CN102783571A - Genetically engineered mouse feed - Google Patents
Genetically engineered mouse feed Download PDFInfo
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- CN102783571A CN102783571A CN2011101271666A CN201110127166A CN102783571A CN 102783571 A CN102783571 A CN 102783571A CN 2011101271666 A CN2011101271666 A CN 2011101271666A CN 201110127166 A CN201110127166 A CN 201110127166A CN 102783571 A CN102783571 A CN 102783571A
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Abstract
The invention relates to a genetically engineered mouse feed, and belongs to the field of the experimental animal nutriology. The feed is a nutritionally-balanced mixed feed concretely prepared through treating corn, flour, wheat bran, soybean, soybean meal, fish meal, calcium hydrogen phosphate, calcium carbonate, plant oil, a mineral salt premix and a vitamin premix as raw materials, mixing the raw materials according to a reasonable ratio, and effectively controlling indexes comprising general inorganic substances and heavy metals, organic compounds (comprising pesticide residues), radioactive substances, microbes and the like in the feed raw materials according to the digestive physiological characteristics of genetically engineered mice. The feed has the advantages of reliable quality and low price, and is an effective mixed feed which can satisfy the growth and breeding nutrition needs of the genetically engineered mice.
Description
Technical field
The present invention relates to a kind of suitable genetic engineering mouse growth and breeding mixed feed, belong to animal used as test nutrition field.
Background technology
The animal model of human diseases has become one of requisite core condition of modern biology and medical research.Because the height homology of mouse and human genome, Physiology and biochemistry and growth course are basic identical, to the reaction of environment and medicine also and similar, so mouse has become construction human diseases correlation model and has studied pathogenetic most important animal used as test.Except that These characteristics, mice study also has ripe genetic engineering modified technological means, has a large amount of inbred strais strains simultaneously, and experimental result has good mutually consistent and comparativity.Mouse is widely used in life science and the medical research as topmost transgenosis model animal.
Because the particularity of genetic engineering mouse self species; It has characteristics such as poor growth, breeding potential are low, can cause that with the conventional big mouse feed genetic engineering mouse of feeding feed intake descends malnutrition; Apogeny, this has just determined the particularity to the feed nutrition needs.Given this, the mixed feed of the little mouse upgrowth breeding of a kind of suitable genetic engineering is demanded research and development urgently, and the inventor is through scientific formula, and experimental observation research mixes this kind feed.
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Summary of the invention
The object of the invention is through preferred feedstuff, each raw material of rational proportion, and the deficiency of improving prior art provides a kind of mixed feed that satisfies genetic engineering mouse desired nutritional.The inventor is that raw material is processed mixed feed with corn, flour, wheat bran, soya bean, dregs of beans, fish meal, calcium monohydrogen phosphate, calcium carbonate, vegetable oil, mineral salt premix, vitamin premix, it is characterized in that: corn 38-40 kilogram, flour 20-22 kilogram, wheat bran 4-11 kilogram, soya bean 5-10 kilogram, dregs of beans 16-17 kilogram, fish meal 1-5 kilogram, calcium monohydrogen phosphate 2-3 kilogram, calcium carbonate 2-3 kilogram, vegetable oil 0.5-1 kilogram, 1 kilogram of salt, 0.8 kilogram of mineral salt premix, vitamin premix 0.01-0.05 kilogram.
Be preferably: 39 kilograms of corns, 21 kilograms in flour, 8 kilograms in wheat bran, 7 kilograms of soya beans, 16.5 kilograms of dregs of beans, 3 kilograms of fish meal, 2.5 kilograms of calcium monohydrogen phosphates, 2.5 kilograms in calcium carbonate, 0.75 kilogram of vegetable oil, 1 kilogram of salt, 0.8 kilogram of mineral salt premix, 0.025 kilogram of vitamin premix
The present invention is directed to genetic engineering mouse digestive physiological characteristics; Select the high feed of utilization rate; Fully satisfy the demand of the little mouse upgrowth breeding of genetic engineering to nutrition, general inorganic matter and control indexes such as heavy metal, organic compound (comprising the residual of agricultural chemicals), radioactive substance and microorganism are in GLP standard allowed band in the feed.This mixed feed is raw materials used from the horse's mouth, and steady quality is cheap.
