CN102793979A - Proton or heavy ion beam cancer treatment device - Google Patents
Proton or heavy ion beam cancer treatment device Download PDFInfo
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- CN102793979A CN102793979A CN2012102641792A CN201210264179A CN102793979A CN 102793979 A CN102793979 A CN 102793979A CN 2012102641792 A CN2012102641792 A CN 2012102641792A CN 201210264179 A CN201210264179 A CN 201210264179A CN 102793979 A CN102793979 A CN 102793979A
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Abstract
The invention relates to a proton or heavy ion beam cancer treatment device which comprises a synchronous accelerator. The device is characterized in that the front end of the synchronous accelerator is provided with an ion source, wherein the ion source is an ECRIS (electron cyclotron resonance ion source); the ECRIS is connected with a radio frequency quodrupole linear accelerator, a first quadrupole magnet, a second quadrupole magnet, a third quadrupole magnet and a fourth quadrupole magnet through a 0Q01 glasser quadrupole lense and a 0Q02 glasser lens and a first dipole magnet, and the first quadrupole magnet, the second quadrupole magnet, the third quadrupole magnet and the fourth quadrupole magnet are arranged on an intermediate energy beam line; a first dipole magnet is arranged between the second quadrupole magnet and the third quadrupole magnet; the fourth quadrupole magnet is connected with a first electrostatic deflecting plate of the synchronous accelerator through a first septum magnet; and a high energy beam line is introduced between the 22nd quadrupole magnet and the 31st quadrupole magnet of the synchronous accelerator. The device has the advantages that the linear accelerator can be used for supplying strong flux, which is over 20 times that of a currently conventional SFC (Securities and Futures Commission) circular accelerator; and more ions can be obtained in the same number of injected turns of the synchronous accelerator by virtue of higher injection flux. Therefore, the transverse pore diameter of a vacuum chamber of the synchronous accelerator can be saved, and the cost for a synchronous storage ring can be reduced.
Description
Technical field
The present invention relates to a kind of proton or HIB cancer-curing apparatus, relate in particular to a kind of proton cancer-curing apparatus, be mainly used in fields such as space flight, biology (medical treatment) and industry linear accelerator and storage rings cascade synchronously.
Background technology
Because have in the proton, the irradiation of HIB that inverse depth dose distributes to organism, less lateral scattering, higher relative biological effectiveness and low characteristics such as oxygen enhancement ratio, make proton and heavy-ion cancer therapy become advanced in the world now effective cancer radiation therapy method; Proton, HIB can be simulated the radiation environment of the outer space, are the effective ways that are used for carrying out space flight single particle effect and the detection of instrument radioprotective; The particle radii of HIB have alternative, are to be used for the effective means that nucleopore membranes is made.
In implementing proton beam, ion beam irradiation, the accelerator that proton beam, ion beam are provided is the most basic device.Accelerator provides proton beam, the ion beam of different-energy according to different experiments and application need; According to the difformity of experimental test target, accurate ion beam current position scan control is provided; According to the effective dose demand, the intensity of different line is provided.Storage rings are to satisfy the most effectively accelerator installation of this type of demand synchronously, and concrete grammar is: through the cut-off frequency and the corresponding magnetic field intensity of regulating the high frequency accelerating cavity, can produce the ion beam of drawing of different-energy; Adopt sweeping magnet that educt beaming flow is carried out high-frequency scanning, can produce the uniform ion bundle and distribute; Inject the strong or control of cumulative flow through control and draw switch, it is strong to regulate the storage of ions line, satisfies the requirement of experiment effective dose.Therefore, setting up with the synchrotron is proton beam, the ion beam accelerator of main body, is the basis of carrying out the ion exposure experiment.
Summary of the invention
The objective of the invention is to avoid the deficiency of prior art that one kind of proton or HIB cancer-curing apparatus are provided.Adopt RFQ or RFQ+DTL (Drift Tube Linac) to inject proton or HIB cancer-curing apparatus as the injection mode of synchrotron as synchrotron injector, the many circles of employing.The present invention can carry out different-energy to target, the ion beam irradiation of different beam intensities.
