CN101631421A - Method and device for accumulating beams in synchrotron for cancer therapy with heavy ions - Google Patents
Method and device for accumulating beams in synchrotron for cancer therapy with heavy ions Download PDFInfo
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- CN101631421A CN101631421A CN 200910000761 CN200910000761A CN101631421A CN 101631421 A CN101631421 A CN 101631421A CN 200910000761 CN200910000761 CN 200910000761 CN 200910000761 A CN200910000761 A CN 200910000761A CN 101631421 A CN101631421 A CN 101631421A
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Abstract
The invention mainly relates to a method and a device for accumulating beams and increasing ion numbers in a synchrotron for cancer therapy with heavy ion beams. The method comprises the following steps: 1. implanting the ion beams provided by an implanting device into the synchrotron; 2. in an electronic cooling device, generating electron beams with the same average velocity as the cooled ion beams; 3. deflecting the electron beams to a cooling section on the synchrotron; 4. enabling the ions to pass through the cooling section to collide with the electrons to act so as to cool the heavy ion beams; 5. deflecting the electrons after acting out. The invention also provides the device. Quadrupolar magnets and helix compensating tubes are sequentially arranged at the upper part of the straight section of the synchrotron; correcting magnets are arranged at the upper parts and lower parts of the helix compensating tubes; the arrangement at the lower part and the upper part of the straight section of the synchrotron is the same and corresponding; a beam cooling device is arranged in the middle section of the straight section of the synchrotron. The invention has the advantages that the ion numbers are obviously increased, the emittance and momentum spread of the ion beams are reduced, the beam quality is improved and the beam life is lengthened.
Description
Technical field:
The present invention relates generally to a kind of beam stacking method and apparatus that improves heavy ion beam cancer therapy synchronous accelerator intermediate ion number.
Background technology:
Because the relative biological effectiveness (RBE) that depth dose distributes at (Bragg peak), lateral scattering is little, higher of reversing and low oxygen enhancement ratio characteristics such as (OER) in proton and the heavy ion beam irradiation, making proton, heavy ion beam control cancer becomes advanced in the world now effectively cancer radiation therapy method.At present, have only minority developed country and China to carry out corresponding research, preliminary clinical treatment experimental study result shows that proton, heavy ion beam control the curative effect that cancer has highly significant, and does not have obvious toxic and side effects.
In implementing the heavy ion beam irradiation treatment, the synchrotron that ion beam is provided is the most basic device.Biological effective dose requirement during according to clinical treatment tumour, need synchrotron can regulate the intensity of ion beam current, and the beam intensity that the injector single provides can be lower than the requirement of some clinical treatment, therefore in the proton-heavy ion treatment of cancer device of practical application, often adopt some beam stacking methods, draw after the line that injector is repeatedly provided is accumulated in synchrotron, make beam intensity satisfy the clinical treatment requirement.
In known proton-heavy-ion cancer therapy device, the electronics cooling technology is a kind of beam stacking method commonly used (Physics Report 196).Known electronic cooler all is to adopt solid electron beam cooling ion beam, and solid electron beam is meant that the horizontal section distribution of electron beam meets Gaussian function, and the electron density that is positioned at the electron beam edge is little, and center density is big.This distribution is the defective of cooling accumulation: first, because cooling rate and electron beam density are approximated to direct ratio, therefore marginal density is little, very slow to the ion cooling that emittance is big, center density is big, it is bigger that the little ion cooling effect of emittance of having cooled off is remained unchanged, and it is unstable to cause ion beam to get.The second, because ion beam is positioned at the center of electron beam after being cooled, so center density causes the electron-ion capture probability to become big greatly, and beam loss increases.
Summary of the invention:
The method and the device thereof that the objective of the invention is to avoid the deficiencies in the prior art part and a kind of accumulating beams in synchrotron for cancer therapy with heavy ions is provided, overcome the ion beam current that the cyclotron single provides by force little, can not satisfy the defective that clinical treatment requires, improve the number of storage of ions, it is applied in the middle of the clinical treatment.
Purpose of the present invention can be by realizing by the following technical solutions: a kind of method of accumulating beams in synchrotron for cancer therapy with heavy ions includes following steps:
1) ion beam that injector is provided is injected in the synchrotron;
2) with in the electronic cooler (1), it is bigger that electron gun produces marginal density, and the hollow electron beam that center density is less utilizes cathode potential that electron beam is accelerated to heavy ion beam and has identical average speed;
3) with the cooling section of the electron beam deflecting to the synchrotron ring;
4) mutual impact effect takes place by cooling section with electronics in ion, the cooling heavy ion beam;
5) electronic deflection after will acting on is gone out, and the gatherer that enters electronic cooler is collected, and heavy ion continues shuttling movement in synchrotron;
6) ion beam repeats by cooling section, and the electron beam of being brought in constant renewal in continues cooling.
