CN102798623B - Double-signal lung cancer exhaled air detection method - Google Patents
Double-signal lung cancer exhaled air detection method Download PDFInfo
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- CN102798623B CN102798623B CN201210331885.4A CN201210331885A CN102798623B CN 102798623 B CN102798623 B CN 102798623B CN 201210331885 A CN201210331885 A CN 201210331885A CN 102798623 B CN102798623 B CN 102798623B
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Abstract
The invention discloses a double-signal lung cancer exhaled air detection method which comprises the following steps of: A, arranging a porphyrin sensor film into an air reaction chamber; B, applying a plurality of excitation light sources to exciting a porphyrin sensor before reaction, and sending detected spectral data into an ARM (Advanced RISC Machines) chip; C, sending image data before reaction, which is detected, by a camera into the ARM chip; D, sending lung cancer exhaled air to be detected into the air reaction chamber, and carrying out reaction on the lung cancer exhaled air and the porphyrin sensor; E, sending image data detected by a camera into the ARM chip; F, applying the plurality of excitation light sources to exciting the porphyrin sensor after reaction, and sending detected spectral data into the ARM chip; and G, carrying out analysis treatment by the ARM chip. According to the double-signal lung cancer exhaled air detection method disclosed by the invention, a fluorescence spectrum signal and a visible light color signal are adopted to carry out simultaneous measurement and carry out detection through crossing response, so that detection is rapid, the sensitivity is high, the accuracy of detection is greatly improved, the cost is low, and the operation is simple.
Description
Technical field
The present invention relates to a kind of lung cancer breath detection method, relate in particular to a kind of dual signal lung cancer breath detection method.
Background technology
Lung cancer is one of modal malignant tumour in the world at present.Since nearly 30 years, although diagnosis and the treatment of people to lung cancer is greatly improved, lung cancer is still the disease of serious threat health of people and life.
Traditional lung cancer detection method mainly contains: use large-scale instrument 1.: X sheet, CT, PET etc., and expensive, ordinary people is difficult to accept; 2. phlegm inspection: accuracy rate is very low; 3. biopsy: have wound, be generally that the large-scale instrument such as CT detects and doubtfully just considers afterwards; 4. conventional breath detects: clinically yet there are no application, also in the experimental phase, need to use the technology such as gas chromatographies (GC), the coupling of gas-matter, and complicated operation, consuming time longer, equipment is also very expensive, and error is larger.
Summary of the invention
For weak point of the prior art, the object of the present invention is to provide a kind of low price, simple to operate, detection is fast, highly sensitive, can effectively improve the dual signal lung cancer breath detection method of accuracy in detection.
In order to solve the problems of the technologies described above, the present invention has adopted following technical scheme:
Dual signal lung cancer breath detection method, adopted in the method a kind of dual signal lung cancer breath detection system, this dual signal lung cancer breath detection system comprises fluorescence detection device, visible detection device, gas reaction device, spectrometer and ARM chip;
Described fluorescence detection device comprises fibre-optical probe, motor I, excitation source transfer table, optical filter installing plate and turning axle I; Described turning axle I through excitation source transfer table and optical filter installing plate and with excitation source transfer table and optical filter installing plate secure fit, turning axle I is driven and is rotated by motor I; Described excitation source transfer table is provided with the excitation source of at least three and different wave lengths equidistant with turning axle I, on optical filter installing plate, be provided with the optical filter equating with excitation source quantity, the optical filter on described optical filter installing plate is corresponding one by one in the axial direction of turning axle I with the excitation source on excitation source transfer table; Described fibre-optical probe is corresponding with the rotational trajectory of the optical filter on optical filter installing plate, and fibre-optical probe is connected with spectrometer by optical fiber;
Described visible detection device comprises LED light source plate and camera; One side of described LED light source plate is provided with a semicircle orifice, and described LED light source plate is provided with multiple and the equidistant LED lamp of semicircle orifice, described camera be positioned at LED light source board directly over;
Described gas reaction device comprises motor II, gas reaction chamber, reaction bench and turning axle II; It is indoor that described reaction bench is positioned at gas reaction, and turning axle II is through the bottom of gas reaction chamber and with its rotation and be sealed and matched, and described reaction bench is fixed on the end of turning axle II, and turning axle II is driven by motor II; The bottom of described gas reaction chamber and the top cover of gas reaction chamber are made by transparent material;
Described gas reaction chamber is between fluorescence detection device and visible detection device, and the position height of gas reaction chamber is higher than LED light source plate and excitation source transfer table, and the position height of described gas reaction chamber is lower than camera and optical filter installing plate.
