400g, Cortex Eucommiae 400g, Semen Astragali Complanati 400g, Fructus Psoraleae 300g, Herba Epimedii 400g, Rhizoma Polygonati 150g, Radix Polygoni Multiflori 900g, Air Bladder pseudosciaenae seu Acipenser 500g, more than 8 flavors soaked 1 hour, heating decocts 3 times; 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn; Merge 3 times extracting liquid filtering, filtrating is concentrated into an amount of, and concentrated solution is put the high speed centrifugation remove impurity of cold back; Add oral liquid adjuvant commonly used, mix homogeneously is processed the 20000ml oral liquid by the oral liquid common process.

Embodiment 2

Take by weighing Chinese crude drug raw meat Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, Radix Polygoni Multiflori 300g, Air Bladder pseudosciaenae seu Acipenser 150g, more than 8 flavors soak 60min, heating decocts 3 times; Add 10 times of amounts of water at every turn, each 2 hours, merge 3 times extracting liquid filtering; Filtrating is put the high speed centrifugation remove impurity of cold back, and concentrating under reduced pressure becomes cream or spraying drying powder-forming, adds tablet adjuvant commonly used; Mix homogeneously is processed various tablets by the tablet common process.

Embodiment 3

Take by weighing Chinese crude drug raw meat Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, Radix Polygoni Multiflori 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, more than 8 flavors soaked 1 hour, heating decocts 3 times; 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn; Merge 3 times extracting liquid filtering, filtrating is concentrated into an amount of, and concentrated solution is put the high speed centrifugation remove impurity of cold back; Add syrup adjuvant commonly used, mix homogeneously is processed syrup by the syrup common process.

Embodiment 4

Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, Radix Polygoni Multiflori

300g, Air Bladder pseudosciaenae seu Acipenser 150g, Semen Nelumbinis 100g, Semen Cuscutae 100g, Poria 50g, Fructus Lycii 50g, Radix Angelicae Sinensis 100g, Fructus Ligustri Lucidi 80g, Radix Rehmanniae Preparata 100g, Radix Morindae Officinalis 50g, Radix Astragali 100g added 95% alcohol reflux 2 hours, obtained alcohol extract behind the recovery ethanol; Medicinal residues add the water heating again and decoct 3 times, each 2 hours, merge alcohol extract and aqueous extract; Filter, filtrating is concentrated into an amount of, and concentrated solution is put the high speed centrifugation remove impurity of cold back and filtered; Add oral liquid adjuvant commonly used, mix homogeneously is processed the 20000ml oral liquid by the oral liquid common process.

Embodiment 5

Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, what head

Crow 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, Semen Nelumbinis 500g, Semen Cuscutae 500g, Poria 300g, Fructus Lycii 300g, Radix Angelicae Sinensis 500g, Fructus Ligustri Lucidi 400g, Radix Rehmanniae Preparata 500g, Radix Morindae Officinalis 180g, Radix Astragali 500g soak above medicine 1 hour decocte with water 2-3 time; Filtered in each 1-3 hour, merging filtrate is concentrated into relative density 1.10-1.40 (55-60 ℃); Add ethanol and reach 50% to containing the alcohol amount, leave standstill filtration in 24 hours, filtrating is reclaimed; Ethanol is concentrated into relative density 1.35-1.38 (55-60 ℃) thick paste, vacuum drying, is ground into fine powder, adds appropriate amount of auxiliary materials; Mixing is granulated, and is pressed into 1000 sugar coatings and promptly gets tablet.

Embodiment 6

Herba Cistanches 400g, Cortex Eucommiae 400g, Semen Astragali Complanati 400g, Fructus Psoraleae 300g, Herba Epimedii 400g, Rhizoma Polygonati 150g, Radix Polygoni Multiflori 900g, Air Bladder pseudosciaenae seu Acipenser 500g, Semen Nelumbinis 400g, Semen Cuscutae 400g, Poria 200g, Fructus Lycii 200g, Radix Angelicae Sinensis 400g, Fructus Ligustri Lucidi 200g, Radix Rehmanniae Preparata 300g, Radix Morindae Officinalis 100g, Radix Astragali 300g; To remove impurity with medicine-feeding; Become 300 mesh sieve smalls with the pulverizer powder; Add additives starch, dextrin, incapsulate and process capsule.

