CN102784100B - Medical biocolloid solution for sterilization and preparation method thereof - Google Patents
Medical biocolloid solution for sterilization and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medical biocolloid solution for sterilization and a preparation method thereof and makes real evaluations on the defects existing in the prior art such as CN1090905C, CN1134213C, CN1262101A and CN1110557A. The product comprises the following components: 0.20-0.50g of bivalent silver ions, 0.10-0.50g of potassium alginate or sodium alginate or medical gelatin, 0.50-1.0g of phosphoric acid or citric acid, 17.0-19.0g of 30% hydrogen peroxide solution, 0.40-0.80g of tartaric acid and the balance of purified water or water for injection, wherein the total weight of all the components is 1000g. The medical biocolloid solution is used for controlling the infection of wounds on the surface of a human body, promoting the occlusion of wounds and reducing the formation of scars.
Description
technical field:
The present invention relates to a kind of medical biocolloid solution for sterilization and preparation method thereof.
background technology:
The authorized company notification number CN100560057C proposed by applicant and name are called in the description page 1 of Wound-protection liquid and preparation method thereof to the describing of page 2 the 1st row, to the traumatic infection medication such as caused by the situation of burn and open wound surface and so on of generally acknowledging both at home and abroad---semi-annular jade pendant amic metadiazine silver frost (also known as ointment) or 3 shortcomings existing for outstanding agent have done objective appraisal.And to prior art such as CN1090905C(powerful disinfectant), the preparation method of CN1134213C(bactericide containing silver), CN1262101A(silver ion disinfectant and preparation method thereof) and CN1110557A(silver nitrate ointment) etc. the defect that exists also done evaluation strictly according to the facts.
Although the technical scheme of the aforesaid CN100560057C namely proposed by applicant has 4 technique effects that Instructions Page 3 the 12 to 17 row is concluded, but owing to monovalence silver ion not being changed into bivalence silver ion in formula, and the bactericidal effect of bivalence silver ion is monovalence silver ion 50 ~ 200 times.
In view of above-mentioned prior art, the applicant has made actively good try, and have found the way overcoming foregoing problems, technical scheme described below produces under this background.
summary of the invention:
The object of this invention is to provide one to contribute to guaranteeing safety, being conducive to guaranteeing stability and being of value to the embodiment feature of environmental protection, and there is excellent permeability and sterilizing function and can promote wound healing and improve healing effect efficiently, reduce cicatrization, and can not untoward reaction be produced to patient and nonirritant, free from extraneous odour and the medical biocolloid solution for sterilization and preparation method thereof without sensitization.
Above-mentioned object is realized by following technical scheme:
A kind of medical biocolloid solution for sterilization, its composition comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection, the weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20-0.50g, described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10-0.50g, described phosphoric acid or the described citric acid weight in the final mean annual increment solution of 1000g weight is 0.50-1.0g, the weight of 30% described hydrogenperoxide steam generator in the final mean annual increment solution of 1000g weight is 17.0-19.0 g, the weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40-0.80g, described purified water or the described water for injection weight in the final mean annual increment solution of 1000g weight is the surplus that 1000g removes above-mentioned various substance weight.
Described medical biocolloid solution for sterilization, described potassium alginate or sodium alginate add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and be the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent of processing and refining.
Described medical biocolloid solution for sterilization, described tartaric acid is the tartaric acid of SILVER REAGENT.
A preparation method for medical biocolloid solution for sterilization, this method has seven steps, and silver nitrate adds in purified water or water for injection and stirs by the first step, obtains monovalence silver ion solution;
Phosphoric acid or citric acid join in monovalence silver ion solution and carry out acidification by second step, obtain the monovalence silver ion mixed liquor after acidification;
Tartaric acid joins in purified water or water for injection and stirs by the 3rd step, obtains tartaric acid solution;
Tartaric acid solution joins in the mixed liquor of the monovalence silver ion after acidification and stirs by the 4th step, obtains stand-by liquid;
Potassium alginate or sodium alginate or medical gelatin are added heating for dissolving in purified water or water for injection and stir by the 5th step, obtain the colloid solution of potassium alginate or sodium alginate or medical gelatin;
The colloid solution of potassium alginate or sodium alginate or medical gelatin joins in stand-by liquid by the 6th step, stirs, and passes into ozone O
35 ~ 10 minutes, monovalence silver ion is oxidized to bivalence silver ion, obtains bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
Bivalence silver ion colloid mixed liquor joins in the container filling purified water or water for injection and stirs by the 7th step, then add 30% hydrogenperoxide steam generator to continue to stir, and adjust ph, add purified water or water for injection to 1000g, stir, leave standstill 12 hours, filter, fill, obtain finished product sterilization biocolloid solution.