Further, after step 6), also include following steps,
7) because ion beam is cooled, and size is dwindled, can accept new ion injection by vacating space, implement ion again and inject synchrotron process.
Further, the heavy ion described in the described step 5) is done cycle movement, is ion is repeated to have an effect with electronics in described step 4), repeats to cool off heavy ion beam.
Further, the device of described a kind of accumulating beams in synchrotron for cancer therapy with heavy ions is provided with level Four magnet (4a successively in the upstream of the straightway of synchrotron, 4b, 4c), compensation helix tube (2a), in the compensation upstream of helix tube and the downstream be provided with correcting magnet (3a, 3b); Downstream at the straightway of synchrotron is provided with identical and corresponding setting with the upstream; Be provided with line cooling device (1) in the straightway stage casing of synchrotron.
Further, described line cooling device is a U-shaped, be provided with electron gun at U-shaped mouth one end, described line cooling device is a U-shaped, be provided with electron gun (5) at U-shaped mouth one end, the exit of electron gun is provided with electron beam channel, and electron beam channel is connected with the cooling section that is provided with at the U-shaped straightway (7), be provided with electrostatic deflection plates (10) in the exit of cooling device, electrostatic deflection plates is connected with the gatherer (11) that the other end that is arranged on the U-shaped mouth is provided with.
Further, described frozen portions is made up of cooling section (7) and solenoid (8), and the import of cooling section and exit are provided with crooked solenoid (12).
Further, locate also to be provided with the crooked solenoid (12) that be arranged in parallel with electrostatic deflection plates, be provided with correcting coil (13) at the solenoidal arrival end of bending in described electrostatic deflection plates (10).
Further, the device of described accumulating beams in synchrotron for cancer therapy with heavy ions, described electron gun include negative electrode (14), anode (16), accelerating tube (17), are provided with the control utmost point (15) between anode (16) and negative electrode (14).
Hollow electron beam produces by special electron gun, comprises oxide coated cathode, is used for the filament of heated oxide thing negative electrode, is used for anode that the electronics that negative electrode produces is drawn, is used to adjust cathode electron beam and distributes, obtains the difform hollow electron beam control utmost point.The principle that this electron gun produces hollow electron beam is by applying different electromotive forces between the control utmost point and the negative electrode, suppress to be positioned at the electron emissivity in cathode center zone, and it is little to reach generation center density, the purpose of the hollow electron beam that marginal density is big.
The invention has the beneficial effects as follows:
1. the ion populations that provides significantly improves.Because the effect of electronics cooling, can realize ion repeat inject, make the ion populations that stores in the synchrotron significantly improve.The experiment of carrying out shows in an embodiment, and its storage gain can reach 40 times.
2. ion beam emittance and momentum disperse to dwindle, and quality of beam improves.Cooling effect makes the size of heavy ion beam current dwindle, and can realize the high accuracy tumor scanning therapy.
3. owing to the application of hollow electron beam, reduced the collision probability of cooling back ion and electronics, known relatively employing solid electron beam cooling means, its beaminstability reduces, and beam loss reduces, the line ILS.
Description of drawings:
Fig. 1 is the line cooling device block diagram on straightway of synchrotron of the present invention;
Fig. 2 CSRm electronic cooler schematic diagram;
Fig. 3 CSRm electronic cooler electron gun schematic diagram.
Embodiment:
Be described in further detail below in conjunction with the most preferred embodiment shown in the accompanying drawing:
Embodiment 1: a kind of method of accumulating beams in synchrotron for cancer therapy with heavy ions includes following steps:
1) ion beam that injector is provided is injected in the synchrotron;
2) with in the electronic cooler, it is bigger that electron gun produces marginal density, and the hollow electron beam that center density is less utilizes cathode potential that electron beam is accelerated to heavy ion beam and has identical average speed;
3) with the straightway (cooling section) of the electron beam deflecting to the synchrotron ring;
4) mutual impact effect takes place by cooling section with electronics in ion, the cooling heavy ion beam;
5) electronic deflection after will acting on is gone out, and the gatherer that enters electronic cooler is collected, and heavy ion continues shuttling movement in synchrotron;
6) ion beam repeats by cooling section, and the electron beam of being brought in constant renewal in continues cooling.