For realizing above-mentioned purpose; The technical scheme that the present invention takes is: a kind of proton or HIB cancer-curing apparatus; Include synchrotron; Its main feature is that the front end at synchrotron is provided with ion source; Described ion source is the electron cyclotron resonace ion source; The electron cyclotron resonace ion source is connected the 1st quadrupole electromagnet, the 2nd quadrupole electromagnet, the 3rd quadrupole electromagnet, the 4th quadrupole electromagnet on radio frequency four polar field linear accelerator, the middle ability bunch through the 0Q01 glasser quadrupole lens on the bunch of source with 0Q02 glasser lens, the 1 two utmost point ferrum, between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, be provided with the 1st dipolar magnet, and the 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron through the 1st septum magnet; Between the 22nd quadrupole electromagnet of described synchrotron and the 31st six pole magnet, draw the high energy bunch.
Described proton or HIB cancer-curing apparatus also include between described radio frequency four polar field linear accelerator and the 1st quadrupole electromagnet and are provided with draft tube linac.
Described proton or HIB cancer-curing apparatus also include described high energy bunch and include a plurality of terminals of drawing.
Described proton or HIB cancer-curing apparatus, described high energy bunch include between the 22nd quadrupole electromagnet of described synchrotron and the 31st six pole magnet and are connected high energy bunch the 1st quadrupole electromagnet, high energy bunch the 2nd quadrupole electromagnet, high energy bunch the 1st dipolar magnet through the 2nd septum magnet; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes being linked in sequence of the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, first high energy bunch the 4th quadrupole electromagnet; The second high energy bunch includes being linked in sequence of the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, second high energy bunch the 4th quadrupole electromagnet.
Described proton or HIB cancer-curing apparatus, described synchrotron include the 1st electrostatic deflection plates between the 11st quadrupole electromagnet, the 62nd quadrupole electromagnet, between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet, are provided with synchrotron the 1st dipolar magnet; The 12nd quadrupole electromagnet connects the 2nd electrostatic deflection plates, connects the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet through the 3rd bumper magnet, between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet; The 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet; Between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, be provided with synchrotron the 3rd dipolar magnet; Between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron high frequency accelerating cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; The 42nd quadrupole electromagnet connection horizontal is to the radio-frequency field exciting bank; And connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet through the 1st bumper magnet; Between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, be provided with synchrotron the 5th dipolar magnet; The 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet through the DC current detector; Between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet, be provided with synchrotron the 6th dipolar magnet; The 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
Described proton or HIB cancer-curing apparatus, the described vacuum pipe line that is connected to connects, and vacuum is 10
-9-10
-11Mbar.
A kind of method of using proton or HIB cancer-curing apparatus, its key step is:
(1) produces ion beam by ecr ion source; 20KV-40KV draws line at the extraction electrode high pressure; Be injected into after the coupling through glasser lens radio frequency quadrupole linac carry out preaceleration or radio frequency quadrupole linac with acceleration of ions to 2-2.5MeV/u, continue to match draft tube linac then and quicken, after the injection energy that arrives synchrotron is 4MeV/u-7MeV/u; Through overmatching and transmission, line is dispensed into the synchrotron inlet again;
(2) after line arrives the synchrotron inlet, utilize the protruding rail in the synchrotron to make ring internal beam current track protruding, make protruding rail height and synchrotron first electrostatic deflection plates suitable from the distance of vacuum pipe.After line was filled with synchrotron one circle, the protruding rail height began to descend, and the 28-30 microsecond equaled to import the number of turns and multiply by the cycle of circling round fall time), inject with many circles of realizing line, injecting the number of turns is the 15-30 circle;
(3) after line is injected into synchrotron, captures and quicken through frequency cavity halved tie stream, treatment and experiment needs according to the terminal accelerate to predetermined power with line, are 70-250MeV for proton, are 100-400MeV/u for heavy ion; Simultaneously, the horizontal operation point of line is progressively moved near 1/3 resonance line;
(4) after line arrived predetermined power, the ferroelectric stream of six types of severe debility disease began to increase, and makes the stable phase space of synchrotron narrow down to the emittance greater than line;
(5) open horizontal RF excited, line is under the effect of transverse electric field, and emittance increases, thereby arrives the range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, is drawn thereby arrive electrostatic deflection plates;
(6) ejected beam is transported to the high energy bunch through the 2nd electrostatic deflection plates and the 2nd septum magnet of synchrotron, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment.
