CN102793979B - Proton or heavy ion beam cancer treatment device - Google Patents
Proton or heavy ion beam cancer treatment device Download PDFInfo
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- CN102793979B CN102793979B CN201210264179.2A CN201210264179A CN102793979B CN 102793979 B CN102793979 B CN 102793979B CN 201210264179 A CN201210264179 A CN 201210264179A CN 102793979 B CN102793979 B CN 102793979B
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Abstract
The invention relates to a proton or heavy ion beam cancer treatment device which comprises a synchronous accelerator. The device is characterized in that the front end of the synchronous accelerator is provided with an ion source, wherein the ion source is an ECRIS (electron cyclotron resonance ion source); the ECRIS is connected with a radio frequency quodrupole linear accelerator, a first quadrupole magnet, a second quadrupole magnet, a third quadrupole magnet and a fourth quadrupole magnet through a 0Q01 glasser quadrupole lense and a 0Q02 glasser lens and a first dipole magnet, and the first quadrupole magnet, the second quadrupole magnet, the third quadrupole magnet and the fourth quadrupole magnet are arranged on an intermediate energy beam line; a first dipole magnet is arranged between the second quadrupole magnet and the third quadrupole magnet; the fourth quadrupole magnet is connected with a first electrostatic deflecting plate of the synchronous accelerator through a first septum magnet; and a high energy beam line is introduced between the 22nd quadrupole magnet and the 31st quadrupole magnet of the synchronous accelerator. The device has the advantages that the linear accelerator can be used for supplying strong flux, which is over 20 times that of a currently conventional SFC (Securities and Futures Commission) circular accelerator; and more ions can be obtained in the same number of injected turns of the synchronous accelerator by virtue of higher injection flux. Therefore, the transverse pore diameter of a vacuum chamber of the synchronous accelerator can be saved, and the cost for a synchronous storage ring can be reduced.
Description
Technical field
The present invention relates to a kind of proton or cancer Therapy with Heavy Ion Beams device, particularly relate to a kind of by the proton therapy device of linear accelerator with synchronous storage rings cascade, be mainly used in the fields such as space flight, biology (medical treatment) and industry.
Background technology
Because proton, HIB are to having the features such as the depth-dose distribution of reversing, less lateral scattering, higher relative biological effectiveness and low oxygen enhancement ratio in the irradiation of organism, proton and heavy-ion cancer therapy is made to become current advanced effective cancer radiation therapy method in the world; Proton, HIB can simulate the radiation environment of the outer space, are used to the effective ways carrying out space flight single particle effect and the detection of instrument radioprotective; The particle radii of HIB have alternative, are the effective means manufactured for nucleopore membranes.
At enforcement proton beam, in ion beam irradiation, proton beam is provided, the accelerator of ion beam is the most basic device.Accelerator, according to different experiment and application needs, provides the proton beam of different-energy, ion beam; The experimentally difformity of target, provides accurate ion beam current position scan control; According to effective dose demand, provide the intensity of different lines.Synchronous storage rings meet the most effective accelerator installation of this type of demand, and concrete grammar is: by regulating the cut-off frequency of radio-frequency acceleration cavity and corresponding magnetic field intensity, can produce the extraction ion beam of different-energy; Adopt sweeping magnet to carry out high-frequency scanning to educt beaming flow, uniform ion beam distribution can be produced; By control injection cumulative flow, strong or control extraction switch, can regulate storage of ions line by force, the requirement of satisfied experiment effective dose.Therefore, setting up the proton beam based on synchrotron, ion beam accelerator, is the basis of carrying out ion exposure experiment.
Summary of the invention
The object of the invention is to avoid the deficiencies in the prior art to provide a kind of proton or cancer Therapy with Heavy Ion Beams device.Adopt RFQ or RFQ+DTL(Drift Tube Linac) as synchrotron injector, adopt multi-turn injection as the proton of the injection mode of synchrotron or cancer Therapy with Heavy Ion Beams device.The present invention, can carry out different-energy to target, the ion beam irradiation of different beam intensity.
