CN102784396B - 抗氧化剂用于基因调节的用途 - Google Patents

抗氧化剂用于基因调节的用途 Download PDF

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Publication number
CN102784396B
CN102784396B CN201210299256.8A CN201210299256A CN102784396B CN 102784396 B CN102784396 B CN 102784396B CN 201210299256 A CN201210299256 A CN 201210299256A CN 102784396 B CN102784396 B CN 102784396B
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China
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gene
food
protein
expression
purposes
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Expired - Fee Related
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CN201210299256.8A
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English (en)
Chinese (zh)
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CN102784396A (zh
Inventor
S.C.齐克尔
I.佩陶-洛宾逊
K.J.韦德金德
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Hills Pet Nutrition Inc
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Hills Pet Nutrition Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • A61K38/063Glutathione
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/116Heterocyclic compounds
    • A23K20/121Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/174Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/40Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/18Antioxidants, e.g. antiradicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
CN201210299256.8A 2004-11-09 2005-11-09 抗氧化剂用于基因调节的用途 Expired - Fee Related CN102784396B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62616204P 2004-11-09 2004-11-09
US60/626162 2004-11-09
CN2005800462156A CN101098623B (zh) 2004-11-09 2005-11-09 抗氧化剂用于基因调节的用途

Related Parent Applications (1)

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CN2005800462156A Division CN101098623B (zh) 2004-11-09 2005-11-09 抗氧化剂用于基因调节的用途

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CN102784396A CN102784396A (zh) 2012-11-21
CN102784396B true CN102784396B (zh) 2015-07-29

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CN2005800462156A Expired - Fee Related CN101098623B (zh) 2004-11-09 2005-11-09 抗氧化剂用于基因调节的用途

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US (1) US11077165B2 (enExample)
EP (1) EP1814394A4 (enExample)
JP (1) JP2008519838A (enExample)
CN (2) CN102784396B (enExample)
AU (1) AU2005304546B2 (enExample)
BR (1) BRPI0517563A (enExample)
CA (1) CA2586936C (enExample)
RU (1) RU2433819C2 (enExample)
WO (1) WO2006053010A2 (enExample)
ZA (1) ZA200704210B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8669282B2 (en) * 2000-10-31 2014-03-11 Hill's Pet Nutrition, Inc. Companion animal compositions including lipoic acid and methods of use thereof
WO2006053010A2 (en) 2004-11-09 2006-05-18 Hill's Pet Nutrition, Inc. Use of antioxidants for gene modulation
CA2784197C (en) * 2004-12-30 2015-09-01 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US20070118295A1 (en) * 2005-03-02 2007-05-24 Al-Murrani Samer Waleed Khedhe Methods and Systems for Designing Animal Food Compositions
CN101287460B (zh) 2005-08-17 2012-04-25 希尔氏宠物营养品公司 预防和治疗肾病的组合物
CN100462074C (zh) * 2007-02-14 2009-02-18 北京东方兴企食品工业技术有限公司 一种具有缓解视疲劳作用的口嚼片
CN102159197A (zh) * 2008-07-18 2011-08-17 希尔氏宠物营养品公司 治疗骨关节炎的组合物和方法
BRPI0915974A2 (pt) * 2008-07-18 2017-05-30 Hill´S Pet Nutrition Inc métodos para modular funções biológicas, para tratar um animal sofrendo de um distúrbio ou doença, para alterar a expressão de pelo menos um peptídeo em um mamífero, e para triar um ou mais compostos de teste para habilidade para alterar a expressão de pelo menos um gene de interesse em um mamífero
WO2010078319A1 (en) * 2008-12-30 2010-07-08 Hill's Pet Nutrition, Inc. Lipoic acid containing compositions for use in the treatment and prevention of ki dney- related disorders in companion animals
JP5902480B2 (ja) * 2008-12-30 2016-04-13 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド コンパニオンアニマルにおける変性関節病、骨関節炎、軟骨損傷、および関連する障害を処置する、または予防する方法
JP5820819B2 (ja) * 2010-01-06 2015-11-24 ネステク ソシエテ アノニム カロリー制限の模倣に有効な食餌療法
JP2013523816A (ja) * 2010-04-06 2013-06-17 エジソン ファーマシューティカルズ, インコーポレイテッド 毛細血管拡張性運動失調症の治療
US10564169B2 (en) 2010-05-12 2020-02-18 Colgate-Palmolive Company Methods for the diagnosis, control and prophylaxis of inflammation and mitigation of inflammatory conditions in canines
RU2525579C2 (ru) * 2010-05-12 2014-08-20 Хилл`С Пет Ньютришн, Инк. Способы контроля и профилактики воспаления и ослабления воспалительных состояний у животных компаньонов
US20120282373A1 (en) * 2011-05-02 2012-11-08 Ashok Premchand Luhadiya Compositions Comprising a Glucose Anti-Metabolite and Selenium
EP2580967A1 (en) * 2011-10-11 2013-04-17 Nestec S.A. Accelerating muscle recovery after immobilization-induced muscle atrophy
JP2014018172A (ja) * 2012-07-20 2014-02-03 Kohjin Life Sciences Co Ltd 過酸化脂質生成を抑制するペットフード
CN103305579B (zh) * 2013-06-29 2014-08-27 吉林大学 一种玉米源辅助增强记忆肽及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136859A (en) * 1997-10-24 2000-10-24 Pharma Nord Aps Pharmaceutical formulation for treating liver disorders
US6184227B1 (en) * 1995-07-21 2001-02-06 Savvipharm Inc. Salts of aminoimidazole carboxamide useful in the prevention and treatment of liver diseases
US6596762B2 (en) * 2001-05-17 2003-07-22 The Regents Of The University Of Colorado Antioxidant compositions and use for treatment of hepatic steatosis and steatohepatitis