This feed formula advantage:
1. mixed feed composition of the present invention, form and smell are fit to habit and the hobby of mouse.
2. this feed good palatability is balanced in nutrition, can satisfy genetic engineering mouse growth and breeding nutritional need.
3. this feed hygiene index meets requirement among " animal used as test full nutrition feed " standard GB 14924.1-2001, meets the GLP standard.
The specific embodiment
The present invention adds vitamin and trace element through adopting the high-quality feed proportioning raw materials, improves feed digestibility and palatability, satisfies genetic engineering mouse nutritional need.Raw materials all in the invention will carry out the detection of nutritive index and polluter before use, and polluters such as the toxin in the raw material, agricultural chemicals, heavy metal are controlled in the GLP standard allowed band.
Embodiment 1
1. raw material pulverizing is put into the pulverizer pulverizing respectively with coarse grained corn, wheat bran, soya bean, dregs of beans, crosses the 800-100 mesh sieve, and is subsequent use.
2. raw material mixes (1) according to each proportion of raw materials content, accurately takes by weighing 40 kilograms of corns, 22 kilograms in flour, wheat bran 11
Kilogram, 10 kilograms of soya beans, 17 kilograms of dregs of beans, 5 kilograms of fish meal, 3 kilograms of calcium monohydrogen phosphates, 3 kilograms in calcium carbonate, 1 kilogram of salt.
(2) accurately take by weighing 0.8 kilogram of mineral salt premix and 0.05 kilogram of abundant mixing of vitamin premix.
The feedstuff that (3) will take by weighing is put in the mixer and is mixed about 2min, behind the abundant mixing of various raw materials, adds 0.5 kilogram of vegetable oil again, mixes 1-2min.
3. the preparation pellet is squeezed into particle under temperature 90-120 ℃, a 2-10 atmospheric pressure, produces diameter 10-13mm, grows
Degree 25mm pellet.
4. the finished product feedstuff nutritional surveillance detects nutritional labeling, heavy metal and the polluter of finished product feedstuff.
Embodiment 2
1. raw material pulverizing is put into the pulverizer pulverizing respectively with coarse grained corn, wheat bran, soya bean, dregs of beans, crosses the 800-100 order
Sieve, subsequent use.
2. raw material mixes (1) according to each proportion of raw materials content, accurately takes by weighing 38 kilograms of corns, 20 kilograms in flour, wheat bran 4 public affairs
Jin, 5 kilograms of soya beans, 16 kilograms of dregs of beans, 1 kilogram of fish meal, 2 kilograms of calcium monohydrogen phosphates, 2 kilograms in calcium carbonate, 1 kilogram of salt.
(2) accurately take by weighing 0.8 kilogram of mineral salt premix and 0.01 kilogram of abundant mixing of vitamin premix.
The feedstuff that (3) will take by weighing is put in the mixer and is mixed about 2min, behind the abundant mixing of various raw materials, adds 1.5 kilograms of vegetable oil again, mixes 1-2min.
3. the preparation pellet is squeezed into particle under temperature 90-120 ℃, a 2-10 atmospheric pressure, produces diameter 10-13mm, length 25mm pellet.
4. the finished product feedstuff nutritional surveillance detects nutritional labeling, heavy metal and the polluter of finished product feedstuff.
Embodiment 3
1. raw material pulverizing is put into the pulverizer pulverizing respectively with coarse grained corn, wheat bran, soya bean, dregs of beans, crosses the 800-100 mesh sieve, and is subsequent use.
