CN102784366A - Medical composition with function of decanting and protecting liver - Google Patents
Medical composition with function of decanting and protecting liver Download PDFInfo
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Abstract
The invention provides a medical composition with functions of clearing heat and nourishing yin, reducing stasis and dredging collateral as well as treating alcoholic liver injury. The medical composition comprises centella, cape jasmine, turmeric, radix paeoniae alba, salvia miltiorrhiza and blueberry. The invention also relates to applications of the composition in preparation of health-care foods for preventing and controlling acute alcoholic liver injury and chronic alcohol liver injury and health-care foods for treating nonalcoholic fatty liver disease. The components of the medical composition provided by the invention interact synergistically well, and have obvious curative effect; and the raw materials are easy to obtain, the preparation is simple, and the cost is relatively low.
Description
Technical field
The invention belongs to medicine and field of food, is a kind of compositions with natural product of preventing and treating relevant diseases such as alcoholic liver injury.
The present invention relates to a kind of compositions, belong to medicine and field of food with natural product of preventing and treating relevant diseases such as alcoholic liver injury.
Background technology
Liver is the maximum body of gland of human body, and it all plays important effect in people's metabolism, bile generation, detoxifcation, blood coagulation, immunity, heat generation and water and electrolytical adjusting.In general, cause hepatic injury to mainly contain two big types of paathogenic factors, one type is by pathogenic microorganism such as viral infection and the liver inflammation that causes, like hepatitis A, hepatitis B etc.Another kind of then is chemical liver injury, and it is by various toxicants, the damage that liver is caused like the ethanol in the food, chemical toxicant and some drugs etc. in the environment.Because liver is the main metabolic organ of human body, the imbalance of liver fat metabolic function can cause such as symptoms such as hyperlipidemia, obesities in addition.
Alcoholic liver injury is meant a series of pathological changes such as liver injury that cause owing to excessive absorption ethanol.Alcoholic liver injury can be divided into acute alcohol liver damage and chronic alcoholic liver injury.The acute alcohol liver damage is that excess intake ethanol causes liver function injury owing to one time, shows as inappetence, feels sick, type acute hepatitis symptom such as the uncomfortable jaundice of liver.Chronic alcoholic liver injury is that the liver immunologic function is destroyed, and often shows as alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis owing to the long-term ethanol of taking in causes the degeneration of hepatocyte fibrosis, necrosis.The medicine of treatment alcoholic liver injury mainly contains: antiendotoxin medicine, antioxidant, glucocorticoid, antagonism and improve the medicine of alcohol metabolism.These medicines have certain curative effect to acute alcohol liver damage and chronic alcoholic liver injury initial stage; But arrived the later stage of alcoholic liver injury; The human immunologic function seriously descends, and liver function damage is serious, only carries out liver transplantation and could be able to significantly improve symptom and increase survival rate.Generally speaking, modern medicine is for treatment acute and chronic alcoholic liver injury and none specially good effect good medicine.Chinese medicine is discussed among the diseases such as " getting sick from drinking too much wine ", " hypochondriac pain ", " alcoholophilia ", " wine drum ", " jaundice " the research of alcoholic liver injury, and its unique Therapeutic Method is arranged.Theory of Chinese medical science thinks, wine is the poisonous article of big heat, crosses must the injuring the taste liver and gall of drink and diseases induced.Pathogenesis then can reduce: deficiency of spleen-QI and stomach-QI, phlegm resistance, retention of water-damp in the body, disharmony between QI and blood, qi depression to blood stasis etc.Wherein, wine impairing the liver spleen, accumulatively wet raise phlegm are the key of morbidity; And plain body innate deficiency, weakness of the spleen and stomach for morbidity this.
Owing to drink and to hinder decomposition of fatty acids for a long time, cause that neutral fat accumulates, because superfluous H
+Can hinder the interior fatty acid of liver cell mitochondria and decompose, cause fatty liver as the energy.Hepatocellular fatization has had a strong impact on the normal function of liver, has suppressed the carrying out of tricarboxylic acid cycle in the body, causes the metabolic pathway of wine to be obstructed, and co-solvents forms vicious cycle to the infringement of normal structure.Therefore study and a kind ofly can reduce ethanol toxicity, and can have the medicine of restitution that bigger social benefit and application prospect are arranged hepatic injury due to the ethanol.
The present invention is exactly with a kind of Chinese medicine composition with control alcoholic liver injury of from natural plants, finding and extracting.Said composition is to become composition of natural products by the effective ingredient innovative combination; From several kinds of different effects mechanism treatment alcoholic liver injury of starting with, many target spots of multicomponent synergism reaches combination of long drives and drop shots; The effect of treating both the principal and secondary aspects of a disease is in the hope of having significant breakthrough and raising from curative effect and safety.