This dual signal lung cancer breath detection method comprises the steps:
A, porphyrin sensors slice, thin piece is put on the indoor reaction bench of gas reaction, on porphyrin sensors slice, thin piece, be along the circumferential direction laid with several porphyrin sensors;
B, gas reaction chamber is moved to fluorescence detection device, open excitation source, porphyrin sensors on porphyrin sensors slice, thin piece before excitation source uses multiple excitation sources to reaction under the drive of motor I excites, and uses spectrometer that the spectroscopic data before the reaction recording is sent into ARM chip;
C, gas reaction chamber is moved to visible detection device, turn on the LED lamp on LED light source plate, and open camera the view data before the reaction recording is sent into ARM chip; Motor II drives reaction bench and porphyrin sensors slice, thin piece Rotate 180 degree, uses camera that the view data before the reaction recording is sent into ARM chip, closes LED lamp;
D, by collect lung cancer breath to be detected send into gas reaction chamber, drive reaction bench and porphyrin sensors slice, thin piece rotation number minute by motor II, lung cancer breath to be detected is uniformly distributed in gas reaction chamber and with the porphyrin sensors on porphyrin sensors slice, thin piece and fully reacts;
E, turn on the LED lamp on LED light source plate, and open camera the reacted view data recording is sent into ARM chip; Motor II drives reaction bench and porphyrin sensors slice, thin piece Rotate 180 degree, uses camera that the reacted view data recording is sent into ARM chip, closes LED lamp;
F, gas reaction chamber is moved to fluorescence detection device, open excitation source, excitation source uses multiple excitation sources to excite the porphyrin sensors on reacted porphyrin sensors slice, thin piece under the drive of motor I, and uses spectrometer that the reacted spectroscopic data recording is sent into ARM chip;
G, close all light sources, ARM chip carries out analyzing and processing to fluorescence and visible ray dual signal, and provides testing result.
Compared with prior art, dual signal lung cancer breath detection method tool of the present invention has the following advantages:
1, the present invention adopts fluorescence spectrum and two kinds of signals of visible light colors to measure simultaneously, detects by cross response, detects fast, highly sensitive, has greatly improved the accuracy detecting, and low price, simple to operate.
2, in this gas detection method, adopt motor to drive reaction bench to rotate, can make lung cancer breath to be measured be uniformly distributed in gas reaction chamber, and control flow velocity, the advection etc. of gas and then gas can be evenly distributed in reaction chamber without design complicated reaction chamber as other some gas-detecting devices.
3, the porphyrin sensors on porphyrin sensors slice, thin piece is the multiple porphyrin designing for lung cancer exhalation gas marker specially, the change of the anti-raw corresponding fluorescence of meeting and visible ray after these porphyrins react with lung cancer symbolic gas.On porphyrin sensors slice, thin piece, use different sensitive materials to can be used for detecting different gas, be not limited to lung cancer breath, also can be industry, the Environmental securities etc. such as ammonia, sulphuric dioxide, formaldehyde other escaping gas detect, system detect gas concentration can reach ppb level.