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090414A (en) * 1970-05-20 2000-07-18 Life Science Labs, Inc. Method and composition to reduce cancer incidence
JPS58129954A (ja) * 1982-01-29 1983-08-03 Riboseren:Kk 新しき健康食品の製造法
US5668117A (en) * 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US20050027004A1 (en) * 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
DE4427079C2 (de) 1994-07-30 2002-12-19 Viatris Gmbh Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure
US6465466B1 (en) * 1995-12-22 2002-10-15 Leif J. I. Lundblad Uses of indolo-2 [2,3b] -quinoxalines
IT1290907B1 (it) * 1997-01-31 1998-12-14 Idi Farmaceutici Spa Composizione per prodotto dietetico efficace nel combattere lo stress ossidativo e il decadimento cellulare.
US6858399B2 (en) * 1998-06-29 2005-02-22 Robert Lamb Test for oxidative stress using cell suspensions
US20030198661A1 (en) * 2000-01-31 2003-10-23 Mars Incorporated Antioxidant compositions and methods for companion animals
GB2367489B (en) * 2000-07-31 2005-02-09 Mars Inc Use of antioxidants
NZ527924A (en) 1999-01-29 2005-01-28 Mars Uk Ltd Antioxidant compositions and methods for companion animals
WO2000057876A1 (en) * 1999-03-26 2000-10-05 Lipogenics, Inc. Novel antioxidant formulations and methods for using them
US6352712B1 (en) * 1999-04-30 2002-03-05 Daniel O. Lukaczer Dietary supplements for treating fatigue-related syndromes
BR0013879B1 (pt) 1999-09-09 2013-07-23 método não terapêutico e nutracêutico para melhorar a condição de saúde, para aumentar a longevidade ou para aumentar a qualidade de vida de um animal de estimação de idade avançada, e alimento para animal de estimação
US20020077349A1 (en) * 1999-11-03 2002-06-20 Hamilton Nathan D. Method of treating age-related vision impairment
US6207702B1 (en) * 1999-11-17 2001-03-27 Mars, Incorporated Method for reducing postprandial oxidative stress using cocoa procyanidins
AUPQ429399A0 (en) * 1999-11-26 1999-12-23 Heart Research Institute, The Oxidized apolipoproteins and methods of use
AU5440901A (en) * 1999-12-20 2001-07-03 Cognis France, S.A. Cosmetic and/or pharmaceutical preparations
EP1250052A1 (en) * 2000-01-25 2002-10-23 Juvenon, Inc. Nutritional supplements for aged pets
IL152004A (en) * 2000-04-18 2005-11-20 Nestle Sa Process for preparing enteral formulations using nutritional modules and nutritional modules for usetherein
MXPA02011528A (es) * 2000-05-25 2003-04-25 Pharmaton Sa Metodo para mejorar la proteccion celular.
US20030036203A1 (en) * 2000-09-26 2003-02-20 Geoff Duke Method and graphic representation for profiling oxidative stress and cardiovascular risk
US20020115710A1 (en) 2000-10-31 2002-08-22 Zicker Steven Curtis Composition and method
US20020076470A1 (en) * 2000-10-31 2002-06-20 Colgate-Palmolive Company Composition and method
DE10057290B4 (de) * 2000-11-17 2004-01-08 Fresenius Kabi Deutschland Gmbh Enteral zu verabreichendes Supplement zur parenteralen Ernährung oder partiellen enteralen/oralen Ernährung bei kritisch Kranken, chronisch Kranken und Mangelernährten
CN1638650A (zh) 2001-03-09 2005-07-13 雀巢制品公司 改善与年龄有关的生理缺陷并延长寿命的组合物
US6964969B2 (en) * 2001-04-19 2005-11-15 Mccleary Edward Larry Composition and method for treating impaired or deteriorating neurological function