For achieving the above object, the technical scheme that the present invention takes is: a kind of proton or cancer Therapy with Heavy Ion Beams device, include synchrotron, its main feature is provided with ion source in the front end of synchrotron, described ion source is Electron cyclotron resonance ion source, Electron cyclotron resonance ion source is by the 0Q01 glasser quadrupole lens on the bunch of source and 0Q02 glasser lens, 1 two pole ferrum connects radio frequency four polar field linear accelerator, the 1st quadrupole electromagnet on middle energy bunch, 2nd quadrupole electromagnet, 3rd quadrupole electromagnet, 4th quadrupole electromagnet, the 1st dipolar magnet is provided with between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron by the 1st septum magnet, high energy bunch is drawn between the 22nd quadrupole electromagnet and the 31st six pole magnet of described synchrotron.
Described proton or cancer Therapy with Heavy Ion Beams device, also include and be provided with draft tube linac between described radio frequency four polar field linear accelerator and the 1st quadrupole electromagnet.
Described proton or cancer Therapy with Heavy Ion Beams device, also include described high energy bunch and include multiple extraction terminal.
Described proton or cancer Therapy with Heavy Ion Beams device, described high energy bunch includes and is connected high energy bunch 1st quadrupole electromagnet, high energy bunch 2nd quadrupole electromagnet, high energy bunch 1st dipolar magnet with between the 31st six pole magnet by the 2nd septum magnet at the 22nd quadrupole electromagnet of described synchrotron; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, being linked in sequence of the first high energy bunch the 4th quadrupole electromagnet; Second high energy bunch includes the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, being linked in sequence of the second high energy bunch the 4th quadrupole electromagnet.
Described proton or cancer Therapy with Heavy Ion Beams device, described synchrotron includes the 1st electrostatic deflection plates between the 11st quadrupole electromagnet, the 62nd quadrupole electromagnet, is provided with synchrotron the 1st dipolar magnet between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet; 12nd quadrupole electromagnet is connected the 2nd electrostatic deflection plates by the 3rd bumper magnet, is connected the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet; 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet, synchrotron the 3rd dipolar magnet is provided with between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron radio-frequency acceleration cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; 42nd quadrupole electromagnet connects horizontal radio-frequency field exciting bank, and connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet by the 1st bumper magnet, synchrotron the 5th dipolar magnet is provided with between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet by DC current detector, synchrotron the 6th dipolar magnet is provided with between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet; 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
Described proton or cancer Therapy with Heavy Ion Beams device, described connection is that vacuum pipe line connects, and vacuum is 10
-9-10
-11mbar.
Use a method for proton or cancer Therapy with Heavy Ion Beams device, its key step is:
(1) ion beam is produced by ecr ion source, at extraction electrode high pressure 20KV-40KV, line is drawn, after the coupling of glasser lens, be injected into radio frequency quadrupole linac carry out preaceleration or radio frequency quadrupole linac by acceleration of ions to 2-2.5MeV/u, then continue to match draft tube linac to accelerate, the Implantation Energy arriving synchrotron is after 4MeV/u-7MeV/u, again through overmatching and transmission, by beam delivery to synchrotron entrance;
(2), after line arrives synchrotron entrance, utilize the protruding rail in synchrotron to make ring internal beam current track protruding, make protruding rail height suitable from the distance of vacuum pipe with synchrotron first electrostatic deflection plates.After line fills synchrotron one circle, protruding rail height starts to decline, and 28-30 microsecond, equaled the input number of turns and be multiplied by the convolution cycle fall time), to realize the multi-turn injection of line, injecting the number of turns is 15-30 circle;
(3) after line is injected into synchrotron, undertaken capturing and accelerating by frequency cavity halved tie stream, according to treatment and the experiment needs of terminal, by beam acceleration to predetermined power, being 70-250MeV for proton, is 100-400MeV/u for heavy ion; Meanwhile, the horizontal operation of line point is progressively moved near 1/3 resonance line;
(4), after line arrives predetermined power, the ferroelectric stream of six types of severe debility disease starts to increase, and makes the stable phase space of synchrotron narrow down to the emittance being greater than line;
(5) open horizontal radio-frequency (RF) excited, line is under the effect of transverse electric field, and emittance increases, thus arrives range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, thus arrival electrostatic deflection plates is drawn;
(6) ejected beam is through the 2nd electrostatic deflection plates of synchrotron and the 2nd septum magnet, is transported to high energy bunch, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment.