Brief description of the drawings
Fig. 1 is the structural representation of dual signal lung cancer breath detection system;
Fig. 2 is the structural representation of shell;
Fig. 3 is the structural representation of excitation source brace table;
Fig. 4 is the structural representation of motor I;
Fig. 5 is the structural representation of excitation source coupling shaft;
Fig. 6 is the structural representation that excitation source transfer table, optical filter installing plate and turning axle I coordinate;
Fig. 7 is the structural representation of excitation source;
Fig. 8 is the structural representation of LED light source plate;
Fig. 9 is the structural representation that reaction bench and turning axle II coordinate;
Figure 10 is the structural representation of porphyrin sensors slice, thin piece;
Figure 11 is the structural representation of gas reaction chamber;
Figure 12 is the structural representation of gas reaction chamber top cover;
Figure 13 is the structural representation that base, guide pole and screw mandrel coordinate;
Figure 14 is the structural representation of sliding table.
In accompanying drawing: 1-fibre-optical probe; 2-excitation source brace table; 3-motor I; 4-excitation source; 5-excitation source transfer table; 6-optical filter installing plate; 7-turning axle I; 8-optical filter; 9-spectrometer; 10-LED light source plate; 11-camera; 12-semicircle orifice; 13-LED lamp; 14-motor II; 15-gas reaction chamber; 16-reaction bench; 17-turning axle II; 18-porphyrin sensors slice, thin piece; 19-air pump; 20-porphyrin sensors; 21-top cover; 22-air intake opening; 23-gas outlet; 24-motor III; 25-base; 26-slide block; 27-nut block; 28-guide pole; 29-screw mandrel; 30-sliding table; 31-laser diode; 32-photoelectric tube; 33-magnetic patch; 34-shell; 35-liquid crystal display; 36-removable cover; 37-fibre-optical probe installing plate; 38-motor mounting plate; 39-web joint; 40-planetary reduction gear; 41-excitation source coupling shaft; 42-power output shaft; 43-dowel hole; 44-round platform; 45-planetary reduction gear; 46-shaft coupling; 47-slice, thin piece register pin; 48-pilot hole; 49-planetary reduction gear; 50-shaft coupling; 51-back up pad; 52-spectrometer fixed station.
Embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
As shown in Figure 1, dual signal lung cancer breath detection method, adopted in the method a kind of dual signal lung cancer breath detection system, this dual signal lung cancer breath detection system comprises fluorescence detection device, visible detection device, gas reaction device, spectrometer 9, ARM chip and shell 34.As shown in Figure 2, fluorescence detection device, visible detection device, gas reaction device and ARM chip are installed in shell 34 structure of shell 34, and spectrometer 9 is fixed on the inwall of shell 34 by spectrometer fixed station 52.Liquid crystal display 35 for touching, control and showing is installed in the front plate of shell 34, is provided with a cavity at the top of shell 34, the removable cover 36(that is provided with a replacing porphyrin sensors slice, thin piece 18 in cavity can be completed and be changed blade technolgy by this removable cover 36).Liquid crystal display 35, for man-machine interaction, is connected with ARM chip, if use USB that system is connected with computing machine, liquid crystal display 35 will be closed automatically, and relevant data analysis also will be carried out analyzing and processing by the software of installing on computers.
