CN102727741A - Medicament for treating anxiety disorder - Google Patents
Medicament for treating anxiety disorder Download PDFInfo
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- CN102727741A CN102727741A CN2012102481331A CN201210248133A CN102727741A CN 102727741 A CN102727741 A CN 102727741A CN 2012102481331 A CN2012102481331 A CN 2012102481331A CN 201210248133 A CN201210248133 A CN 201210248133A CN 102727741 A CN102727741 A CN 102727741A
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Abstract
The invention relates to a medicament for treating anxiety disorder. The medicament is prepared by materials according to the following weight ratios: seed of wild jujube, ophiopogon, rehmannia root, fruit of Chinese magnoliavine, cinnamon, root of herbaceous peony, polygala, platycodon grandiflorum, angelica, pericarpium citri reticulatae, bryozoatum, achyranthes, lily, flos albiziae, safflower and rhizoma acori graminei. All ingredients of the medicament for treating anxiety disorder are natural materials, so that the medicament has better safety and is suitable for large-scale generalization in clinic.
Description
Technical field
The present invention relates to the psychosis prevention field, relate in particular to a kind of medicament of treating anxiety neurosis.
Background technology
Anxiety disorder has caused people's extensive concern in recent years, and is paid much attention to and study by the doctor of department of neurology and psychiatric department, and the clinical use from anxiety assessment scale to many anxiolytic drugs is for clinician and anxiety neurosis patient bring dawn and future.But the appearance long and side effect the course of treatment of taking of Western medicine brings worries and worry to clinician and patient again.
Summary of the invention
The purpose of this invention is to provide a kind of medicament of treating anxiety neurosis.
In order to realize the object of the invention; The present invention provides a kind of medicament of treating anxiety neurosis, and it is to be processed by following materials by weight: Semen Ziziphi Spinosae 3-5 part, Radix Ophiopogonis 1-3 part, Radix Rehmanniae 1-3 part, Fructus Schisandrae Chinensis 2-5 part, Cortex Cinnamomi 0.1-0.5 part, Radix Paeoniae Alba 1-3 part, Radix Polygalae 2-5 part, Radix Platycodonis 1-3 part, Radix Angelicae Sinensis 3-5 part, Pericarpium Citri Reticulatae 3-5 part, Pumex 1-3 part, Radix Achyranthis Bidentatae 5-8 part, Bulbus Lilii 1-3 part, Flos Albiziae 1-3 part, Flos Carthami 3-5 part and Rhizoma Acori Graminei 1-3 part.
Preferably, the medicament of treatment anxiety neurosis of the present invention is to be processed by following materials by weight: 1 part of 3 parts of Semen Ziziphi Spinosaes, 2 parts of Radix Ophiopogonis, 3 parts of Radix Rehmanniae, 2 parts of Fructus Schisandrae Chinensis, 0.3 part of Cortex Cinnamomi, 2 parts of the Radix Paeoniae Albas, 4 parts of Radix Polygalaes, 2 parts of Radix Platycodoniss, 4 parts of Radix Angelicae Sinensis, 3 parts of Pericarpium Citri Reticulataes, 2 parts of Pumexs, 6 parts of Radix Achyranthis Bidentataes, 2 parts of Bulbus Liliies, 2 parts of Flos Albiziaes, 4 parts on Flos Carthami and Rhizoma Acori Graminei.
Preferably, medicament of the present invention can be tablet, dispersible tablet, capsule or decoction.Can adopt method well known to those skilled in the art to carry out preparation of medicaments.As required, can add various pharmaceutically acceptable carriers.Described carrier comprises the conventional diluent of pharmaceutical field, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc.Medicament of the present invention in the preparation, selectable filler has: starch, Icing Sugar, calcium phosphate, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
Whole compositions of the medicament of treatment anxiety neurosis of the present invention all are natural materials, and safety is better, are suitable for large-scale promotion clinically.
The specific embodiment
Further specify the present invention through embodiment below.It should be understood that embodiments of the invention are to be used to explain the present invention rather than limitation of the present invention.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the present invention and requires the scope protected.Except as otherwise noted, otherwise the percent among the present invention is percetage by weight.
Embodiment
Take by weighing Semen Ziziphi Spinosae 30 gram, Radix Ophiopogonis 20 gram, Radix Rehmanniae 30 grams, Fructus Schisandrae Chinensis 20 grams, Cortex Cinnamomi 3 grams, the Radix Paeoniae Alba 20 grams, Radix Polygalae 40 grams, Radix Platycodonis 20 grams, Radix Angelicae Sinensis 40 grams, Pericarpium Citri Reticulatae 30 grams, Pumex 20 grams, Radix Achyranthis Bidentatae 60 grams, Bulbus Lilii 20 grams, Flos Albiziae 20 grams, Flos Carthami 40 grams and Rhizoma Acori Graminei 10 grams; Add 2000 milliliters of entry; Heating is 3 hours under the condition that refluxes; Filter, make filtrating be cooled to room temperature, promptly get decoction.
Experimental example
Diagnostic criteria
The performance of anxiety neurosis symptom is arranged clinically; Meet " Chinese mental disorder classification and diagnostic criteria " (psychiatric department branch of Chinese Medical Association. Chinese mental disorder classification and diagnostic criteria .3 version. Jinan: Shandong science tech publishing house; 2001:105) anxiety neurosis diagnostic criteria, and 14 total points >=14 of Hamilton Manifest Anxiety Scale (HAMA) minute (Zhang Mingyuan. psychiatric department scale evaluation handbook. Changsha: the .1993:34-137.121-126.198-202 of Hunan science tech publishing house).
