CN101933938A - Sustained-release in-vivo pathogen killing agent and preparation and using methods thereof - Google Patents
Sustained-release in-vivo pathogen killing agent and preparation and using methods thereof Download PDFInfo
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- CN101933938A CN101933938A CN 201010264497 CN201010264497A CN101933938A CN 101933938 A CN101933938 A CN 101933938A CN 201010264497 CN201010264497 CN 201010264497 CN 201010264497 A CN201010264497 A CN 201010264497A CN 101933938 A CN101933938 A CN 101933938A
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Abstract
The invention relates to a sustained-release in-vivo pathogen killing agent and preparation and using methods thereof, which belong to the technical field of medicaments. The pathogen killing agent comprises the following components: aqueous solution of sodium chlorite serving as an agent A, aqueous solution of citric acid serving as an agent B or 3 to 5 percent acetic acid or vinegar. A preparation process comprises the following steps of: recrystallizing a commodity, namely, sodium chlorite to remove harmful impurities, mixing the recrystallized sodium chlorite and water to obtain aqueous solution, refrigerating the aqueous solution and removing a chlorate impurity by filtering; and mixing the aqueous solution of sodium chlorite and aqueous solution of citric acid or acetic acid according to proportion and adding water into the mixture for drinking. After being taken, the pathogen killing agent can continuously supply chlorine dioxide into bodies so as to selectively kill multiple in-vivo pathogens such as bacteria, viruses, protozoa, fungi, parasites and the like. The pathogen killing agent is used for treating patients suffered from difficult miscellaneous diseases, has the advantages of safety, high efficiency, low price and easy popularization and fills the blank of the treatment of human diseases by using chlorine dioxide in China.
Description
Technical field
The present invention relates to pathogen agent for killing and preparation and using method in a kind of slow release gonosome, belong to medical technical field.
Background technology
Nearly all pathogen all is that the electronics that is rich in electronics is supplied with body, and oxidant is a receptor of very easily admitting electronics, thereby utilization is captured electronics for body harmless's strong oxidizer and is killed the selection that morbific pathogen is a kind of science, the broad-spectrum high efficacy of the crucial oxidant of problem and to the being perfectly safe property of human body.Adopting exhausted oxidant in history has oxygen, hydrogen peroxide, ozone etc., but or because of fail wide popularization and application to the side effect of health or because of asthenoxia always, Kuai Sufazhan chlorine dioxide technology provides opportunity in recent years.Over more than 100 year, countries in the world use chlorine dioxide as drinking water disinfect more and more widely, and then as food additive, World Health Organization (WHO) announces that then it is unique A1 level disinfectant in food industry.Reason is the safety because chlorine dioxide is efficient all, and U.S. analyst association announced that chlorine dioxide was the most powerful known pathogen killer in 1999.Certainly can not be directly used in human body as the chlorine dioxide goods of doing disinfectant (working concentration is hundreds of to thousands of ppm usually).The key issue that need to solve is a slow release (can reach 12 hours deenergized period) and to the safe dose (about 1ppm) of human body.
Chlorine dioxide is strong oxidizer and has strong volatility, is the effective and the most intelligent killer of pathogen.Chlorine dioxide can be dissolved in blood as oxygen, and Red blood corpuscle can not distinguished chlorine dioxide and oxygen, thus also portability chlorine dioxide, enter in the body to health everywhere.The pH value of sick cell all is lower than 7, when chlorine dioxide when running into these sick cells, as the electronics high energy acceptor more much better than than oxygen, can moment (comprise deleterious antibacterial from pathogen, virus, toxin, protozoon, fungus and parasite) in capture five electronics, this means the oxidized elimination of sick cell, chloride ion in the chlorine dioxide then becomes harmless sodium chloride, ionic state oxygen then absorbs intravital hydrion and becomes water, but being higher than 7 healthy cell and beneficial bacteria chlorine dioxide for pH value is inert, they are unaffected, and this thus preparation is a safety, efficient and intelligent sick cell killer.If chlorine dioxide does not run into pathogen or toxin, degenerate into stable salt the most at last, being gone back principle fully can not become hypochlorous acid in some cases, hypochlorous acid is the necessary chemical compound of immune system, can kill parasite, cancerous cell, lack hypochlorous acid in the body, medically be referred to as myeloperoxidase deficiency.In addition, because the volatility of chlorine dioxide makes it have the ability that " long-range " attacked, so sterilizing ability is stronger.