Embodiment 7

Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, what head

Crow 300g, Air Bladder pseudosciaenae seu Acipenser 150g, Semen Nelumbinis 100g, Semen Cuscutae 100g, Poria 50g, Fructus Lycii 50g, Radix Angelicae Sinensis 100g, Fructus Ligustri Lucidi 80g, Radix Rehmanniae Preparata 100g, Radix Morindae Officinalis 50g, Radix Astragali 100g, Caulis Spatholobi 80g, Semen Sesami Nigrum 80g, Radix Polygalae 80g, Herba Ecliptae 80g, Rhizoma Dioscoreae 100g, Semen Platycladi 100g, Fructus Mori 100g, Radix Glehniae 100g, Rhizoma Atractylodis Macrocephalae 100g, Fructus Corni 100g, Radix Aucklandiae 100g, Fructus Broussonetiae 80g, Radix Salviae Miltiorrhizae 100g, rose hip 100g; With above medicine respectively 80-105 ℃ of oven dry; Moisture is pulverized less than 8%; Cross sieve No. one, press solid-liquid ratio 1:5-10, temperature 60-98 ℃ following flooding 3-12 hour; Repeat twice; Filter and remove residue is got supernatant, merging filtrate; Filtrating sucks vacuum concentration pot; Under 0.04-0.08MPa vacuum, be concentrated into the heavy 1/2-3/4 of material; Concentrate feed carries out spray drying, and 160-180 ℃ of spray drying control EAT processed dissolved granule after dry product dextrin, maltodextrin, cyclodextrin, the soluble starch.

Embodiment 8

Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, what

Radix Polygoni Multiflori 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, Semen Nelumbinis 500g, Semen Cuscutae 500g, Poria 300g, Fructus Lycii 300g, Radix Angelicae Sinensis 500g, Fructus Ligustri Lucidi 400g, Radix Rehmanniae Preparata 500g, Radix Morindae Officinalis 180g, Radix Astragali 500g, Caulis Spatholobi 300g, Semen Sesami Nigrum 350g, Radix Polygalae 300g, Herba Ecliptae 350g, Rhizoma Dioscoreae 500g, Semen Platycladi 400g, Fructus Mori 500 g, Radix Glehniae 500g, Rhizoma Atractylodis Macrocephalae 500g, Fructus Corni 400g, Radix Aucklandiae 300g, Fructus Broussonetiae 280g, Radix Salviae Miltiorrhizae 250g, rose hip 400g; Above medicine is removed impurity, drying, sterilization; Become 200 order dusting cover smalls with the pulverizer powder; Add additives; Like soybean oil, Oleum Sesami, starch, sucrose, stevioside, citric acid, sodium bicarbonate, dextrin, make the watered pill.

Embodiment 9

Herba Cistanches 400g, Cortex Eucommiae 400g, Semen Astragali Complanati 400g, Fructus Psoraleae 300g, Herba Epimedii 400g, Rhizoma Polygonati 150g, Radix Polygoni Multiflori 900g, Air Bladder pseudosciaenae seu Acipenser 500g, Semen Nelumbinis 400g, Semen Cuscutae 400g, Poria 200g, Fructus Lycii 200g, Radix Angelicae Sinensis 400g, Fructus Ligustri Lucidi 200g, Radix Rehmanniae Preparata 300g, Radix Morindae Officinalis 100g, Radix Astragali 300g, Caulis Spatholobi 150g, Semen Sesami Nigrum 300g, Radix Polygalae 150g, Herba Ecliptae 200g, Rhizoma Dioscoreae 350g, Semen Platycladi 200g, Fructus Mori 300g, Radix Glehniae 300g, Rhizoma Atractylodis Macrocephalae 250g, Fructus Corni 300g, Radix Aucklandiae 120g, Fructus Broussonetiae 200g, Radix Salviae Miltiorrhizae 200g, rose hip 300g; More than 31 the flavor, 80-105 ℃ the oven dry medical materials; Make moisture ± 8%; Pulverized 200 mesh sieves, smalls adds the Mel mediation and is pill.

Embodiment 10

Get Herba Cistanches 600g, Cortex Eucommiae 550g, Semen Astragali Complanati 550g, Fructus Psoraleae 400g, Herba Epimedii 550g, Rhizoma Polygonati 200g, Radix Polygoni Multiflori 1200g, Air Bladder pseudosciaenae seu Acipenser 550g, more than 8 flavors soaked 1 hour, heating decocts 2 times; 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn; Merge 2 times extracting liquid filtering, filtrating is concentrated into an amount of, and concentrated solution is put the high speed centrifugation remove impurity of cold back; Concentrating under reduced pressure becomes clear paste, and spraying drying powder-forming is processed composite powder.

