CN102813642A - Freckle removal and anti-skin aging compound preparation - Google Patents
Freckle removal and anti-skin aging compound preparation Download PDFInfo
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- CN102813642A CN102813642A CN2012103379010A CN201210337901A CN102813642A CN 102813642 A CN102813642 A CN 102813642A CN 2012103379010 A CN2012103379010 A CN 2012103379010A CN 201210337901 A CN201210337901 A CN 201210337901A CN 102813642 A CN102813642 A CN 102813642A
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- compound preparation
- skin aging
- tranexamic acid
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- skin
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Abstract
The invention discloses a freckle removal and anti-skin aging compound preparation which is paste prepared from 0.2-5% of idebenone and 0.5-10% of tranexamic acid by mass as effective active ingredients and emulsifiable paste matrix. The preparation disclosed by the invention is prepared into an external compound cosmeceutical preparation with delicate appearance and good anti-skin aging and freckle removal functions by use of the new indications of idebenone and tranexamic acid and the synergistic effect of the combination of idebenone and tranexamic acid so as to solve the problems of freckles, skin aging, wrinkles and the like.
Description
Technical field
The present invention relates to a kind of beauty treatment medicine and make up preparation, be specifically related to a kind of compound preparation with speckle dispelling, anti aging effect function.
Background technology
Without the qi depression to blood stasis and the pathological changes at position, all can relatively partly show in the body at face with speckle; Simultaneously, the cosmetics that Exposure to Sunlight and life-time service contain lead, hydrargyrum, hormones chemical substance can destroy epidermis open weave structure, increase the weight of the formation of deposits of mottle.And with advancing age, face also can engender microgroove and wrinkle, and therefore, various speckle dispelling and antidotal skin care item are existing thereupon.But no matter be which kind of skin care item, effect is neither good, and with rebound phenomena.
The stupid quinone in Chinese mugwort ground is a kind of jonquilleous liquid; Be to split synthetic being transformed through coenzyme q-10 being carried out biomolecule catalysis; Specific drug and the brain function metabolism and the mental symptom that are novel anti-ageing year dementia are improved medicine; Can improve the metabolism of brain-capacity, improve brain function, and slight hypotensive effect is arranged.Be used to occur patients such as disordered brain function, consciousness that cerebral infarction, cerebral hemorrhage and arteriosclerosis sequela cause are low, emotionally disturbed, aphasis, dementia clinically.The stupid quinone in Chinese mugwort ground has very strong antioxidation; Be the most effective external antioxidant in the existing product; Can effectively engulf the free radical that causes the skin body aging, the protection foeign element is to the injury that skin caused, and the delaying skin collagen protein runs off; And provide skin metabolism required energy, let skin compact, smoothly.The more left-handed C of composition is more stable, tie up the A milder, more than all advantages make idebenone become the popular composition of anti aging effect.
That tranexamic acid is mainly used in is acute or chronic, various hemorrhage due to limitation or the general hyperfibrinolysis.Big in recent years quantity research shows that tranexamic acid has the very strong black speckle function of removing of moving back, and its effect is higher about 50 times than vitamin C, be nearly about 10 times of fruit acid, and its safety is good, has become at present to move back the black speckle medicine that removes preferably.
Though Chinese mugwort stupid quinone in ground and tranexamic acid have anti aging effect and the effect of moving back black speck respectively, will not end stupid quinone in ground and tranexamic acid are processed the report of compound formulation.
Summary of the invention
Technical problem to be solved by this invention is: to the deficiency of above-mentioned prior art, a kind of compound preparation of speckle removing, antisenescence is provided.
In order to solve the problems of the technologies described above; The technical scheme that the present invention adopted is: a kind of compound preparation of speckle dispelling anti aging effect; Be characterized in: by mass percentage, it is to contain the stupid quinone in Chinese mugwort ground 0.2%~5%, and the paste that forms as effective active components and emulsifiable paste matrix of tranexamic acid 0.5%~10%.
The compound preparation of speckle dispelling anti aging effect of the present invention can be by known method preparation in the pharmaceuticals industry; Promptly mix with emulsifiable paste matrix (85-99% mass ratio) and get through will end stupid quinone in ground and tranexamic acid; Can process the compound recipe dosage form that is suitable for external application, be generally ointment.The emulsifiable paste matrix of external application compound cream agent can contain in the pharmaceuticals industry carrier and/or adjuvant commonly used, like carrier (like monoglyceride, stearic acid, lanoline, carbomer), 16-18 alcohol, No. 26 white oils, white vaseline, homemade 305, CRODA GP200; DC200 (350cst); HANSHENGJIAO, isomery ten alkane etc.), emulsifying agent (like tween 80), diluent (like purified water, propylene glycol), antiseptic (methyl hydroxybenzoate; Ethyl hydroxybenzoate), wetting agent (glycerol etc.).