The generation of chlorine dioxide is that above-mentioned A agent and B agent mix the result that the back produces chemical action, and this chemical action is slow and lasting, therefore can guarantee to produce continuously the chlorine dioxide of low dosage, has promptly guaranteed the slow-releasing and the low dosage of this preparation.Usually after drinking this preparation, can in 12 hours time, discharge the about 12-20 milligram of total amount chlorine dioxide continuously.And chlorine dioxide retention time in vivo is about 2 hours, so its average amount retained in vivo is about the 1-2 milligram, this dosage is safe to the people, and is fatal for pathogen.
Recent years, existing report U.S. scientist utilizes similar techniques and product at first to be used for the treatment of multiple difficult miscellaneous diseases such as acquired immune deficiency syndrome (AIDS), malaria, cancer, hepatitis, Lyme disease, monilial infection, the infection of hole chamber in South America and Africa, 75000 none death of malaria patient have for example been given treatment on African Malawi and other places, in Uganda 390 aids patients are given treatment to, big portion recovery from illness in 8 months time, have only two people failure, we can say and obtained miraculous effect.But still relevant so far patent, and they adopt is the raw material of industry that contains the plurality of impurities composition, and raw material and solution all do not pass through purification process, bring many harmful components unavoidably into.
The development of domestic chlorine dioxide technology reaches its maturity, but is used for the technology of human body aspect and uses still belonging to blank.
Summary of the invention
The objective of the invention is to propose pathogen agent for killing and preparation and using method in a kind of slow release gonosome,, comprise antibacterial, virus, protozoon, fungus, parasite etc. to kill the various microorganisms that cause host disease fast.
Pathogen agent for killing in the slow release gonosome that the present invention proposes, the mass percentage concentration of each composition is:
The A agent: concentration is the sodium chlorite aqueous solution of 20-25%;
The B agent: concentration is the aqueous citric acid solution of 5-15%, or concentration is acetic acid or the tablet vinegar of 3-5%.
The preparation and the using method of pathogen agent for killing in the above-mentioned slow release gonosome that the present invention proposes may further comprise the steps:
(1) the commodity sodium chlorite is carried out 2～3 recrystallization and handles, to remove objectionable impurities, be mixed with the aqueous solution that concentration is 20-25% with deionized water or distilled water after, be refrigerated to subzero 6～8 ℃, filter and remove chlorate impurity;
(2) with 1 part of concentration be 20～25% sodium chlorite (NaClO
2) aqueous solution and 4～10 parts of concentration aqueous citric acid solution that is 5-15% or the concentration acetic acid or the tablet vinegar that are 3-5% mixed 3-10 minute mutually, add 50～100 milliliters in water again after, in 1 hour, drink.
Pathogen agent for killing and preparation and using method in the slow release gonosome that the present invention proposes, continue and chemical action slowly by two kinds of compositions of A, B, the chlorine dioxide of the about 12-20 milligram of total amount was provided in body in 12 hours continuously, can optionally kill multiple pathogen in the body, comprise antibacterial, virus, protozoon, fungus, parasite etc., be used to give treatment to the difficult miscellaneous diseases patient, safety, efficient, cheap, be easy to promote, filled up the domestic blank that chlorine dioxide is used for the human body diseases treatment.
The specific embodiment
Pathogen agent for killing in the slow release gonosome that the present invention proposes, the mass percentage concentration of each composition is:
The A agent: concentration is the sodium chlorite aqueous solution of 20-25%;
The B agent: concentration is any in the aqueous citric acid solution of 5-15%, acetic acid or tablet vinegar that concentration is 3-5% or the fruit juice that contains corresponding composition.
The preparation and the using method of pathogen agent for killing in the above-mentioned slow release gonosome that the present invention proposes may further comprise the steps:
(1) the commodity sodium chlorite is carried out 2～3 recrystallization and handles, to remove objectionable impurities, be mixed with the aqueous solution that concentration is 20-25% with deionized water or distilled water after, be refrigerated to subzero 6～8 ℃, filter and remove chlorate impurity;
(2) with 1 part of concentration be 20～25% sodium chlorite (NaClO
2) aqueous solution and 4～10 parts of aqueous citric acid solutions that concentration is 5-15%, or be that acetic acid or the tablet vinegar of 3-5% mixed 3-10 minute mutually with concentration, add 50～100 milliliters in water again after, in 1 hour, drink.
The A agent of at every turn drinking is dripped number and can be dripped for 0.5-15, and the number of times of drinking every day can be decided according to the physical condition of user, and principle is from less to more, gradually dosage.
The using method of pathogen agent for killing of the present invention also can be with A liquid through making with extra care the back according to from less to more, and the principle of dosage drips and be used for intravenous injection or drop in glucose injection gradually.