The preparation method of described medical biocolloid solution for sterilization, the processing time of the acidification in described second step is 15 ~ 40min, and pH value is 1.5 ~ 2.
The preparation method of described medical biocolloid solution for sterilization, the heating-up temperature in the 5th described step is 50 ~ 60 DEG C, and mixing time is 5 ~ 10min.
The preparation method of described medical biocolloid solution for sterilization, the mixing time in the 7th described step is 5-10min, and adjust ph is 3 ~ 4; Be filtered into 100 mesh filter screens to filter.
Beneficial effect:
1. step of the present invention is terse, preparation condition is not harsh and can realize industrialized great production and can ensure comprehensive embodiment of technique effect of sterilization biocolloid solution.
2. monovalence silver ion is changed into bivalence silver ion by the present invention, and the bactericidal effect of bivalence silver ion is monovalence silver ion 50 ~ 200 times.
3. the present invention can penetrate into wound surface deep tissues, the antibacterial at deep layer position and endotoxin is killed, and slough, pus block, clot are loosened to dissolve and excreted, and helps lend some impetus to wound healing, reduces the formation of cicatrix.
4. the present invention uses for a long time, can not form obvious medicine film and develop immunity to drugs, effectively can shorten treatment cycle.
5. the present invention to patient without any side effects and product free from extraneous odour, without sensitization; Method processing step is few, and condition is not harsh, can adapt to mass production requirement.
6. the ozonator that the present invention is used is per hour can produce 80g ozone.
detailed description of the invention:
Embodiment 1:
A kind of medical biocolloid solution for sterilization, its composition comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection, the weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20-0.50g, described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10-0.50g, described phosphoric acid or the described citric acid weight in the final mean annual increment solution of 1000g weight is 0.50-1.0g, the weight of 30% described hydrogenperoxide steam generator in the final mean annual increment solution of 1000g volume is 17.0-19.0g, the weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40-0.80g, described purified water or the described water for injection weight in the final mean annual increment solution of 1000g weight is the surplus that 1000g removes above-mentioned various substance weight.
Described medical biocolloid solution for sterilization, described potassium alginate or sodium alginate add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and be the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent of processing and refining.
Described medical biocolloid solution for sterilization, described tartaric acid is the tartaric acid of SILVER REAGENT.
Embodiment 2:
Medical biocolloid solution for sterilization described in embodiment 1, its composition comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection, the weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20 or 0.30 or 0.40 or 0.50g, described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10 or 0.20 or 0.30 or 0.40 or 0.50g, described phosphoric acid or the described citric acid weight in the final mean annual increment solution of 1000g weight is 0.50 or 0.60 or 0.70 or 0.80 or 0.90 or 1.0g, the weight of 30% described hydrogenperoxide steam generator in the final mean annual increment solution of 1000g weight is 17.0 or 18.0 or 19.0g, the weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40 or 0.50 or 0.60 or 0.70 or 0.80g, described purified water or the described water for injection weight in the final mean annual increment solution of 1000g weight is the surplus that 1000g removes above-mentioned various substance weight.
Described medical biocolloid solution for sterilization, described potassium alginate or sodium alginate add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and be the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent of processing and refining.
Described medical biocolloid solution for sterilization, described tartaric acid is the tartaric acid of SILVER REAGENT.
Embodiment 3:
A preparation method for medical biocolloid solution for sterilization, this method has seven steps, and silver nitrate adds in purified water or water for injection and stirs by the first step, obtains monovalence silver ion solution;
Phosphoric acid or citric acid join in monovalence silver ion solution and carry out acidification by second step, obtain the monovalence silver ion mixed liquor after acidification;
Tartaric acid joins in purified water or water for injection and stirs by the 3rd step, obtains tartaric acid solution;
Tartaric acid solution joins in the mixed liquor of the monovalence silver ion after acidification and stirs by the 4th step, obtains stand-by liquid;
Potassium alginate or sodium alginate or medical gelatin are added heating for dissolving in purified water or water for injection and stir by the 5th step, obtain the colloid solution of potassium alginate or sodium alginate or medical gelatin;
The colloid solution of potassium alginate or sodium alginate or medical gelatin joins in stand-by liquid by the 6th step, stirs, and passes into ozone O
35 ~ 10 minutes, monovalence silver ion is oxidized to bivalence silver ion, obtains bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
Bivalence silver ion colloid mixed liquor joins in the container filling purified water or water for injection and stirs by the 7th step, then add 30% hydrogenperoxide steam generator to continue to stir, and adjust ph, add purified water or water for injection to 1000g, stir, leave standstill 12 hours, filter, fill, obtain finished product sterilization biocolloid solution.