Herba Centellae is the herb of samphire Herba Centellae Centella asiatica Linn., and another name has the jorum of collapsing, Herba Centellae, Herba Calthae Membranaceae, Gotu Kola etc.Beginning is stated from Shennong's Herbal, classifies middle article as, and is bitter, hot, cold, returns the liver,spleen,kidney warp, has clearing away heat-damp and promoting diuresis, the effect of removing toxic substances and promoting subsidence of swelling.Be used for jaundice due to damp-heat, heatstroke diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, traumatic injury.China is among the people to be usually used in treating flu, tonsillitis, infectious hepatitis, dysentery, traumatic injury, furuncle swelling toxin, epidemic cerebrospinal meningitis etc.Each about eight liang to one jin of jorum is collapsed in " south of the Five Ridges herbal " record, fries in shallow oil the water clothes, is used for the dirty enlargement of treating the liver." Jiangxi traditional herbal medicine " record Herba Centellae one or two, crystal sugar one or two is decocted in water for oral dose, and is used to control jaundice due to damp-heat.The record of " Guangdong Chinese medicine " II, Herba Centellae has clearing away summer-heat heat, remuval of damp and hot, effects such as treating the liver enlargement.The effective ingredient of Herba Centellae is asiatic centella total saponins, asiatic acid, Madecassic acid etc.In recent years research report Herba Centellae has the promotion wound healing, softening cicatrix, and psoriasis, antidepressant, resisting hyperplasia of mammary glands, anti-hepatic fibrosis, anticancer, the treatment edema protects the liver the effects such as treatment of blood sugar lowering and complication.Patents of invention such as Wang Shenghao (publication number: CN100441201C) reported that Herba Centellae total glycosides has treatment wound, operation wound, burn, keloid and scleroderma and antidepressant and the effect of treatment Liver and kidney fibrosis.Domestic patent discloses asiatic acid and derivant to be had treatment skin trauma, antidepressant, anti-Alzheimer disease and protects the liver, protects cardiovascular and cerebrovascular vessel and inducing tumor cell is transferred multiple effect (CN1238692, CN1248918, CN1543964 and CN1582946) such as die.Asiatic acid is treated hepatic fibrosis, pulmonary fibrosis effect (number of patent application: 200610122561.4,200610118041.6) in addition.Li Hongzhong research shows asiaticoside, and hepatic injury has the significant protection effect to chmice acute.Zhang Lina research shows that asiaticoside causes acute liver damage to the mice sepsis and has the significant protection effect.
Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis, and the beginning is stated from Shennong's Herbal, bitter in the mouth cold in nature, and GUIXIN, lung, tri-jiao channel have the pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body.It is vexed to be used for calentura, jaundice due to damp-heat, and blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles.Fructus Gardeniae function of gallbladder promoting, jaundice eliminating effect are stronger, and it is best that the article of giving birth to are treated the icterohepatitis effect.Modern study finds that contain iridoid glycoside constituents such as jasminoidin (Gardenoside), gardoside, Gardenoside in the Fructus Gardeniae, this constituents is the main effective site of Fructus Gardeniae.Bibliographical information is arranged, give ICR rat Fructus Gardeniae extract in advance, can prevent the explosive hepatic injury of bringing out because of galactosamine.Give jasminoidin and can effectively reduce the rat transaminase rising that causes by the isothiocyanic acid α-Nai Zhi.Rabbit and rat digestive tract give Fructus Gardeniae extract can increase bile secretion, tires quite with sodium dehydrocholate.The clinical literature report, single oral with the Fructus Gardeniae decocting, for icterohepatitis satisfied promoting the function of the gallbladder to alleviate jaundice curative effect is arranged promptly, in the various disease stage of dissimilar hepatitis, oral Fructus Gardeniae decocting fluid power enough obtains comparatively significantly function for protecting liver and reducing enzyme activity.Fructus Gardeniae extract can significantly reduce serum bilirubin level, ALT and AST is active, to hepatocyte have protective effect (cloudy strong, the Guo Li bow. Chinese medicine modern study and clinical practice II. Beijing: Xueyuan Press, front page .1993,473).In treatment hepatic disease Chinese medicine compound recipe, Fructus Gardeniae is flavour of a drug commonly used.