When (7) the terminal effective dose reaches preset value, can through stop transversely excited be used for stop line continue draw.
The invention has the beneficial effects as follows:
1. adopt synchrotron than adopting other devices to have bigger advantage.
Present main flow accelerator is divided into into three types, is respectively linear accelerator, cyclotron and synchrotron.Adopt linear accelerator can accomplish the conversion of beam intensity, but be the cost that line accelerates to the linear accelerator of same energy quite a few times of synchrotron.The cyclotron cost is lower, but can't realize the Fast transforms of energy.And adopt synchrotron to compare and to circle round and linear accelerator according to the needs at the terminal energy and the intensity of conversion educt beaming flow rapidly, simple and convenient, and more economical.
2. it is strong that the design of adopting linear accelerator to do infusion appliance can obtain higher injection stream.
Adopt linear accelerator as infusion appliance than adopting cyclotron to be that as the maximum advantage of infusion appliance linear accelerator can provide higher stream strong (be nearly thing present more than 20 times of SFC cyclotron beam intensity) and littler beam emittance.High more injection stream can make synchrotron injecting under the same number of turns by force, obtains more number of ions; More little injection beam emittance can inject the more number of turns, that is obtain more injection number of ions under the situation of less synchrotron horizontal aperture.So just, can practice thrift the horizontal aperture of synchrotron vacuum chamber, and then reduce the cost of stores synchronized ring.
Description of drawings:
Fig. 1 is the main sketch map of looking of the present invention.
Among the figure: ECR: the electron cyclotron resonace ion source; RFQ: radio frequency four polar field accelerator; D: two utmost point ferrum; Q: quadrupole ferrum; S: six types of severe debility disease ferrum; RF: high frequency accelerating cavity; DCCT: DC current detector; ES: electrostatic deflection plates; MS: septum magnet; KNO: horizontal radio-frequency field; BP: bumper magnet; Numeral before the element names is represented respectively: 0. source bunch (p_ECR and i_ECR represent proton-electron cyclotron resonance ion source and heavy ion electron cyclotron resonace ion source respectively); 1. middle ability bunch; 2. synchrotron; 3. high energy bunch; P_0Q1: first galasser lens of proton source bunch; P_0Q2: second galasser lens of proton source bunch; I_0Q1: first galasser lens of heavy ion source bunch; I_0Q2: second galasser lens of heavy ion source bunch; 0D1: source bunch dipolar magnet.
The specific embodiment
Below principle of the present invention and characteristic are described, institute gives an actual example and only is used to explain the present invention, is not to be used to limit scope of the present invention.
Embodiment 1: see Fig. 1; A kind of proton beam cancer-curing apparatus; Include synchrotron 2; Front end at synchrotron 2 is provided with ion source 1, and described ion source 1 is electron cyclotron resonace ion source p_ECR, and the electron cyclotron resonace ion source is through glasser lens and ability bunch the 1st quadrupole electromagnet, the 2nd quadrupole electromagnet, the 3rd quadrupole electromagnet, the 4th quadrupole electromagnet during the radio frequency four polar field linear accelerator is connected; Between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, be provided with the 1st dipolar magnet, the 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron 2 through the 1st septum magnet; Between the 22nd quadrupole electromagnet of described synchrotron 2 and the 31st six pole magnet, draw high energy bunch 3.