Compound preparation of the present invention mainly utilizes Chinese mugwort stupid quinone in ground and the new indication of tranexamic acid; And the synergism between the two is prepared from; Through our clinical trial; Compound preparation of the present invention has new curative effect, and better anti aging effect and effect of dispelling spots describe with concrete experimental data below.
1, irritation test
Choose 6 medical white rabbit (certification of fitness: SCXK (Hunan) 2009-0012 buys the wound laboratory animal company limited in east, Hunan), male and female are not limit; Body weight 2.2~2.5kg cuts tame rabbit back spinal column diamond wool the about 3cm of scope before the test; Wherein a side is coated about 0.5g preparation of the present invention; And cover with cellophane, opposite side is as contrast, respectively at 1,24,48,72h observes the zest phenomenon; Phenomenons such as erythema, edema all do not appear in the result, and this result also obtains checking on one's body volunteer subsequently.
2, clinical trial
18 female volunteers of picked at random, the age is 28~45 years old, face has mottle and the photoaging of skin of face moderate, carries out 30 days preliminary clinical research evaluation.Method for using and consumption: spread on face outward, early, the evening each once.Speckle dispelling uses 0.05-0.1g/cm at every turn
2Anti aging effect uses 0.3-0.5g/cm at every turn
2In the needs position.
Evaluation result is mainly controlled oneself to give a mark by the volunteer and is estimated effect of the present invention; Scoring requires as follows: increase skin elasticity 3 minutes; Skin becomes fine and smooth 5 minutes more by coarse, and mottle was removed 10 fens, and standards of grading are: increase skin elasticity 3 and be divided into effectively; Skin by coarse become more fine and smooth more than 4 minutes for effectively, it is effective more than 6 minutes that mottle is removed.Its result is following:
Result of the test by last table shows: the present invention has antidotal effect, owing to be pharmaceutical composition, its freckle effect effect is remarkable equally, has shown the crease-resistant and speckle dispelling space that the present invention is brand-new simultaneously.
So, compound preparation of the present invention can reduce facial microgroove and wrinkle with the stupid quinone in Chinese mugwort ground, improves the skin glossiness greatly; And tranexamic acid has the very strong black speckle function of removing of moving back, and the two is combined, and has synergism; Be convenient to solve the yellowbird speckle, skin aging, problem such as wrinkling.
The specific embodiment
Below contain different component among each embodiment ointment all can adopt the known method preparation of pharmaceuticals industry.
Embodiment 1
Embodiment 2
Embodiment 3
Embodiment 4
Embodiment 5
Claims (2)
1. the compound preparation of a speckle dispelling anti aging effect is characterized in that: by mass percentage, it is to contain the stupid quinone in Chinese mugwort ground 0.2%~5%, and the paste that forms as effective active components and emulsifiable paste matrix of tranexamic acid 0.5%~10%.
2. the compound preparation of a kind of speckle dispelling anti aging effect as claimed in claim 1 is characterized in that: the dosage form of said compound preparation is an ointment.
Priority Applications (1)
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CN2012103379010A CN102813642A (en) | 2012-09-13 | 2012-09-13 | Freckle removal and anti-skin aging compound preparation |
Applications Claiming Priority (1)
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CN2012103379010A CN102813642A (en) | 2012-09-13 | 2012-09-13 | Freckle removal and anti-skin aging compound preparation |
Publications (1)
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CN102813642A true CN102813642A (en) | 2012-12-12 |
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CN2012103379010A Pending CN102813642A (en) | 2012-09-13 | 2012-09-13 | Freckle removal and anti-skin aging compound preparation |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1953742A (en) * | 2004-01-06 | 2007-04-25 | 利普泰股份公司 | Use of idebennone in preparation of topical applied depigmenation composition and correspondent composition |
CN101027032A (en) * | 2004-09-22 | 2007-08-29 | 大塚制药株式会社 | Composition for prevention or alleviation of pigmentation |
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2012
- 2012-09-13 CN CN2012103379010A patent/CN102813642A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1953742A (en) * | 2004-01-06 | 2007-04-25 | 利普泰股份公司 | Use of idebennone in preparation of topical applied depigmenation composition and correspondent composition |
CN101027032A (en) * | 2004-09-22 | 2007-08-29 | 大塚制药株式会社 | Composition for prevention or alleviation of pigmentation |
Non-Patent Citations (2)
Title |
---|
周宇 等: "氨甲环酸治疗黄褐斑作用研究", 《浙江中西医结合杂志》 * |
来吉祥 等: "皮肤衰老机理及延缓衰老化妆品的研究进展", 《中国美容医学》 * |
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Application publication date: 20121212 |