2. raw material mixing (1) accurately takes by weighing each component raw material according to following proportioning content:
Be preferably: 39 kilograms of corns, 21 kilograms in flour, 8 kilograms in wheat bran, 7 kilograms of soya beans, 16.5 kilograms of dregs of beans, 3 kilograms of fish meal, 2.5 kilograms of calcium monohydrogen phosphates, 2.5 kilograms in calcium carbonate, 0.75 kilogram of vegetable oil, 1 kilogram of salt
(2) accurately take by weighing 0.8 kilogram of mineral salt premix and 0.025 kilogram of abundant mixing of vitamin premix.
The feedstuff that (3) will take by weighing is put in the mixer and is mixed about 2min, behind the abundant mixing of various raw materials, adds 0.75 kilogram of vegetable oil again, mixes 1-2min.
3. the preparation pellet is squeezed into particle under temperature 90-120 ℃, a 2-10 atmospheric pressure, produces diameter 10-13mm, length 25mm pellet.
4. the finished product feedstuff nutritional surveillance detects nutritional labeling, heavy metal and the polluter of finished product feedstuff.
Claims (4)
1. feed formula that promotes the little mouse upgrowth breeding of genetic engineering, it is characterized in that: this prescription is to be processed by the raw material of following weight portion: corn 38-40 kilogram, flour 20-22 kilogram, wheat bran 4-11 kilogram, soya bean 5-10 kilogram, dregs of beans 16-17 kilogram, fish meal 1-5 kilogram, calcium monohydrogen phosphate 2-3 kilogram, calcium carbonate 2-3 kilogram, vegetable oil 0.5-1 kilogram, 1 kilogram of salt, 0.8 kilogram of mineral salt premix and vitamin premix 0.01-0.05 kilogram.
2. a kind of feed formula that promotes the little mouse upgrowth breeding of genetic engineering according to claim 1, wherein the consumption of each raw material is: 39 kilograms of corns, 21 kilograms in flour, 8 kilograms in wheat bran, 7 kilograms of soya beans, 16.5 kilograms of dregs of beans, 3 kilograms of fish meal, 2.5 kilograms of calcium monohydrogen phosphates, 2.5 kilograms in calcium carbonate, 0.75 kilogram of vegetable oil, 1 kilogram of salt, 0.8 kilogram of mineral salt premix, 0.025 kilogram of vitamin premix.
3.1. claim 1 or 2 described a kind of compound methods that promote the feed of the little mouse upgrowth breeding of genetic engineering, it comprises the following steps:
1. take by weighing various raw materials: corn, flour, wheat bran, soya bean, dregs of beans, fish meal, calcium monohydrogen phosphate, calcium carbonate, vegetable oil, salt, mineral salt premix, vitamin premix; Wherein corn, wheat bran, soya bean, dregs of beans are pulverized; Cross the 800-100 mesh sieve, subsequent use;
2. mineral salt premix and the abundant mixing of vitamin premix with said weight proportion gets mixed material 1;
Feedstuff that 3. will take by weighing and mixed material 1 are put into and are mixed 15-25min in the mixer, fully behind the mixing, add vegetable oil 0.70-0.80 kilogram, mix 10-15min, make mixture 2.