Rhizoma Curcumae Longae is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae Curcuma longa L., and the traditional Chinese medical science thinks that the Rhizoma Curcumae Longae nature and flavor are hot, bitter, temperature.Return spleen, Liver Channel.The circulation of qi promoting of function removing blood stasis, inducing menstruation to relieve menalgia.Be used for the twinge of the breast side of body, amenorrhea, note of the ancient Chinese abdominal mass etc.Modern pharmacology research shows that Rhizoma Curcumae Longae mainly contains quintessence oil, fatty wet goods volatile oil and curcumin composition.Wherein the Curcuminoids class is a diphenyl alkynes constituents, and phenol property and non-phenolic constituent are arranged.The yellow substance of Rhizoma Curcumae Longae is for having a little tart phenolic substance; It is the amalgam of curcumin, demethoxycurcumin, bisdemethoxycurcumin; Being referred to as curcumin, be the main component of Rhizoma Curcumae Longae performance pharmacological action, and curcumin is wherein most important active component.Research shows, Rhizoma Curcumae Longae has antiinflammatory, antioxidation, protects the liver, to fibrosis, effect such as anticancer.Evidence, Rhizoma Curcumae Longae and curcumin in vivo with external to various poisonous substances such as carbon tetrachloride, flavacin B
1, acetaminophen, ferrum and the inductive hepatic injury of cyclophosphamide all have protective effect, can suppress flavacin B
1The sudden change of inducible strain thyphimurium salmonella TA98 and TA100, suppression ratio surpasses 80%.In addition; Curcumin can significantly reduce the content of cholesterol, TG and free fatty in blood neutral and alkali phosphatase, gamma glutamyltransferase and the tissue that ethanol adds polyunsaturated fatty acid feed animal; Phospholipid in liver and the nephridial tissue is significantly reduced, and the result is consistent with histopathology.Therefore the effect of curcumin with the experimental fatty liver of preventing.It is generally acknowledged hepatoprotective effect realization indirectly of curcumin through anti peroxidation of lipid.In the hepatic injury rat of tetrachloro-methane induction, curcumin can reduce the expression of liver collagen deposition, α-smooth muscle actin positive staining area and type i collagen mRNA; External, curcumin can reduce the synthetic of spider cell DNA, the expression of downward modulation α-smooth muscle actin, type i collagen albumen and α 1 chain mRNA.No matter in vivo still the external curcumin of all pointing out possibly be a kind of fibrosis preparation.People's such as the Liu Yonggang of No.1 Military Medical Univ. result of study proves that curcumin has the significant protection effect to the hepatic injury of 3 kinds of experimental animal models.Curcumin can significantly reduce Serum ALT due to the hepatic injury, AST, and the rising of NO reduces the content of damage hepatic tissue MDA.Another of Liu Yonggang evidence; Curcumin can make HA, LN, the liver Hyp level of rising significantly reduce; And pathological observation prompting Rhizoma Curcumae Longae can obviously suppress the hypertrophy of collagen fiber; Explain that curcumin really can suppress the synthetic and sedimentation of liver collagen fiber, have the effect of anti-hepatic fibrosis, its mechanism is relevant with the generation that suppresses MDA.
The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lacticilore Pall.Main chemical compositions is a Radix Paeoniae Alba total glucosides." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, it is painful to end abdomen, and sealing rushes down, it is painful to receive adverse flow of liver-QI, takes good care of conscience spleen channel blood, relaxes through sending down the abnormal ascending QI, ends irritability pain "." China's book on Chinese herbal medicine " record Radix Paeoniae Alba is used to treat hepatitis, and the Radix Paeoniae Alba has protecting the liver, falls the effect of enzyme, and it is albuminous synthetic to think that at present the Radix Paeoniae Alba can promote.Radix Paeoniae Alba extract raises to hepatic injury due to the D-galactosamine and SGPT has tangible antagonism, SGPT is reduced, and make hepatocellular pathological changes recover normal with downright bad.The ethanol extraction of the Radix Paeoniae Alba can make flavacin B
1The lactic acid dehydrogenase that the rat acute hepatic injury that causes is showed and the gross activity of isozyme raise and are minimized.Radix Paeoniae Alba total glucosides can suppress carbon tetrachloride induced mice Plasma glutamate-pyruvate transaminase and lactic acid dehydrogenase and raise, and to liver organization bite acid denaturation, necrosis has certain antagonism.Research thinks, the hepatic injury due to the carbon tetrachloride is to destroy because of membrane structure generation peroxidation, makes that glutamate pyruvate transaminase and lactic acid dehydrogenase raise in the blood, and Radix Paeoniae Alba total glucosides possibly have protective effect to hepatocyte injury, therefore the transaminase is reduced.Radix Paeoniae Alba total glucosides (60,120,240mg/kg) gastric infusion all can reduce the transaminase level that raises in the blood plasma, and pathologic finding finds that also it can obviously alleviate necrosis of liver tissue scope and degree, reduces cell infiltration.Find that simultaneously Radix Paeoniae Alba total glucosides can reduce the MDA level that raises in the LH, the LH SOD of reduction, GSH-Px enzymatic activity are raise.Explain that Radix Paeoniae Alba total glucosides is to CCl
4Cause the chmice acute chemical liver injury and have protective effect, its mechanism is relevant with the activity etc. of its free radical resisting, raising antioxidant enzyme.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge, has effects such as activating blood and removing stasis, calming heart and tranquilizing mind, pain relieving.Danshensu, TANSHINONES are its main pharmacology compositions.Modern pharmacological research shows that Radix Salviae Miltiorrhizae is natural antioxidant, and Radix Salviae Miltiorrhizae has the effect of removing the toxicity free radical, suppressing normally and damaging the hepatocyte lipid peroxidation.Danshensu, TANSHINONES have protective effect to the rat liver fibrosis of carbon tetrachloride and inductive chmice acute hepatic injury of D-Gal and tetrachloro-methane induction.The evidence of the Li Jing of Nanjing Medical University etc., danshensu can make normal liver cell propagation, ability elimination activity oxygen-derived free radicals, and enhance hepatocyte SOD vigor, the lipid peroxidation of inhibition film alleviates the hepatocellular degeneration necrosis.People's such as the leaf Red Army of Norman Bethune Medical University research shows that Radix Salviae Miltiorrhizae alleviates hepatic necrosis, steatosis, promotion liver cell regeneration, improves liver spleen blood circulation and alleviates its congestion and the ischemic state effect all is superior to ubiquinone
10The research of the Wu Bailing of Hospital Attached to Liaoning Inst. of Traditional Chinese Medicine shows that Radix Salviae Miltiorrhizae can suppress ALT, the AST enzymatic activity increases, and its effect is because Radix Salviae Miltiorrhizae has significant lipoid peroxidization resistant.People's such as the Zheng Xiao guest of Mountain Western Medicine S University research has proved that it possibly be the release that has reduced TNF-α that Radix Salviae Miltiorrhizae is prevented and treated one of approach of experimental hepatic injury, has reduced the toxicity of TNF-α and plays a role.People such as the Liu Yisheng of Hospital Attached to Nanjing Railway Medical College research shows that Radix Salviae Miltiorrhizae is to CCl
4Due to hepatic injury the significant protection effect is arranged.Radix Salviae Miltiorrhizae can obviously reduce Serum ALT, serum and LH MDA and hepatocellular calcium content, also can reduce the decline of serum and hepatic tissue SOD vigor, and the hepatic tissue pathology pathological changes obviously alleviates under light microscopic and the Electronic Speculum; Find that simultaneously Radix Salviae Miltiorrhizae can obviously reduce serum TNF-α; The mechanism of action that shows Radix Salviae Miltiorrhizae is through alleviating the liver plasma membrane lipid peroxidation, keep radical scavenging activity, alleviating calcium overload; Suppress the release of TNF-α simultaneously, quicken its deactivation.