7) because ion beam is cooled, and size is dwindled, can accept new ion injection by vacating space, implement ion again and inject synchrotron process.
Below in actual motion, once complete step,
1) ecr ion source provides
12C
4+Ion, accelerating to energy through fan focusing cyclotron SFC (energy constant K=69) is 7.0MeV/u, and is delivered to the CSRm inlet, stream is 4.8 microamperes by force;
2) injection element of triggering CSRm is realized the once injection of ion beam;
3) ion is implemented the hollow electron beam cooling in CSRm; The cooling section of electronic cooler is positioned at a straightway part of synchrotron, and ion moves in synchrotron, periodically repeats to pass through cooling section.Along with ion repeats repeatedly to pass through cooling section, finally to poised state, this moment, synchrotron had new space to be used to receive the ion that re-injects to ion beam, and the ion that assurance has stored can not lost in the volume-diminished of phase space; Hollow electron beam is produced in electron gun, and is accelerated to the synchrotron heavy ion by high voltage electric field and to have identical average speed, under the effect of guiding magnetic field and electrostatic deflection plates, enters cooling section; In cooling section, ion and electronics interact, because the temperature of electron beam is much smaller than the temperature of ion beam, ion beam is cooled, and its emittance, momentum disperse significantly to reduce; Electronic deflection after the effect goes out cooling section, and ion continues to quicken wherein cycle movement synchronously, to enter cooling section next time, restarts step 3 and describes process;
4) trigger the injection element of CSRm again, realize the new injection of ion beam, because the spatial volume of existing ion beam significantly dwindles under the electronics cooling effect among this moment synchrotron CSRm, therefore refilling process can not cause its loss;
5) process of repeated several times step 2,3,4 descriptions makes the ion populations that stores in the synchrotron inject than single and significantly improves that until satisfying the clinical treatment demand, the ion populations that stores in the synchrotron is about 10
8Magnitude.
6) begin high frequency accelerating cavity and corresponding magnetic field power supply system synchronously, with what store
12C
4+Ion accelerates to 200MeV/u;
7) beginning is drawn slowly, with 200MeV/u's in the synchrotron
12C
4+Ion was drawn CSRm uniformly, and was transported in 3 second time controls the cancer terminal;
8) controlling the cancer terminal, modulating through a series of line modulation element halved tie streams, the most at last 200MeV/u
12C
4+Ion exposure is carried out the heavy ion beam irradiation treatment to tumour cell.
Embodiment 2: see Fig. 1, Fig. 2, Fig. 3, a kind of device of accumulating beams in synchrotron for cancer therapy with heavy ions, the device of described a kind of accumulating beams in synchrotron for cancer therapy with heavy ions is provided with level Four magnet 4a successively in the upstream of the straightway of synchrotron, 4b, 4c, 4d, 4e, 4f, compensation helix tube 2a, 2b, at compensation helix tube 2a, the upstream of 2b and downstream are provided with correcting magnet 3a, 3b, 3c, 3d; Downstream at the straightway of synchrotron is provided with identical and corresponding setting with the upstream; Straightway stage casing at synchrotron is provided with the line cooling device.Described line cooling device is a U-shaped, be provided with electron gun 5 at U-shaped mouth one end, the exit of electron gun 5 is provided with electron beam channel 6, electron beam channel 6 is connected with the cooling device 1 that is provided with at the U-shaped straightway, be provided with electrostatic deflection plates 10 in the exit of cooling device 1, electrostatic deflection plates 10 is connected with the gatherer 11 that the other end that is arranged on the U-shaped mouth is provided with.Described refrigerating plant 1 is made up of cooling section 7 and solenoid 8, and the exit of cooling section 7 is provided with solenoid 8.10 places also are provided with the crooked solenoid 12 that be arranged in parallel with electrostatic deflection plates 10 in described electrostatic deflection plates, are provided with correcting coil 13 at the arrival end of crooked solenoid 12.Described electron gun includes negative electrode 14, anode 16, accelerating tube 17, is provided with the control utmost point 15 between anode 16 and negative electrode 14.
