CN102803507B - 用于微流体装置中在板反应剂的脱水储存的组合物及方法 - Google Patents

用于微流体装置中在板反应剂的脱水储存的组合物及方法 Download PDF

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Publication number
CN102803507B
CN102803507B CN201080029480.4A CN201080029480A CN102803507B CN 102803507 B CN102803507 B CN 102803507B CN 201080029480 A CN201080029480 A CN 201080029480A CN 102803507 B CN102803507 B CN 102803507B
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microfluidic
microfluidic cartridge
spots
reagent
cartridge
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CN102803507A (zh
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C·F·拜特瑞尔
D·M·霍克斯特拉
J·哈伯
J·R·维利福德
S·N·盖茨
E·R·莱博尔
I·斯普拉格
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Ruifudi Health Science Co
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Micronics Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
CN201080029480.4A 2009-06-12 2010-06-10 用于微流体装置中在板反应剂的脱水储存的组合物及方法 Active CN102803507B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18644209P 2009-06-12 2009-06-12
US61/186,442 2009-06-12
PCT/US2010/038141 WO2010144683A2 (en) 2009-06-12 2010-06-10 Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices

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CN102803507A CN102803507A (zh) 2012-11-28
CN102803507B true CN102803507B (zh) 2016-05-25

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US (2) US8921085B2 (https=)
EP (1) EP2440672B1 (https=)
JP (2) JP5953229B2 (https=)
CN (1) CN102803507B (https=)
AU (1) AU2010258716B2 (https=)
WO (1) WO2010144683A2 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010144683A2 (en) 2009-06-12 2010-12-16 Micronics, Inc. Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
CA2786569C (en) 2010-01-29 2019-04-09 Perkinelmer Health Sciences, Inc. Sample-to-answer microfluidic cartridge
WO2011116256A2 (en) * 2010-03-18 2011-09-22 The Regents Of The University Of Michigan Multiphase microarrays and uses thereof
EP2582850B1 (en) 2010-06-21 2016-11-09 Life Technologies Corporation Compositions, kits, and methods for synthesis and/or detection of nucleic acids
CA2824404C (en) * 2011-01-06 2023-01-03 Meso Scale Technologies, Llc Assay cartridges for pcr analysis and methods of use thereof
US9075042B2 (en) * 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
AU2013334189B2 (en) 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP6349327B2 (ja) * 2012-12-17 2018-06-27 レウコドゥックス,リミテッド 化学的状態を判定するためのシステムおよび方法
KR20150096788A (ko) 2012-12-21 2015-08-25 마이크로닉스 인코포레이티드. 마이크로 유체공학 용도를 위한 저탄성 막
JP6498125B2 (ja) 2012-12-21 2019-04-10 マイクロニクス, インコーポレイテッド 流体回路および関連する製造方法
CN104919035B (zh) 2012-12-21 2017-08-11 精密公司 便携式荧光检测系统和微测定盒
KR101632886B1 (ko) 2013-03-14 2016-06-23 지멘스 헬쓰케어 다이아그노스틱스 인크. 밀봉된 온-보드 시약을 갖는 미세유체 칩
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス, インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
EP2994543B1 (en) 2013-05-07 2018-08-15 Micronics, Inc. Device for preparation and analysis of nucleic acids
CA2911303C (en) 2013-05-07 2021-02-16 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
GB2516669B (en) * 2013-07-29 2015-09-09 Atlas Genetics Ltd A method for processing a liquid sample in a fluidic cartridge
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US9937239B2 (en) * 2014-05-21 2018-04-10 The Johns Hopkins University Preservation and reconstitution of cell-free protein expression systems
DK3152291T3 (da) * 2014-06-09 2021-10-18 Somnio Global Holdings Llc Fremgangsmåder og indretninger til kapillar-understøttet vitrificering
KR20170016915A (ko) 2014-06-11 2017-02-14 마이크로닉스 인코포레이티드. 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치
EP3015553A1 (de) * 2014-10-30 2016-05-04 Biotecon Diagnostics GmbH Stabilisierte Reaktionsmischung
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10227634B2 (en) * 2015-04-15 2019-03-12 University Of Washington Isotachophoresis enhanced isothermal nucleic acid amplification
JP6820865B2 (ja) 2015-04-29 2021-01-27 ペルキネルマー ヘルス サイエンシーズ, インコーポレイテッド 試料収集および送達装置
US10124340B2 (en) 2015-12-08 2018-11-13 Electronics And Telecommunications Research Institute Reagent storage device and bio-reaction apparatus including the same
JP6631420B2 (ja) 2016-06-28 2020-01-15 株式会社デンソー 光センサ
NZ751531A (en) * 2016-09-30 2023-02-24 Tel Array Diagnostics Inc Microfluidic device
GB201704760D0 (en) 2017-01-05 2017-05-10 Illumina Inc Reagent nozzle sipper mixing system and method
CN112041659A (zh) * 2018-02-06 2020-12-04 瓦罗贝克两合公司 微流体装置、系统、基础设施、其用途以及使用其用于基因工程改造的方法
CN109673515A (zh) * 2019-02-13 2019-04-26 广西壮族自治区药用植物园 羊齿天门冬超低温培养方法
CN109792954A (zh) * 2019-02-13 2019-05-24 广西壮族自治区药用植物园 石刁柏超低温保存培养方法
CN109644874A (zh) * 2019-02-13 2019-04-19 广西壮族自治区药用植物园 绣线菊超低温保存培养方法
US20220193678A1 (en) * 2019-04-08 2022-06-23 Technion Research And Development Foundation, Ltd. Multiplexed array of nanoliter droplet array device
US11856947B2 (en) 2020-02-17 2024-01-02 Cook Medical Technologies Llc System for automated permeation of a biological material and method of using same
JP2022060807A (ja) * 2020-10-05 2022-04-15 キヤノンメディカルシステムズ株式会社 乾燥試薬、試薬キット、乾燥試薬の製造方法、分析方法及び核酸増幅方法
WO2023113787A1 (en) * 2021-12-15 2023-06-22 Hewlett-Packard Development Company, L.P. Microfluidic devices with dehydrated reagents
WO2025137109A1 (en) * 2023-12-20 2025-06-26 Abbott Point Of Care Inc. Whole blood cmp in a dmf device without dilution