Described high energy bunch 3 includes 2 and draws the terminal.Between the 22nd quadrupole electromagnet of described synchrotron 2 and the 31st six pole magnet, be connected high energy bunch the 1st quadrupole electromagnet, high energy bunch the 2nd quadrupole electromagnet, high energy bunch the 1st dipolar magnet through the 2nd septum magnet; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes being linked in sequence of the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, first high energy bunch the 4th quadrupole electromagnet; The second high energy bunch includes being linked in sequence of elements such as the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, the second high energy bunch the 4th quadrupole electromagnet.
Described synchrotron 2 includes the 1st electrostatic deflection plates and connects the 11st quadrupole electromagnet, the 12nd quadrupole electromagnet, between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet, is provided with synchrotron the 1st dipolar magnet; The 12nd quadrupole electromagnet connects the 2nd electrostatic deflection plates, connects the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet through the 3rd bumper magnet, between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet; The 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet; Between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, be provided with synchrotron the 3rd dipolar magnet; Between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron high frequency accelerating cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; The 42nd quadrupole electromagnet connection horizontal is to radio-frequency field; And connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet through the 1st bumper magnet; Between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, be provided with synchrotron the 5th dipolar magnet; The 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet through the DC current detector, between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet, is provided with synchrotron the 6th dipolar magnet; The 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
The described vacuum pipe line that is connected to connects, and vacuum is 10
-9-10
-10Mbar.
Embodiment 2: see Fig. 1, a kind of proton beam cancer-curing apparatus is provided with draft tube linac between described radio frequency four polar field accelerator and the 1st quadrupole electromagnet.All the other structures are identical with embodiment 1.
Embodiment 3: a kind of proton beam cancer-curing apparatus, described high energy bunch 3 includes more than 2 draws the terminal, according to experiment and terminal needs, can continue to isolate more high energy bunch from the first or second high energy bunch.All the other structures are identical with embodiment 1 or embodiment 2.
Embodiment 4: a kind of HIB cancer-curing apparatus; Include synchrotron 2; Front end at synchrotron 2 is provided with ion source 1; Described ion source 1 is electron cyclotron resonace ion source i_ECR; The electron cyclotron resonace ion source is connected the 1st quadrupole electromagnet, the 2nd quadrupole electromagnet, the 3rd quadrupole electromagnet, the 4th quadrupole electromagnet through the glasser lens with radio frequency four polar field accelerator, between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, be provided with the 1st dipolar magnet, and the 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron 2 through the 1st septum magnet; Between the 22nd quadrupole electromagnet of described synchrotron 2 and the 31st six pole magnet, draw high energy bunch 3.
Described high energy bunch 3 includes 2 and draws the terminal.Between the 22nd quadrupole electromagnet of described synchrotron 2 and the 31st six pole magnet, be connected high energy bunch the 1st quadrupole electromagnet, high energy bunch the 2nd quadrupole electromagnet, high energy bunch the 1st dipolar magnet through the 2nd septum magnet; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes being linked in sequence of the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, first high energy bunch the 4th quadrupole electromagnet; The second high energy bunch includes being linked in sequence of the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, second high energy bunch the 4th quadrupole electromagnet.
Described synchrotron 2 includes the 1st electrostatic deflection plates and connects the 11st quadrupole electromagnet, the 12nd quadrupole electromagnet, between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet, is provided with synchrotron the 1st dipolar magnet; The 12nd quadrupole electromagnet connects the 2nd electrostatic deflection plates, connects the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet through the 3rd bumper magnet, between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet; The 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet; Between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, be provided with synchrotron the 3rd dipolar magnet; Between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron high frequency accelerating cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; The 42nd quadrupole electromagnet connection horizontal is to radio-frequency field; And connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet through the 1st bumper magnet; Between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, be provided with synchrotron the 5th dipolar magnet; The 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet through the DC current detector, between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet, is provided with synchrotron the 6th dipolar magnet; The 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
The described vacuum pipe line that is connected to connects, and vacuum is 10
-10-10
-11Mbar.
All the other structures are identical with embodiment 1.
