CN102784100A - Medical biocolloid solution for sterilization and preparation method thereof - Google Patents
Medical biocolloid solution for sterilization and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medical biocolloid solution for sterilization and a preparation method thereof and makes real evaluations on the defects existing in the prior art such as CN1090905C, CN1134213C, CN1262101A and CN1110557A. The product comprises the following components: 0.20-0.50g of bivalent silver ions, 0.10-0.50g of potassium alginate or sodium alginate or medical gelatin, 0.50-1.0g of phosphoric acid or citric acid, 17.0-19.0g of 30% hydrogen peroxide solution, 0.40-0.80g of tartaric acid and the balance of purified water or water for injection, wherein the total weight of all the components is 1000g. The medical biocolloid solution is used for controlling the infection of wounds on the surface of a human body, promoting the occlusion of wounds and reducing the formation of scars.
Description
Technical field:
The present invention relates to a kind of antibacterial with medical bio colloid solution and preparation method thereof.
Background technology:
The notification number CN100560057C of authorized company that is proposed by the applicant and name are called in the narration of description page 1 to page 2 the 1st row of Wound-protection liquid and preparation method thereof, to the traumatic infection medication that causes such as the situation by burn and open wound surface of generally acknowledging both at home and abroad---and semi-annular jade pendant amic metadiazine silver frost (claiming ointment) or existing 3 shortcomings of outstanding agent have been done objective appraisal.And to prior art for example the defective of CN1090905C (powerful disinfectant), CN1134213C (method for preparing of bactericide containing silver), CN1262101A (silver ion disinfectant and preparation method thereof) and CN1110557A existence such as (silver nitrate ointments) also done evaluation strictly according to the facts.
Though the technical scheme of the aforesaid CN100560057C that is promptly proposed by the applicant has 4 technique effects that Instructions Page 3 the 12nd to 17 row is concluded; But owing to the monovalence silver ion is not changed into the bivalence silver ion in the prescription, and the bactericidal effect of bivalence silver ion is 50 ~ 200 times of monovalence silver ions.
In view of above-mentioned prior art, the applicant has done actively and good try has found the way that overcomes foregoing problems, and the technical scheme that will introduce below produces under this background.
Summary of the invention:
The purpose of this invention is to provide and a kind ofly help to guarantee safety, help guaranteeing stability and be of value to the embodiment feature of environmental protection; And have excellent permeation property and sterilizing function and can promote wound healing and improve healing effect efficiently; Reduce cicatrization, and the antibacterial that can not produce untoward reaction and nonirritant, free from extraneous odour and not have sensitization the patient is with medical bio colloid solution and preparation method thereof.
Above-mentioned purpose realizes through following technical scheme:
Medical bio colloid solution is used in a kind of antibacterial; Its composition comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection; The weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20-0.50g; Described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10-0.50g; Described phosphoric acid or the weight of described citric acid in the final mean annual increment solution of 1000g weight are 0.50-1.0g; The weight of described 30% hydrogenperoxide steam generator in the final mean annual increment solution of 1000g weight is 17.0-19.0 g; The weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40-0.80g, and described purified water or the weight of described water for injection in the final mean annual increment solution of 1000g weight are the surplus that 1000g removes above-mentioned various substance weights.
Medical bio colloid solution is used in described antibacterial, and described potassium alginate or sodium alginate are to add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and are the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent that processing and refining forms.
Medical bio colloid solution is used in described antibacterial, and described tartaric acid is the tartaric acid of SILVER REAGENT.
