CN104188808A - Freckle and chloasma removing gel and preparation method thereof - Google Patents
Freckle and chloasma removing gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses freckle and chloasma removing gel and a preparation method thereof. The gel comprises the following substances: evening primrose oil, grape seed oil, wheatgerm oil, creour agel SIMULGEL EG, olive emulsifier, ice forming agent AVC, 1% gel forming agent STABILEZE QM solution, sodium alginate, carbomer 941, 1,3-butanediol, 1,2-propylene glycol, rosemary extract, myosotis sylvatica extract, 7% ethylparaben alcoholic solution (75% ethanol) and distilled water. Compared with the prior art, the freckle and chloasma removing gel is milk white, transparent and glittering, has proper viscosity, mild property and good stability, is moistened and nourishing, has aromatic smell, and is capable of supplying nutrition to facial skin and removing freckle and chloasma, so that skin can be deeply nourished, moistened and elastic.
Description
Technical field
The present invention relates to a kind of preparation method of gel, be specifically related to a kind of speckle dispelling yellow gel and preparation method thereof of dispelling.
Background technology
Mottle is apt to occur in facial area, for light brown, deeply brown, taupe pigmentation spots, comprises freckle, black speck, chloasma and senile plaque etc., belongs to pigment obstacle dermatoses.Doctor trained in Western medicine thinks that it is the variation of a kind of photoallergic dermatitis or photoxic dermatitis, a lot of cases have and chemical article and cosmetics contact history inferior, cosmetic product is the even mottle that also can cause of some composition in applying some make up as performer's greasepaint or family, and usually postemphasis is shone in day illumination.Electromagnetic oscillation can excite the melanin of skin, and for a long time in the face of the radiation of computer, sleep in evening is bad or there is no rest fully, and mental pressure and operating pressure are large, all can cause mottle.In addition malnutrition and other factors also may cause primary disease.The clear content of copper ion of Most patients increases, and may be the mark that TYR enzymatic activity strengthens.
And the processing method of this mottle is had substantially following several at present:
1,, by pure physical means, with powder fat or thick mastic covering skin, make it to avoid daylight and pollute infringement.But anti-outer do not control interior, can not improve skin color and luster, and side effect is larger.Or adopt laser beautifying to remove speckle, and be mainly to use laser therapeutic apparatus to send specific wavelength, the laser of different wave length can be drawn by the color in skin or pigment, and after pigment is slowly drawn by health, the color relation of mottle can be thereupon thin out.But to remove speckle be to rely on " the mandatory speckle that goes " of external force to laser after all, can not block from source the born of speckle.
2, fruit acid changes skin and removes speckle: selected fruit acid is the acid naturally of extracting from fruit, fruit acid changes skin and goes speckle can remove the speckle that is positioned at epiderm skin shallow-layer, but helpless to being positioned at the pigment spot of epiderm skin deep layer (basal layer) or skin corium.In addition, use fruit acid change skin go speckle require high, first want severe aseptic manipulation; Secondly owing to adopting high concentration fruit acid, can not escape by luck and will injure keratodermatitis, the function that makes skin resist extraneous infringement reduces, and also makes the transition of skin moisture lose simultaneously, very easily occurs aging.
3, adopt the cosmetics of selling on the market at present, but it is main mainly with chemical raw material, through national quality inspection organization sampling observation, the harmful substance contents such as its lead, hydrargyrum, hydroquinone exceed the hundred times of required standard, and what have even exceedes more than 1000 times.Lead, hydrargyrum etc. are to human body skin, and the material that nervous system is poisonous is the most serious to the organ injury such as liver, kidney especially, can produce chronic poisoning, and its contained toxic substance also can cause skin carcinogenic.There is serious skin lesion phenomenon at painting erasure in some user also, leave the black speck and the cicatrix that are difficult to healing, and bounce-back rate is high.Though plumbous, the heavy metal ion such as hydrargyrum can act on the tryrosinase in the born process of pigment, and it is lost activity, thereby have prevented the formation of mottle, allow whiteness of skin.But this effect is of short duration, the ultimate consequence causing is tryrosinase or the unrestrictedly regeneration of catalysis pigment, makes skin darkening, and heavy metal poisoning speckle, even appears in pigment bounce-back.Present a lot of countries have banned use of above-mentioned hypertoxic medicine for anti-freckle agent, and China also clearly specifies that inaccurate use or the hypertoxic medicine of this class of limiting the quantity are for speckle dispelling or other cosmetics.