Embodiment 5: a kind of HIB cancer-curing apparatus is provided with draft tube linac between described radio frequency four polar field accelerator and the 1st quadrupole electromagnet.All the other structures are identical with embodiment 4.
Embodiment 6: a kind of HIB cancer-curing apparatus, described high energy bunch 3 includes more than 2 draws the terminal.All the other structures are identical with embodiment 4 or embodiment 5.
Embodiment 7: a kind of method of using the proton beam cancer-curing apparatus, and its key step is:
(1) produces ion beam by ecr ion source; 20KV-40KV draws line at the extraction electrode high pressure; Be injected into radio frequency quadrupole linac after the coupling through the glasser lens and carry out preaceleration; After arriving the injection energy 4MeV/u-7MeV/u of synchrotron,, line is dispensed into the synchrotron inlet again through overmatching and transmission;
(2) after line arrives the synchrotron inlet, utilize the protruding rail in the synchrotron to make ring internal beam current track protruding, make protruding rail height and synchrotron first electrostatic deflection plates suitable from the distance of vacuum pipe.After line was filled with synchrotron one circle, the protruding rail height progressively descended, and about 30 microseconds fall time (approximate the input number of turns and multiply by the cycle of circling round) realize that many circles of line inject, and injecting the number of turns is the 15-30 circle;
(3) after line is injected into synchrotron, captures and quicken through frequency cavity halved tie stream, according to the treatment and the experiment needs at terminal; Line is accelerated to predetermined power; For proton is 70-250MeV, simultaneously, the horizontal operation point of line is progressively moved near 1/3 resonance line;
(4) after line arrived predetermined power, the ferroelectric stream of six types of severe debility disease began to increase, and makes the stable phase space of synchrotron narrow down to the emittance greater than line;
(5) open horizontal RF excited, line is under the effect of transverse electric field, and emittance increases, thereby arrives the range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, is drawn thereby arrive electrostatic deflection plates;
(6) ejected beam is transported to the high energy bunch through the 2nd electrostatic deflection plates and the 2nd septum magnet of synchrotron, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment.
When (7) the terminal effective dose reaches preset value, can through stop transversely excited be used for stop line continue draw.
Embodiment 8: a kind of method of using the proton beam cancer-curing apparatus; Its key step (1) is to produce ion beam by ecr ion source; 20KV-40KV draws line at the extraction electrode high pressure, is injected into radio frequency quadrupole linac after the coupling through the glasser lens, and radio frequency quadrupole linac arrives 2-2.5MeV/u with acceleration of ions; Continuing to match draft tube linac then quickens; After arriving the injection energy 4MeV/u-7MeV/u of synchrotron,, line is dispensed into the synchrotron inlet again through overmatching and transmission.All the other steps are identical with embodiment 7.
With the nearly thing HIRFL of institute device is example; Present fan-shaped cyclotron SFC draws about the strong 15uA of being of C6+ stream; Horizontal emittance is about 25pi mm mrad; Synchrotron CSRm transverse horizontal acceptance is 200pi mm mrad, adopts many circles to inject, and ideal situation injects the about by force 100uA of the highest stream down.If adopt linear accelerator as infusion appliance: linear accelerator draw that stream is strong to be 200uA, horizontal emittance is 6-12pi mm mrad, then injects stream by force in the milliampere magnitude.