Wherein, fluorescence detection device comprises fibre-optical probe 1, excitation source brace table 2, motor I 3, excitation source transfer table 5, optical filter installing plate 6, turning axle I 7 and excitation source coupling shaft 41.The structure of excitation source brace table 2 as shown in Figure 3, the top of excitation source brace table 2 is fibre-optical probe installing plate 37, the bottom of excitation source brace table 2 is motor mounting plate 38, there is a plate 39 at the back side of excitation source brace table 2, by the bolt hole of this web joint 39, this excitation source brace table 2 is fixedly connected on the inwall of shell 34.Motor I 3 adopts stepper motor, and as shown in Figure 4, this stepper motor is with planetary reduction gear 40, and motor I 3 is arranged on motor mounting plate 38, and the power output shaft 42 of planetary reduction gear 40 upwards.Excitation source coupling shaft 41 is hollow structure, as shown in Figure 5, the bottom of excitation source coupling shaft 41 is enclosed within the power output shaft 42 of planetary reduction gear 40, turning axle I 7 through excitation source transfer table 5 and optical filter installing plate 6 and with excitation source transfer table 5 and optical filter installing plate 6 secure fit, insert in the top-portion apertures of excitation source coupling shaft 41 bottom of turning axle I 7, by on excitation source coupling shaft 41 arrange dowel hole 43 interior insertion locking positioning pin and turning axle I 7 is fixed on excitation source coupling shaft 41, turning axle I 7 drives rotation by motor I 3.The structure of excitation source transfer table 5 and optical filter installing plate 6 as shown in Figure 6, in the cavity that excitation source transfer table 5 and optical filter installing plate 6 all form between fibre-optical probe installing plate 37 and motor mounting plate 38, fibre-optical probe installing plate 37 and motor mounting plate 38 are parallel to each other.Excitation source transfer table 5 is provided with in excitation source 4(the present embodiment of at least three and different wave lengths equidistant with turning axle I 7, on excitation source transfer table 5, be provided with three excitation sources 4), as shown in Figure 7, all excitation sources 4 are all positioned in a semi-circumference on excitation source transfer table 5 structure of excitation source.On optical filter installing plate 6, be provided with in the optical filter 8(the present embodiment equating with excitation source 4 quantity, on optical filter installing plate 6, be provided with three optical filters 8), all optical filters 8 are all positioned in a semi-circumference on optical filter installing plate 6, and the optical filter 8 on optical filter installing plate 6 is corresponding one by one in the axial direction of turning axle I 7 with the excitation source 4 on excitation source transfer table 5.On fibre-optical probe installing plate 37, be provided with the round platform 44 that is threaded hole, fibre-optical probe 1 is arranged on round platform 44 and is corresponding with the rotational trajectory in the vertical direction of the optical filter 8 on optical filter installing plate 6, and fibre-optical probe 1 is connected with spectrometer 9 by optical fiber.To see through the fluorescence spectrum signal input spectrum instrument 9 of filter plate 8 by fibre-optical probe 1, spectrometer 9 is sent the spectroscopic data recording into ARM chip.
Visible detection device comprises LED light source plate 10 and camera 11.The structure of LED light source plate as shown in Figure 8, one side of LED light source plate 10 is provided with a semicircle orifice 12, LED light source plate 10 is provided with the multiple and equidistant LED lamp 13 of semicircle orifice 12, camera 11 be positioned at LED light source board 10 directly over, camera 11 is connected with ARM chip, and camera 11 is sent visible light colors signal (being view data) into ARM chip.
Gas reaction device comprises the driving mechanism that motor II 14, gas reaction chamber 15, reaction bench 16, turning axle II 17, porphyrin sensors slice, thin piece 18, air pump 19 and drive motor II 14 move horizontally.Reaction bench 16 is positioned at gas reaction chamber 15, turning axle II 17 is rotated and is sealed and matched through the bottom of gas reaction chamber 15 and by the bottom of sealing bearing and gas reaction chamber 15, reaction bench 16 is fixed on the end of turning axle II 17, and the structure that reaction bench 16 is connected with turning axle II 17 as shown in Figure 9.Motor II 14 adopts stepper motor, and this stepper motor is with planetary reduction gear 45, and the bottom of turning axle II 17 is connected with the power output shaft of planetary reduction gear 45 by shaft coupling 46, and turning axle II 17 is driven by motor II 14.On the upper surface of reaction bench 16, be provided with three slice, thin piece register pins 47, the structure of porphyrin sensors slice, thin piece 18 as shown in figure 10, on porphyrin sensors slice, thin piece 18, be provided with the pilot hole 48 being used in conjunction with three slice, thin piece register pins 47, this porphyrin sensors slice, thin piece 18 is placed on reaction bench 16, three slice, thin piece register pins 47 insert respectively in corresponding pilot hole 48, and then make that porphyrin sensors slice, thin piece 18 is dismountable to be arranged on reaction bench 16, on porphyrin sensors slice, thin piece 18, be laid with several and the equidistant porphyrin sensors 20 of turning axle II 17.The bottom of gas reaction chamber 15 and the top cover of gas reaction chamber 21 are made by transparent material, the structure of gas reaction chamber 15 as shown in figure 11, the structure of top cover 21 as shown in figure 12, is provided with air intake opening 22 and gas outlet 23 on the sidewall of gas reaction chamber 15, and air pump 19 is connected with air intake opening 22.In this gas reaction chamber 15, pass into lung cancer breath, stepper motor driving gas reaction chamber 15 rotates, can make lung cancer breath to be measured be uniformly distributed in gas reaction chamber 15, this gas reaction device can make lung cancer breath and porphyrin sensors 20 react.