The B agent that the inventive method is used also can be for containing corresponding composition but do not contain the fruit juice of tieing up C.
Below introduce embodiments of the invention:
Embodiment 1:
With content be 85% industrial sodium chlorite through twice recrystallization, obtain the pure sodium chlorite crystalline solid of purity more than 95%, it is dissolved in deionized water or the distilled water, concentration reaches capacity.This solution concentration is 24-25%, is the A agent.Pipette 1 part of A agent and 4 parts of concentration are 10% citric acid solution with the glass dropper, be the B agent, in glass, mixed 3 minutes, add 50 milliliters in water, in 1 hour, drink.Each 10-15 dripped (about 0.6-1 milliliter) A agent in first day, 60 B agent, and every two hours once, second day is same, continuous three days.Use this pathogen agent for killing, Africa treatment malaria patient, 98% patient in 4-8 hour, its heating, feel cold, transference cures such as aching pain of muscles, arthritis, headache.
Therefore illustrate that pathogen agent for killing of the present invention is applicable to the malaria patient.
Embodiment 2:
Purified sodium chlorite crystalline solid is dissolved in deionized water or the distilled water, making concentration and be about sodium chlorite aqueous solution's (A agent) of 20%, is the B agent with tablet vinegar or white vinegar, in 1 part of A agent the ratio of 10 parts of B agent is mixed both 3 minutes in glass, add 50 milliliters in water, in 1 hour, drink.10 B agent of each once a day 1 A agent (0.06 milliliter) (about 0.6 milliliter) in first day, general patient can reach each 15 A agent to 150 B agent, takes every day three times, continuously a couple of days.The people who is in a bad way individually can be according to the suitable dosage of the state of an illness.The criterion of suitable dose is, can vomit after drinking, feels sick, healing crisis such as diarrhoea, local pain, at this moment dosage reduced 1-2 and drips and get final product, and treats behind these transference cures dosage gradually again.Reactions such as patient sends vomiting the initial stage of taking medicine, feels sick, diarrhoea, local pain, this is that removing and eliminating pathogen and multiple toxin cause in vivo for the chlorine dioxide that produces in the mechanism to human body owing to pathogen agent for killing of the present invention.
Present embodiment illustrates that pathogen agent for killing of the present invention is applicable to asthma, emphysema, breast carcinoma, intestinal cancer, pulmonary tuberculosis, anthrax, pneumonia, gastric ulcer, tularemia, Lyme disease, A/B/C/D/E type hepatitis, herpes or the like most of disease.
Embodiment 3:
Purified sodium chlorite crystalline solid is dissolved in deionized water or the distilled water, makes concentration and be about sodium chlorite aqueous solution's (A agent) of 20%, be used for intravenous drip.First day, drip from 2-5, being added to 6-7 in second day drips the A agent, drips with 20-22 in the 3rd day.Independent A agent is added in 500 milliliters the sucrose drip liquid bottle, regulates 500 milliliters about two hours of the speed of drop, continuous more than 30 days, check up to HIV (human immunodeficiency virus) negative.
When patient be sick in the stomach, when vomitting, the same day, treatment should be stopped immediately, but do not stop whole treatment, just reduced 2 next time.Feeling sick is a good signal, and this shows that this preparation has played effect, and is very bad if the patient feels, can drink one glass of water that is added with 1 gram dimension C.
Present embodiment illustrates that pathogen agent for killing of the present invention is applicable to the treatment acquired immune deficiency syndrome (AIDS).
Pathogen agent for killing of the present invention can be used for killing multiple pathogen and gives treatment to or alleviate corresponding disease, comprising:
Bacterial pathogen: as the antibacterial that causes urinary tract infection, peritonitis, typhoid fever, food origin disease (being Salmonella, escherichia coli), pulmonary tuberculosis, pneumonia, gastric ulcer, tularemia, Lyme disease etc.
Viral pathogens: as cause the virus of acquired immune deficiency syndrome (AIDS), A/B/C/D/E type hepatitis, herpes, human papilloma, wart, chickenpox, variola, measles, flu, influenza (being H5N1 virus, bird flu).
Protozoon sexually transmitted disease (STD) substance: as the protozoon that causes malaria, lambliosis, recessive robe parasitosis, South American trypanosomiasis.
The fungoid disease substance: as the fungus that causes tinea, candidiasis (being yeast infection), histoplasmosis, recessive coccus disease.
Parasitic pathogen: as ascarid, cestode.
The protein sickness substance: as cause the pathogen of bovine spongiform encephalopathy, modification storehouse Jia Shi disease.