A kind of antibacterial is with the method for preparing of medical bio colloid solution, and this method had for seven steps, and the first step adds silver nitrate in purified water or the water for injection and stirs, and obtains the monovalence silver ion solution;
Second step joined phosphoric acid or citric acid carries out acidification in the monovalence silver ion solution, obtain the monovalence silver ion mixed liquor after the acidification;
The 3rd step joined tartaric acid in purified water or the water for injection and stirs, and obtained tartaric acid solution;
The 4th step joined tartaric acid solution in the mixed liquor of the monovalence silver ion after the acidification and stirs, and obtained liquid for use;
The 5th step obtained the colloid solution of potassium alginate or sodium alginate or medical gelatin with heating for dissolving and stirring in potassium alginate or sodium alginate or medical gelatin adding purified water or the water for injection;
The colloid solution of the 6th step with potassium alginate or sodium alginate or medical gelatin joins in the liquid for use, stirs, and feeds ozone O
35 ~ 10 minutes, the monovalence silver ion is oxidized to the bivalence silver ion, obtain bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
The 7th step joined bivalence silver ion colloid mixed liquor in the container that fills purified water or water for injection and stirs; Adding 30% hydrogenperoxide steam generator then continues to stir; And the adjusting pH value adds purified water or water for injection to 1000g, stirs; Leave standstill 12 hours, filtration, fill, obtain the finished product antibacterial and use biocolloid solution.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the processing time of the acidification in described second step is 15 ~ 40min, and pH value is 1.5 ~ 2.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the heating-up temperature in described the 5th step is 50 ~ 60 ℃, and mixing time is 5 ~ 10min.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the mixing time in described the 7th step is 5-10min, and regulating pH value is 3 ~ 4; Being filtered into 100 mesh filter screens filters.
Beneficial effect:
1. step of the present invention is terse, preparation condition is not harsh and can realize industrialized great production and can ensure the comprehensive embodiment of antibacterial with the technique effect of biocolloid solution.
2. the present invention changes into the bivalence silver ion with the monovalence silver ion, and the bactericidal effect of bivalence silver ion is 50 ~ 200 times of monovalence silver ions.
3. the present invention can be penetrated into the wound surface deep tissues, the antibacterial and the endotoxin at deep layer position is killed, and slough, pus piece, loosening the dissolving of clot are excreted, and helps lend some impetus to wound healing, reduces the formation of cicatrix.
4. the present invention uses for a long time, can not form obvious medicine film and develop immunity to drugs, and can shorten treatment cycle effectively.
The present invention to the patient without any side effects and product free from extraneous odour, no sensitization; The method processing step is few, and condition is not harsh, can adapt to the mass production requirement.
6. the used ozonator of the present invention per hour can produce 80g ozone.
The specific embodiment:
Embodiment 1:
Medical bio colloid solution is used in a kind of antibacterial; Its composition comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection; The weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20-0.50g; Described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10-0.50g; Described phosphoric acid or the weight of described citric acid in the final mean annual increment solution of 1000g weight are 0.50-1.0g; The weight of described 30% hydrogenperoxide steam generator in the final mean annual increment solution of 1000g volume is 17.0-19.0g; The weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40-0.80g, and described purified water or the weight of described water for injection in the final mean annual increment solution of 1000g weight are the surplus that 1000g removes above-mentioned various substance weights.
Medical bio colloid solution is used in described antibacterial, and described potassium alginate or sodium alginate are to add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and are the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent that processing and refining forms.
Medical bio colloid solution is used in described antibacterial, and described tartaric acid is the tartaric acid of SILVER REAGENT.
Embodiment 2:
Medical bio colloid solution is used in embodiment 1 described antibacterial; Its composition comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection; The weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20 or 0.30 or 0.40 or 0.50g; Described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10 or 0.20 or 0.30 or 0.40 or 0.50g; Described phosphoric acid or the weight of described citric acid in the final mean annual increment solution of 1000g weight are 0.50 or 0.60 or 0.70 or 0.80 or 0.90 or 1.0g; The weight of described 30% hydrogenperoxide steam generator in the final mean annual increment solution of 1000g weight is 17.0 or 18.0 or 19.0g; The weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40 or 0.50 or 0.60 or 0.70 or 0.80g, and described purified water or the weight of described water for injection in the final mean annual increment solution of 1000g weight are the surplus that 1000g removes above-mentioned various substance weights.
Medical bio colloid solution is used in described antibacterial, and described potassium alginate or sodium alginate are to add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and are the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent that processing and refining forms.
Medical bio colloid solution is used in described antibacterial, and described tartaric acid is the tartaric acid of SILVER REAGENT.