Embodiment 11

Get Herba Cistanches 100g, Cortex Eucommiae 100g, Semen Astragali Complanati 100g, Fructus Psoraleae 80g, Herba Epimedii 100g, Rhizoma Polygonati 50g, what head

Crow 300g, Air Bladder pseudosciaenae seu Acipenser 150g, Semen Nelumbinis 100g, Semen Cuscutae 100g, Poria 50g, Fructus Lycii 50g, Radix Angelicae Sinensis 100g, Fructus Ligustri Lucidi 80g, Radix Rehmanniae Preparata 100g, Radix Morindae Officinalis 50g, Radix Astragali 100g, Caulis Spatholobi 80g, Semen Sesami Nigrum 80g, Radix Polygalae 80g, Herba Ecliptae 80g, Rhizoma Dioscoreae 100g, Semen Platycladi 100g, Fructus Mori 100g, Radix Glehniae 100g, Rhizoma Atractylodis Macrocephalae 100g, Fructus Corni 100g, Radix Aucklandiae 100g, Fructus Broussonetiae 80g, Radix Salviae Miltiorrhizae 100g, rose hip 100g; More than 31 flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time; Each 1 hour later on; Add 8 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrating is concentrated into an amount of; Concentrated solution is put the high speed centrifugation remove impurity of cold back; Concentrating under reduced pressure becomes clear paste, and spraying drying powder-forming is processed composite powder.

Claims

1. a compositions is characterized in that containing following raw material and perhaps is made up of as active ingredient the water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser.

2. compositions according to claim 1 is characterized in that further containing following raw material and perhaps is made up of as active ingredient the water and/or the alcohol extract of following raw material: a kind of or combination in any in Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, the rose hip.

3. compositions according to claim 2 is characterized in that further containing following raw material and perhaps is made up of as active ingredient the water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali.

4. compositions according to claim 2 is characterized in that further containing following raw material and perhaps is made up of as active ingredient the water and/or the alcohol extract of following raw material: Herba Cistanches, the Cortex Eucommiae, Semen Astragali Complanati, Fructus Psoraleae, Herba Epimedii, Rhizoma Polygonati, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Semen Nelumbinis, Semen Cuscutae, Poria, Fructus Lycii, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Morindae Officinalis, the Radix Astragali, Caulis Spatholobi, Semen Sesami Nigrum, Radix Polygalae, Herba Ecliptae, Rhizoma Dioscoreae, Semen Platycladi, Fructus Mori, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Radix Aucklandiae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, rose hip.

5. compositions according to claim 1 is characterized in that further containing the raw material of following weight parts or being made up of as active ingredient the water and/or the alcohol extract of following raw material: Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part.

6. compositions according to claim 5 is characterized in that further containing the raw material of following weight parts or being made up of as active ingredient the water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts in Air Bladder pseudosciaenae seu Acipenser.

7. compositions according to claim 2 is characterized in that containing the raw material of following weight parts or being made up of as active ingredient the water and/or the alcohol extract of following raw material: a kind of or combination in any in Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part, Caulis Spatholobi 8-30 part, Semen Sesami Nigrum 8-35 part, Radix Polygalae 8-30 part, Herba Ecliptae 8-35 part, Rhizoma Dioscoreae 10-50 part, Semen Platycladi 10-40 part, Fructus Mori 10-50 part, Radix Glehniae 10-50 part, Rhizoma Atractylodis Macrocephalae 10-50 part, Fructus Corni 10-40 part, Radix Aucklandiae 10-30 part, Fructus Broussonetiae 8-28 part, Radix Salviae Miltiorrhizae 10-25 part, rose hip 10-40 part.

8. compositions according to claim 7 is characterized in that containing the raw material of following weight parts or is made up of as active ingredient the water and/or the alcohol extract of following raw material: a kind of or combination in any in 30 parts in 40 parts in the Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts in Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts in Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 30 parts of Semen Sesami Nigrums, 15 parts of Radix Polygalaes, 20 parts of Herba Ecliptaes, 35 parts of Rhizoma Dioscoreaes, 20 parts of Semen Platycladi, 30 parts in Fructus Mori, 30 parts of Radix Glehniaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Corni, 12 parts of the Radix Aucklandiae, 20 parts of Fructus Broussonetiaes, 20 parts of Radix Salviae Miltiorrhizaes, rose hip.

9. compositions according to claim 3 is characterized in that containing the raw material of following weight parts or being made up of as active ingredient the water and/or the alcohol extract of following raw material: Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part, Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part.

10. compositions according to claim 9 is characterized in that containing the raw material of following weight parts or being made up of as active ingredient the water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts in Air Bladder pseudosciaenae seu Acipenser, 40 parts in Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts in Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts in Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali.