Blue berry (Pericarpium Citri tangerinae) is the mature fruit of ericad Vaccinium uliginosum.The content of anthocyanin is very high in the blue berry, is its most important bioactive ingredients.What the blue berry anthocyanin was common has 15 kinds, is mainly anthocyanidin (cyanidin).Not only the molecule of anthocyanidin is superior in the blue berry extract; And containing special dietary compositions such as abundant organic germanium, organic selenium, arbutin, aminoacid, fruit acid and vitamin, these special dietary materials just have useful especially effect to Human Physiology in free state; If be embedded in the oligomer anthocyanidin molecule, along with the raising of bioavailability, its effect is more obvious.The pectin content of blue berry is also very high, and effectively cholesterol reducing prevents atherosclerosis, promotes cardiovascular health.Its fruit acid, sweet, flat can fill blood, and the liver benefiting is cloudy, relaxing muscles and tendons to promote blood circulation, and the warming the stomach spleen invigorating, relieving restlessness is quenched one's thirst.Contained polyphenols is natural free radical scavenger, has very strong antioxidant activity, can adjust the function of liver cell effectively, resists or reduces their injury of radical pair.Anthocyanidin has strong oxidation resistance, in vivo its antioxidation, to remove the free radical ability be 50 times, ascorbic 20 times of vitamin E.Hepatic injury has prevention and therapeutical effect to the blue berry extract to ethanol, and carbon tetrachloride hepatic injury is also had certain therapeutical effect.The lipid peroxidation that can suppress erythrocyte membrane and low density lipoprotein, LDL.Can also promote the formation of endotheliocyte relaxation factor NO, the damage of pair cell and tissue shields.Cheng Yanjie finds to take the drunk rate that anthocyanidin can obviously reduce animal after deliberation; Improve the tolerance of animal to ethanol; Improve the liver function of the animal of taking ethanol for a long time; Reduce the deposition of lipid peroxide in liver, increase the tolerance of animal, can obviously improve the back headache crowd's that drinks for a long time headache symptom simultaneously pain.
In sum, the Six-element medicine share with different effective substances has very clear and definite control ethanol to think the effect of liver damage from different action target spots and approach, can effectively prevent and treat alcoholic liver injury.Therefore said composition can be used for preparing medicine and the health product with control alcoholic liver injury.
Summary of the invention
The present invention provides a kind of clearing away heat and nourishing YIN that has, and the effect of disperse blood stasis and dredge collateral is used to treat the alcoholic liver injury pharmaceutical composition.
The inventor rest on a scientific basis theory, through repetition test; Selected six kinds of Ministry of Public Health regulations such as Herba Centellae, Fructus Gardeniae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, blue berry for use be food be again medicine and the raw material that can be used for health food, so should form as safe as a house, without any side effects by prescription.The health food that has the control alcoholic liver injury in order to preparation the present invention.When each raw material of choosing health food of the present invention carries out combination collocation, consider effect that they can be brought into play separately and the trade-off effect that they are arranged in pairs or groups and can produce.This compositions (is added the product of types such as analeptic, analgesic, vitamin and mineral with American-European, Japanese Medicament for Alcoholism salable; The symptom of can only respite being still drank after a night and causing, but do not have definite curative effect) has tangible difference for the hepatic injury that ethanol causes; Compare with present existing liver-protecting and alcoholism-relieving class health food simultaneously, it is more definite to have activity, and chemical composition has tangible characteristic, and this is outstanding contributions of the present invention.