4. according to preparation method described in the claim 3, the mixture 2 that wherein 3. step is made is squeezed into particle under temperature 90-120 ℃, a 2-10 atmospheric pressure, produce diameter 10-13mm, length 25mm particle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101271666A CN102783571A (en) | 2011-05-17 | 2011-05-17 | Genetically engineered mouse feed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101271666A CN102783571A (en) | 2011-05-17 | 2011-05-17 | Genetically engineered mouse feed |
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| CN102783571A true CN102783571A (en) | 2012-11-21 |
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| CN2011101271666A Pending CN102783571A (en) | 2011-05-17 | 2011-05-17 | Genetically engineered mouse feed |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105028994A (en) * | 2015-06-16 | 2015-11-11 | 北京华阜康生物科技股份有限公司 | ApoE mouse formula feed |
| CN105104883A (en) * | 2015-09-23 | 2015-12-02 | 江苏省协同医药生物工程有限责任公司 | Immunodeficiency mouse feed and preparation method thereof |
| CN105360663A (en) * | 2015-12-21 | 2016-03-02 | 中国农业科学院兰州畜牧与兽药研究所 | Feed special for SPF-stage inbred strain mice |
| CN105685426A (en) * | 2014-11-26 | 2016-06-22 | 广西大学 | Special feed for laboratory mice and preparation method thereof |
| CN107048048A (en) * | 2017-05-27 | 2017-08-18 | 武汉市万千佳兴生物科技有限公司 | A kind of gene editing tests mouse feed |
| CN107259171A (en) * | 2017-07-11 | 2017-10-20 | 芜湖永昌生物科技有限公司 | A kind of biological small white mouse breeding feed |
| CN109007397A (en) * | 2018-08-23 | 2018-12-18 | 广东仁源生物科技有限公司 | A kind of fodder compound and preparation method thereof that can improve mouse heart morphosis and function |
| CN109123079A (en) * | 2018-09-27 | 2019-01-04 | 江苏省协同医药生物工程有限责任公司 | A kind of transgenic experiments mouse feed and preparation method thereof |
| CN113243460A (en) * | 2021-05-17 | 2021-08-13 | 海南大学 | Immunodeficiency mouse feed and preparation method thereof |
| CN113545423A (en) * | 2021-07-09 | 2021-10-26 | 江苏美迪森生物医药有限公司 | Genetic engineering laboratory mouse feed and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101301038A (en) * | 2008-07-07 | 2008-11-12 | 中国医学科学院实验动物研究所 | GLP big and small mouse upgrowth breeding feed |
-
2011
- 2011-05-17 CN CN2011101271666A patent/CN102783571A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101301038A (en) * | 2008-07-07 | 2008-11-12 | 中国医学科学院实验动物研究所 | GLP big and small mouse upgrowth breeding feed |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105685426A (en) * | 2014-11-26 | 2016-06-22 | 广西大学 | Special feed for laboratory mice and preparation method thereof |
| CN105028994A (en) * | 2015-06-16 | 2015-11-11 | 北京华阜康生物科技股份有限公司 | ApoE mouse formula feed |
| CN105028994B (en) * | 2015-06-16 | 2018-11-09 | 北京华阜康生物科技股份有限公司 | A kind of ApoE mouse mixed feed |
| CN105104883A (en) * | 2015-09-23 | 2015-12-02 | 江苏省协同医药生物工程有限责任公司 | Immunodeficiency mouse feed and preparation method thereof |
| CN105360663A (en) * | 2015-12-21 | 2016-03-02 | 中国农业科学院兰州畜牧与兽药研究所 | Feed special for SPF-stage inbred strain mice |
| CN107048048A (en) * | 2017-05-27 | 2017-08-18 | 武汉市万千佳兴生物科技有限公司 | A kind of gene editing tests mouse feed |
| CN107259171A (en) * | 2017-07-11 | 2017-10-20 | 芜湖永昌生物科技有限公司 | A kind of biological small white mouse breeding feed |
| CN109007397A (en) * | 2018-08-23 | 2018-12-18 | 广东仁源生物科技有限公司 | A kind of fodder compound and preparation method thereof that can improve mouse heart morphosis and function |
| CN109123079A (en) * | 2018-09-27 | 2019-01-04 | 江苏省协同医药生物工程有限责任公司 | A kind of transgenic experiments mouse feed and preparation method thereof |
| CN113243460A (en) * | 2021-05-17 | 2021-08-13 | 海南大学 | Immunodeficiency mouse feed and preparation method thereof |
| CN113545423A (en) * | 2021-07-09 | 2021-10-26 | 江苏美迪森生物医药有限公司 | Genetic engineering laboratory mouse feed and preparation method thereof |
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Addressee: Beijing HFK Bioscience Co., Ltd. Shi Liang Document name: Review of business letter |
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Application publication date: 20121121 |