EP1381373B1 (en) * 2001-04-25 2006-06-14 Cobalz Limited Medical compositions for use in the treatment or prevention of a functional vitamin b12 deficienfcy
GB0119052D0 (en) * 2001-08-03 2001-09-26 Mars Uk Ltd Foodstuff
AU2005243741B2 (en) * 2001-09-18 2010-01-28 Bioexpertise Llc Methods for delivering MBD peptide- linked agent into cells under conditions of cellular stress
WO2003033662A2 (en) * 2001-10-16 2003-04-24 Atherogenics, Inc. Protection against oxidative stress and inflammation by a cytoprotective response element
NO323683B1 (no) * 2002-03-14 2007-06-25 Pronova Biocare As Anvendelse av marine og/eller vegetabilske oljer som er behandlet med urea og/eller andre aminer eller amider i fôr til marine arter
PT1542670E (pt) * 2002-09-24 2013-07-11 Suntory Holdings Ltd Composição com efeitos na prevenção do declínio, melhoramento ou aumento de respostas normais de aptidões cognitivas de uma pessoa saudável
US6974841B1 (en) * 2002-09-27 2005-12-13 Rapisarda Family Irrevocable Trust Pet anti-aging wellness supplement
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
AU2004238375A1 (en) * 2003-05-13 2004-11-25 The Regents Of The University Of Colorado Diagnostic and therapeutic treatments related to mitochondrial disorders
RU2349312C2 (ru) 2003-07-03 2009-03-20 Хилл`С Пет Ньютришн, Инк. Композиция и способ для ингибирования ухудшения умственных способностей у кошек
ATE519380T1 (de) * 2003-07-21 2011-08-15 Unilever Nv Unterstützung der kognitiven funktion
US7078202B2 (en) * 2003-11-18 2006-07-18 Ultra Biotech Limited Methods and compositions for treating vascular dementia
KR20070007837A (ko) * 2004-03-23 2007-01-16 라이프라인 뉴트러세티컬스 코포레이션 포유류에서 염증과 산화적 스트레스 완화를 위한 조성물 및방법
EP1755406B1 (en) * 2004-04-16 2012-09-26 Nestec S.A. Compositions for reducing oxidative stress in an animal
US20050266051A1 (en) 2004-05-27 2005-12-01 The Procter & Gamble Company Pet food compositions and methods
US20060094734A1 (en) * 2004-11-04 2006-05-04 Newman Arnold L Composition and method for inducing alertness
WO2006053010A2 (en) 2004-11-09 2006-05-18 Hill's Pet Nutrition, Inc. Use of antioxidants for gene modulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184227B1 (en) * 1995-07-21 2001-02-06 Savvipharm Inc. Salts of aminoimidazole carboxamide useful in the prevention and treatment of liver diseases
US6136859A (en) * 1997-10-24 2000-10-24 Pharma Nord Aps Pharmaceutical formulation for treating liver disorders
US6596762B2 (en) * 2001-05-17 2003-07-22 The Regents Of The University Of Colorado Antioxidant compositions and use for treatment of hepatic steatosis and steatohepatitis

Also Published As

Publication number Publication date
CN101098623B (zh) 2012-10-10
WO2006053010A3 (en) 2006-07-13
RU2433819C2 (ru) 2011-11-20
US11077165B2 (en) 2021-08-03
RU2007121735A (ru) 2008-12-20
ZA200704210B (en) 2008-09-25
JP2008519838A (ja) 2008-06-12
CN102784396A (zh) 2012-11-21
CN101098623A (zh) 2008-01-02
WO2006053010A2 (en) 2006-05-18
CA2586936C (en) 2019-08-20
AU2005304546A1 (en) 2006-05-18
AU2005304546B2 (en) 2011-07-21
CA2586936A1 (en) 2006-05-18
BRPI0517563A (pt) 2008-10-14
EP1814394A2 (en) 2007-08-08
US20080069834A1 (en) 2008-03-20
EP1814394A4 (en) 2009-08-19

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