CN102781462A - 新的核苷膦酸酯及类似物 - Google Patents
新的核苷膦酸酯及类似物 Download PDFInfo
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- CN102781462A CN102781462A CN2010800496558A CN201080049655A CN102781462A CN 102781462 A CN102781462 A CN 102781462A CN 2010800496558 A CN2010800496558 A CN 2010800496558A CN 201080049655 A CN201080049655 A CN 201080049655A CN 102781462 A CN102781462 A CN 102781462A
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- Prior art keywords
- alkyl
- chemical compound
- substituted
- hydrogen
- methyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23767909P | 2009-08-27 | 2009-08-27 | |
| US61/237,679 | 2009-08-27 | ||
| PCT/US2010/047054 WO2011031567A1 (en) | 2009-08-27 | 2010-08-27 | Novel nucleoside phosphonates and analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102781462A true CN102781462A (zh) | 2012-11-14 |
Family
ID=43732752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800496558A Pending CN102781462A (zh) | 2009-08-27 | 2010-08-27 | 新的核苷膦酸酯及类似物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20130018018A1 (ja) |
| EP (1) | EP2470194A4 (ja) |
| JP (1) | JP2013503197A (ja) |
| KR (1) | KR20120124383A (ja) |
| CN (1) | CN102781462A (ja) |
| AU (1) | AU2010292500A1 (ja) |
| BR (1) | BR112012008050A2 (ja) |
| CA (1) | CA2772261A1 (ja) |
| IL (1) | IL218276A0 (ja) |
| MX (1) | MX2012002368A (ja) |
| RU (1) | RU2012106469A (ja) |
| WO (1) | WO2011031567A1 (ja) |
| ZA (1) | ZA201202032B (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017011686A1 (en) * | 2015-07-14 | 2017-01-19 | University Of Iowa Research Foundation | Fluorescent prodrugs |
| WO2020210354A1 (en) | 2019-04-08 | 2020-10-15 | EQX Global LLC | Height adjusted seismic base isolation system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5247085A (en) * | 1987-11-30 | 1993-09-21 | Beecham Group P.L.C. | Antiviral purine compounds |
| US20060052346A1 (en) * | 2004-02-17 | 2006-03-09 | Averett Devron R | Nucleoside phosphonate derivatives useful in the treatment of HIV infections |
| WO2006137953A1 (en) * | 2005-04-01 | 2006-12-28 | The Regents Of The Univerisity Of California | Phosphono-pent-2-en-1-yl nucleosides and analogs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4182759A (en) * | 1978-06-05 | 1980-01-08 | Sterling Drug Inc. | Arylalkyl and aryloxyalkyl phosphonates and use as antiviral agents |
| CA1288098C (en) * | 1984-08-24 | 1991-08-27 | Richard L. Tolman | 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity |
| EP0338168A1 (en) * | 1988-04-19 | 1989-10-25 | Merrell Dow Pharmaceuticals Inc. | Phosphonoalkylpurine derivatives |
| US5302585A (en) * | 1990-04-20 | 1994-04-12 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents |
| CZ287745B6 (cs) * | 1991-10-11 | 2001-01-17 | Ústav organické chemie a biochemie AV ČR | Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu |
| JP5320284B2 (ja) * | 2006-05-03 | 2013-10-23 | キメリクス，インコーポレーテッド | 抗ウイルス性または抗増殖性のホスホネート、ヌクレオシドホスホネートおよびヌクレオシドホスフェートの代謝安定性アルコキシアルキルエステル |
-
2010
- 2010-08-27 WO PCT/US2010/047054 patent/WO2011031567A1/en active Application Filing
- 2010-08-27 BR BR112012008050A patent/BR112012008050A2/pt not_active IP Right Cessation
- 2010-08-27 AU AU2010292500A patent/AU2010292500A1/en not_active Abandoned
- 2010-08-27 US US13/391,145 patent/US20130018018A1/en not_active Abandoned
- 2010-08-27 CN CN2010800496558A patent/CN102781462A/zh active Pending
- 2010-08-27 JP JP2012527052A patent/JP2013503197A/ja active Pending
- 2010-08-27 RU RU2012106469/04A patent/RU2012106469A/ru unknown
- 2010-08-27 MX MX2012002368A patent/MX2012002368A/es not_active Application Discontinuation
- 2010-08-27 KR KR1020127007856A patent/KR20120124383A/ko not_active Application Discontinuation
- 2010-08-27 EP EP10815903A patent/EP2470194A4/en not_active Withdrawn
- 2010-08-27 CA CA2772261A patent/CA2772261A1/en not_active Abandoned
-
2012
- 2012-02-23 IL IL218276A patent/IL218276A0/en unknown
- 2012-03-19 ZA ZA2012/02032A patent/ZA201202032B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5247085A (en) * | 1987-11-30 | 1993-09-21 | Beecham Group P.L.C. | Antiviral purine compounds |
| US20060052346A1 (en) * | 2004-02-17 | 2006-03-09 | Averett Devron R | Nucleoside phosphonate derivatives useful in the treatment of HIV infections |
| WO2006137953A1 (en) * | 2005-04-01 | 2006-12-28 | The Regents Of The Univerisity Of California | Phosphono-pent-2-en-1-yl nucleosides and analogs |
Non-Patent Citations (1)
| Title |
|---|
| TOMOYUKI ONISHI等: "Synthesis of phosphonate analogues of the antiviral cyclopropane nucleoside A-5021", 《NUCLEOSIDES,NUCLEOTIDES & NUCLEIC ACIDS》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010292500A1 (en) | 2012-03-15 |
| US20130018018A1 (en) | 2013-01-17 |
| MX2012002368A (es) | 2012-07-25 |
| JP2013503197A (ja) | 2013-01-31 |
| BR112012008050A2 (pt) | 2017-07-04 |
| CA2772261A1 (en) | 2011-03-17 |
| EP2470194A1 (en) | 2012-07-04 |
| RU2012106469A (ru) | 2013-11-10 |
| IL218276A0 (en) | 2012-04-30 |
| ZA201202032B (en) | 2012-12-27 |
| EP2470194A4 (en) | 2013-03-06 |
| WO2011031567A1 (en) | 2011-03-17 |
| KR20120124383A (ko) | 2012-11-13 |
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