Gas reaction chamber 15 is between fluorescence detection device and visible detection device, and the position height of gas reaction chamber 15 is higher than LED light source plate 10 and excitation source transfer table 5, and the position height of gas reaction chamber 15 is lower than camera 11 and optical filter installing plate 6.Driving mechanism can move to fluorescence detection device and visible detection device by driving gas reaction chamber 15.
Driving mechanism comprises that motor III 24(adopts stepper motor), in planetary reduction gear 49, shaft coupling 50, base 25, slide block 26, nut block 27, guide pole 28(the present embodiment, guide pole 28 is two), screw mandrel 29 and sliding table 30.The two ends of two guide poles 28 are fixed in the back up pad 51 of two ends setting of base 25, in the back up pad 51 that the two ends of screw mandrel 29 arrange by the rotating two ends that are arranged on base 25 of bearing, screw mandrel 29 is between two guide poles 28, guide pole 28 is parallel with screw mandrel 29, as shown in figure 13, motor III 24 drives screw mandrel 29 to rotate by planetary reduction gear 49 and shaft coupling 50.Slide block 26 and nut block 27 are fixed on the below of sliding table 30, motor II 14 is arranged on sliding table 30, slide block 26 and nut block 27 are all slidably matched with base 25, on two guide poles 28, all cover has slide block 26, slide block 26 is slidably matched with guide pole 28, nut block 27 rotation sets on screw mandrel 29 and with screw mandrel 29 threaded engagement.On a side of base 25, be provided with three laser diodes 31, the side of sliding table 30 is provided with photoelectric tube 32(as shown in figure 14), photoelectric tube 32 can be corresponding successively with three laser diodes 31 in sliding table 30 moving process.Fluorescence detection device and visible detection device are corresponding one by one with two laser diode 31 in the vertical directions near two ends on base 25.
In the top circumference of gas reaction chamber 15, be provided with four grooves, magnet is installed in groove, on the top cover 21 of gas reaction chamber 15, be provided with four with groove in the magnet 33 inhaled mutually of the magnet installed, the top cover 21 of gas reaction chamber 15 is adsorbed on gas reaction chamber 15 and by encapsulant and is coordinated with the top seal of gas reaction chamber 15 by the magnet 33 of mutual absorption.
ARM chip is connected with spectrometer 9, camera 11 and PIC single-chip microcomputer (adopting PIC16F877A) respectively, and motor I 3, motor II 14, motor III 24, air pump 19, excitation source 4, LED lamp 13 and laser diode 31 are by PIC Single-chip Controlling.ARM chip and PIC single-chip microcomputer are arranged on circuit board, and circuit board is arranged in shell 34, and ARM chip uses serial ports communication with it as the host computer of PIC single-chip microcomputer.Embedded system ARM adopts ARM9 chip S3C2440, also can adopt other embedded system chips.System is reserved 2 USB interface, and one is for copying out ARM result and related data, and another can be used for the communication between computing machine.