Claims (8)
1. the method for beam stacking in the heavy-ion cancer therapy synchronous accelerator includes following steps:
1) ion beam that injector is provided is injected in the synchrotron;
2) with in the electronic cooler (1), the electron beam that electron gun produces accelerates to heavy ion beam has identical average speed;
3) with the cooling section of the electron beam deflecting to the synchrotron ring;
4) mutual impact effect takes place by cooling section with electronics in ion, the cooling heavy ion beam;
5) electronic deflection after will acting on is gone out, and the gatherer that enters electronic cooler is collected, and heavy ion continues shuttling movement in synchrotron;
6) ion beam repeats by cooling section, and the electron beam of being brought in constant renewal in continues cooling.
2. the method for a kind of accumulating beams in synchrotron for cancer therapy with heavy ions as claimed in claim 1 is characterized in that, also includes following steps after step 6),
7) because ion beam is cooled, and radial dimension dwindles, can accept new ion injection by vacating space, implement ion again and inject synchrotron process.
3. the method for a kind of accumulating beams in synchrotron for cancer therapy with heavy ions as claimed in claim 1, it is characterized in that, heavy ion described in the described step 5) is done cycle movement, is ion is repeated to have an effect with electronics in described step 4), repeats to cool off heavy ion beam.
4. the device of a kind of accumulating beams in synchrotron for cancer therapy with heavy ions as claimed in claim 1, it is characterized in that, in the upstream of the straightway of synchrotron, be provided with level Four magnet (4a successively, 4b, 4c), compensation helix tube (2a), in the compensation upstream of helix tube and the downstream be provided with correcting magnet (3a, 3b); Downstream at the straightway of synchrotron is provided with identical and corresponding setting with the upstream; Be provided with line cooling device (1) in the straightway stage casing of synchrotron.
5. the device of accumulating beams in synchrotron for cancer therapy with heavy ions as claimed in claim 4, it is characterized in that, described line cooling device is a U-shaped, be provided with electron gun (5) at U-shaped mouth one end, the exit of electron gun is provided with electron beam channel, electron beam channel is connected with the cooling section that is provided with at the U-shaped straightway (7), is provided with electrostatic deflection plates (10) in the exit of cooling device, and electrostatic deflection plates is connected with the gatherer (11) that the other end that is arranged on the U-shaped mouth is provided with.
6. the device of accumulating beams in synchrotron for cancer therapy with heavy ions as claimed in claim 5 is characterized in that, described frozen portions is made up of cooling section (7) and solenoid (8), and the import of cooling section and exit are provided with crooked solenoid (12).
7. the device of accumulating beams in synchrotron for cancer therapy with heavy ions as claimed in claim 5, it is characterized in that, locate also to be provided with the crooked solenoid (12) that be arranged in parallel with electrostatic deflection plates in described electrostatic deflection plates (10), be provided with correcting coil (13) at the solenoidal arrival end of bending.
8. the device of accumulating beams in synchrotron for cancer therapy with heavy ions as claimed in claim 5, it is characterized in that, described electron gun includes negative electrode (14), anode (16), accelerating tube (17), is provided with the control utmost point (15) between anode (16) and negative electrode (14).
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910000761 CN101631421B (en) | 2009-01-12 | 2009-01-12 | Method and device for accumulating beams in synchrotron for cancer therapy with heavy ions |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102548182A (en) * | 2012-01-14 | 2012-07-04 | 中国科学院近代物理研究所 | Operation method for eliminating hysteresis effect influence of synchronous accelerator |
| CN105659709A (en) * | 2013-08-22 | 2016-06-08 | Tera癌症强子治疗基金会 | Use of linear ion accelerators for the treatment of atrial fibrillation and ion accelerator system there for |
| CN116056305A (en) * | 2023-02-01 | 2023-05-02 | 中国科学院近代物理研究所 | Beam loss control device and injection static deflection plate |
-
2009
- 2009-01-12 CN CN 200910000761 patent/CN101631421B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102548182A (en) * | 2012-01-14 | 2012-07-04 | 中国科学院近代物理研究所 | Operation method for eliminating hysteresis effect influence of synchronous accelerator |
| CN105659709A (en) * | 2013-08-22 | 2016-06-08 | Tera癌症强子治疗基金会 | Use of linear ion accelerators for the treatment of atrial fibrillation and ion accelerator system there for |
| CN116056305A (en) * | 2023-02-01 | 2023-05-02 | 中国科学院近代物理研究所 | Beam loss control device and injection static deflection plate |
| CN116056305B (en) * | 2023-02-01 | 2023-08-25 | 中国科学院近代物理研究所 | Beam loss control device and injection static deflection plate |
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| CN101631421B (en) | 2010-10-13 |
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