Embodiment 3:
A kind of antibacterial is with the method for preparing of medical bio colloid solution, and this method had for seven steps, and the first step adds silver nitrate in purified water or the water for injection and stirs, and obtains the monovalence silver ion solution;
Second step joined phosphoric acid or citric acid carries out acidification in the monovalence silver ion solution, obtain the monovalence silver ion mixed liquor after the acidification;
The 3rd step joined tartaric acid in purified water or the water for injection and stirs, and obtained tartaric acid solution;
The 4th step joined tartaric acid solution in the mixed liquor of the monovalence silver ion after the acidification and stirs, and obtained liquid for use;
The 5th step obtained the colloid solution of potassium alginate or sodium alginate or medical gelatin with heating for dissolving and stirring in potassium alginate or sodium alginate or medical gelatin adding purified water or the water for injection;
The colloid solution of the 6th step with potassium alginate or sodium alginate or medical gelatin joins in the liquid for use, stirs, and feeds ozone O
35 ~ 10 minutes, the monovalence silver ion is oxidized to the bivalence silver ion, obtain bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
The 7th step joined bivalence silver ion colloid mixed liquor in the container that fills purified water or water for injection and stirs; Adding 30% hydrogenperoxide steam generator then continues to stir; And the adjusting pH value adds purified water or water for injection to 1000g, stirs; Leave standstill 12 hours, filtration, fill, obtain the finished product antibacterial and use biocolloid solution.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the processing time of the acidification in described second step is 15 ~ 40min, and pH value is 1.5 ~ 2.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the heating-up temperature in described the 5th step is 50 ~ 60 ℃, and mixing time is 5 ~ 10min.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the mixing time in described the 7th step is 5 ~ 10min, and regulating pH value is 3 ~ 4; Being filtered into 100 mesh filter screens filters.
Embodiment 4:
Embodiment 3 described antibacterials are with the method for preparing of medical bio colloid solution, and this method has seven
In the step, the first step adds silver nitrate in purified water or the water for injection and stirs, and obtains the monovalence silver ion solution;
Second step joined phosphoric acid or citric acid carries out acidification in the monovalence silver ion solution, obtain the monovalence silver ion mixed liquor after the acidification;
The 3rd step joined tartaric acid in purified water or the water for injection and stirs, and obtained tartaric acid solution;
The 4th step joined tartaric acid solution in the mixed liquor of the monovalence silver ion after the acidification and stirs, and obtained liquid for use;
The 5th step obtained the colloid solution of potassium alginate or sodium alginate or medical gelatin with heating for dissolving and stirring in potassium alginate or sodium alginate or medical gelatin adding purified water or the water for injection;
The colloid solution of the 6th step with potassium alginate or sodium alginate or medical gelatin joins in the liquid for use, stirs, and feeds ozone O
35 or 6 or 7 or 8 or 9 or 10 minutes, the monovalence silver ion is oxidized to the bivalence silver ion, obtain bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
The 7th step joined bivalence silver ion colloid mixed liquor in the container that fills purified water or water for injection and stirs; Adding 30% hydrogenperoxide steam generator then continues to stir; And the adjusting pH value adds purified water or water for injection to 1000g, stirs; Leave standstill 12 hours, filtration, fill, obtain the finished product antibacterial and use biocolloid solution.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the processing time of the acidification in described the 3rd step is 15 or 20 or 25 or 30 or 35 or 40min, and pH value is 1.5 ~ 2.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the heating-up temperature in described the 5th step is 50 or 55 or 60 ℃, and mixing time is 5 or 6 or 7 or 8 or 9 or 10min.
Described antibacterial is with the method for preparing of medical bio colloid solution, and the mixing time in described the 7th step is 5 or 6 or 7 or 8 or 9 or 10min, and regulating pH value is 3 ~ 4; Being filtered into 100 mesh filter screens filters.