Pure Chinese herbal medicine speckle dispelling compound preparation is to generally acknowledge one of speckle dispelling method the most safely and effectively, also by dermatologist is praised highly.A kind of new speckle dispelling that contains natural component extracting solution provided by the present invention yellow gel of dispelling, can brighten, Glycerin, and this speckle dispelling yellow gel of dispelling is very high to tyrosinase activity suppression ratio, effective to mottle, and its safety is good.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of speckle dispelling yellow gel of dispelling.
The preparation method that the present invention also provides a kind of speckle dispelling to dispel yellow gel.
A kind of speckle dispelling yellow gel of dispelling, contains following material in 100g gel:
Described Myosotis sylvatica extracting solution is prepared by the following method:
Take Myosotis sylvatica appropriate, reflux, extract, 3 times in the water of 90-100 DEG C, adds the 5-25 times of water yield the 1st time, extracts 0.5-2h, the 2nd time by the 5-20 times of water yield, extract 0.5-1.5h, add the 5-10 times of water yield the 3rd time, extract 0.5-1h, filter with 3 layers of gauze at every turn, merging filtrate, heating is concentrated into 5-20 times of g/ml of Myosotis sylvatica weight, obtains Myosotis sylvatica extracting solution.
Described Herba Rosmarini Officinalis extracting solution is prepared by the following method:
Take the Herba Rosmarini Officinalis of constant weight, reflux, extract, 3 times in the water of 90-100 DEG C, adds 5-25 times of water gaging for the first time, extract 0.5-2h, by three layers of filtered through gauze, add for the second time 5-20 times of water gaging, extract 0.5-1.5h, filter, for the third time with 5-15 times of water gaging, extract 0.2-1h, filter, mix three times filtrate, heating is concentrated into 5-15 times of g/ml of Herba Rosmarini Officinalis weight, obtains Herba Rosmarini Officinalis extracting solution.
The dispel preparation method of yellow gel of a kind of speckle dispelling provided by the invention, described preparation method comprises the following steps:
A) taking ice crystal forming agent AVC 0.1-0.3g, add 15-25ml distilled water, stir it is dissolved, is thickening agent 1;
B) take carbomer 0.05-0.15g, add 10-20ml distilled water, leave standstill and make it swelling, the wiring solution-forming that stirs, is thickening agent 2;
C) take sodium alginate 0.02-0.2g, adding distil water 10-20ml, leaves standstill and makes it swelling, and the wiring solution-forming that stirs, is thickening agent 3;
D) take respectively Radix Oenotherae erythrosepalae oil 1-3g, Semen Tritici aestivi germ oil 1-3g, Oleum Vitis viniferae 1-3g, simple and easy emulsifying agent SIMULGEL EG 0.1-1.0g, olive oil emulsifying agent 0.1-1.0g, be placed in 1 li, beaker, beaker 1 is placed in the water-bath of 60-90 DEG C and heats, as oil phase;
E) measure respectively 1,2-PD 1-9ml, distilled water 10-30ml pours beaker 2 into again, beaker 2 is placed in the water-bath of 60-90 DEG C and heats, as water;
Etc. f) water and oil phase reach after uniform temp, water in beaker 2 are to thread shape pour oil phase into, and limit edged stirs, until form uniform emulsion bases;
G) in emulsion bases, add Myosotis sylvatica extracting solution 0.1-2g, Herba Rosmarini Officinalis extracting solution 0.1-2g, 1,3 butylene glycol 0.1-2g, 7% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 1-3ml, uniform stirring;
H) in beaker, add thickening agent 1, thickening agent 2, thickening agent 3,1% gel former STABILEZE QM solution 1-5g again, uniform stirring, obtains the speckle dispelling yellow gel of dispelling.
Various compositions in the present invention are as follows:
Myosotis sylvatica is rich in vitamin C, can slow down the generation of wrinkle and black speck, skin whitening, liver heat removing and eyesight improving, enriching yin and nourishing kidney, blood-supplementing blood-nourishing, and can promote body metabolism, delaying cell aging, improves immunity, avoids the generation of wrinkle and black speck, particularly freckle, acne are had to certain elimination effect, skin-protecting face nursing, enhance metabolism, can effectively regulate women's physiological problem.