(7), when terminal effective dose reaches preset value, can draw by stopping the continuation of line that is used for stopping of transversely excited.
The invention has the beneficial effects as follows:
1. adopt synchrotron than adopting other devices to have larger advantage.
Current free-stream acceleration device is divided into into three classes, is linear accelerator respectively, cyclotron and synchrotron.Adopt linear accelerator can accomplish the conversion of beam intensity, but be several times of synchrotron to the cost of the linear accelerator of same energy beam acceleration.Cyclotron cost is lower, but cannot realize the Fast transforms of energy.And adopt synchrotron according to the energy and the intensity that need to convert rapidly educt beaming flow of terminal, convolution and linear accelerator can be compared, simple and convenient, and more economical.
2. it is strong that the design adopting linear accelerator to do infusion appliance can obtain higher injection stream.
Linear accelerator is adopted to be that linear accelerator can provide higher stream strong (be more than 20 times of nearly thing current SFC cyclotron beam intensity) and less beam emittance than adopting cyclotron as the advantage that infusion appliance is maximum as infusion appliance.Higher injection stream can make by force synchrotron injecting under the same number of turns, obtains more number of ions; Less injection beam emittance, can inject the more number of turns when less synchrotron horizontal aperture, that is obtain more injection number of ions.So just, the horizontal aperture of synchrotron vacuum chamber can be saved, and then reduce the cost of stores synchronized ring.
Accompanying drawing illustrates:
Fig. 1 is schematic front view of the present invention.
In figure: ECR: Electron cyclotron resonance ion source; RFQ: radio frequency four polar field accelerator; D: two pole ferrum; Q: quadrupole ferrum; S: six types of severe debility disease ferrum; RF: radio-frequency acceleration cavity; DCCT: DC current detector; ES: electrostatic deflection plates; MS: septum magnet; KNO: horizontal radio-frequency field; BP: bumper magnet; Numeral before element names represents respectively: 0. source bunch (p_ECR and i_ECR represents proton-electron cyclotron resonance ion source and heavy ion Electron cyclotron resonance ion source respectively); 1. energy bunch in; 2. synchrotron; 3. high energy bunch; P_0Q1: proton source bunch first piece of galasser lens; P_0Q2: proton source bunch second piece of galasser lens; I_0Q1: heavy ion source bunch first piece of galasser lens; I_0Q2: heavy ion source bunch second piece of galasser lens; 0D1: source bunch dipolar magnet.
Detailed description of the invention
Be described principle of the present invention and feature below, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1: see Fig. 1, a kind of proton beam tumor therapy device, include synchrotron 2, ion source 1 is provided with in the front end of synchrotron 2, described ion source 1 is Electron cyclotron resonance ion source p_ECR, energy bunch the 1st quadrupole electromagnet during Electron cyclotron resonance ion source is connected with radio frequency four polar field linear accelerator by glasser lens, 2nd quadrupole electromagnet, 3rd quadrupole electromagnet, 4th quadrupole electromagnet, the 1st dipolar magnet is provided with between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron 2 by the 1st septum magnet, high energy bunch 3 is drawn between the 22nd quadrupole electromagnet and the 31st six pole magnet of described synchrotron 2.