The present invention seeks to; Based on modern pathology molecular mechanism and the bonded principle of Traditional Chinese medical theory; Have significant curative effect through a large amount of present compositions of discovering for the treatment of alcoholic liver injury, can be used for being prepared into the medicine or the health product of control alcoholic liver injury.This modern composition of natural products has wherein contained a large amount of anti-hepatic fibrosis, repairs and damages tissue; Increase bile secretion, transaminase lowering, it is active to reduce serum bilirubin level, ALT and AST; Reduce the content of cholesterol, TG and free fatty in alkali phosphatase, gamma glutamyltransferase and the tissue, reduce the liver collagen deposition, reduce hepatic necrosis, steatosis; Promote liver cell regeneration, eliminate chemical constituent compositions such as oxygen-derived free radicals.These chemical constituents are collaborative each other, many target spots, multipath effect, and hepatic injury people's body is fundamentally regulated in the combination of six medicines comprehensively, improves physical condition.The present invention is applicable to the more person that causes the alcoholic liver injury that drinks; Through reducing the concentration of ethanol in blood, promote alcoholic acid removing, eliminate the interior excessive free radicals that produces of body after drinking; Hinder the formation of lipid peroxide; Thereby alleviated the damage of ethanol, played assistant protection function, and the effect of beauty and skin care has been arranged hepatic injury to hepatic tissue.Have tangible novelty and technological progress.
It is monarch drug that the present invention selects the Herba Centellae of conventional Chinese medicine among the people for use, and Herba Centellae is used to treat jaundice due to damp-heat, hepatomegaly early than on the books in ancient book " south of the Five Ridges herbal ", " Jiangxi traditional herbal medicine ", " Guangdong Chinese medicine " II.Modern study shows that asiaticoside and asiatic acid have anti-hepatic fibrosis, repair pharmacologically actives such as damaging tissue, antiinflammatory.The present invention is that the purposes according to Herba Centellae in the ancient prescription combines with modern composition chemofacies; Through evidence; Activity with tangible anti-liver injury is taken into account theory of Chinese medical science simultaneously, with Fructus Gardeniae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, blue berry prescription; With the difference and significantly technological progress that the medicine that is used to treat alcoholic liver injury in the market has essence, also be the innovative point that has of the present invention.
The invention provides can improve, headache dizzy after drinking, feel sick with treatment, the pharmaceutical composition of vomiting, gastric malaise symptoms and alcoholic liver injury, fatty liver.Said composition has clearing away heat and nourishing YIN, disperse blood stasis and dredge collateral, detoxifcation, and the liver stomach is also controlled, and row is held back mutually and is held concurrently, and brings into play the health-care efficacy of relieving alcoholism and protecting the liver jointly from too many levels.Meet the research of composition chemistry, also meet theory of Chinese medical science, " interior warp " cloud simultaneously: " liver is bitter anxious, anxious food sweet flavor has the effect of relaxing.The liver desire is loose, and anxious food is hot loosing it, with sweet benefit it, acid is rushed down it ".The important relationship of its angle from theory of Chinese medical science has been pointed out hot, sweet, sour three flavors and hepatopathy.Herba Centellae, bitter, hot, cold, return the liver,spleen,kidney warp, have clearing away heat-damp and promoting diuresis, the effect of removing toxic substances and promoting subsidence of swelling is used for jaundice due to damp-heat.Fructus Gardeniae, bitter in the mouth cold in nature, GUIXIN, lung, tri-jiao channel have the pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body, it is vexed to be used for calentura, the jaundice dark coloured urine.Rhizoma Curcumae Longae regulating the liver and spleen, removing blood stasis circulation of qi promoting, stomach-invigorating and gall bladder-invigorating.The Radix Paeoniae Alba, property is bitter, acid, be slightly cold, and mainly returns through, spleen channel suppressing liver-YANG, the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain.Radix Salviae Miltiorrhizae, blood circulation promoting and blood stasis dispelling, heat clearing and tranquillizing.Blue berry, sour, sweet, flat, the diuresis detoxifcation.All medicines share, and play Dealcoholic sobering-up altogether, liver is held up in nourishing the liver, has clearing away heat and nourishing YIN, the effect of disperse blood stasis and dredge collateral.
Technical problem to be solved by this invention is from natural plants Herba Centellae, Fructus Gardeniae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, blue berry, to extract active component, the preparation composition of natural products with the effect of control alcoholic liver injury.
The invention provides the compositions that a kind of Chinese medicine with control alcoholic liver injury is processed, said composition comprises Herba Centellae 100-500 part, Fructus Gardeniae 100-500 part, Rhizoma Curcumae Longae 50-250 part, Radix Paeoniae Alba 50-250 part, Radix Salviae Miltiorrhizae 50-250 part, blue berry 50-250 part.250 parts of preferred Herba Centellaes, 150 parts of Fructus Gardeniaes, 100 parts in Rhizoma Curcumae Longae, 100 parts of the Radix Paeoniae Albas, 80 parts of Radix Salviae Miltiorrhizaes, 80 parts of blue berries; Also can form by above Six-element medicament extract; Herba Centellae extract 25-150 part, Fructus Gardeniae extract 25-150 part, Rhizoma Curcumae Longae extract 10-50 part, Radix Paeoniae Alba extract 10-50 part, Radix Salviae Miltiorrhizae extract 10-50 part, blue berry extract 10-50 part, 50 parts of preferred Herba Centellae extracts, 30 parts of Fructus Gardeniae extracts, 20 parts of Rhizoma Curcumae Longae extracts, 20 parts of Radix Paeoniae Alba extracts, 20 parts of Radix Salviae Miltiorrhizae extracts, 15 parts of blue berry extracts.Process according to aforementioned proportion mixing composition active ingredient and pharmaceutic adjuvant.