Embodiment 5:
The described medical bio colloid solution of the foregoing description comprises in the final mean annual increment solution of every 1000g weight: bivalence silver ion 0.20-0.50g, potassium alginate (or sodium alginate or medical gelatin) 0.10-0.50g, phosphoric acid or citric acid 0.50-1.0g, 30% hydrogenperoxide steam generator, 17.0-19.0g, tartaric acid 0.40-0.80 g, surplusly be purified water (or water for injection).
In a concrete embodiment of the present invention, described purified water (or water for injection) should meet the pharmacopeia requirement.
In another concrete embodiment of the present invention, described potassium alginate (or sodium alginate) adds alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and is the polysaccharide carbohydrate of potassium alginate (or sodium alginate) through the main constituent that processing and refining forms for belonging to.
In another concrete embodiment of the present invention, described tartaric acid is the tartaric acid of SILVER REAGENT.
Embodiment 6:
The described antibacterial of the foregoing description is with the method for preparing of medical bio colloid solution, and this method may further comprise the steps:
The first step adds silver nitrate in the purified water (or water for injection) and stirs, and obtains the monovalence silver ion solution;
Second step joined phosphoric acid (or citric acid) carries out acidification and regulates pH value in the monovalence silver ion solution, obtain the monovalence silver ion mixed liquor after the acidification;
The 3rd step joined tartaric acid in the purified water (or water for injection) and stirs, and obtained tartaric acid solution;
The 4th step joined tartaric acid solution in the mixed liquor of the monovalence silver ion after the acidification and stirs, and obtained liquid for use;
The 5th step added heating for dissolving and stirring in the purified water (or water for injection) with potassium alginate (or sodium alginate or medical gelatin), obtained potassium alginate (or sodium alginate or medical gelatin) colloid solution;
The 6th step joined potassium alginate (or sodium alginate or medical gelatin) colloid solution in the liquid for use, stirred, and fed ozone (O
3) 5 ~ 10 minutes, the monovalence silver ion is oxidized to the bivalence silver ion, obtain bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
The 7th step joined bivalence silver ion colloid mixed liquor in the container that fills purified water (or water for injection) and stirs; Adding 30% hydrogenperoxide steam generator then continues to stir; And the adjusting pH value adds purified water (or water for injection) to 1000g, stirs; Leave standstill 12 hours, filtration and fill, obtain the finished product antibacterial and use medical bio colloid solution.
Also have among the concrete embodiment of the present invention, the processing time of the acidification described in step the second step is 15 ~ 40min, and described pH value is 1.5 ~ 2.
In a concrete embodiment of the present invention, the mixing time described in three steps of step the is 15 ~ 40min.
more of the present invention and among concrete embodiment, the heating-up temperature described in five steps of step the is 50 ~ 60 ℃, mixing time is 5 ~ 10min.
In of the present invention and then concrete embodiment, the mixing time described in seven steps of step the is 5 ~ 10min, and described adjusting pH value is 3 ~ 4; Described 100 mesh filter screens that are filtered into filter.
Embodiment 7:
The method for preparing of the described medical bio colloid solution of the foregoing description, this method may further comprise the steps:
A) will by commercially available acquisition for example to join the deionized water for stirring of 10g by the SILVER REAGENT silver nitrate 0.40g of good technological company limited production of intelligence source, Chinese Guangdong province Shenzhen section and sale even; Used container is vinyon container or rustless steel container; Be able to abundant dissolving until silver nitrate, thereby obtain the monovalence silver ion solution;
B) phosphoric acid with the 0.80g SILVER REAGENT joins by A) carry out acidification in the resulting silver ion solution of step, the time of acidification is 30min, obtains the monovalence silver ion mixed solution after the acidification;
C) will join the 10g deionized water for stirring 20 minutes by the tartaric acid 0.70g of the SILVER REAGENT of for example producing and selling of commercially available acquisition, obtain tartaric acid solution by Chinese Shanghai reagent one factory;
D) with step C) resulting tartaric acid solution joins by step B) stir in the resulting monovalence silver ion solution mixed liquor after acidification, obtain liquid for use;
E) will join in the 10g deionized water by the medical grade sodium alginate 0.4g that for example produces of commercially available acquisition by the woods biotechnology development corporation, Ltd. in sea, Qingdao, Chinese Shandong Province; Heating for dissolving and stirring 5 minutes under 60 ℃ of temperature obtains sodium alginate colloid solution;
F) sodium alginate colloid solution is joined in the liquid for use, stirred 5 minutes, feed ozone (O
3) 8 minutes, the monovalence silver ion is oxidized to the bivalence silver ion, obtain bivalence silver ion colloid mixed liquor;
G) bivalence silver ion colloid mixed liquor is joined in the container of the deionized water that fills 900g stirred 10 minutes; Adding 30% hydrogenperoxide steam generator 18.0g then continues to stir 10 minutes; And regulate pH value 3.4, add deionized water, stirred 20 minutes to 1000g; Leave standstill 12 hours, filtration and fill, obtain the finished product antibacterial and use biocolloid solution.