Exclusion standard
(1) gets rid of serious body and nervous system disease (like hyperthyroidism, coronary heart disease, hypertension, cerebrovascular accident etc.); (2) ethanol and drug dependence person; (3) taking antianxiety drug and psychotropic drugs person; (4) anemia of pregnant woman and women breast-feeding their children.
Choose patient's totally 100 examples that meet above-mentioned standard, wherein male 50 examples, women 50 examples, 42 years old mean age, average course of disease 1.5 years.
The preparation decoction is treated for above-mentioned patient among the use embodiment, and one day twice, each 30 milliliters.With 21 days be a course of treatment, carry out two courses of treatment continuously.
Standards of grading
Adopt the HAMA scale to evaluate, before treatment, respectively evaluate 1 time for the 1st, 2,4,6 weekends with treatment.Subtract branch rate evaluation curative effect by HAMA 6 weekends.Scale is evaluated by 3 Psycses, and the average correlation coefficient of scale concordance test is 0.83.
Criterion of therapeutical effect
4 grade standards of drafting according to Society of Neurology and Psychiatry of China.Cure: treating for the 6th weekend, HAMA subtracts branch rate＞75%; Marked improvement: HAMA subtracts branch rate 50%～75%; Progressive: HAMA subtracts branch rate 25%～49%; Invalid: HAMA subtracts branch rate＜25%.
Through the treatment of a course of treatment, find that 73 patients were treating for the 6th weekend, HAMA subtracts branch rate＞75%, meets the criterion of therapeutical effect of healing; 27 patients subtract branch rate 50%～75% at treatment HAMA at the 6th weekend, meet the criterion of therapeutical effect of marked improvement.
Claims (3)
1. medicament of treating anxiety neurosis; It is characterized in that it is to be processed by following materials by weight: Semen Ziziphi Spinosae 3-5 part, Radix Ophiopogonis 1-3 part, Radix Rehmanniae 1-3 part, Fructus Schisandrae Chinensis 2-5 part, Cortex Cinnamomi 0.1-0.5 part, Radix Paeoniae Alba 1-3 part, Radix Polygalae 2-5 part, Radix Platycodonis 1-3 part, Radix Angelicae Sinensis 3-5 part, Pericarpium Citri Reticulatae 3-5 part, Pumex 1-3 part, Radix Achyranthis Bidentatae 5-8 part, Bulbus Lilii 1-3 part, Flos Albiziae 1-3 part, Flos Carthami 3-5 part and Rhizoma Acori Graminei 1-3 part.
2. the medicament of treatment anxiety neurosis according to claim 1; It is characterized in that it is to be processed by following materials by weight: 1 part of 3 parts of Semen Ziziphi Spinosaes, 2 parts of Radix Ophiopogonis, 3 parts of Radix Rehmanniae, 2 parts of Fructus Schisandrae Chinensis, 0.3 part of Cortex Cinnamomi, 2 parts of the Radix Paeoniae Albas, 4 parts of Radix Polygalaes, 2 parts of Radix Platycodoniss, 4 parts of Radix Angelicae Sinensis, 3 parts of Pericarpium Citri Reticulataes, 2 parts of Pumexs, 6 parts of Radix Achyranthis Bidentataes, 2 parts of Bulbus Liliies, 2 parts of Flos Albiziaes, 4 parts on Flos Carthami and Rhizoma Acori Graminei.
3. the medicament of treatment anxiety neurosis according to claim 1 is characterized in that, said medicament is tablet, dispersible tablet, capsule or decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210248133 CN102727741B (en) | 2012-07-18 | 2012-07-18 | Medicament for treating anxiety disorder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210248133 CN102727741B (en) | 2012-07-18 | 2012-07-18 | Medicament for treating anxiety disorder |
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| Publication Number | Publication Date |
|---|---|
| CN102727741A true CN102727741A (en) | 2012-10-17 |
| CN102727741B CN102727741B (en) | 2013-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201210248133 Expired - Fee Related CN102727741B (en) | 2012-07-18 | 2012-07-18 | Medicament for treating anxiety disorder |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709475A (en) * | 2005-06-22 | 2005-12-21 | 贵州同济堂制药股份有限公司 | Chinese medicine formulation for treating extensive anxiety, and its preparing method |
| CN1861116A (en) * | 2005-03-08 | 2006-11-15 | 郑乐建 | Traditional Chinese medicine prepn. for treating anxiety disorders and depressive disorders |
| CN101496865A (en) * | 2009-03-19 | 2009-08-05 | 杨颖� | Chinese medicament preparation for treating depression and anxiety as well as preparation method thereof |
| CN102274423A (en) * | 2011-08-29 | 2011-12-14 | 阮玖琼 | Medicament for treating anxiety |
-
2012
- 2012-07-18 CN CN 201210248133 patent/CN102727741B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861116A (en) * | 2005-03-08 | 2006-11-15 | 郑乐建 | Traditional Chinese medicine prepn. for treating anxiety disorders and depressive disorders |
| CN1709475A (en) * | 2005-06-22 | 2005-12-21 | 贵州同济堂制药股份有限公司 | Chinese medicine formulation for treating extensive anxiety, and its preparing method |
| CN101496865A (en) * | 2009-03-19 | 2009-08-05 | 杨颖� | Chinese medicament preparation for treating depression and anxiety as well as preparation method thereof |
| CN102274423A (en) * | 2011-08-29 | 2011-12-14 | 阮玖琼 | Medicament for treating anxiety |
Non-Patent Citations (2)
| Title |
|---|
| 王秋菊等: "养血安神汤治疗焦虑症200例", 《陕西中医》 * |
| 陈志兴等: "中西医结合治疗焦虑症", 《河南中医》 * |
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| CN102727741B (en) | 2013-08-07 |
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