Claims (4)
1. pathogen agent for killing in the slow release gonosome is characterized in that the mass percentage concentration of each composition in this pathogen agent for killing is:
The A agent: concentration is the sodium chlorite aqueous solution of 20-25%;
The B agent: concentration is the aqueous citric acid solution of 5-15%, or concentration is acetic acid or the tablet vinegar of 3-5%.
2. the preparation and the using method of pathogen agent for killing in the slow release gonosome as claimed in claim 1 is characterized in that this method may further comprise the steps:
(1) the commodity sodium chlorite is carried out 2～3 recrystallization and handles, to remove objectionable impurities, be mixed with the aqueous solution that concentration is 20-25% with deionized water or distilled water after, be refrigerated to subzero 6～8 ℃, filter and remove chlorate impurity;
(2) with 1 part of concentration be sodium chlorite aqueous solution and 4～10 parts of aqueous citric acid solutions that concentration is 5-15% of 20～25%, or with concentration be acetic acid or the tablet vinegar of 3-5%, mixed mutually 3-10 minute, add 50～100 milliliters in water again after, in 1 hour, drink.
3. the preparation and the using method of pathogen agent for killing is characterized in that it is 0.5～15 that number is dripped in the A agent of at every turn drinking in the slow release gonosome as claimed in claim 2, the number of times of drinking every day from less to more, dosage gradually.
4. the preparation and the using method of pathogen agent for killing in the slow release gonosome as claimed in claim 2 is characterized in that above-mentioned A agent through refining back according to from less to more, and dosage gradually drips be used for intravenous injection or drop in glucose injection.
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| CN 201010264497 CN101933938A (en) | 2010-08-27 | 2010-08-27 | Sustained-release in-vivo pathogen killing agent and preparation and using methods thereof |
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| CN 201010264497 CN101933938A (en) | 2010-08-27 | 2010-08-27 | Sustained-release in-vivo pathogen killing agent and preparation and using methods thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666330A (en) * | 2015-03-17 | 2015-06-03 | 周伟文 | Disinfector for internal use |
| WO2018202897A1 (en) * | 2017-05-04 | 2018-11-08 | Schaub Walter | Compositions and treatment procedures for the treatment of pathogenic infections |
| CN111685119A (en) * | 2020-07-27 | 2020-09-22 | 海南三帝制药有限公司 | Stable environment-friendly disinfectant |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1035477A (en) * | 1989-01-31 | 1989-09-13 | 中国人民解放军59174部队 | The method of producing chlorine dioxide by acidifying chlorous sodium |
| CN1122189A (en) * | 1995-06-29 | 1996-05-15 | 叶中良 | Bactericidal disinfectant |
| CN1554239A (en) * | 2003-12-27 | 2004-12-15 | 胡银安 | Superoxide disinfectant |
| CN1556046A (en) * | 2003-12-30 | 2004-12-22 | 成都柯邦药业有限公司 | Synergism type chlorine dioxide bactericide and its manufacturing method and use in aquatic culture |
| CN101172579A (en) * | 2007-10-17 | 2008-05-07 | 艾雪莉 | Chlorine dioxide generating agent |
-
2010
- 2010-08-27 CN CN 201010264497 patent/CN101933938A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1035477A (en) * | 1989-01-31 | 1989-09-13 | 中国人民解放军59174部队 | The method of producing chlorine dioxide by acidifying chlorous sodium |
| CN1122189A (en) * | 1995-06-29 | 1996-05-15 | 叶中良 | Bactericidal disinfectant |
| CN1554239A (en) * | 2003-12-27 | 2004-12-15 | 胡银安 | Superoxide disinfectant |
| CN1556046A (en) * | 2003-12-30 | 2004-12-22 | 成都柯邦药业有限公司 | Synergism type chlorine dioxide bactericide and its manufacturing method and use in aquatic culture |
| CN101172579A (en) * | 2007-10-17 | 2008-05-07 | 艾雪莉 | Chlorine dioxide generating agent |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666330A (en) * | 2015-03-17 | 2015-06-03 | 周伟文 | Disinfector for internal use |
| WO2018202897A1 (en) * | 2017-05-04 | 2018-11-08 | Schaub Walter | Compositions and treatment procedures for the treatment of pathogenic infections |
| CN110996941A (en) * | 2017-05-04 | 2020-04-10 | 沃尔特·绍布 | Compositions and therapeutic procedures for treating pathogen infections |
| CN111685119A (en) * | 2020-07-27 | 2020-09-22 | 海南三帝制药有限公司 | Stable environment-friendly disinfectant |
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Application publication date: 20110105 |