Another object of the present invention has provided this preparation of compositions method:
(1) blue berry powder is broken into coarse powder;
(2) alcoholic solution of medicinal 8-15 times 40%-95% in Fructus Gardeniae, Rhizoma Curcumae Longae, Radix Salviae Miltiorrhizae, blue berry coarse powder four flavors extracts 2-3 time, and each 1-3 hour, filter, filtrate recycling ethanol concentrates, and drying is pulverized, and promptly gets ethanol extraction;
(3) medicinal 8-20 times deionized water in Herba Centellae, the Radix Paeoniae Alba two flavors extracts 2-4 time, and each 1-3 hour, to filter, filtrating concentrates, and drying is pulverized, and promptly gets water extract;
(4) with after ethanol extraction, the water extract mixing, be mixed together with pharmaceutic adjuvant again, process oral formulations by conventional method.
Because the present invention discloses the effect that the compositions of being made up of Herba Centellae, Fructus Gardeniae, Rhizoma Curcumae Longae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, blue berry has the control alcoholic liver injury first; Therefore; This compositions cooperated separately or with other active constituent or adjuvant process medicament; So long as this medicament is used for prevention and treatment alcoholic liver injury, all belong to protection scope of the present invention.Compositions of the present invention all has the effect of prevention and treatment alcoholic liver injury when processing any dosage form.
The compositions of being made up of Herba Centellae, Fructus Gardeniae, Rhizoma Curcumae Longae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, blue berry (abbreviation compositions) has the effect of control alcoholic liver injury, is confirmed through following pharmacodynamic experiment.
1, the present composition is to the protective effect of alcoholic liver injury
60 of mices are divided into 6 groups at random, i.e. basic, normal, high three dose groups of the present composition, ethanol model group, blank group and positive controls.Present composition group respectively by 200,400 and 800mg/kg irritate the stomach mice, positive controls (bifendate drop pill) 60mg/kg, 1 time/d, 14d altogether, ethanol model group and blank control group matched group are irritated stomach equal-volume distilled water respectively, 1 time/d, common 14d.Fasting is 12 hours after the last administration, except that the blank group is still irritated stomach equivalent distilled water, and other 5 treated animals (basic, normal, high three dose groups of the present composition; Positive drug control group, the ethanol model group) irritate stomach 50% ethanol 15mL/kg respectively, vena ophthalmica is got blood behind the 6h; Measure alanine aminotransferase (ALT) and aspartate amino transferase (AST) content in the serum; Get mouse liver and weigh, measure liver device index, get (SOD) that lobus dexter is measured superoxide dismutase; Glutathione peroxidase (GSH-PX) activity, malonaldehyde (MDA) content.
Table 1 present composition is to the influence (
) of alcohol damaged mice serum ALT, AST and liver coefficient
Compare with the blank group: * P 0.05, * * P 0.01, * * * P < 0.001; The ethanol group is Δ p＜0.05 relatively, Δ Δ p＜0.01.
Can know from table 1, irritate stomach ethanol the Mouse Liver index is significantly increased, irritate the stomach present composition alcohol damaged mouse liver index is significantly reduced.Irritate stomach ethanol mice serum ALT, AST are significantly increased, irritate the stomach present composition alcohol damaged mice serum ALT, AST are significantly reduced.Positive control drug can make mice serum ALT, AST significantly reduce, and also can significantly reduce the mouse liver index.
Table 2 present composition is to the influence (
) of alcohol damaged mouse liver MDA, GSH-PX, SOD
Compare with the blank group: * P 0.05, * * P 0.01, * * * P < 0.001; The ethanol group is Δ p＜0.05 relatively, Δ Δ p＜0.01.
The result shows from table 2, and ethanol can cause that mouse liver MDA content significantly raises, causes GSH-PX enzyme, the active significantly reduction of SOD, and the present composition can significantly reduce MDA content, the GSH-PX enzyme that can significantly raise, SOD activity.Positive control drug also can significantly reduce MDA content, significantly raise GSH-PX enzyme, SOD is active, and dosage is suitable in active and the present composition.
2, the present composition fatty liver that ethanol is caused improves function
120 of test rats are divided into the normal control group at random; The fatty liver model group; Positive control drug DONGBAO GANTAI 600mg/kg dosage group: the present composition is established 200mg/kg, 40mg/kg and three dosage groups of 800mg/kg.Totally 6 groups, 20 every group.Except that the normal control group, all the other are respectively organized rat 8:30 in morning every day filling stomach and give (56% ethanol+0.5mL fish oil) 1 time, and ethanol dosage begins to be 7g/kg, increases progressively 0.2g/kg subsequently weekly, continuous 4 weeks.Rats in normal control group is irritated stomach and is given isocaloric 56% glucose+0.5mL fish oil.Receive the reagent thing to be mixed with suspension with distilled water, 1:00 filling in afternoon every day stomach gives 1 time, and normal control group and model control group rat oral gavage give the distilled water of equivalent, irritate the long-pending 10ml/kg/d of being of body of stomach.The rat drinking-water of freely ingesting is weighed in weekly 1 time in the process of the test, with the adjustment dosage.The dead animal in end around administration the.Collection of specimens and observation index; Result of the test is added and subtracted standard deviation (
) expression with mean, t check between statistical procedures method employing group.Experimental result is seen table 3 and table 4.