Described high energy bunch 3 includes 2 and draws terminal.High energy bunch the 1st quadrupole electromagnet, high energy bunch the 2nd quadrupole electromagnet, high energy bunch the 1st dipolar magnet is connected with between the 31st six pole magnet by the 2nd septum magnet at the 22nd quadrupole electromagnet of described synchrotron 2; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, being linked in sequence of the first high energy bunch the 4th quadrupole electromagnet; Second high energy bunch includes being linked in sequence of the elements such as the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, the second high energy bunch the 4th quadrupole electromagnet.
Described synchrotron 2 includes the 1st electrostatic deflection plates and connects the 11st quadrupole electromagnet, the 12nd quadrupole electromagnet, is provided with synchrotron the 1st dipolar magnet between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet; 12nd quadrupole electromagnet is connected the 2nd electrostatic deflection plates by the 3rd bumper magnet, is connected the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet; 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet, synchrotron the 3rd dipolar magnet is provided with between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron radio-frequency acceleration cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; 42nd quadrupole electromagnet connects horizontal radio-frequency field, and connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet by the 1st bumper magnet, synchrotron the 5th dipolar magnet is provided with between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet by DC current detector, synchrotron the 6th dipolar magnet is provided with between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet; 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
Described connection is that vacuum pipe line connects, and vacuum is 10
-9-10
-10mbar.
Embodiment 2: see Fig. 1, a kind of proton beam tumor therapy device, is provided with draft tube linac between described radio frequency four polar field accelerator and the 1st quadrupole electromagnet.All the other structures are identical with embodiment 1.
Embodiment 3: a kind of proton beam tumor therapy device, described high energy bunch 3 includes more than 2 and draws terminal, experimentally needs with terminal, can continue to isolate more high energy bunch from the first or second high energy bunch.All the other structures are identical with embodiment 1 or embodiment 2.
Embodiment 4: a kind of cancer Therapy with Heavy Ion Beams device, include synchrotron 2, ion source 1 is provided with in the front end of synchrotron 2, described ion source 1 is Electron cyclotron resonance ion source i_ECR, Electron cyclotron resonance ion source is connected the 1st quadrupole electromagnet, the 2nd quadrupole electromagnet, the 3rd quadrupole electromagnet, the 4th quadrupole electromagnet by glasser lens with radio frequency four polar field accelerator, between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, be provided with the 1st dipolar magnet, the 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron 2 by the 1st septum magnet; High energy bunch 3 is drawn between the 22nd quadrupole electromagnet and the 31st six pole magnet of described synchrotron 2.
Described high energy bunch 3 includes 2 and draws terminal.High energy bunch the 1st quadrupole electromagnet, high energy bunch the 2nd quadrupole electromagnet, high energy bunch the 1st dipolar magnet is connected with between the 31st six pole magnet by the 2nd septum magnet at the 22nd quadrupole electromagnet of described synchrotron 2; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, being linked in sequence of the first high energy bunch the 4th quadrupole electromagnet; Second high energy bunch includes the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, being linked in sequence of the second high energy bunch the 4th quadrupole electromagnet.
Described synchrotron 2 includes the 1st electrostatic deflection plates and connects the 11st quadrupole electromagnet, the 12nd quadrupole electromagnet, is provided with synchrotron the 1st dipolar magnet between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet; 12nd quadrupole electromagnet is connected the 2nd electrostatic deflection plates by the 3rd bumper magnet, is connected the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet; 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet, synchrotron the 3rd dipolar magnet is provided with between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron radio-frequency acceleration cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; 42nd quadrupole electromagnet connects horizontal radio-frequency field, and connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet by the 1st bumper magnet, synchrotron the 5th dipolar magnet is provided with between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet by DC current detector, synchrotron the 6th dipolar magnet is provided with between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet; 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
Described connection is that vacuum pipe line connects, and vacuum is 10
-10-10
-11mbar.