The preparation method of described medical biocolloid solution for sterilization, the processing time of the acidification in described second step is 15 ~ 40min, and pH value is 1.5 ~ 2.
The preparation method of described medical biocolloid solution for sterilization, the heating-up temperature in the 5th described step is 50 ~ 60 DEG C, and mixing time is 5 ~ 10min.
The preparation method of described medical biocolloid solution for sterilization, the mixing time in the 7th described step is 5 ~ 10min, and adjust ph is 3 ~ 4; Be filtered into 100 mesh filter screens to filter.
Embodiment 4:
The preparation method of the medical biocolloid solution for sterilization described in embodiment 3, this method has seven
Step, silver nitrate adds in purified water or water for injection and stirs by the first step, obtains monovalence silver ion solution;
Phosphoric acid or citric acid join in monovalence silver ion solution and carry out acidification by second step, obtain the monovalence silver ion mixed liquor after acidification;
Tartaric acid joins in purified water or water for injection and stirs by the 3rd step, obtains tartaric acid solution;
Tartaric acid solution joins in the mixed liquor of the monovalence silver ion after acidification and stirs by the 4th step, obtains stand-by liquid;
Potassium alginate or sodium alginate or medical gelatin are added heating for dissolving in purified water or water for injection and stir by the 5th step, obtain the colloid solution of potassium alginate or sodium alginate or medical gelatin;
The colloid solution of potassium alginate or sodium alginate or medical gelatin joins in stand-by liquid by the 6th step, stirs, and passes into ozone O
35 or 6 or 7 or 8 or 9 or 10 minutes, monovalence silver ion is oxidized to bivalence silver ion, obtains bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
Bivalence silver ion colloid mixed liquor joins in the container filling purified water or water for injection and stirs by the 7th step, then add 30% hydrogenperoxide steam generator to continue to stir, and adjust ph, add purified water or water for injection to 1000g, stir, leave standstill 12 hours, filter, fill, obtain finished product sterilization biocolloid solution.
The preparation method of described medical biocolloid solution for sterilization, processing time of the acidification in the 3rd described step is 15 or 20 or 25 or 30 or 35 or 40min, and pH value is 1.5 ~ 2.
The preparation method of described medical biocolloid solution for sterilization, the heating-up temperature in the 5th described step is 50 or 55 or 60 DEG C, and mixing time is 5 or 6 or 7 or 8 or 9 or 10min.
The preparation method of described medical biocolloid solution for sterilization, the mixing time in the 7th described step is 5 or 6 or 7 or 8 or 9 or 10min, and adjust ph is 3 ~ 4; Be filtered into 100 mesh filter screens to filter.
Embodiment 5:
Medical bio colloid solution described in above-described embodiment, comprises in the final mean annual increment solution of every 1000g weight: bivalence silver ion 0.20-0.50g, potassium alginate (or sodium alginate or medical gelatin) 0.10-0.50g, phosphoric acid or citric acid 0.50-1.0g, 30% hydrogenperoxide steam generator 17.0-19.0g, tartaric acid 0.40-0.80 g, remaining be purified water (or water for injection).
In a specific embodiment of the present invention, described purified water (or water for injection) should meet pharmacopoeial requirements.
In another specific embodiment of the present invention, described potassium alginate (or sodium alginate) for belong to Brown algae plant category Thallus Laminariae (Thallus Eckloniae) in add alkaline extraction and be the polysaccharide carbohydrate of potassium alginate (or sodium alginate) through the main constituent of processing and refining.
In another specific embodiment of the present invention, described tartaric acid is the tartaric acid of SILVER REAGENT.
Embodiment 6:
The preparation method of the medical biocolloid solution for sterilization described in above-described embodiment, this method comprises the following steps:
Silver nitrate adds in purified water (or water for injection) and stirs by the first step, obtains monovalence silver ion solution;
Phosphoric acid (or citric acid) joins in monovalence silver ion solution and carries out acidification and adjust ph by second step, obtains the monovalence silver ion mixed liquor after acidification;
Tartaric acid joins in purified water (or water for injection) and stirs by the 3rd step, obtains tartaric acid solution;
Tartaric acid solution joins in the mixed liquor of the monovalence silver ion after acidification and stirs evenly by the 4th step, obtains stand-by liquid;
Potassium alginate (or sodium alginate or medical gelatin) is added heating for dissolving in purified water (or water for injection) and stirs by the 5th step, obtains potassium alginate (or sodium alginate or medical gelatin) colloid solution;
Potassium alginate (or sodium alginate or medical gelatin) colloid solution joins in stand-by liquid, stirs by the 6th step, passes into ozone (O
3) 5 ~ 10 minutes, monovalence silver ion is oxidized to bivalence silver ion, obtains bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
Bivalence silver ion colloid mixed liquor joins in the container filling purified water (or water for injection) and stirs by the 7th step, then add 30% hydrogenperoxide steam generator to continue to stir, and adjust ph, add purified water (or water for injection) to 1000g, stir, leave standstill 12 hours, filter and fill, obtain finished product medical biocolloid solution for sterilization.