Herba Rosmarini Officinalis is a kind of natural spice berry, mainly contain carnosic acid, carnosol, rosmarinic acid, rosmanol, flavonoid etc. from the natural anti-oxidation composition extracting in Herba Rosmarini Officinalis, the degraded of free radical and the inhibition human body protein of human body be can effectively remove, thereby elasticity and the gloss of skin kept.Herba Rosmarini Officinalis extract is confirmed fully in the character of antibacterial, mutation and the aspect such as anticancer.
Radix Oenotherae erythrosepalae oil main component has oleic acid, linoleic acid, gamma-Linolenic acid etc., these materials are important additives of cosmetics, make skin have resilient flexible sense, its sense of touch and ductility are fine, and are easily absorbed by skin blood capillary, energy blood circulation promoting, prevent epidermis cell keratinization, make skin keep lubricated, delay skin aging.Monounsaturated fatty acid molecule in Radix Oenotherae erythrosepalae oil, for skin texture provides sufficient toughness and prevents moisture of skin loss, can recover the normal barrier function of skin, moisturizing agent and wetting agent outstanding in cosmetics, skin moisturizing ability is strengthened, be rich in moisture feeling, promote skin stretching, after use, do not have too much greasy feeling.
Semen Tritici aestivi germ oil rich in vitamin E, linoleic acid, linolenic acid, sweet eight carbon alcohol and multiple physiologically active component, there is the characteristic of free radical resisting, can delay skin aging, moistness is strong, can desalinate microgroove, striae gravidarum, cicatrix, increase skin wetting power, to dry, hydropenia, aging, wrinkle skin is extremely helpful, can reduce the left vestige of long comedo on the face, be applicable to various skin quality, black speck, chronic eczema, eczema are had to certain effect, also there is sun-screening function, can be used for health sun-proof.
Oleum Vitis viniferae contains abundant vitamin E and a certain amount of vitamin A, D and various trace element.Oleum Vitis viniferae is one of potent free radical scavenger, is a kind of efficient antioxidation and the beauty and skin care health-care good product of removing free radical, and is easy to skin connective tissue absorption; can assist to protect skin to avoid ultraviolet damage; nourishes rough skin, reduces dermatosis and wrinkle, even eliminates cicatrix.Oleum Vitis viniferae serves a dual purpose to skin, on the one hand it can to promote that collagen protein forms appropriately crosslinked, on the other hand, it is as the effective free radical scavenger of one, can prevent skin " excessively crosslinked ", thereby stop the appearance of wrinkle of skin and vesicle, keep the soft and moist smooth of skin.
Compare with prior art, the present invention, by adding Myosotis sylvatica extracting solution, Herba Rosmarini Officinalis extracting solution, Radix Oenotherae erythrosepalae oil, Semen Tritici aestivi germ oil and Semen Vitis viniferae wet goods pure natural components, improves the effect that the present invention prepares crease-resistant, light speckle, whitening and the moisturizing of gel.A kind of new speckle dispelling that contains natural component extracting solution provided by the present invention yellow gel of dispelling, can brighten, Glycerin, and this speckle dispelling yellow gel of dispelling is very high to tyrosinase activity suppression ratio, effective to mottle, and its safety is good.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Radix Oenotherae erythrosepalae oil of the present invention, Semen Tritici aestivi germ oil, Oleum Vitis viniferae are commercially available.
Embodiment 1
The preparation of 1.1 Myosotis sylvatica extracting solution:
Take Myosotis sylvatica 20g, reflux, extract, 3 times in the water of 95 DEG C, adds 20 times of water yields the 1st time, extracts 2h, 15 times of water yields of the 2nd use, extract 1.5h, add 10 times of water yields the 3rd time, extract 1h, filter with 3 layers of gauze at every turn, merging filtrate, heating is concentrated into 15 times of g/ml of Myosotis sylvatica weight, obtains Myosotis sylvatica extracting solution.
The preparation of 1.2 Herba Rosmarini Officinalis extracting solution:
Take Herba Rosmarini Officinalis 10g, reflux, extract, 3 times in the water of 100 DEG C, adds 25 times of water gagings for the first time, heating decocts extracts 2h, by three layers of filtered through gauze, adds for the second time 20 times of water gagings, extract 1.5h, filter, use for the third time 15 times of water gagings, heating decocts extracts 1h, filter, mix three times filtrate, heating is concentrated into 15 times of g/ml of Herba Rosmarini Officinalis weight, obtains Herba Rosmarini Officinalis extracting solution.