All the other structures are identical with embodiment 1.
Embodiment 5: a kind of cancer Therapy with Heavy Ion Beams device, is provided with draft tube linac between described radio frequency four polar field accelerator and the 1st quadrupole electromagnet.All the other structures are identical with embodiment 4.
Embodiment 6: a kind of cancer Therapy with Heavy Ion Beams device, described high energy bunch 3 includes more than 2 and draws terminal.All the other structures are identical with embodiment 4 or embodiment 5.
Embodiment 7: a kind of method using proton beam tumor therapy device, its key step is:
(1) ion beam is produced by ecr ion source, at extraction electrode high pressure 20KV-40KV, line is drawn, after the coupling of glasser lens, be injected into radio frequency quadrupole linac carry out preaceleration, after arriving the Implantation Energy 4MeV/u-7MeV/u of synchrotron, again through overmatching and transmission, by beam delivery to synchrotron entrance;
(2), after line arrives synchrotron entrance, utilize the protruding rail in synchrotron to make ring internal beam current track protruding, make protruding rail height suitable from the distance of vacuum pipe with synchrotron first electrostatic deflection plates.After line fills synchrotron one circle, protruding rail height progressively declines, and microsecond fall time about 30 (approximate the input number of turns and be multiplied by the convolution cycle), realize the multi-turn injection of line, injecting the number of turns is 15-30 circle;
(3) after line is injected into synchrotron, undertaken capturing and accelerating by frequency cavity halved tie stream, according to treatment and the experiment needs of terminal, by beam acceleration to predetermined power, be 70-250MeV for proton, meanwhile, the horizontal operation of line point progressively moved near 1/3 resonance line;
(4), after line arrives predetermined power, the ferroelectric stream of six types of severe debility disease starts to increase, and makes the stable phase space of synchrotron narrow down to the emittance being greater than line;
(5) open horizontal radio-frequency (RF) excited, line is under the effect of transverse electric field, and emittance increases, thus arrives range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, thus arrival electrostatic deflection plates is drawn;
(6) ejected beam is through the 2nd electrostatic deflection plates of synchrotron and the 2nd septum magnet, is transported to high energy bunch, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment.
(7), when terminal effective dose reaches preset value, can draw by stopping the continuation of line that is used for stopping of transversely excited.
Embodiment 8: a kind of method using proton beam tumor therapy device, its key step (1) is for produce ion beam by ecr ion source, at extraction electrode high pressure 20KV-40KV, line is drawn, radio frequency quadrupole linac is injected into after the coupling of glasser lens, radio frequency quadrupole linac by acceleration of ions to 2-2.5MeV/u, then continue to match draft tube linac to accelerate, after arriving the Implantation Energy 4MeV/u-7MeV/u of synchrotron, again through overmatching and transmission, by beam delivery to synchrotron entrance.All the other steps are identical with embodiment 7.
For nearly thing institute HIRFL device, it is about 15uA by force that current fan-shaped cyclotron SFC draws C6+ stream, horizontal emittance is about 25pi mm mrad, synchrotron CSRm transverse horizontal acceptance is 200pi mm mrad, adopt multi-turn injection, ideally inject the strong about 100uA of the highest stream.If adopt linear accelerator as infusion appliance: the extraction stream of linear accelerator is by force 200uA, and horizontal emittance is 6-12pi mm mrad, then inject stream strong in milliampere magnitude.