Also have in a specific embodiment of the present invention, the processing time of the acidification described in step second step is 15 ~ 40min, and described pH value is 1.5 ~ 2.
In a specific embodiment of the present invention, the mixing time described in step the three step is 15 ~ 40min.
More of the present invention and in a specific embodiment, the heating-up temperature described in step the five step is 50 ~ 60 DEG C, mixing time is 5 ~ 10min.
In an of the present invention and then specific embodiment, the mixing time described in step the seven step is 5 ~ 10min, and described adjust ph is 3 ~ 4; Described 100 mesh filter screens that are filtered into filter.
Embodiment 7:
The preparation method of the medical bio colloid solution described in above-described embodiment, this method comprises the following steps:
A) by by commercially available acquisition such as produced by Zhi Yuan Ke Jia Technology Co., Ltd. of Shenzhen of Chinese Guangdong province and the Reagent grade nitric acid sold silver 0.40g to join the deionized water for stirring of 10g even, container used is vinyon container or rustless steel container, until silver nitrate is able to abundant dissolving, thus obtain monovalence silver ion solution;
B) phosphoric acid of 0.80g SILVER REAGENT is joined by A) carry out acidification in the silver ion solution that obtains of step, the time of acidification is 30min, obtains the monovalence silver ion mixed solution after acidification;
C) by by commercially available acquisition such as produced by Chinese Shanghai reagent one factory and the tartaric acid 0.70g of the SILVER REAGENT of selling joins 10g deionized water for stirring 20 minutes, obtain tartaric acid solution;
D) by step C) tartaric acid solution that obtains joins by step B) stir in the monovalence silver ion solution mixed liquor after acidification that obtains, obtain stand-by liquid;
E) the medical grade sodium alginate 0.4g such as produced by the woods biotechnology development corporation, Ltd. in sea, Shandong Province of China province Qingdao by commercially available acquisition is joined in 10g deionized water, heating for dissolving at 60 DEG C of temperature and stir 5 minutes, obtains sodium alginate colloid solution;
F) sodium alginate colloid solution is joined in stand-by liquid, stir 5 minutes, pass into ozone (O
3) 8 minutes, monovalence silver ion is oxidized to bivalence silver ion, obtains bivalence silver ion colloid mixed liquor;
G) bivalence silver ion colloid mixed liquor is joined in the container of the deionized water filling 900g and stir 10 minutes, then add 30% hydrogenperoxide steam generator 18.0g and continue stirring 10 minutes, and adjust ph 3.4, add deionized water to 1000g, stir 20 minutes, leave standstill 12 hours, filter and fill, obtain finished product sterilization biocolloid solution.
Mixing speed involved by above steps is all as the criterion with 60-100n/min.
1. by above-mentioned example operation, get silver nitrate 0.40g and join in the deionized water of 10g, stir, 0.80g phosphoric acid is added wherein, stirs.
2. 0.70g tartaric acid is joined in 10g deionized water, stir, add 1., obtain stand-by liquid.
3. 0.40g sodium alginate is joined in 10g deionized water, heating for dissolving, add in stand-by liquid and stir, obtain colloid mixed liquor.
4. the colloid mixed liquor 3. prepared is divided into two equal portions, portion adds deionized water to 450g, stirs, and adjust ph 3 ~ 4 adds deionized water to 500g, stirs, and leaves standstill 12h, filters, obtains reference substance 1 solution.
Another part leads to ozone (O
3) 4 minutes, the same reference substance solution of remaining operations, obtains sample solution.
Get silver nitrate 0.40g to join in 1000g deionized water, stir, obtain reference substance 2 solution.
5. sample solution and reference substance solution specify to carry out sterilization experiment according to " carrier soaks quantitative disinfecting test operation sequence " of Ministry of Health of the People's Republic of China's " disinfection technology standard " version in 2008.Staphylococcus aureus bacterium sheet (2.4 × 10
6cfu/ sheet), in 2min, sample sets does not kill total plate count is 1.34 × 10
3cfu/ sheet, sterilizing rate reaches more than 99.9%.It is 1.39 × 10 that matched group 1 does not kill total plate count
5cfu/ sheet; It is 2.33 × 10 that matched group 2 does not kill total plate count
5cfu/ sheet.