The related mixing speed of above-mentioned each step all is as the criterion with 60-100n/min.
1. by above-mentioned example operation, get in the deionized water that silver nitrate 0.40g joins 10g, stir, 0.80g phosphoric acid is added wherein, stir.
2. 0.70g tartaric acid is joined in the 10g deionized water, stir, in the adding 1., obtain liquid for use.
3. the 0.40g sodium alginate is joined in the 10g deionized water, heating for dissolving adds in the liquid for use and stirs, and obtains the colloid mixed liquor.
The colloid mixed liquor that 4. will 3. prepare is divided into two equal portions, and portion adds deionized water to 450g, stirs, and regulates pH value 3 ~ 4, adds deionized water to 500g, stirs, and leaves standstill 12h, filters, and obtains reference substance 1 solution.
Logical ozone (the O of another part
3) 4 minutes, the same reference substance solution of remaining operation, sample solution.
Get silver nitrate 0.40g and join in the 1000g deionized water, stir, obtain reference substance 2 solution.
5. sample solution and reference substance solution are carried out sterilization experiment according to " carrier soaks the quantitative disinfecting test operation sequence " regulation of Ministry of Health of the People's Republic of China's " disinfection technology standard " version in 2008.Staphylococcus aureus bacterium sheet (2.4 * 10
6The cfu/ sheet), in 2min sample sets not kill total plate count be 1.34 * 10
3The cfu/ sheet, sterilizing rate reaches more than 99.9%.It is 1.39 * 10 that matched group 1 is not killed total plate count
5The cfu/ sheet; It is 2.33 * 10 that matched group 2 is not killed total plate count
5The cfu/ sheet.
The comparison of table 1 bactericidal effect (sterilizing time 2min) cfu/ sheet
Sample sets is compared with matched group, and bactericidal effect obviously is superior to matched group.
The 5th hospital burn department has the clinical effectiveness shown in the table 2 to patient's clinical practice with comparing as the silver sulfadiazine of matched group through Harbin with medical gels solution finished product (claim treatment group) to obtain antibacterial of the present invention with the foregoing description.
Table 2 treatment group and matched group wound healing time (x ± s)
Compare with matched group, 1 week, 2 weeks, 3 all bacterial positive rate obviously reduce (P＜0.05) behind burn.Burn back residual wound bacterial positive rate reaches 100%, is main with staphylococcus aureus, prolongs bacterial positive rate totally descend (P＜0.05) with treatment time.Show that through the evaluation of antibacterial kind bactericidal liquid of the present invention all has inhibitory action to bacillus pyocyaneus, escherichia coli and staphylococcus aureus.And treatment group case is not found part and systemic adverse reactions, routine urinalysis and hepatic and renal function no abnormality seen, and wound healing is level and smooth than matched group, and treatment time significantly shortens, no Drug resistance.