Table 3 present composition is to alcoholic fatty liver rat blood serum ALT, AST and the active influence of LDH (
)
Compare with the normal control group: * P 0.05, * * P 0.01, * * * P < 0.001; Model group is Δ p＜0.05 relatively, Δ Δ p＜0.01, Δ Δ Δ p＜0.001.
Present composition height, middle dose groups animal serum ALT and AST activity very significantly are lower than model group; This result of the test shows; The present composition can obviously reduce the unusual ALT that raises, the activity of AST in the alcoholic fatty liver rat blood serum, explains that the present composition has good protective action to hepatocyte.The present composition is high, middle dose groups has tangible reduction effect to the unusual rising of alcoholic fatty liver animal serum LDH level, and this result of the test shows, the present composition has good protective effect to fatty liver due to the ethanol.
Table 4 present composition is to the influence (
) of alcoholic fatty liver Serum TC, TG and MDA content and hepatic tissue TG content
Compare with the normal control group: * P 0.05, * * P 0.01, * * * P < 0.001; Model group is Δ p＜0.05 relatively, Δ Δ p＜0.01.
The present composition can reduce fatty liver animal pattern Content of MDA, hepatocellular lipid peroxidation when suppressing fatty liver, thereby the effect that performance protection hepatocyte avoids damaging.The present composition is high, in two dose groups animal serums TC, TG content and hepatic tissue TG content significantly be lower than model control group.Show that the present composition can reduce the rising of fatty liver rat fat content and liver lipid content due to the ethanol, has the effect that liver fat is piled up that suppresses.
Can know that from above pharmacodynamic experiment the present composition has prevention and treats the effect of alcoholic liver injury, alcoholic fatty liver, and takes for a long time and be free from side effects.
The present invention carries out detailed explanation through following embodiment, but does not mean that the present invention only limits to this, and specific embodiments is following:
Embodiment 1,(tablet)
(1) with blue berry 160g, is ground into coarse powder;
(2) medicinal 10 times 70% alcoholic solution in Fructus Gardeniae 300g, Rhizoma Curcumae Longae 200g, Radix Salviae Miltiorrhizae 160g, blue berry coarse powder four flavors extracts 3 times, and each 2 hours, filter, filtrate recycling ethanol concentrates, and drying is pulverized, and promptly gets ethanol extraction;
(3) medicinal 12 times of deionized waters in Herba Centellae 500g, Radix Paeoniae Alba 200g two flavors extract 2 times, and each 2 hours, to filter, filtrating concentrates, and drying is pulverized, and promptly gets water extract;
(4) with after ethanol extraction, the water extract mixing, add appropriate amount of starch, mixing is granulated, drying, and granulate, tabletting is processed 1000, promptly gets.Each 2, every day 3 times.
Embodiment 2, (capsule)
(1) with blue berry 160g, is ground into coarse powder;
(2) medicinal 10 times 70% alcoholic solution in Fructus Gardeniae 300g, Rhizoma Curcumae Longae 200g, Radix Salviae Miltiorrhizae 160g, blue berry coarse powder four flavors extracts 3 times, and each 2 hours, filter, filtrate recycling ethanol concentrates, and drying is pulverized, and promptly gets ethanol extraction;
(3) medicinal 12 times of deionized waters in Herba Centellae 500g, Radix Paeoniae Alba 200g two flavors extract 2 times, and each 2 hours, to filter, filtrating concentrates, and drying is pulverized, and promptly gets water extract;
(4) with after ethanol extraction, the water extract mixing, add appropriate amount of starch, mixing is granulated, drying, and granulate, encapsulated, process 1000, promptly get.Each 2, every day 3 times.
Claims (8)
1. the Chinese medicine composition with clearing away heat and nourishing YIN, disperse blood stasis and dredge collateral effect is characterized in that: formed by Herba Centellae, Fructus Gardeniae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, blue berry prescription.
2. Chinese medicine composition according to claim 1 is characterized in that, it is to be processed by the raw material of following weight parts:
Herba Centellae 100-500 part Fructus Gardeniae 100-500 part
Rhizoma Curcumae Longae 50-250 part Radix Paeoniae Alba 50-250 part
Radix Salviae Miltiorrhizae 50-250 part blue berry 50-250 part.
3. Chinese medicine composition according to claim 1 is characterized in that, it is to be processed by the raw material of following weight parts:
150 parts of 250 portions of Fructus Gardeniaes of Herba Centellae
100 parts of 100 portions of Radix Paeoniae Albas of Rhizoma Curcumae Longae
80 parts of 80 parts of blue berries of Radix Salviae Miltiorrhizae.