11. compositions according to claim 4 is characterized in that containing the raw material of following weight parts or being made up of as active ingredient the water and/or the alcohol extract of following raw material: Herba Cistanches 10-60 part, Cortex Eucommiae 10-55 part, Semen Astragali Complanati 10-55 part, Fructus Psoraleae 8-40 part, Herba Epimedii 10-55 part, Rhizoma Polygonati 5-20 part, Radix Polygoni Multiflori 30-120 part, Air Bladder pseudosciaenae seu Acipenser 15-55 part, Semen Nelumbinis 10-50 part, Semen Cuscutae 10-50 part, Poria 5-30 part, Fructus Lycii 5-30 part, Radix Angelicae Sinensis 10-50 part, Fructus Ligustri Lucidi 8-40 part, Radix Rehmanniae Preparata 10-50 part, Radix Morindae Officinalis 5-18 part, Radix Astragali 10-50 part, Caulis Spatholobi 8-30 part, Semen Sesami Nigrum 8-35 part, Radix Polygalae 8-30 part, Herba Ecliptae 8-35 part, Rhizoma Dioscoreae 10-50 part, Semen Platycladi 10-40 part, Fructus Mori 10-50 part, Radix Glehniae 10-50 part, Rhizoma Atractylodis Macrocephalae 10-50 part, Fructus Corni 10-40 part, Radix Aucklandiae 10-30 part, Fructus Broussonetiae 8-28 part, Radix Salviae Miltiorrhizae 10-25 part, rose hip 10-40 part.

12. compositions according to claim 11 is characterized in that containing the raw material of following weight parts or being made up of as active ingredient the water and/or the alcohol extract of following raw material: 40 parts of Herba Cistanches, 40 parts of the Cortexs Eucommiae, 40 parts of Semen Astragali Complanatis, 30 parts of Fructus Psoraleaes, 40 parts of Herba Epimedii, 15 parts of Rhizoma Polygonatis, 90 parts of Radix Polygoni Multiflori, 50 parts in Air Bladder pseudosciaenae seu Acipenser, 40 parts in Semen Nelumbinis, 40 parts of Semen Cuscutae, 20 parts in Poria, 20 parts of Fructus Lycii, 40 parts of Radix Angelicae Sinensis, 20 parts of Fructus Ligustri Lucidi, 30 parts in Radix Rehmanniae Preparata, 10 parts of Radix Morindae Officinaliss, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 30 parts of Semen Sesami Nigrums, 15 parts of Radix Polygalaes, 20 parts of Herba Ecliptaes, 35 parts of Rhizoma Dioscoreaes, 20 parts of Semen Platycladi, 30 parts in Fructus Mori, 30 parts of Radix Glehniaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Corni, 12 parts of the Radix Aucklandiae, 20 parts of Fructus Broussonetiaes, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of rose hips.

13. according to the arbitrary described compositions of claim 1-12, it is characterized in that: alcohol is methanol or ethanol.

14. compositions according to claim 13 is characterized in that: methanol concentration 5-95%, concentration of alcohol are 5-95%.

15. according to the arbitrary described compositions of claim 1-12, it is characterized in that: said composition can add that acceptable additives are prepared into any dosage form in health product or medicine or the product.

16. compositions according to claim 15 is characterized in that: this dosage form can be any one in tablet, oral liquid, granule, capsule, soft extract, drop pill, pill, powder, lozenge, fluid extract, extractum, injection, the syrup.

17., it is characterized in that may further comprise the steps according to the arbitrary described preparation of compositions technology of claim 1-12:

Take by weighing the Chinese crude drug raw material;

, obtain extracting solution and do active ingredient above-mentioned medical material reflux, extract, with alcohol or water, add additives, process various dosage forms.

18., it is characterized in that and can also may further comprise the steps according to the arbitrary described preparation of compositions technology of claim 1-12:

Raw material is prepared: take by weighing the Chinese crude drug raw material;

Extract and concentrate: after the raw material of handling well in the step 1 was soaked, heating decocted repeatedly, and merge extractive liquid, filters, and filtrating is concentrated into an amount of, and concentrated solution is put the high speed centrifugation remove impurity of cold back, and is subsequent use;

The preparation preparation: the independent or adding acceptable accessories with the concentrated solution of gained in the step 2, process required preparation by common process.

19., it is characterized in that according to claim 18 preparation of compositions technology:

Step 2) after soak time was 20 minutes-120 minutes in, heating decocted 1～3 time, each 1～2 hour.

20. the bolus quantities preparation technology of compositions according to claim 16 is characterized in that may further comprise the steps:

1), takes by weighing the Chinese crude drug raw material;

3), smalls adds Mel and is in harmonious proportion and is pill.

21. the application in the arbitrary described preparation of compositions antioxidant food of claim 1-12 or medicine or the product.