Claims (7)
1. medical bio colloid solution is used in an antibacterial; Its composition comprises: bivalence silver ion, potassium alginate or sodium alginate or medical gelatin, phosphoric acid or citric acid, 30% hydrogenperoxide steam generator, tartaric acid, purified water or water for injection; It is characterized in that: the weight of described bivalence silver ion in the final mean annual increment solution of 1000g weight is 0.20-0.50g; Described potassium alginate or described sodium alginate or the weight of described medical gelatin in the final mean annual increment solution of 1000g weight are 0.10-0.50g; Described phosphoric acid or the weight of described citric acid in the final mean annual increment solution of 1000g weight are 0.50-1.0g; The weight of described 30% hydrogenperoxide steam generator in the final mean annual increment solution of 1000g weight is 17.0-19.0g; The weight of described tartaric acid in the final mean annual increment solution of 1000g weight is 0.40-0.80g, and described purified water or the weight of described water for injection in the final mean annual increment solution of 1000g weight are the surplus that 1000g removes above-mentioned various substance weights.
2. medical bio colloid solution is used in antibacterial according to claim 1, it is characterized in that: described potassium alginate or sodium alginate are to add alkaline extraction in the Thallus Laminariae (Thallus Eckloniae) of Brown algae plant category and are the polysaccharide carbohydrate of potassium alginate or sodium alginate through the main constituent that processing and refining forms.
3. medical bio colloid solution is used in the antibacterial of stating according to claim 1, it is characterized in that: described tartaric acid is the tartaric acid of SILVER REAGENT.
4. an antibacterial is with the method for preparing of medical bio colloid solution, and it is characterized in that: this method has seven
In the step, the first step adds silver nitrate in purified water or the water for injection and stirs, and obtains the monovalence silver ion solution;
Second step joined phosphoric acid or citric acid carries out acidification in the monovalence silver ion solution, obtain the monovalence silver ion mixed liquor after the acidification;
The 3rd step joined tartaric acid in purified water or the water for injection and stirs, and obtained tartaric acid solution;
The 4th step joined tartaric acid solution in the mixed liquor of the monovalence silver ion after the acidification and stirs, and obtained liquid for use;
The 5th step obtained the colloid solution of potassium alginate or sodium alginate or medical gelatin with heating for dissolving and stirring in potassium alginate or sodium alginate or medical gelatin adding purified water or the water for injection;
The colloid solution of the 6th step with potassium alginate or sodium alginate or medical gelatin joins in the liquid for use, stirs, and feeds ozone O
35 ~ 10 minutes, the monovalence silver ion is oxidized to the bivalence silver ion, obtain bivalence silver ion colloid mixed liquor;
2Ａｇ
+＋2Ｏ
３→2Ａｇ
2+＋3Ｏ
２↑；
The 7th step joined bivalence silver ion colloid mixed liquor in the container that fills purified water or water for injection and stirs; Adding 30% hydrogenperoxide steam generator then continues to stir; And the adjusting pH value adds purified water or water for injection to 1000g, stirs; Leave standstill 12 hours, filtration, fill, obtain the finished product antibacterial and use medical bio colloid solution.
5. antibacterial according to claim 4 is characterized in that with the method for preparing of medical bio colloid solution: the processing time of the acidification in described second step is 15 ~ 40min, and pH value is 1.5 ~ 2.
6. antibacterial according to claim 4 is characterized in that with the method for preparing of medical bio colloid solution: the heating-up temperature in described the 5th step is 50 ~ 60 ℃, and mixing time is 5 ~ 10min.
7. antibacterial according to claim 4 is characterized in that with the method for preparing of medical bio colloid solution: the mixing time in described the 7th step is 5 ~ 10min, and regulating pH value is 3 ~ 4; Being filtered into 100 mesh filter screens filters.
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| CN108566954A (en) * | 2017-03-10 | 2018-09-25 | 洛阳惠中兽药有限公司 | A kind of disinfectant and its preparation method and application |
| CN108976265A (en) * | 2017-06-02 | 2018-12-11 | 台湾艾所生物科技股份有限公司 | Method for preparing metal crystal-containing alginic acid monomer |
| CN111450114A (en) * | 2020-05-21 | 2020-07-28 | 苏州汇涵医用科技发展有限公司 | Compound disinfectant liquid containing hydrogen peroxide and silver ions and preparation method thereof |
| CN111820239A (en) * | 2020-06-30 | 2020-10-27 | 东莞东阳光科研发有限公司 | Liquid composition and preparation method and application thereof |
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