This dual signal lung cancer breath detection method comprises the steps:
A, startup self-detection, put into porphyrin sensors slice, thin piece 18 on the reaction bench 16 of gas reaction chamber 15 by removable cover 36
B, motor III 24 drive screw mandrel 29 drive sliding table 30 and on parts move to the fluorescence detection device (fluoroscopic examination station) on right side from initial station (middle laser diode position); Open excitation source 4, each porphyrin sensors 20 on porphyrin sensors slice, thin piece 18 before excitation source 4 uses multiple excitation sources 4 to reaction under the drive of motor I 3 excites, and uses spectrometer 9 that the spectroscopic data before the reaction recording is sent into ARM chip;
C, motor III 24 drive screw mandrel 29 drive sliding table 30 and on parts from fluoroscopic examination station move to left side visible detection device (visible detection station); Automatically turn on the LED lamp 13 on LED light source plate 10, and open camera 11 view data before the reaction recording is sent into ARM chip; Motor II 14 drives reaction bench 16 and porphyrin sensors slice, thin piece 18 Rotate 180 degree, uses camera 11 that the view data before the reaction recording is sent into ARM chip, closes LED lamp;
D, by collect and standardized lung cancer breath to be detected send into gas reaction chamber 15 by air pump 19; Drive reaction bench 16 and porphyrin sensors slice, thin piece 18 rotation numbers minute by motor II 14, lung cancer breath to be detected is uniformly distributed in gas reaction chamber 15 and with the sensitive spot (being porphyrin sensors 20) on porphyrin sensors slice, thin piece 18 and fully reacts;
E, turn on the LED lamp 13 on LED light source plate 10, and open camera 11 the reacted view data recording is sent into ARM chip; Motor II 14 drives reaction bench 16 and porphyrin sensors slice, thin piece 18 Rotate 180 degree, uses camera 11 that the reacted view data recording is sent into ARM chip, closes LED lamp 13;
F, motor III 24 drive screw mandrel 29 drive sliding table 30 and on parts move to fluoroscopic examination station from visible detection station; Open excitation source 4, excitation source 4 uses multiple light sources to excite the sensitive spot on reacted porphyrin sensors slice, thin piece 18 (being porphyrin sensors 20) under the drive of motor I 3, and uses spectrometer 9 that the reacted data that record are sent into ARM chip;
G, close all light sources; The logical whole gas reaction chamber 15 of nitrogen purge of air pump 19 and gas circuit, reclaim waste gas; Motor III 24 drive screw mandrel 29 drive sliding table 30 and on parts get back to initial station; ARM chip carries out analyzing and processing to fluorescence and visible ray dual signal, and provides testing result.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not departing from aim and the scope of the technical program, it all should be encompassed in the middle of claim scope of the present invention.
Claims (1)
1. dual signal lung cancer breath detection method, it is characterized in that: adopted in the method a kind of dual signal lung cancer breath detection system, this dual signal lung cancer breath detection system comprises fluorescence detection device, visible detection device, gas reaction device, spectrometer (9) and ARM chip;
Described fluorescence detection device comprises fibre-optical probe (1), motor I (3), excitation source transfer table (5), optical filter installing plate (6) and turning axle I (7); Described turning axle I (7) through excitation source transfer table (5) and optical filter installing plate (6) and with excitation source transfer table (5) and optical filter installing plate (6) secure fit, turning axle I (7) is by motor I (3) driving rotation; Described excitation source transfer table (5) is provided with the excitation source (4) of at least three and different wave lengths equidistant with turning axle I (7), on optical filter installing plate (6), be provided with the optical filter (8) equating with excitation source (4) quantity, the optical filter (8) on described optical filter installing plate (6) is corresponding one by one in the axial direction of turning axle I (7) with the excitation source (4) on excitation source transfer table (5); Described fibre-optical probe (1) is corresponding with the rotational trajectory of the optical filter (8) on optical filter installing plate (6), and fibre-optical probe (1) is connected with spectrometer (9) by optical fiber;