4. Chinese medicine composition according to claim 1 is characterized in that every kind of raw material all can be replaced by its extract, and the composition weight ratio of extract is:
Herba Centellae extract 25-150 part Fructus Gardeniae extract 25-150 part
Rhizoma Curcumae Longae extract 10-50 part Radix Paeoniae Alba extract 10-50 part
Radix Salviae Miltiorrhizae extract 10-50 part blue berry extract 10-50 part.
5. pharmaceutical composition according to claim 1 is characterized in that every kind of raw material all can be replaced by its extract, and the composition weight ratio of extract is:
30 parts of 50 parts of Fructus Gardeniae extracts of Herba Centellae extract
20 parts of 20 parts of Radix Paeoniae Alba extracts of Rhizoma Curcumae Longae extract
15 parts of 20 parts of blue berry extracts of Radix Salviae Miltiorrhizae extract.
6. Chinese medicine composition according to claim 1 is characterized in that: the method for preparing of said Chinese medicine composition may further comprise the steps:
(1) blue berry powder is broken into coarse powder;
(2) alcoholic solution of medicinal 8-15 times 40%-95% in Fructus Gardeniae, Rhizoma Curcumae Longae, Radix Salviae Miltiorrhizae, blue berry coarse powder four flavors extracts 2-3 time, and each 1-3 hour, filter, filtrate recycling ethanol concentrates, and drying is pulverized, and promptly gets ethanol extraction;
(3) medicinal 8-20 times deionized water in Herba Centellae, the Radix Paeoniae Alba two flavors extracts 2-4 time, and each 1-3 hour, to filter, filtrating concentrates, and drying is pulverized, and promptly gets water extract;
(4) with after ethanol extraction, the water extract mixing, be mixed together with pharmaceutic adjuvant again, process oral formulations by conventional method.
7. according to the said Chinese medicine composition of claim 1, it is characterized in that: it is in hard capsule, soft capsule, tablet, granule, powder, pill, teabag, the medicated wine one or more.
8. Chinese medicine composition according to claim 1 has the health product of alcoholic liver injury auxiliary protection function and the application in the medicine in preparation.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083573A (en) * | 2013-01-20 | 2013-05-08 | 崔英坤 | Traditional Chinese medicine used for treating alcoholic fatty liver |
| CN103932173A (en) * | 2014-03-25 | 2014-07-23 | 姜利 | Composition for dispelling alcohol effect and protecting liver |
| CN104189303A (en) * | 2014-08-29 | 2014-12-10 | 济南科纳信息科技有限公司 | Hangover alleviating traditional Chinese medicine composition |
| CN107056874A (en) * | 2016-12-28 | 2017-08-18 | 福建广生堂药业股份有限公司 | A kind of compound of asiatic acid tenofovir dipivoxil and preparation method thereof |
| CN113304173A (en) * | 2021-05-11 | 2021-08-27 | 奥启(深圳)创投科技有限公司 | Stem cell preparation for improving liver dysfunction |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559463A (en) * | 2004-02-18 | 2005-01-05 | 刚 刘 | Medicine for treating viral hepatitis B |
| CN101143202A (en) * | 2006-09-11 | 2008-03-19 | 上海汇伦生命科技有限公司 | Compound oral administration preparation with protective function to chemical liver injury |
| CN101284064A (en) * | 2008-05-27 | 2008-10-15 | 李亚东 | Preparation method of kudzuvine root and indigowoad root tablets for reducing fat and alleviating hangover |
-
2012
- 2012-09-03 CN CN2012103197934A patent/CN102784366B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559463A (en) * | 2004-02-18 | 2005-01-05 | 刚 刘 | Medicine for treating viral hepatitis B |
| CN101143202A (en) * | 2006-09-11 | 2008-03-19 | 上海汇伦生命科技有限公司 | Compound oral administration preparation with protective function to chemical liver injury |
| CN101284064A (en) * | 2008-05-27 | 2008-10-15 | 李亚东 | Preparation method of kudzuvine root and indigowoad root tablets for reducing fat and alleviating hangover |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083573A (en) * | 2013-01-20 | 2013-05-08 | 崔英坤 | Traditional Chinese medicine used for treating alcoholic fatty liver |
| CN103083573B (en) * | 2013-01-20 | 2014-04-02 | 李孝芹 | Traditional Chinese medicine used for treating alcoholic fatty liver |
| CN103932173A (en) * | 2014-03-25 | 2014-07-23 | 姜利 | Composition for dispelling alcohol effect and protecting liver |
| CN103932173B (en) * | 2014-03-25 | 2016-01-13 | 张海燕 | A kind of composition of relieving alcoholism and protecting liver |
| CN104189303A (en) * | 2014-08-29 | 2014-12-10 | 济南科纳信息科技有限公司 | Hangover alleviating traditional Chinese medicine composition |
| CN107056874A (en) * | 2016-12-28 | 2017-08-18 | 福建广生堂药业股份有限公司 | A kind of compound of asiatic acid tenofovir dipivoxil and preparation method thereof |
| CN113304173A (en) * | 2021-05-11 | 2021-08-27 | 奥启(深圳)创投科技有限公司 | Stem cell preparation for improving liver dysfunction |
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| CN102784366B (en) | 2013-07-31 |
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