The dispel preparation method of yellow gel of 1.3 speckle dispelling
A) taking ice crystal forming agent AVC 0.2g, add 15ml distilled water, stir it is dissolved, is thickening agent 1;
B) take Carbopol 941 0.09g, add 10ml distilled water, leave standstill and make it swelling, the wiring solution-forming that stirs, is thickening agent 2;
C) take sodium alginate 0.15g, adding distil water 15ml, leaves standstill and makes it swelling, and the wiring solution-forming that stirs, is thickening agent 3;
D) take respectively Radix Oenotherae erythrosepalae oil 1.5g, Semen Tritici aestivi germ oil 2g, Oleum Vitis viniferae 2g, simple and easy emulsifying agent SIMULGEL EG 0.3g, olive oil emulsifying agent 0.5g, be placed in 1 li, beaker, beaker 1 is placed in the water-bath of 75 DEG C and heats, as oil phase;
E) measure respectively 1,2-PD 5ml, distilled water 15ml pours beaker 2 into again, beaker 2 is placed in the water-bath of 75 DEG C and heats, as water;
Etc. f) water and oil phase reach after uniform temp, water in beaker 2 are to thread shape pour oil phase into, and limit edged stirs, until form uniform emulsion bases;
G) in emulsion bases, add Myosotis sylvatica extracting solution 1g, Herba Rosmarini Officinalis extracting solution 1g, 1,3 butylene glycol 1g, 7% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 2ml, uniform stirring;
H) in beaker, add thickening agent 1, thickening agent 2, thickening agent 3,1% gel former STABILEZE QM solution 2g again, uniform stirring, obtains the speckle dispelling yellow gel of dispelling.
Embodiment 2
The preparation of 2.1 Myosotis sylvatica extracting solution:
Take Myosotis sylvatica 25g, in the water of 100 DEG C, extract 3 times, add 25 times of water yields the 1st time, extract 1.5h, 15 times of water yields of the 2nd use, extract 1h, add 8 times of water yields the 3rd time, extract 0.5h, filter with 3 layers of gauze at every turn, merging filtrate, heating is concentrated into 15 times of g/ml of Myosotis sylvatica weight, obtains Myosotis sylvatica extracting solution.
The preparation of 2.2 Herba Rosmarini Officinalis extracting solution:
Take Herba Rosmarini Officinalis 15g, reflux, extract, 3 times in the water of 100 DEG C, adds 20 times of water gagings for the first time, extract 1.5h, by three layers of filtered through gauze, add for the second time 15 times of water gagings, extract 1h, filter, use for the third time 10 times of water gagings, extract 0.5h, filter, merge three times filtrate, heating is concentrated into 10 times of g/ml of Herba Rosmarini Officinalis weight, obtains Herba Rosmarini Officinalis extracting solution.
The dispel preparation method of yellow gel of 2.3 speckle dispelling
A) taking ice crystal forming agent AVC 0.3g, add 25ml distilled water, stir it is dissolved, is thickening agent 1;
B) take Carbopol 941 0.15g, add 20ml distilled water, leave standstill and make it swelling, the wiring solution-forming that stirs, is thickening agent 2;
C) take sodium alginate 0.2g, adding distil water 20ml, leaves standstill and makes it swelling, and the wiring solution-forming that stirs, is thickening agent 3;
D) take respectively Radix Oenotherae erythrosepalae oil 3g, Semen Tritici aestivi germ oil 3g, Oleum Vitis viniferae 3g, simple and easy emulsifying agent SIMULGEL EG 1.0g, olive oil emulsifying agent 1.0g, be placed in 1 li, beaker, beaker 1 is placed in the water-bath of 90 DEG C and heats, as oil phase;
E) measure respectively 1,2-PD 9ml, distilled water 10ml pours beaker 2 into again, beaker 2 is placed in the water-bath of 90 DEG C and heats, as water;
Etc. f) water and oil phase reach after uniform temp, water in beaker 2 are to thread shape pour oil phase into, and limit edged stirs, until form uniform emulsion bases;
G) in emulsion bases, add Myosotis sylvatica extracting solution 1.5g, Herba Rosmarini Officinalis extracting solution 1.5g, 1,3 butylene glycol 1.5g, 7% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 2ml, uniform stirring;
H) in beaker, add thickening agent 1, thickening agent 2, thickening agent 3,1% gel former STABILEZE QM solution 2g again, uniform stirring, obtains the speckle dispelling yellow gel of dispelling.