Embodiment 9: a kind of method using cancer Therapy with Heavy Ion Beams device, its key step is:
(1) ion beam is produced by ecr ion source, at extraction electrode high pressure 20KV-40KV, line is drawn, after the coupling of glasser lens, be injected into radio frequency quadrupole linac accelerate, arrive the Implantation Energy 2-4MeV/u of synchrotron, again through overmatching and transmission, by beam delivery to synchrotron entrance;
(2), after line arrives synchrotron entrance, utilize the protruding rail in synchrotron to make ring internal beam current track protruding, make protruding rail height suitable from the distance of vacuum pipe with synchrotron first electrostatic deflection plates.After line fills synchrotron one circle, protruding rail height progressively declines, and microsecond fall time about 30 (approximate the input number of turns and be multiplied by the convolution cycle), realize the multi-turn injection of line, injecting the number of turns is 15-30 circle;
(3) after line is injected into synchrotron, being undertaken capturing and accelerating by frequency cavity halved tie stream, according to treatment and the experiment needs of terminal, by beam acceleration to predetermined power, is 100-400MeV/u for heavy ion; Meanwhile, the horizontal operation of line point is progressively moved near 1/3 resonance line;
(4), after line arrives predetermined power, the ferroelectric stream of six types of severe debility disease starts to increase, and makes the stable phase space of synchrotron narrow down to the emittance being greater than line;
(5) open horizontal radio-frequency (RF) excited, line is under the effect of transverse electric field, and emittance increases, thus arrives range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, thus arrival electrostatic deflection plates is drawn;
(6) ejected beam is through the 2nd electrostatic deflection plates of synchrotron and the 2nd septum magnet, is transported to high energy bunch, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment.
(7), when terminal effective dose reaches preset value, can draw by stopping the continuation of line that is used for stopping of transversely excited.
Embodiment 10: a kind of method using cancer Therapy with Heavy Ion Beams device, its key step (1) is for produce ion beam by ecr ion source, at extraction electrode high pressure 20KV-40KV, line is drawn, radio frequency quadrupole linac is injected into after the coupling of glasser lens, radio frequency quadrupole linac by acceleration of ions to 2-2.5MeV/u, then continue to match draft tube linac to accelerate, after arriving the Implantation Energy 4MeV/u-7MeV/u of synchrotron, again through overmatching and transmission, by beam delivery to synchrotron entrance.All the other steps are identical with embodiment 9.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. a kind of proton or cancer Therapy with Heavy Ion Beams device, include synchrotron, it is characterized in that being provided with ion source in the front end of synchrotron, described ion source is Electron cyclotron resonance ion source, Electron cyclotron resonance ion source is by the 0Q01 glasser lens on the bunch of source and 0Q02 glasser lens, 1 two pole ferrum connects radio frequency four polar field linear accelerator, the 1st quadrupole electromagnet on middle energy bunch, 2nd quadrupole electromagnet, 3rd quadrupole electromagnet, 4th quadrupole electromagnet, the 1st dipolar magnet is provided with between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron by the 1st septum magnet, high energy bunch is drawn between the 22nd quadrupole electromagnet and the 31st six pole magnet of described synchrotron, described synchrotron includes the 1st electrostatic deflection plates between the 11st quadrupole electromagnet, the 62nd quadrupole electromagnet, is provided with synchrotron the 1st dipolar magnet between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet, 12nd quadrupole electromagnet is connected the 2nd electrostatic deflection plates by the 3rd bumper magnet, is connected the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet, 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet, synchrotron the 3rd dipolar magnet is provided with between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron radio-frequency acceleration cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet, 42nd quadrupole electromagnet connects horizontal radio-frequency field exciting bank, and connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet by the 1st bumper magnet, synchrotron the 5th dipolar magnet is provided with between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet by DC current detector, synchrotron the 6th dipolar magnet is provided with between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet, 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
2. proton as claimed in claim 1 or cancer Therapy with Heavy Ion Beams device, characterized by further comprising and be provided with draft tube linac between described radio frequency four polar field linear accelerator and the 1st quadrupole electromagnet.
3. proton as claimed in claim 1 or cancer Therapy with Heavy Ion Beams device, characterized by further comprising described high energy bunch and include multiple extraction terminal.