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007106579A2 (en) * 2006-03-15 2007-09-20 Micronics, Inc. Integrated nucleic acid assays

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2748132A1 (de) 1977-10-27 1979-05-03 Behringwerke Ag Stabilisator fuer polysaccharid
US4457916A (en) 1982-08-31 1984-07-03 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
JPH0779694B2 (ja) 1985-07-09 1995-08-30 カドラント バイオリソ−シズ リミテツド 蛋白質および同類品の保護
US4762857A (en) 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
GB9010742D0 (en) * 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances
US5200399A (en) 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US5565318A (en) 1994-09-02 1996-10-15 Pharmacia Biotech, Inc. Room temperature stable reagent semi-spheres
US5593824A (en) 1994-09-02 1997-01-14 Pharmacia Biotech, Inc. Biological reagent spheres
GB9508691D0 (en) 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US6825047B1 (en) * 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US5876992A (en) 1996-07-03 1999-03-02 Molecular Biology Resources, Inc. Method and formulation for stabilization of enzymes
US5861251A (en) 1996-10-15 1999-01-19 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
US6021533A (en) * 1997-08-25 2000-02-08 Hill-Rom, Inc. Mattress apparatus having a siderail down sensor
US6153412A (en) 1998-12-07 2000-11-28 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
ES2180416B1 (es) * 2001-03-12 2004-06-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
US20020173016A1 (en) 2001-03-27 2002-11-21 Helmut Wurst High-throughput nucleic acid polymerase devices and methods for their use
US20030017567A1 (en) * 2001-04-24 2003-01-23 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
US6830535B2 (en) 2002-09-11 2004-12-14 Daimlerchrysler Corporation Fluid lock double displacement engine
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
JP4758891B2 (ja) 2003-06-06 2011-08-31 マイクロニクス, インコーポレイテッド 微小流体デバイス上の加熱、冷却および熱サイクリングのためのシステムおよび方法
GB0327094D0 (en) * 2003-11-21 2003-12-24 Inverness Medical Switzerland Laminated device
US20050142571A1 (en) 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US7727710B2 (en) * 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
FI20040768A0 (fi) * 2004-06-04 2004-06-04 Teemu Korpimaeki Menetelmä määritysreagenssien stabiloimiseksi, stabilisoituja määritysreagensseja sisältävä reagenssisäiliö ja sen käyttö
EP1796838B1 (de) 2004-10-15 2014-10-08 Boehringer Ingelheim Vetmedica GmbH Verfahren zur durchführung einer elektrochemischen messung an einer flüssigen messprobe in einer über leitungen zugänglichen messkammer
US7618777B2 (en) 2005-03-16 2009-11-17 Agilent Technologies, Inc. Composition and method for array hybridization
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7807354B2 (en) * 2005-12-28 2010-10-05 Agilent Technologies, Inc. Low volume hybridization
EP2210955A3 (en) * 2006-05-23 2010-09-15 Molecular Detection, Inc. Ambient temperature stable kits for molecular diagnostics
JP5479895B2 (ja) * 2006-07-25 2014-04-23 アジレント・テクノロジーズ・インク Dnaポリメラーゼの保存及び使用のための両性イオン洗剤
JP5989957B2 (ja) * 2006-09-18 2016-09-07 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション ガラス化生物試薬の調製
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US20080155524A1 (en) 2006-12-26 2008-06-26 Fuja Shone Firmware Updating and Extending Method for Application Specific Integrated Circuit
GB0711683D0 (en) * 2007-06-16 2007-07-25 Enigma Diagnostics Ltd Compositions
JP5721704B2 (ja) 2009-06-12 2015-05-20 マイクロニクス, インコーポレイテッド マイクロ流体デバイス内のtaqポリメラーゼを乾燥保存するための再水和可能なマトリックス
WO2010144683A2 (en) 2009-06-12 2010-12-16 Micronics, Inc. Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007106579A2 (en) * 2006-03-15 2007-09-20 Micronics, Inc. Integrated nucleic acid assays

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
连续流动式PCR芯片相关技术研究进展;章春笋;《分析测试学报》;20041231(第6期);14-118 *

Also Published As

Publication number Publication date
US8921085B2 (en) 2014-12-30
WO2010144683A3 (en) 2011-02-03
JP2016127869A (ja) 2016-07-14
JP6097862B2 (ja) 2017-03-15
CN102803507A (zh) 2012-11-28
US20120156750A1 (en) 2012-06-21
JP5953229B2 (ja) 2016-07-20
AU2010258716B2 (en) 2015-11-12
US20150152481A1 (en) 2015-06-04
EP2440672B1 (en) 2016-03-30
JP2012529888A (ja) 2012-11-29
US9938571B2 (en) 2018-04-10
WO2010144683A2 (en) 2010-12-16
AU2010258716A1 (en) 2012-01-12
EP2440672A2 (en) 2012-04-18

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