Described visible detection device comprises LED light source plate (10) and camera (11); One side of described LED light source plate (10) is provided with a semicircle orifice (12), and described LED light source plate (10) is provided with multiple and the equidistant LED lamp of semicircle orifice (12) (13), described camera (11) be positioned at LED light source board (10) directly over;
Described gas reaction device comprises motor II (14), gas reaction chamber (15), reaction bench (16) and turning axle II (17); Described reaction bench (16) is positioned at gas reaction chamber (15), turning axle II (17) is through the bottom of gas reaction chamber (15) and with its rotation and be sealed and matched, described reaction bench (16) is fixed on the end of turning axle II (17), and turning axle II (17) is driven by motor II (14); The top cover (21) of the bottom of described gas reaction chamber (15) and gas reaction chamber is made by transparent material;
Described gas reaction chamber (15) is between fluorescence detection device and visible detection device, the position height of gas reaction chamber (15) is higher than LED light source plate (10) and excitation source transfer table (5), and the position height of described gas reaction chamber (15) is lower than camera (11) and optical filter installing plate (6);
This dual signal lung cancer breath detection method comprises the steps:
A, that porphyrin sensors slice, thin piece (18) is put into the reaction bench (16) of gas reaction chamber (15) is upper, is along the circumferential direction laid with several porphyrin sensors (20) on porphyrin sensors slice, thin piece (18);
B, gas reaction chamber (15) is moved to fluorescence detection device, open excitation source (4), porphyrin sensors (20) on porphyrin sensors slice, thin piece (18) before excitation source (4) uses multiple excitation sources (4) to reaction under the drive of motor I (3) excites, and uses spectrometer (9) that the spectroscopic data before the reaction recording is sent into ARM chip;
C, gas reaction chamber (15) is moved to visible detection device, turn on the LED lamp (13) on LED light source plate (10), and open camera (11) view data before the reaction recording is sent into ARM chip; Motor II (14) drives reaction bench (16) and porphyrin sensors slice, thin piece (18) Rotate 180 degree, uses camera (11) that the view data before the reaction recording is sent into ARM chip, closes LED lamp;
D, by collect lung cancer breath to be detected send into gas reaction chamber (15), drive reaction bench (16) and porphyrin sensors slice, thin piece (18) rotation number minute by motor II (14), lung cancer breath to be detected is uniformly distributed in gas reaction chamber (15) and with the porphyrin sensors (20) on porphyrin sensors slice, thin piece (18) and fully reacts;
E, turn on the LED lamp (13) on LED light source plate (10), and open camera (11) the reacted view data recording is sent into ARM chip; Motor II (14) drives reaction bench (16) and porphyrin sensors slice, thin piece (18) Rotate 180 degree, uses camera (11) that the reacted view data recording is sent into ARM chip, closes LED lamp (13);
F, gas reaction chamber (15) is moved to fluorescence detection device, open excitation source (4), excitation source (4) uses multiple excitation sources (4) to excite the porphyrin sensors (20) on reacted porphyrin sensors slice, thin piece (18) under the drive of motor I (3), and uses spectrometer (9) that the reacted spectroscopic data recording is sent into ARM chip;
G, close all light sources, ARM chip carries out analyzing and processing to fluorescence and visible ray dual signal, and provides testing result.
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| CN105004673B (en) * | 2015-08-24 | 2018-10-19 | 北京雪迪龙科技股份有限公司 | A kind of infrared spectrum sampling platform and infrared spectrum detecting system |
| CN105424608B (en) * | 2015-11-03 | 2017-11-03 | 重庆大学 | Dual signal visualizes gas-liquid Dual system detection means |
| CN105259153B (en) * | 2015-11-03 | 2017-10-10 | 重庆大学 | Device for liquid detecting |
| CN109001445A (en) * | 2018-05-30 | 2018-12-14 | 袁永刚 | A kind of exhaled gas detection reaction unit for lung cancer |
| CN110907448A (en) * | 2019-12-13 | 2020-03-24 | 江苏师范大学 | Standardized collection and sensing method for clinical breath sample in noninvasive lung cancer screening |
| CN110907447A (en) * | 2019-12-13 | 2020-03-24 | 江苏师范大学 | Dual-channel self-calibration multi-parameter sensing device for rapidly identifying lung cancer |
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| CN101334399B (en) * | 2008-07-15 | 2012-06-27 | 重庆大学 | Portable device for pulmonary cancer diagnosis |
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