Comparison (sterilizing time 2min) the cfu/ sheet of table 1 bactericidal effect
Sample sets is compared with matched group, and bactericidal effect is obviously better than matched group.
The 5th hospital burn department, to the clinical practice of patient, has the clinical effectiveness shown in table 2 compared with silver sulfadiazine as a control group through Harbin to obtain sterilization medical gels solution finished product (title treatment group) of the present invention with above-described embodiment.
Table 2 treatment group and matched group wound healing time (x ± s)
Compared with matched group, obviously reduce (P < 0.05) in burnt degree 1 week, 2 weeks, 3 weeks bacterial positive rate.Burnt degree residual wound bacterial positive rate reaches 100%, and based on staphylococcus aureus, extend with treatment time, bacterial positive rate totally declines (P < 0.05).Show that bactericidal liquid of the present invention all has inhibitory action to bacillus pyocyaneus, escherichia coli and staphylococcus aureus by thin strain identification.And treatment group case does not find local and systemic adverse reactions, routine urinalysis and hepatic and renal function no abnormality seen, wound healing comparatively matched group is level and smooth, and treatment time significantly shortens, without Drug resistance.
Claims (4)
1. the preparation method of a medical biocolloid solution for sterilization, it is characterized in that: the composition of described medical biocolloid solution for sterilization comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection, it is characterized in that: the weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20-0.50g, described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10-0.50g, described phosphoric acid or the described citric acid weight in the final mean annual increment solution of 1000g weight is 0.50-1.0g, the weight of 30% described hydrogenperoxide steam generator in the final mean annual increment solution of 1000g weight is 17.0-19.0g, the weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40-0.80g, described purified water or the described water for injection weight in the final mean annual increment solution of 1000g weight is the surplus that 1000g removes above-mentioned various substance weight,
Described potassium alginate or sodium alginate add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and be the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent of processing and refining;
Described tartaric acid is the tartaric acid of SILVER REAGENT;
This method has seven steps,
Silver nitrate adds in purified water or water for injection and stirs by the first step, obtains monovalence silver ion solution;
Phosphoric acid or citric acid join in monovalence silver ion solution and carry out acidification by second step, obtain the monovalence silver ion mixed liquor after acidification;
Tartaric acid joins in purified water or water for injection and stirs by the 3rd step, obtains tartaric acid solution;
Tartaric acid solution joins in the mixed liquor of the monovalence silver ion after acidification and stirs by the 4th step, obtains stand-by liquid;
Potassium alginate or sodium alginate or medical gelatin are added heating for dissolving in purified water or water for injection and stir by the 5th step, obtain the colloid solution of potassium alginate or sodium alginate or medical gelatin;
The colloid solution of potassium alginate or sodium alginate or medical gelatin joins in stand-by liquid by the 6th step, stirs, and passes into ozone O
35 ~ 10 minutes, monovalence silver ion is oxidized to bivalence silver ion, obtains bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
Bivalence silver ion colloid mixed liquor joins in the container filling purified water or water for injection and stirs by the 7th step, then add 30% hydrogenperoxide steam generator to continue to stir, and adjust ph, add purified water or water for injection to 1000g, stir, leave standstill 12 hours, filter, fill, obtain finished product medical biocolloid solution for sterilization.
2. the preparation method of medical biocolloid solution for sterilization according to claim 1, is characterized in that: the processing time of the acidification in described second step is 15 ~ 40min, and pH value is 1.5 ~ 2.
3. the preparation method of medical biocolloid solution for sterilization according to claim 1, is characterized in that: the heating-up temperature in the 5th described step is 50 ~ 60 DEG C, and mixing time is 5 ~ 10min.
4. the preparation method of medical biocolloid solution for sterilization according to claim 1, is characterized in that: the mixing time in the 7th described step is 5 ~ 10min, and adjust ph is 3 ~ 4; Be filtered into 100 mesh filter screens to filter.
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| CN111450114A (en) * | 2020-05-21 | 2020-07-28 | 苏州汇涵医用科技发展有限公司 | Compound disinfectant liquid containing hydrogen peroxide and silver ions and preparation method thereof |
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| CN102218079A (en) * | 2011-06-02 | 2011-10-19 | 苏州汇涵医用科技发展有限公司 | Biological colloid dispersant used for wound-protection and its preparation method |
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