Embodiment 3
The physical and chemical index of embodiment 1,2 is as follows
3.1 character
This product is that viscosity is suitable, good stability, abnormal smells from the patient fragrance, fine and smooth milky, transparent sparkling and crystal-clear gel uniformly.
3.2 pH value inspections
Get this product, measure with pH reagent paper, recording pH value is 6-7.
3.3 caloric test
Gel is packaged in transparent dressing product bottle, within one month, observes without lamination in the refrigerator cold-storages of 4 DEG C.24h in the calorstat of 55 DEG C, this gel is without layering, the phenomenon such as spoiled.
3.4 centrifugal test
Gel is packaged in to 3000r/min in tool plug test tube, and centrifugal 20min, without lamination.
3.5 room temperatures are placed experiment
Embodiment 1,2 made gels are placed in to bottle for cosmetics, and room temperature leaves standstill investigates 6 months, and without lamination, use aftersensation is unchanged, abnormal smells from the patient is unchanged.
3.6 irritation tests, anaphylaxis experiment
White mice back cuts off hair, smears respectively by the gel of embodiment 1,2 preparation in cutting plucked position, and is not coated with position and compares, and result does not have zest and anaphylaxis.
Get embodiment 1,2 and be applied in right amount in volunteer (20-50 year, 40 people) gesture and facial expression, observe after spending 30 minutes, all do not occur rubescent, dermexanthesis, foaming phenomenon.
Embodiment 4
The speckle dispelling yellow effect experiment of dispelling
Women's object on probation of choosing 100 20-50 year age bracket, is divided into arbitrarily two groups, and respectively with the gel of embodiment 1,2 preparations, every day totally 2 times sooner or later, be three months service time.Wherein, in embodiment 1,50 example, 35 years old following 24 example, 35 years old above 26 example.In embodiment 2,50 examples, 35 years old following 22 example, 35 years old above 28 example.Selected women generally has that xerosis cutis is dark yellow, the situation of wrinkle, freckle, mottle in various degree.
Effect standard: effective, mottle, wrinkle shoal, thin out even disappearance, and skin is obviously ruddy many, and aging phenomenon is not obvious; Effectively, dark yellowly relent gradually, skin is relatively moist, but wrinkle mottle is subdued not yet; Invalid, skin problem does not improve and alleviates, and the colour of skin is still dark yellow dry.The results are shown in Table 1:
The table 1 speckle dispelling yellow experimental result of dispelling
Embodiment 5
Gel resultant effect is investigated
Below utilize effect of feeling to come the gel that Evaluation operation example 1,2 produces on probation.Adopt public-opinion poll point system, choose people's object on probation of 70 20-50 year age bracket, be divided into arbitrarily two groups, respectively with the gel emulsion of embodiment 1,2 preparations.Every day totally 2 times sooner or later, be two months service time.Every result of use total score is 5 points: five are divided into best result, represents better, very satisfied; 4 be divided into fine; 3 are divided into and can accept; 3 points is bad below, can not accept.Be below every average, the results are shown in Table 2:
Table 2 resultant effect is investigated
| Result of use | The every average of embodiment 1 | The every average of embodiment 2 |
| Light stricture of vagina | 4.6 | 4.5 |
| Moisture retention | 4.8 | 4.7 |
| Nourishing property | 4.9 | 4.8 |
| Speckle dispelling | 4.6 | 4.5 |
In sum, this made gel of the present invention has the effect of good light stricture of vagina, moisturizing, speckle dispelling, nourishing.
