CN102821759A - 用于治疗具有慢性活性b细胞受体信号传导的b细胞淋巴瘤的pkc抑制剂 - Google Patents

用于治疗具有慢性活性b细胞受体信号传导的b细胞淋巴瘤的pkc抑制剂 Download PDF

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Publication number
CN102821759A
CN102821759A CN2011800155365A CN201180015536A CN102821759A CN 102821759 A CN102821759 A CN 102821759A CN 2011800155365 A CN2011800155365 A CN 2011800155365A CN 201180015536 A CN201180015536 A CN 201180015536A CN 102821759 A CN102821759 A CN 102821759A
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CN
China
Prior art keywords
inhibitor
pkc
additional agent
diketone
methyl
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Pending
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CN2011800155365A
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English (en)
Chinese (zh)
Inventor
W·舒勒
F·P·施特格梅尔
M·瓦姆斯
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Novartis Vaccines and Diagnostics Inc
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Novartis Vaccines and Diagnostics Inc
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Publication of CN102821759A publication Critical patent/CN102821759A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800155365A 2010-03-30 2011-03-28 用于治疗具有慢性活性b细胞受体信号传导的b细胞淋巴瘤的pkc抑制剂 Pending CN102821759A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31901310P 2010-03-30 2010-03-30
US61/319,013 2010-03-30
US201061425525P 2010-12-21 2010-12-21
US61/425,525 2010-12-21
PCT/EP2011/054709 WO2011120911A1 (en) 2010-03-30 2011-03-28 Pkc inhibitors for the treatment of b-cell lymphoma having chronic active b-cell-receptor signalling

Publications (1)

Publication Number Publication Date
CN102821759A true CN102821759A (zh) 2012-12-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800155365A Pending CN102821759A (zh) 2010-03-30 2011-03-28 用于治疗具有慢性活性b细胞受体信号传导的b细胞淋巴瘤的pkc抑制剂

Country Status (12)

Country Link
US (1) US8748428B2 (https=)
EP (1) EP2552428A1 (https=)
JP (1) JP2013523678A (https=)
KR (2) KR101461767B1 (https=)
CN (1) CN102821759A (https=)
AR (1) AR080737A1 (https=)
AU (1) AU2011234644B2 (https=)
BR (1) BR112012024585A2 (https=)
CA (1) CA2795456A1 (https=)
MX (1) MX2012011341A (https=)
RU (1) RU2012146083A (https=)
WO (1) WO2011120911A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106795151A (zh) * 2014-08-06 2017-05-31 诺华股份有限公司 蛋白激酶c抑制剂和它们的使用方法
WO2019218810A1 (zh) * 2018-05-17 2019-11-21 复旦大学附属肿瘤医院 治疗非霍奇金氏淋巴瘤的药物组合物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4556010A3 (en) 2011-11-30 2025-07-23 Emory University Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
KR101723786B1 (ko) 2014-03-28 2017-04-06 가톨릭대학교 산학협력단 Ｉｌ―２１을 발현하는 중간엽 줄기세포를 포함하는 ｂ 세포 림프종 예방 또는 치료용 조성물
JP2019524700A (ja) * 2016-07-14 2019-09-05 ミングサイト ファーマシューティカルズ，インク． 癌の処置
WO2020092924A1 (en) * 2018-11-02 2020-05-07 Board Of Regents, The University Of Texas System Combination therapy for the treatment of egfr tyrosine kinase inhibitor resistant cancer

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106795151A (zh) * 2014-08-06 2017-05-31 诺华股份有限公司 蛋白激酶c抑制剂和它们的使用方法
US10508101B2 (en) 2014-08-06 2019-12-17 Novartis Ag Protein kinase C inhibitors and methods of their use
CN106795151B (zh) * 2014-08-06 2021-05-07 诺华股份有限公司 蛋白激酶c抑制剂和它们的使用方法
US11059804B2 (en) 2014-08-06 2021-07-13 Novartis Ag Protein kinase C inhibitors and methods of their use
US11505541B2 (en) 2014-08-06 2022-11-22 Novartis Ag Protein kinase C inhibitors and methods of their use
WO2019218810A1 (zh) * 2018-05-17 2019-11-21 复旦大学附属肿瘤医院 治疗非霍奇金氏淋巴瘤的药物组合物
CN110496223A (zh) * 2018-05-17 2019-11-26 复旦大学附属肿瘤医院 一种治疗非霍奇金氏淋巴瘤的药物组合物

Also Published As

Publication number Publication date
BR112012024585A2 (pt) 2016-05-31
AU2011234644A1 (en) 2012-10-11
KR101461767B1 (ko) 2014-11-13
EP2552428A1 (en) 2013-02-06
US20110245256A1 (en) 2011-10-06
KR20140107685A (ko) 2014-09-04
AR080737A1 (es) 2012-05-02
MX2012011341A (es) 2012-11-12
US8748428B2 (en) 2014-06-10
JP2013523678A (ja) 2013-06-17
AU2011234644B2 (en) 2014-07-17
KR20120133389A (ko) 2012-12-10
CA2795456A1 (en) 2011-10-06
WO2011120911A1 (en) 2011-10-06
RU2012146083A (ru) 2014-05-10

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