Embodiment 9: a kind of method of using the HIB cancer-curing apparatus, and its key step is:
(1) produces ion beam by ecr ion source; 20KV-40KV draws line at the extraction electrode high pressure; Being injected into radio frequency quadrupole linac after the coupling through the glasser lens quickens; Arrive the injection energy 2-4MeV/u of synchrotron,, line is dispensed into the synchrotron inlet again through overmatching and transmission;
(2) after line arrives the synchrotron inlet, utilize the protruding rail in the synchrotron to make ring internal beam current track protruding, make protruding rail height and synchrotron first electrostatic deflection plates suitable from the distance of vacuum pipe.After line was filled with synchrotron one circle, the protruding rail height progressively descended, and about 30 microseconds fall time (approximate the input number of turns and multiply by the cycle of circling round) realize that many circles of line inject, and injecting the number of turns is the 15-30 circle;
(3) after line is injected into synchrotron, captures and quicken through frequency cavity halved tie stream, treatment and experiment needs according to the terminal accelerate to predetermined power with line, are 100-400MeV/u for heavy ion; Simultaneously, the horizontal operation point of line is progressively moved near 1/3 resonance line;
(4) after line arrived predetermined power, the ferroelectric stream of six types of severe debility disease began to increase, and makes the stable phase space of synchrotron narrow down to the emittance greater than line;
(5) open horizontal RF excited, line is under the effect of transverse electric field, and emittance increases, thereby arrives the range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, is drawn thereby arrive electrostatic deflection plates;
(6) ejected beam is transported to the high energy bunch through the 2nd electrostatic deflection plates and the 2nd septum magnet of synchrotron, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment.
When (7) the terminal effective dose reaches preset value, can through stop transversely excited be used for stop line continue draw.
Embodiment 10: a kind of method of using the HIB cancer-curing apparatus; Its key step (1) is to produce ion beam by ecr ion source; 20KV-40KV draws line at the extraction electrode high pressure, is injected into radio frequency quadrupole linac after the coupling through the glasser lens, and radio frequency quadrupole linac arrives 2-2.5MeV/u with acceleration of ions; Continuing to match draft tube linac then quickens; After arriving the injection energy 4MeV/u-7MeV/u of synchrotron,, line is dispensed into the synchrotron inlet again through overmatching and transmission.All the other steps are identical with embodiment 9.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a kind of proton or HIB cancer-curing apparatus; Include synchrotron; It is characterized in that being provided with ion source at the front end of synchrotron; Described ion source is the electron cyclotron resonace ion source; The electron cyclotron resonace ion source is connected the 1st quadrupole electromagnet, the 2nd quadrupole electromagnet, the 3rd quadrupole electromagnet, the 4th quadrupole electromagnet on radio frequency four polar field linear accelerator, the middle ability bunch through the 0Q01 glasser quadrupole lens on the bunch of source with 0Q02glasser lens, the 1 two utmost point ferrum, between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, be provided with the 1st dipolar magnet, and the 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron through the 1st septum magnet; Between the 22nd quadrupole electromagnet of described synchrotron and the 31st six pole magnet, draw the high energy bunch.
2. proton as claimed in claim 1 or HIB cancer-curing apparatus is characterized in that also including between described radio frequency four polar field linear accelerator and the 1st quadrupole electromagnet and are provided with draft tube linac.
3. proton as claimed in claim 1 or HIB cancer-curing apparatus is characterized in that also including described high energy bunch and include a plurality of terminals of drawing.
4. proton as claimed in claim 3 or HIB cancer-curing apparatus is characterized in that described high energy bunch includes between the 22nd quadrupole electromagnet of described synchrotron and the 31st six pole magnet and are connected high energy bunch the 1st quadrupole electromagnet, high energy bunch the 2nd quadrupole electromagnet, high energy bunch the 1st dipolar magnet through the 2nd septum magnet; Draw the first high energy bunch and the second high energy bunch respectively by high energy bunch the 1st dipolar magnet, the first high energy bunch includes being linked in sequence of the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, first high energy bunch the 4th quadrupole electromagnet; The second high energy bunch includes being linked in sequence of the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, second high energy bunch the 4th quadrupole electromagnet.
5. proton as claimed in claim 1 or HIB cancer-curing apparatus; It is characterized in that described synchrotron includes the 1st electrostatic deflection plates between the 11st quadrupole electromagnet, the 62nd quadrupole electromagnet, is provided with synchrotron the 1st dipolar magnet between the 11st quadrupole electromagnet and the 12nd quadrupole electromagnet; The 12nd quadrupole electromagnet connects the 2nd electrostatic deflection plates, connects the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet through the 3rd bumper magnet, between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet, is provided with synchrotron the 2nd dipolar magnet; The 22nd quadrupole electromagnet connects the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet; Between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, be provided with synchrotron the 3rd dipolar magnet; Between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron high frequency accelerating cavity, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; The 42nd quadrupole electromagnet connection horizontal is to the radio-frequency field exciting bank; And connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet through the 1st bumper magnet; Between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, be provided with synchrotron the 5th dipolar magnet; The 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet through the DC current detector; Between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet, be provided with synchrotron the 6th dipolar magnet; The 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.