4. proton as claimed in claim 3 or cancer Therapy with Heavy Ion Beams device, is characterized in that described high energy bunch includes and be connected high energy bunch 1st quadrupole electromagnet, high energy bunch 2nd quadrupole electromagnet, high energy bunch 1st dipolar magnet with between the 31st six pole magnet by the 2nd septum magnet at the 22nd quadrupole electromagnet of described synchrotron; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, being linked in sequence of the first high energy bunch the 4th quadrupole electromagnet; Second high energy bunch includes the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, being linked in sequence of the second high energy bunch the 4th quadrupole electromagnet.
5. the proton as described in as arbitrary in Claims 1-4 or cancer Therapy with Heavy Ion Beams device, it is characterized in that described connection is that vacuum pipe line connects, vacuum is 10
-9-10
-11mbar.
6. use a method for proton or cancer Therapy with Heavy Ion Beams device, it is characterized in that step is:
(1) ion beam is produced by ecr ion source, under extraction electrode high pressure 20KV-40KV, line is drawn, after the coupling of glasser lens, be injected into radio frequency quadrupole linac carry out preaceleration or radio frequency quadrupole linac by acceleration of ions to 2-2.5MeV/u, then continue to match draft tube linac to accelerate, the Implantation Energy arriving synchrotron is after 4MeV/u-7MeV/u, again through overmatching and transmission, by beam delivery to synchrotron entrance;
(2), after line arrives synchrotron entrance, utilize the protruding rail in synchrotron to make ring internal beam current track protruding, make protruding rail height suitable from the distance of vacuum pipe with synchrotron first electrostatic deflection plates; After line fills synchrotron one circle, protruding rail height starts to decline, and fall time is 28-30 microsecond, equals the input number of turns and is multiplied by the convolution cycle, and to realize the multi-turn injection of line, injecting the number of turns is 15-30 circle;
(3) after line is injected into synchrotron, undertaken capturing and accelerating by frequency cavity halved tie stream, according to treatment and the experiment needs of terminal, by beam acceleration to predetermined power, being 70-250MeV for proton, is 100-400MeV/u for heavy ion; Meanwhile, the horizontal operation of line point is progressively moved near 1/3 resonance line;
(4), after line arrives predetermined power, the ferroelectric stream of six types of severe debility disease starts to increase, and makes the stable phase space of synchrotron narrow down to the emittance being greater than line;
(5) open horizontal radio-frequency (RF) excited, line is under the effect of transverse electric field, and emittance increases, thus arrives range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, thus arrival electrostatic deflection plates is drawn;
(6) ejected beam is through the 2nd electrostatic deflection plates of synchrotron and the 2nd septum magnet, is transported to high energy bunch, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment;
(7), when terminal effective dose reaches preset value, can draw by stopping the continuation of line that is used for stopping of transversely excited.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001217100A (en) * | 2000-02-01 | 2001-08-10 | Hitachi Ltd | Medical system |
| CN102387836A (en) * | 2009-03-04 | 2012-03-21 | 普罗汤姆封闭式股份公司 | Multi-field charged particle cancer therapy method and apparatus |
| CN202982960U (en) * | 2012-07-28 | 2013-06-12 | 中国科学院近代物理研究所 | Proton or heavy ion beam cancer therapy device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11169470A (en) * | 1997-12-12 | 1999-06-29 | Mitsubishi Electric Corp | Neutron generator |
-
2012
- 2012-07-28 CN CN201210264179.2A patent/CN102793979B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001217100A (en) * | 2000-02-01 | 2001-08-10 | Hitachi Ltd | Medical system |
| CN102387836A (en) * | 2009-03-04 | 2012-03-21 | 普罗汤姆封闭式股份公司 | Multi-field charged particle cancer therapy method and apparatus |
| CN202982960U (en) * | 2012-07-28 | 2013-06-12 | 中国科学院近代物理研究所 | Proton or heavy ion beam cancer therapy device |
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