Claims (4)
1. the speckle dispelling yellow gel of dispelling, is characterized in that, contains following material in 100g gel:
2. the speckle dispelling according to claim 1 yellow gel of dispelling, is characterized in that: described Myosotis sylvatica extracting solution is prepared by the following method:
Take Myosotis sylvatica appropriate, reflux, extract, 3 times in the water of 90-100 DEG C, adds the 5-25 times of water yield the 1st time, extracts 0.5-2h, the 2nd time by the 5-20 times of water yield, extract 0.5-1.5h, add the 5-10 times of water yield the 3rd time, extract 0.5-1h, filter with 3 layers of gauze at every turn, merging filtrate, heating is concentrated into 5-20 times of g/ml of Myosotis sylvatica weight, obtains Myosotis sylvatica extracting solution.
3. the speckle dispelling according to claim 1 yellow gel of dispelling, is characterized in that: described Herba Rosmarini Officinalis extracting solution is prepared by the following method:
Take the Herba Rosmarini Officinalis of constant weight, reflux, extract, 3 times in the water of 90-100 DEG C, adds 5-25 times of water gaging for the first time, extract 0.5-2h, by three layers of filtered through gauze, add for the second time 5-20 times of water gaging, extract 0.5-1.5h, filter, for the third time with 5-15 times of water gaging, extract 0.2-1h, filter, mix three times filtrate, heating is concentrated into 5-15 times of g/ml of Herba Rosmarini Officinalis weight, obtains Herba Rosmarini Officinalis extracting solution.
4. the speckle dispelling claimed in claim 1 preparation method for yellow gel of dispelling, is characterized in that: said method comprising the steps of:
A) taking ice crystal forming agent AVC 0.1-0.3g, add 15-25ml distilled water, stir it is dissolved, is thickening agent 1;
B) take carbomer 0.05-0.15g, add 10-20ml distilled water, leave standstill and make it swelling, the wiring solution-forming that stirs, is thickening agent 2;
C) take sodium alginate 0.02-0.2g, adding distil water 10-20ml, leaves standstill and makes it swelling, and the wiring solution-forming that stirs, is thickening agent 3;
D) take respectively Radix Oenotherae erythrosepalae oil 1-3g, Semen Tritici aestivi germ oil 1-3g, Oleum Vitis viniferae 1-3g, simple and easy emulsifying agent SIMULGEL EG 0.1-1.0g, olive oil emulsifying agent 0.1-1.0g, be placed in 1 li, beaker, beaker 1 is placed in the water-bath of 60-90 DEG C and heats, as oil phase;
E) measure respectively 1,2-PD 1-9ml, distilled water 10-30ml pours beaker 2 into again, beaker 2 is placed in the water-bath of 60-90 DEG C and heats, as water;
Etc. f) water and oil phase reach after uniform temp, water in beaker 2 are to thread shape pour oil phase into, and limit edged stirs, until form uniform emulsion bases;
G) in emulsion bases, add Myosotis sylvatica extracting solution 0.1-2g, Herba Rosmarini Officinalis extracting solution 0.1-2g, 1,3 butylene glycol 0.1-2g, 7% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 1-3ml, uniform stirring;
H) in beaker, add thickening agent 1, thickening agent 2, thickening agent 3,1% gel former STABILEZE QM solution 1-5g again, uniform stirring, obtains the speckle dispelling yellow gel of dispelling.
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| CN105078868A (en) * | 2015-09-18 | 2015-11-25 | 皖南医学院 | Whitening and moisturizing freckle removal lotion and preparation method thereof |
| CN107496190A (en) * | 2017-10-15 | 2017-12-22 | 广州汀兰生物科技有限公司 | A kind of whitening spot-eliminating composition and its application |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434740A (en) * | 2014-12-16 | 2015-03-25 | 皖南医学院 | Traditional Chinese medicine gel for removing acnes and preparation method of traditional Chinese medicine gel |
| CN104434740B (en) * | 2014-12-16 | 2018-04-10 | 皖南医学院 | A kind of Chinese medicine blemish clearing gel agent and preparation method thereof |
| CN105078868A (en) * | 2015-09-18 | 2015-11-25 | 皖南医学院 | Whitening and moisturizing freckle removal lotion and preparation method thereof |
| CN105078868B (en) * | 2015-09-18 | 2018-03-27 | 皖南医学院 | A kind of nti-freckle emulsion of skin whitening, moisturizing and preparation method thereof |
| CN107496190A (en) * | 2017-10-15 | 2017-12-22 | 广州汀兰生物科技有限公司 | A kind of whitening spot-eliminating composition and its application |
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| CN104188808B (en) | 2017-04-05 |
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