6. like arbitrary described proton of claim 1 to 5 or HIB cancer-curing apparatus, it is characterized in that the described vacuum pipe line that is connected to connects, vacuum is 10
-9-10
-11Mbar.
7. method of using proton or HIB cancer-curing apparatus is characterized in that step is:
(1) produces ion beam by ecr ion source; Under extraction electrode high pressure 20KV-40KV, line is drawn; Be injected into after the coupling through glasser lens radio frequency quadrupole linac carry out preaceleration or radio frequency quadrupole linac with acceleration of ions to 2-2.5MeV/u, continue to match draft tube linac then and quicken, after the injection energy that arrives synchrotron is 4MeV/u-7MeV/u; Through overmatching and transmission, line is dispensed into the synchrotron inlet again;
(2) after line arrives the synchrotron inlet, utilize the protruding rail in the synchrotron to make ring internal beam current track protruding, make protruding rail height and synchrotron first electrostatic deflection plates suitable from the distance of vacuum pipe; After line was filled with synchrotron one circle, the protruding rail height began to descend, and be the 28-30 microsecond fall time, equaled to import the number of turns and multiply by the cycle of circling round, and injected with many circles of realizing line, and injecting the number of turns is the 15-30 circle;
(3) after line is injected into synchrotron, captures and quicken through frequency cavity halved tie stream, treatment and experiment needs according to the terminal accelerate to predetermined power with line, are 70-250MeV for proton, are 100-400MeV/u for heavy ion; Simultaneously, the horizontal operation point of line is progressively moved near 1/3 resonance line;
(4) after line arrived predetermined power, the ferroelectric stream of six types of severe debility disease began to increase, and makes the stable phase space of synchrotron narrow down to the emittance greater than line;
(5) open horizontal RF excited, line is under the effect of transverse electric field, and emittance increases, thereby arrives the range of instability, and beam emittance increases rapidly along the demarcation line of range of instability then, is drawn thereby arrive electrostatic deflection plates;
(6) ejected beam is transported to the high energy bunch through the 2nd electrostatic deflection plates and the 2nd septum magnet of synchrotron, through the dispensing of high energy bunch, arrives treatment or experimental terminal, carries out associated treatment or experiment;
When (7) the terminal effective dose reaches preset value, can through stop transversely excited be used for stop line continue draw.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11169470A (en) * | 1997-12-12 | 1999-06-29 | Mitsubishi Electric Corp | Neutron generator |
| JP2001217100A (en) * | 2000-02-01 | 2001-08-10 | Hitachi Ltd | Medical system |
| CN102387836A (en) * | 2009-03-04 | 2012-03-21 | 普罗汤姆封闭式股份公司 | Multi-field charged particle cancer therapy method and apparatus |
| CN202982960U (en) * | 2012-07-28 | 2013-06-12 | 中国科学院近代物理研究所 | Proton or heavy ion beam cancer therapy device |
-
2012
- 2012-07-28 CN CN201210264179.2A patent/CN102793979B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11169470A (en) * | 1997-12-12 | 1999-06-29 | Mitsubishi Electric Corp | Neutron generator |
| JP2001217100A (en) * | 2000-02-01 | 2001-08-10 | Hitachi Ltd | Medical system |
| CN102387836A (en) * | 2009-03-04 | 2012-03-21 | 普罗汤姆封闭式股份公司 | Multi-field charged particle cancer therapy method and apparatus |
| CN202982960U (en) * | 2012-07-28 | 2013-06-12 | 中国科学院近代物理研究所 | Proton or heavy ion beam cancer therapy device |
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